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Dr. Oriana Ciani

Dr. Oriana Ciani

Postdoctoral Research Fellow

+44 (0) 7575918306

South Cloisters 218

Oriana is a part-time Postdoctoral Research Fellow at the Institue of Health Research and ESMI. She is also part-time research fellow at the Centre for Research in Health and Social Care Managment at Bocconi University (Milan, Italy).

Oriana joined UEMS (previously PCMD) as PhD student in 2011 and she gained her PhD in 2014 from PenTAG. She holds a BSc in Bioengineering (2005) and MSc in Bioengineering/Biomedical signal processing (2008) from Politecnico di Milano. She earned a MSc in Health Economics and Management (2010) from Bocconi University. Her research interests are centred on the methods for comparative effectiveness research and the use of evidence synthesis techniques to inform policy decisions in health care.

 

Qualifications

  • 2014 PhD Health Technology Assessment (UEMS)
  • 2010 MSc Health Economics and Management (Bocconi University)
  • 2008 MSc Bioengineering/ Biomedical Signal Processing (Politecnico di Milano)
  • 2005 BSc Bioengineering (Politecnico di Milano)

Research

Research interests

Oriana has a broad interest in comparative effectiveness research and meta-epidemiological studies, cost-effectiveness analyses as well as evidence synthesis and policy evaluation to inform decision-making. Oriana's specific research interests deal with the validation of surrogate endpoints to support licensing and coverage decisions of health technologies. She has also an interest in methods for the Health Technology Assessment of Medical Devices. 

Oriana has got experience in teaching postgraduate students about systematic reviews, evidence synthesis and methods for health technology assessment. She is coordinator of a module in Public Health for students at the Master in Health Economics, Policy and Management at SDA Bocconi. 

Research projects

  • The role of surrogate outcomes in Health Technology Assessment (PhD Thesis)
  • Methods for Health Technology Assessment of Medical Devices: A European Perspective - MedtecHTA - FP7 305694
  • Mapping Non-Communicable Diseases Research Activities and their impact - FP7 602536

 

Key publications | Publications by category | Publications by year

Publications by category


Books

Ciani O, Tarricone R, Taylor RS (eds)(2016). Comparing Drug and Non-drug Technologies in Comparative Effectiveness Research., Springer. Abstract.  Full text.

Journal articles

Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V (In Press). Trans-arterial radioembolization in intermediate-advanced hepatocellular carcinoma: systematic review and meta-analyses. Oncotarget, 7(44), 72343-72355. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2017). Time to Review the Role of Surrogate end Points in Health Policy: State of the Art and the Way Forward. Value in Health, 20(3), 487-495. Abstract.
Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, et al (2016). A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn Abstract.  Author URL.  Full text.
Ciani O, Armeni P, Boscolo PR, Cavazza M, Jommi C, Tarricone R (2016). De innovatione: the concept of innovation for medical technologies and its implications for healthcare policy-making. Health Policy and Technology, 5(1), 47-64. Full text.
Ciani O, Arendsen E, Romancik M, Lunik R, Costantini E, Di Biase M, Morgia G, Fragalà E, Roman T, Bernat M, et al (2016). Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open, 6(3). Abstract.  Author URL.  Full text.
Ciani O, Pascarelli NA, Giannitti C, Galeazzi M, Meregaglia M, Fattore G, Fioravanti A (2016). Mud-bath therapy in addition to usual care in bilateral knee osteoarthritis: Economic evaluation alongside a randomized controlled trial. Arthritis Care Res (Hoboken) Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2016). Use of surrogate end points in healthcare policy: a proposal for adoption of a validation framework. Nat Rev Drug Discov, 15(7). Author URL.  Full text.
Ciani O, Taylor RS (2016). Validation of surrogate end points for overall survival in advanced colorectal cancer: a harmonized approach is needed. J Clin Epidemiol, 70, 277-278. Author URL.
Generali D, Venturini S, Rognoni C, Ciani O, Pusztai L, Loi S, Jerusalem G, Bottini A, Tarricone R (2015). A network meta-analysis of everolimus plus exemestane versus chemotherapy in the first- and second-line treatment of estrogen receptor-positive metastatic breast cancer. Breast Cancer Res Treat, 152(1), 95-117. Abstract.  Author URL.
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). Health technology assessment of medical devices: a survey of non-European union agencies. Int J Technol Assess Health Care, 31(3), 154-165. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Garside R, Peters J, Saad ED, Stein K, Taylor RS (2015). Meta-analyses of randomized controlled trials show suboptimal validity of surrogate outcomes for overall survival in advanced colorectal cancer. J Clin Epidemiol, 68(7), 833-842. Abstract.  Author URL.  Full text.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis Int J Cardiol. 2014 Jul 1;174(3):683-7. International Journal of Cardiology
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis. Int J Cardiol, 174(3), 683-687. Abstract.  Author URL.
Ciani O, Jommi C (2014). The role of health technology assessment bodies in shaping drug development. Drug Des Devel Ther, 8, 2273-2281. Abstract.  Author URL.  Full text.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad ED, Buyse M, Taylor RS (2014). Validation of surrogate endpoints in advanced solid tumors: systematic review of statistical methods, results, and implications for policy makers. Int J Technol Assess Health Care, 30(3), 312-324. Abstract.  Author URL.  Full text.
Ciani O, Grassi D, Tarricone R (2013). An economic perspective on urinary tract infection: the "costs of resignation". Clin Drug Investig, 33(4), 255-261. Abstract.  Author URL.
Ciani O, Buyse M, Garside R, Pavey T, Stein K, Sterne JAC, Taylor RS (2013). Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study. BMJ, 346 Abstract.  Author URL.
Ciani O, Hoyle M, Pavey T, Cooper C, Garside R, Rudin C, Taylor R (2013). Complete cytogenetic response and major molecular response as surrogate outcomes for overall survival in first-line treatment of chronic myelogenous leukemia: a case-study for technology appraisal on the basis of surrogate outcomes evidence. Value in Health, 6(16), 1081-1090.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Econ, 22(2), 251-252. Abstract.  Author URL.
Pavey T, Hoyle M, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia: Systematic reviews and economic analyses. Health Technology Assessment, 16, 1-278. Abstract.  Author URL.
Mota REM, Tarricone R, Ciani O, Bridges JFP, Drummond M (2012). Determinants of demand for total hip and knee arthroplasty: a systematic literature review. BMC Health Serv Res, 12 Abstract.  Author URL.  Full text.
Ciani O, Tarricone R, Torbica A (2012). Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems?. Health Policy, 108(2-3), 194-202. Abstract.  Author URL.
Ciani O, Taylor RS (2011). A more evidence based approach to the use of surrogate end points in policy making. BMJ, 343 Author URL.
Ciani O, Taylor RS (2011). SURROGATE END POINT SCRUTINY a more evidence based approach to the use of surrogate end points in policy making. BRITISH MEDICAL JOURNAL, 343 Author URL.

Conferences

Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices.  Author URL.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad E, Buyse M, Taylor R (2013). VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS.
Hoyle M, Pavey T, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). GENERAL METHODOLOGICAL ISSUES IN COST-EFFECTIVENESS ANALYSIS INSPIRED BY THE ASSESSMENT OF DASATINIB, NILOTINIB AND IMATINIB FOR 1ST-LINE CHRONIC MYELOID LEUKAEMIA.  Author URL.
Boscolo PR, Ciani O, Torbica A (2012). HOSPITAL-BASED HTA IN ITALY: DIFFUSION AND POTENTIAL IMPACT.  Author URL.
Ciani O, Piccini L, Parini S, Rullo A, Bagnoli F, Marti P, Andreoni G (2008). Pervasive technology in Neonatal Intensive Care Unit: a prototype for newborns unobtrusive monitoring.  Abstract.  Author URL.

Publications by year


In Press

Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V (In Press). Trans-arterial radioembolization in intermediate-advanced hepatocellular carcinoma: systematic review and meta-analyses. Oncotarget, 7(44), 72343-72355. Abstract.  Author URL.  Full text.

2017

Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2017). Time to Review the Role of Surrogate end Points in Health Policy: State of the Art and the Way Forward. Value in Health, 20(3), 487-495. Abstract.

2016

Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, et al (2016). A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn Abstract.  Author URL.  Full text.
Ciani O, Tarricone R, Taylor RS (eds)(2016). Comparing Drug and Non-drug Technologies in Comparative Effectiveness Research., Springer. Abstract.  Full text.
Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices.  Author URL.
Ciani O, Armeni P, Boscolo PR, Cavazza M, Jommi C, Tarricone R (2016). De innovatione: the concept of innovation for medical technologies and its implications for healthcare policy-making. Health Policy and Technology, 5(1), 47-64. Full text.
Ciani O, Arendsen E, Romancik M, Lunik R, Costantini E, Di Biase M, Morgia G, Fragalà E, Roman T, Bernat M, et al (2016). Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open, 6(3). Abstract.  Author URL.  Full text.
Ciani O, Pascarelli NA, Giannitti C, Galeazzi M, Meregaglia M, Fattore G, Fioravanti A (2016). Mud-bath therapy in addition to usual care in bilateral knee osteoarthritis: Economic evaluation alongside a randomized controlled trial. Arthritis Care Res (Hoboken) Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2016). Use of surrogate end points in healthcare policy: a proposal for adoption of a validation framework. Nat Rev Drug Discov, 15(7). Author URL.  Full text.
Ciani O, Taylor RS (2016). Validation of surrogate end points for overall survival in advanced colorectal cancer: a harmonized approach is needed. J Clin Epidemiol, 70, 277-278. Author URL.

2015

Generali D, Venturini S, Rognoni C, Ciani O, Pusztai L, Loi S, Jerusalem G, Bottini A, Tarricone R (2015). A network meta-analysis of everolimus plus exemestane versus chemotherapy in the first- and second-line treatment of estrogen receptor-positive metastatic breast cancer. Breast Cancer Res Treat, 152(1), 95-117. Abstract.  Author URL.
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). Health technology assessment of medical devices: a survey of non-European union agencies. Int J Technol Assess Health Care, 31(3), 154-165. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Garside R, Peters J, Saad ED, Stein K, Taylor RS (2015). Meta-analyses of randomized controlled trials show suboptimal validity of surrogate outcomes for overall survival in advanced colorectal cancer. J Clin Epidemiol, 68(7), 833-842. Abstract.  Author URL.  Full text.

2014

Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis Int J Cardiol. 2014 Jul 1;174(3):683-7. International Journal of Cardiology
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis. Int J Cardiol, 174(3), 683-687. Abstract.  Author URL.
Ciani O, Jommi C (2014). The role of health technology assessment bodies in shaping drug development. Drug Des Devel Ther, 8, 2273-2281. Abstract.  Author URL.  Full text.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad ED, Buyse M, Taylor RS (2014). Validation of surrogate endpoints in advanced solid tumors: systematic review of statistical methods, results, and implications for policy makers. Int J Technol Assess Health Care, 30(3), 312-324. Abstract.  Author URL.  Full text.

2013

Ciani O, Grassi D, Tarricone R (2013). An economic perspective on urinary tract infection: the "costs of resignation". Clin Drug Investig, 33(4), 255-261. Abstract.  Author URL.
Ciani O, Buyse M, Garside R, Pavey T, Stein K, Sterne JAC, Taylor RS (2013). Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study. BMJ, 346 Abstract.  Author URL.
Ciani O, Hoyle M, Pavey T, Cooper C, Garside R, Rudin C, Taylor R (2013). Complete cytogenetic response and major molecular response as surrogate outcomes for overall survival in first-line treatment of chronic myelogenous leukemia: a case-study for technology appraisal on the basis of surrogate outcomes evidence. Value in Health, 6(16), 1081-1090.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Econ, 22(2), 251-252. Abstract.  Author URL.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad E, Buyse M, Taylor R (2013). VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS.

2012

Pavey T, Hoyle M, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia: Systematic reviews and economic analyses. Health Technology Assessment, 16, 1-278. Abstract.  Author URL.
Mota REM, Tarricone R, Ciani O, Bridges JFP, Drummond M (2012). Determinants of demand for total hip and knee arthroplasty: a systematic literature review. BMC Health Serv Res, 12 Abstract.  Author URL.  Full text.
Ciani O, Tarricone R, Torbica A (2012). Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems?. Health Policy, 108(2-3), 194-202. Abstract.  Author URL.
Hoyle M, Pavey T, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). GENERAL METHODOLOGICAL ISSUES IN COST-EFFECTIVENESS ANALYSIS INSPIRED BY THE ASSESSMENT OF DASATINIB, NILOTINIB AND IMATINIB FOR 1ST-LINE CHRONIC MYELOID LEUKAEMIA.  Author URL.
Boscolo PR, Ciani O, Torbica A (2012). HOSPITAL-BASED HTA IN ITALY: DIFFUSION AND POTENTIAL IMPACT.  Author URL.

2011

Ciani O, Taylor RS (2011). A more evidence based approach to the use of surrogate end points in policy making. BMJ, 343 Author URL.
Ciani O, Taylor RS (2011). SURROGATE END POINT SCRUTINY a more evidence based approach to the use of surrogate end points in policy making. BRITISH MEDICAL JOURNAL, 343 Author URL.

2008

Ciani O, Piccini L, Parini S, Rullo A, Bagnoli F, Marti P, Andreoni G (2008). Pervasive technology in Neonatal Intensive Care Unit: a prototype for newborns unobtrusive monitoring.  Abstract.  Author URL.

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