COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr. Oriana Ciani

Dr. Oriana Ciani

Research Fellow

 South Cloisters 

 

South Cloisters, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

Overview

Oriana is 2020 Fulbright Research Scholar at Yale School of Medicine and Yale School of Publiuc Health. She is a part-time Research Fellow at the Institue of Health Research and ESMI. She is Associate Professor of Practice at SDA Bocconi (Milan, Italy).

Oriana joined UEMS (previously PCMD) as PhD student in 2011 and she gained her PhD in 2014 from PenTAG. She holds a BSc in Bioengineering (2005) and MSc in Bioengineering/Biomedical signal processing (2008) from Politecnico di Milano. She earned a MSc in Health Economics and Management (2010) from Bocconi University. Her research interests are centred on the methods for comparative effectiveness research and the use of evidence synthesis techniques to inform policy decisions in health care.

 

Qualifications

  • 2014 PhD Health Technology Assessment (UEMS)
  • 2010 MSc Health Economics and Management (Bocconi University)
  • 2008 MSc Bioengineering/ Biomedical Signal Processing (Politecnico di Milano)
  • 2005 BSc Bioengineering (Politecnico di Milano)

Links

Research

Research interests

Oriana has a broad interest in comparative effectiveness research and meta-epidemiological studies, cost-effectiveness analyses as well as evidence synthesis and policy evaluation to inform decision-making. Oriana's specific research interests deal with the validation of surrogate endpoints to support licensing and coverage decisions of health technologies. She has also an interest in methods for the Health Technology Assessment of Medical Devices. 

Oriana has got experience in teaching postgraduate students about systematic reviews, evidence synthesis and methods for health technology assessment. She is coordinator of a module in Public Health for students at the Master in Health Economics, Policy and Management at SDA Bocconi. 

Research projects

  • The role of surrogate outcomes in Health Technology Assessment (PhD Thesis)
  • Methods for Health Technology Assessment of Medical Devices: A European Perspective - MedtecHTA - FP7 305694
  • Mapping Non-Communicable Diseases Research Activities and their impact - FP7 602536
  • Pushing the boundaries of Cost and Outcome analysis of Medical Technologies (COMED) - #779306

 

Links


Publications

Key publications | Publications by category | Publications by year

Publications by category


Books

Ciani O, Tarricone R, Taylor RS (eds)(2016). Comparing Drug and Non-drug Technologies in Comparative Effectiveness Research., Springer. Abstract.  Full text.

Journal articles

Papanikos T, Thompson J, Abrams K, Staedler N, Ciani O, Taylor R, Bujkiewicz S (In Press). A Bayesian hierarchical meta-analytic method for modelling surrogate. relationships that vary across treatment classes using aggregate data.  Abstract.  Author URL.
Taylor R, Walker S, Smart N, Warren FC, Piepoli MF, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, et al (In Press). Impact of exercise-based rehabilitation in patients with heart failure (ExTraMATCH II) on exercise capacity and health-related quality of life: a and meta-analysis of individual participant data from randomised trials. Journal of the American College of Cardiology Full text.
Taylor R, Walker S, Ciani O, Warren F, Smart N, Piepoli M, Davos C (2019). Exercise Training for Chronic Heart Failure (ExTraMATCH II): Individual participant data meta-analysis of randomised controlled trials. NIHR Journals Library, 23 Full text.
Smart NA, Taylor R, Walker S, Warren F, Ciani O, Davos CH, Piepoli M (2019). Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal. Eur J Prev Cardiol, 26(11), 1229-1231. Author URL.
Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, et al (2019). Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis. Journal of the American College of Cardiology, 73(12), 1430-1443. Abstract.  Full text.
Ciani O, Cucciniello M, Petracca F, Apolone G, Merlini G, Novello S, Pedrazzoli P, Zilembo N, Broglia C, Capelletto E, et al (2019). Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer. BMJ Open, 9(2). Abstract.  Author URL.
Fioravanti A, Ciani O, Cheleschi S, Tenti S (2018). Balneotherapy in knee osteoarthritis: a cost/effectiveness analysis alongside an italian randomized controlled clinical trial. Boletin Sociedad Española Hidrologia Medica, 33(S1), 61-62.
Wallach JD, Ciani O, Pease AM, Gonsalves GS, Krumholz HM, Taylor RS, Ross JS (2018). Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study. BMC Med, 16(1). Abstract.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2018). Cost-effectiveness analysis of treatments involving radioembolization in intermediate-stage hepatocellular carcinoma. J Comp Eff Res, 7(3), 209-221. Abstract.  Author URL.
Ciani O, Epstein D, Rothery C, Taylor RS, Sculpher M (2018). Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms. COST EFFECTIVENESS AND RESOURCE ALLOCATION, 16 Author URL.
Polisena J, Castaldo R, Ciani O, Federici C, Borsci S, Ritrovato M, Clark D, Pecchia L (2018). HEALTH TECHNOLOGY ASSESSMENT METHODS GUIDELINES FOR MEDICAL DEVICES: HOW CAN WE ADDRESS THE GAPS? THE INTERNATIONAL FEDERATION OF MEDICAL AND BIOLOGICAL ENGINEERING PERSPECTIVE. Int J Technol Assess Health Care, 34(3), 276-289. Abstract.  Author URL.
Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, O'Connor C, Whellan D, Keteyian SJ, Coats A, et al (2018). Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials. Eur J Heart Fail, 20(12), 1735-1743. Abstract.  Author URL.  Full text.
Pallari E, Lewison G, Ciani O, Tarricone R, Sommariva S, Begum M, Sullivan R (2018). The impacts of diabetes research from 31 European Countries in 2002 to 2013. RESEARCH EVALUATION, 27(3), 270-282. Author URL.
Rognoni C, Ciani O, Sommariva S, Bargellini I, Bhoori S, Cioni R, Facciorusso A, Golfieri R, Gramenzi A, Mazzaferro V, et al (2018). Trans-arterial radioembolization for intermediate-advanced hepatocellular carcinoma: a budget impact analysis. BMC Cancer, 18(1). Abstract.  Author URL.
Ciani O, Piepoli M, Smart N, Uddin J, Walker S, Warren FC, Zwisler AD, Davos CH, Taylor RS (2018). Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: a Meta-Analysis of Randomized Controlled Trials. JACC: Heart Failure, 6(7), 596-604. Abstract.  Full text.
Schnell-Inderst P, Iglesias CP, Arvandi M, Ciani O, Matteucci Gothe R, Peters J, Blom AW, Taylor RS, Siebert U (2017). A bias-adjusted evidence synthesis of RCT and observational data: the case of total hip replacement. Health Econ, 26 Suppl 1, 46-69. Abstract.  Author URL.  Full text.
Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, et al (2017). A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn, 36(4), 1178-1186. Abstract.  Author URL.  Full text.
Begum M, Lewison G, Sommariva S, Ciani O, Tarricone R, Sullivan R (2017). European diabetes research and its funding, 2002-2013. Diabet Med, 34(10), 1354-1360. Abstract.  Author URL.
Ciani O, Wilcher B, van Giessen A, Taylor RS (2017). Linking the Regulatory and Reimbursement Processes for Medical Devices: the Need for Integrated Assessments. Health Econ, 26 Suppl 1, 13-29. Abstract.  Author URL.
Ciani O, Pascarelli NA, Giannitti C, Galeazzi M, Meregaglia M, Fattore G, Fioravanti A (2017). Mud-Bath Therapy in Addition to Usual Care in Bilateral Knee Osteoarthritis: an Economic Evaluation Alongside a Randomized Controlled Trial. Arthritis Care Res (Hoboken), 69(7), 966-972. Abstract.  Author URL.  Full text.
Stephani V, Sommariva S, Spranger A, Ciani O (2017). Non-communicable diseases: mapping research funding organisations, funding mechanisms and research practices in Italy and Germany. Health Res Policy Syst, 15(1). Abstract.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2017). Real-World Data for the Evaluation of Transarterial Radioembolization versus Sorafenib in Hepatocellular Carcinoma: a Cost-Effectiveness Analysis. Value Health, 20(3), 336-344. Abstract.  Author URL.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2017). Time to Review the Role of Surrogate end Points in Health Policy: State of the Art and the Way Forward. Value in Health, 20(3), 487-495. Abstract.
Ciani O, Armeni P, Boscolo PR, Cavazza M, Jommi C, Tarricone R (2016). De innovatione: the concept of innovation for medical technologies and its implications for healthcare policy-making. Health Policy and Technology, 5(1), 47-64. Full text.
Ciani O, Arendsen E, Romancik M, Lunik R, Costantini E, Di Biase M, Morgia G, Fragalà E, Roman T, Bernat M, et al (2016). Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open, 6(3). Abstract.  Author URL.  Full text.
Berg Brigham K, Darlington M, Wright JSF, Lewison G, Kanavos P, Durand-Zaleski I (2016). Mapping research activity on mental health disorders in Europe: study protocol for the Mapping_NCD project. Health Research Policy and Systems, 14(1).
Compagni A, Fosti G, Longo F, Tozzi V, Amatucci F, Armeni P, Callea G, Ciani O, Cusumano N, Jommi C, et al (2016). SSN fast forward. Proposals to make the most effective, equitable and sustainable National Health Service. Mecosan, 24(97), 101-124.
Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V (2016). Trans-arterial radioembolization in intermediate-advanced hepatocellular carcinoma: systematic review and meta-analyses. Oncotarget, 7(44), 72343-72355. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2016). Use of surrogate end points in healthcare policy: a proposal for adoption of a validation framework. Nat Rev Drug Discov, 15(7). Author URL.  Full text.
Ciani O, Taylor RS (2016). Validation of surrogate end points for overall survival in advanced colorectal cancer: a harmonized approach is needed. J Clin Epidemiol, 70, 277-278. Author URL.
Generali D, Venturini S, Rognoni C, Ciani O, Pusztai L, Loi S, Jerusalem G, Bottini A, Tarricone R (2015). A network meta-analysis of everolimus plus exemestane versus chemotherapy in the first- and second-line treatment of estrogen receptor-positive metastatic breast cancer. Breast Cancer Res Treat, 152(1), 95-117. Abstract.  Author URL.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2015). Erratum: Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis (Int J Cardiol. (2014) 174:3 (683-687) DOI: http://dx.doi.org/10.1016/j.ijcard.2014.04.203). International Journal of Cardiology, 193
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). HEALTH TECHNOLOGY ASSESSMENT OF MEDICAL DEVICES: a SURVEY OF NON-EUROPEAN UNION AGENCIES. International Journal of Technology Assessment in Health Care, 31(3), 154-165. Abstract.
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). Health technology assessment of medical devices: a survey of non-European union agencies. Int J Technol Assess Health Care, 31(3), 154-165. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Garside R, Peters J, Saad ED, Stein K, Taylor RS (2015). Meta-analyses of randomized controlled trials show suboptimal validity of surrogate outcomes for overall survival in advanced colorectal cancer. J Clin Epidemiol, 68(7), 833-842. Abstract.  Author URL.  Full text.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis Int J Cardiol. 2014 Jul 1;174(3):683-7. International Journal of Cardiology
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis. International Journal of Cardiology, 174(3), 683-687. Abstract.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis. Int J Cardiol, 174(3), 683-687. Abstract.  Author URL.
Ciani O, Jommi C (2014). The role of health technology assessment bodies in shaping drug development. Drug Des Devel Ther, 8, 2273-2281. Abstract.  Author URL.  Full text.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad ED, Buyse M, Taylor RS (2014). Validation of surrogate endpoints in advanced solid tumors: systematic review of statistical methods, results, and implications for policy makers. Int J Technol Assess Health Care, 30(3), 312-324. Abstract.  Author URL.  Full text.
Ciani O, Grassi D, Tarricone R (2013). An economic perspective on urinary tract infection: the "costs of resignation". Clin Drug Investig, 33(4), 255-261. Abstract.  Author URL.
Taylor RS (2013). Comparision of treatment effect sizes associated with surrogate outcomes and final patient related outcomes in randomised controlled trials. BMJ: British Medical Journal
Ciani O, Buyse M, Garside R, Pavey T, Stein K, Sterne JAC, Taylor RS (2013). Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study. BMJ, 346 Abstract.  Author URL.
Oriana C, Martin H, Toby P, Chris C, Ruth G, Claudius R, Rod T (2013). Complete Cytogenetic Response and Major Molecular Response as Surrogate Outcomes for Overall Survival in First-Line Treatment of Chronic Myelogenous Leukemia: a Case Study for Technology Appraisal on the Basis of Surrogate Outcomes Evidence. VALUE IN HEALTH, 16(6), 1081-1090. Author URL.
Ciani O, Hoyle M, Pavey T, Cooper C, Garside R, Rudin C, Taylor R (2013). Complete cytogenetic response and major molecular response as surrogate outcomes for overall survival in first-line treatment of chronic myelogenous leukemia: a case-study for technology appraisal on the basis of surrogate outcomes evidence. Value in Health, 6(16), 1081-1090.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Econ, 22(2), 251-252. Abstract.  Author URL.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Economics (United Kingdom), 22(2), 251-252. Abstract.
Pavey T, Hoyle M, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia: Systematic reviews and economic analyses. Health Technology Assessment, 16, 1-278. Abstract.  Author URL.
Mota REM, Tarricone R, Ciani O, Bridges JFP, Drummond M (2012). Determinants of demand for total hip and knee arthroplasty: a systematic literature review. BMC Health Serv Res, 12 Abstract.  Author URL.  Full text.
Ciani O, Tarricone R, Torbica A (2012). Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems?. Health Policy, 108(2-3), 194-202. Abstract.  Author URL.
Ciani O, Taylor RS (2011). A more evidence based approach to the use of surrogate end points in policy making. BMJ, 343 Author URL.
Armeni P, Ciani O, Tarricone R, Palla I, Pierotti F, Turchetti G (2011). Diagnostic, clinical and therapeutic pathway for bariatric surgery: the experience of six Italian centers. Mecosan, 20(79), 9-22. Abstract.
Armeni P, Ciani O, Vella VA, Cavallo MC, Tarricone R (2011). Medical devices in Italy: One sector, many markets. Mecosan, 19(76), 23-40. Abstract.
Ciani O, Taylor RS (2011). SURROGATE END POINT SCRUTINY a more evidence based approach to the use of surrogate end points in policy making. BMJ-BRITISH MEDICAL JOURNAL, 343 Author URL.
Ciani O, Taylor RS (2011). Surrogate end point scrutiny: a more evidence based approach to the use of surrogate end points in policy making. BMJ (Online), 343(7829).
Ciani O, Taylor RS (2011). Treatment effect bias in randomised controlled trials using surrogate outcomes: a preliminary cohort study analysis. Trials, 12(S1).
Cavallo MC, Ciani O, Gugiatti A, Jommi C, Tarricone R (2010). Management of technological innovations in health care: Analysis and comparison of some regional policies in Italy. Mecosan, 19(74), 37-65. Abstract.

Chapters

Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices. In  (Ed) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, Springer International Publishing, 1345-1348.

Conferences

Ciani O, Grigore B, Taylor R (2019). WHAT METHODS ARE APPLIED IN ASSESSESSING THE CLINICAL AND COST EFFECTIVENESS OF HEALTH TECHNOLOGIES BASED ON THE USE OF SURROGATE OUTCOMES: a COMPARISON OF EVALUATION REPORTS ACROSS INTERNATIONAL HEALTH TECHNOLOGY ASSESSMENT AGENCIES.  Author URL.
Ciani O, Meregaglia M, Jayawardana S, Carney C, Salcher M, Williamson P (2018). CLINICAL CORE OUTCOMES SETS IN REAL WORLD DATA.  Author URL.
Ciani O, Walker S, Taylor RS, ExTraMATCH IISCR (2018). IMPACT OF EXERCISE-BASED REHABILITATION IN PATIENTS WITH HEART FAILURE (EXTRAMATCH II) ON EXERCISE CAPACITY AND HEALTH-RELATED QUALITY OF LIFE: a META-ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM RANDOMISED TRIALS.  Author URL.
Ciani O, Federici C, Pecchia L (2018). The evaluation of medical devices: are we getting closer to solve the puzzle? a review of recent trends.  Author URL.
Walker S, Ciani O, Taylor RS, ExTraMATCH IISCR (2017). RESULTS OF INDIVIDUAL PARTICIPANT DATA META-ANALYSIS VS AGGREGATE DATA META-ANALYSIS OF RCTS OF EXERCISE REHABILITATION IN CHRONIC HEART FAILURE.  Author URL.
Borsoi L, Meregaglia M, Ciani O, Tarricone R (2016). COST-EFFECTIVENESS ANALYSIS OF a POTENTIAL TREATMENT INTRODUCTION FOR ANOREXIA-CACHEXIA IN NON-SMALL CELL LUNG CANCER PATIENTS.  Author URL.
Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices.  Author URL.
Ciani O, Epstein D, Rothery C, Taylor RS, Sculpher M (2016). DECISION UNCERTAINTY AND THE NEED FOR FURTHER RESEARCH: a CASE STUDY IN FENESTRATED ENDOVASCULAR ANEURYSM REPAIR FOR COMPLEX ABDOMINAL AORTIC ANEURYSMS.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2016). DIFFUSION OF TRANS-ARTERIAL RADIOEMBOLIZATION FOR THE TREATMENT OF INTERMEDIATE-ADVANCED HEPATOCELLULAR CARCINOMA IN ITALY: a BUDGET IMPACT ANALYSIS.  Author URL.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad E, Buyse M, Taylor R (2013). VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS.
Hoyle M, Pavey T, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). GENERAL METHODOLOGICAL ISSUES IN COST-EFFECTIVENESS ANALYSIS INSPIRED BY THE ASSESSMENT OF DASATINIB, NILOTINIB AND IMATINIB FOR 1ST-LINE CHRONIC MYELOID LEUKAEMIA.  Author URL.
Bassi PF, Tarricone R, Ciani O, Lazzeri M, Romancik M (2012). Glycosaminoglycan therapy - a new approach to the prevention of recurrent urinary tract infections: Summary of presentations given at a satellite symposium at the 27th Annual European Association of Urology Congress, Paris, 24-28 February 2012.  Abstract.
Boscolo PR, Ciani O, Torbica A (2012). HOSPITAL-BASED HTA IN ITALY: DIFFUSION AND POTENTIAL IMPACT.  Author URL.
Andreoni G, Mazzola M, Ciani O, Zambetti M, Romero M, Costa F, Preatoni E (2009). Method for Movement and Gesture Assessment (MMGA) in Ergonomics.  Author URL.
Ciani O, Piccini L, Parini S, Rullo A, Bagnoli F, Marti P, Andreoni G (2008). Pervasive technology in Neonatal Intensive Care Unit: a prototype for newborns unobtrusive monitoring.  Abstract.  Author URL.

Reports

Taylor R, Walker S, Ciani O, Warren FC, Smart NA, Piepoli M, Davos CH (2019). Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Full text.

Publications by year


In Press

Papanikos T, Thompson J, Abrams K, Staedler N, Ciani O, Taylor R, Bujkiewicz S (In Press). A Bayesian hierarchical meta-analytic method for modelling surrogate. relationships that vary across treatment classes using aggregate data.  Abstract.  Author URL.
Taylor R, Walker S, Smart N, Warren FC, Piepoli MF, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, et al (In Press). Impact of exercise-based rehabilitation in patients with heart failure (ExTraMATCH II) on exercise capacity and health-related quality of life: a and meta-analysis of individual participant data from randomised trials. Journal of the American College of Cardiology Full text.

2019

Taylor R, Walker S, Ciani O, Warren F, Smart N, Piepoli M, Davos C (2019). Exercise Training for Chronic Heart Failure (ExTraMATCH II): Individual participant data meta-analysis of randomised controlled trials. NIHR Journals Library, 23 Full text.
Smart NA, Taylor R, Walker S, Warren F, Ciani O, Davos CH, Piepoli M (2019). Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal. Eur J Prev Cardiol, 26(11), 1229-1231. Author URL.
Taylor R, Walker S, Ciani O, Warren FC, Smart NA, Piepoli M, Davos CH (2019). Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Full text.
Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, et al (2019). Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis. Journal of the American College of Cardiology, 73(12), 1430-1443. Abstract.  Full text.
Ciani O, Cucciniello M, Petracca F, Apolone G, Merlini G, Novello S, Pedrazzoli P, Zilembo N, Broglia C, Capelletto E, et al (2019). Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer. BMJ Open, 9(2). Abstract.  Author URL.
Ciani O, Grigore B, Taylor R (2019). WHAT METHODS ARE APPLIED IN ASSESSESSING THE CLINICAL AND COST EFFECTIVENESS OF HEALTH TECHNOLOGIES BASED ON THE USE OF SURROGATE OUTCOMES: a COMPARISON OF EVALUATION REPORTS ACROSS INTERNATIONAL HEALTH TECHNOLOGY ASSESSMENT AGENCIES.  Author URL.

2018

Fioravanti A, Ciani O, Cheleschi S, Tenti S (2018). Balneotherapy in knee osteoarthritis: a cost/effectiveness analysis alongside an italian randomized controlled clinical trial. Boletin Sociedad Española Hidrologia Medica, 33(S1), 61-62.
Ciani O, Meregaglia M, Jayawardana S, Carney C, Salcher M, Williamson P (2018). CLINICAL CORE OUTCOMES SETS IN REAL WORLD DATA.  Author URL.
Wallach JD, Ciani O, Pease AM, Gonsalves GS, Krumholz HM, Taylor RS, Ross JS (2018). Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study. BMC Med, 16(1). Abstract.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2018). Cost-effectiveness analysis of treatments involving radioembolization in intermediate-stage hepatocellular carcinoma. J Comp Eff Res, 7(3), 209-221. Abstract.  Author URL.
Ciani O, Epstein D, Rothery C, Taylor RS, Sculpher M (2018). Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms. COST EFFECTIVENESS AND RESOURCE ALLOCATION, 16 Author URL.
Polisena J, Castaldo R, Ciani O, Federici C, Borsci S, Ritrovato M, Clark D, Pecchia L (2018). HEALTH TECHNOLOGY ASSESSMENT METHODS GUIDELINES FOR MEDICAL DEVICES: HOW CAN WE ADDRESS THE GAPS? THE INTERNATIONAL FEDERATION OF MEDICAL AND BIOLOGICAL ENGINEERING PERSPECTIVE. Int J Technol Assess Health Care, 34(3), 276-289. Abstract.  Author URL.
Ciani O, Walker S, Taylor RS, ExTraMATCH IISCR (2018). IMPACT OF EXERCISE-BASED REHABILITATION IN PATIENTS WITH HEART FAILURE (EXTRAMATCH II) ON EXERCISE CAPACITY AND HEALTH-RELATED QUALITY OF LIFE: a META-ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM RANDOMISED TRIALS.  Author URL.
Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, O'Connor C, Whellan D, Keteyian SJ, Coats A, et al (2018). Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials. Eur J Heart Fail, 20(12), 1735-1743. Abstract.  Author URL.  Full text.
Ciani O, Federici C, Pecchia L (2018). The evaluation of medical devices: are we getting closer to solve the puzzle? a review of recent trends.  Author URL.
Pallari E, Lewison G, Ciani O, Tarricone R, Sommariva S, Begum M, Sullivan R (2018). The impacts of diabetes research from 31 European Countries in 2002 to 2013. RESEARCH EVALUATION, 27(3), 270-282. Author URL.
Rognoni C, Ciani O, Sommariva S, Bargellini I, Bhoori S, Cioni R, Facciorusso A, Golfieri R, Gramenzi A, Mazzaferro V, et al (2018). Trans-arterial radioembolization for intermediate-advanced hepatocellular carcinoma: a budget impact analysis. BMC Cancer, 18(1). Abstract.  Author URL.
Ciani O, Piepoli M, Smart N, Uddin J, Walker S, Warren FC, Zwisler AD, Davos CH, Taylor RS (2018). Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: a Meta-Analysis of Randomized Controlled Trials. JACC: Heart Failure, 6(7), 596-604. Abstract.  Full text.

2017

Schnell-Inderst P, Iglesias CP, Arvandi M, Ciani O, Matteucci Gothe R, Peters J, Blom AW, Taylor RS, Siebert U (2017). A bias-adjusted evidence synthesis of RCT and observational data: the case of total hip replacement. Health Econ, 26 Suppl 1, 46-69. Abstract.  Author URL.  Full text.
Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, et al (2017). A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn, 36(4), 1178-1186. Abstract.  Author URL.  Full text.
Begum M, Lewison G, Sommariva S, Ciani O, Tarricone R, Sullivan R (2017). European diabetes research and its funding, 2002-2013. Diabet Med, 34(10), 1354-1360. Abstract.  Author URL.
Ciani O, Wilcher B, van Giessen A, Taylor RS (2017). Linking the Regulatory and Reimbursement Processes for Medical Devices: the Need for Integrated Assessments. Health Econ, 26 Suppl 1, 13-29. Abstract.  Author URL.
Ciani O, Pascarelli NA, Giannitti C, Galeazzi M, Meregaglia M, Fattore G, Fioravanti A (2017). Mud-Bath Therapy in Addition to Usual Care in Bilateral Knee Osteoarthritis: an Economic Evaluation Alongside a Randomized Controlled Trial. Arthritis Care Res (Hoboken), 69(7), 966-972. Abstract.  Author URL.  Full text.
Stephani V, Sommariva S, Spranger A, Ciani O (2017). Non-communicable diseases: mapping research funding organisations, funding mechanisms and research practices in Italy and Germany. Health Res Policy Syst, 15(1). Abstract.  Author URL.
Walker S, Ciani O, Taylor RS, ExTraMATCH IISCR (2017). RESULTS OF INDIVIDUAL PARTICIPANT DATA META-ANALYSIS VS AGGREGATE DATA META-ANALYSIS OF RCTS OF EXERCISE REHABILITATION IN CHRONIC HEART FAILURE.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2017). Real-World Data for the Evaluation of Transarterial Radioembolization versus Sorafenib in Hepatocellular Carcinoma: a Cost-Effectiveness Analysis. Value Health, 20(3), 336-344. Abstract.  Author URL.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2017). Time to Review the Role of Surrogate end Points in Health Policy: State of the Art and the Way Forward. Value in Health, 20(3), 487-495. Abstract.

2016

Borsoi L, Meregaglia M, Ciani O, Tarricone R (2016). COST-EFFECTIVENESS ANALYSIS OF a POTENTIAL TREATMENT INTRODUCTION FOR ANOREXIA-CACHEXIA IN NON-SMALL CELL LUNG CANCER PATIENTS.  Author URL.
Ciani O, Tarricone R, Taylor RS (eds)(2016). Comparing Drug and Non-drug Technologies in Comparative Effectiveness Research., Springer. Abstract.  Full text.
Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices.  Author URL.
Ciani O, Federici C, Tarricone R (2016). Current and Future Trends in the HTA of Medical Devices. In  (Ed) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, Springer International Publishing, 1345-1348.
Ciani O, Epstein D, Rothery C, Taylor RS, Sculpher M (2016). DECISION UNCERTAINTY AND THE NEED FOR FURTHER RESEARCH: a CASE STUDY IN FENESTRATED ENDOVASCULAR ANEURYSM REPAIR FOR COMPLEX ABDOMINAL AORTIC ANEURYSMS.  Author URL.
Rognoni C, Ciani O, Sommariva S, Tarricone R (2016). DIFFUSION OF TRANS-ARTERIAL RADIOEMBOLIZATION FOR THE TREATMENT OF INTERMEDIATE-ADVANCED HEPATOCELLULAR CARCINOMA IN ITALY: a BUDGET IMPACT ANALYSIS.  Author URL.
Ciani O, Armeni P, Boscolo PR, Cavazza M, Jommi C, Tarricone R (2016). De innovatione: the concept of innovation for medical technologies and its implications for healthcare policy-making. Health Policy and Technology, 5(1), 47-64. Full text.
Ciani O, Arendsen E, Romancik M, Lunik R, Costantini E, Di Biase M, Morgia G, Fragalà E, Roman T, Bernat M, et al (2016). Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open, 6(3). Abstract.  Author URL.  Full text.
Berg Brigham K, Darlington M, Wright JSF, Lewison G, Kanavos P, Durand-Zaleski I (2016). Mapping research activity on mental health disorders in Europe: study protocol for the Mapping_NCD project. Health Research Policy and Systems, 14(1).
Compagni A, Fosti G, Longo F, Tozzi V, Amatucci F, Armeni P, Callea G, Ciani O, Cusumano N, Jommi C, et al (2016). SSN fast forward. Proposals to make the most effective, equitable and sustainable National Health Service. Mecosan, 24(97), 101-124.
Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V (2016). Trans-arterial radioembolization in intermediate-advanced hepatocellular carcinoma: systematic review and meta-analyses. Oncotarget, 7(44), 72343-72355. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Drummond M, Rasi G, Saad ED, Taylor RS (2016). Use of surrogate end points in healthcare policy: a proposal for adoption of a validation framework. Nat Rev Drug Discov, 15(7). Author URL.  Full text.
Ciani O, Taylor RS (2016). Validation of surrogate end points for overall survival in advanced colorectal cancer: a harmonized approach is needed. J Clin Epidemiol, 70, 277-278. Author URL.

2015

Generali D, Venturini S, Rognoni C, Ciani O, Pusztai L, Loi S, Jerusalem G, Bottini A, Tarricone R (2015). A network meta-analysis of everolimus plus exemestane versus chemotherapy in the first- and second-line treatment of estrogen receptor-positive metastatic breast cancer. Breast Cancer Res Treat, 152(1), 95-117. Abstract.  Author URL.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2015). Erratum: Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis (Int J Cardiol. (2014) 174:3 (683-687) DOI: http://dx.doi.org/10.1016/j.ijcard.2014.04.203). International Journal of Cardiology, 193
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). HEALTH TECHNOLOGY ASSESSMENT OF MEDICAL DEVICES: a SURVEY OF NON-EUROPEAN UNION AGENCIES. International Journal of Technology Assessment in Health Care, 31(3), 154-165. Abstract.
Ciani O, Wilcher B, Blankart CR, Hatz M, Rupel VP, Erker RS, Varabyova Y, Taylor RS (2015). Health technology assessment of medical devices: a survey of non-European union agencies. Int J Technol Assess Health Care, 31(3), 154-165. Abstract.  Author URL.  Full text.
Ciani O, Buyse M, Garside R, Peters J, Saad ED, Stein K, Taylor RS (2015). Meta-analyses of randomized controlled trials show suboptimal validity of surrogate outcomes for overall survival in advanced colorectal cancer. J Clin Epidemiol, 68(7), 833-842. Abstract.  Author URL.  Full text.

2014

Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Corrigendum to exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis Int J Cardiol. 2014 Jul 1;174(3):683-7. International Journal of Cardiology
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis. International Journal of Cardiology, 174(3), 683-687. Abstract.
Taylor RS, Piepoli MF, Smart N, Coats AJS, Ellis S, Dalal H, O'Connor CM, Warren FC, Whellan D, Ciani O, et al (2014). Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis. Int J Cardiol, 174(3), 683-687. Abstract.  Author URL.
Ciani O, Jommi C (2014). The role of health technology assessment bodies in shaping drug development. Drug Des Devel Ther, 8, 2273-2281. Abstract.  Author URL.  Full text.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad ED, Buyse M, Taylor RS (2014). Validation of surrogate endpoints in advanced solid tumors: systematic review of statistical methods, results, and implications for policy makers. Int J Technol Assess Health Care, 30(3), 312-324. Abstract.  Author URL.  Full text.

2013

Ciani O, Grassi D, Tarricone R (2013). An economic perspective on urinary tract infection: the "costs of resignation". Clin Drug Investig, 33(4), 255-261. Abstract.  Author URL.
Taylor RS (2013). Comparision of treatment effect sizes associated with surrogate outcomes and final patient related outcomes in randomised controlled trials. BMJ: British Medical Journal
Ciani O, Buyse M, Garside R, Pavey T, Stein K, Sterne JAC, Taylor RS (2013). Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study. BMJ, 346 Abstract.  Author URL.
Oriana C, Martin H, Toby P, Chris C, Ruth G, Claudius R, Rod T (2013). Complete Cytogenetic Response and Major Molecular Response as Surrogate Outcomes for Overall Survival in First-Line Treatment of Chronic Myelogenous Leukemia: a Case Study for Technology Appraisal on the Basis of Surrogate Outcomes Evidence. VALUE IN HEALTH, 16(6), 1081-1090. Author URL.
Ciani O, Hoyle M, Pavey T, Cooper C, Garside R, Rudin C, Taylor R (2013). Complete cytogenetic response and major molecular response as surrogate outcomes for overall survival in first-line treatment of chronic myelogenous leukemia: a case-study for technology appraisal on the basis of surrogate outcomes evidence. Value in Health, 6(16), 1081-1090.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Econ, 22(2), 251-252. Abstract.  Author URL.
Ciani O, Taylor RS (2013). Surrogate, friend or foe? the need for case studies of the use of surrogate outcomes in cost-effectiveness analyses. Health Economics (United Kingdom), 22(2), 251-252. Abstract.
Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad E, Buyse M, Taylor R (2013). VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS.

2012

Pavey T, Hoyle M, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia: Systematic reviews and economic analyses. Health Technology Assessment, 16, 1-278. Abstract.  Author URL.
Mota REM, Tarricone R, Ciani O, Bridges JFP, Drummond M (2012). Determinants of demand for total hip and knee arthroplasty: a systematic literature review. BMC Health Serv Res, 12 Abstract.  Author URL.  Full text.
Ciani O, Tarricone R, Torbica A (2012). Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems?. Health Policy, 108(2-3), 194-202. Abstract.  Author URL.
Hoyle M, Pavey T, Ciani O, Crathorne L, Jones-Hughes T, Cooper C, Osipenko L, Venkatachalam M, Rudin C, Ukoumunne O, et al (2012). GENERAL METHODOLOGICAL ISSUES IN COST-EFFECTIVENESS ANALYSIS INSPIRED BY THE ASSESSMENT OF DASATINIB, NILOTINIB AND IMATINIB FOR 1ST-LINE CHRONIC MYELOID LEUKAEMIA.  Author URL.
Bassi PF, Tarricone R, Ciani O, Lazzeri M, Romancik M (2012). Glycosaminoglycan therapy - a new approach to the prevention of recurrent urinary tract infections: Summary of presentations given at a satellite symposium at the 27th Annual European Association of Urology Congress, Paris, 24-28 February 2012.  Abstract.
Boscolo PR, Ciani O, Torbica A (2012). HOSPITAL-BASED HTA IN ITALY: DIFFUSION AND POTENTIAL IMPACT.  Author URL.

2011

Ciani O, Taylor RS (2011). A more evidence based approach to the use of surrogate end points in policy making. BMJ, 343 Author URL.
Armeni P, Ciani O, Tarricone R, Palla I, Pierotti F, Turchetti G (2011). Diagnostic, clinical and therapeutic pathway for bariatric surgery: the experience of six Italian centers. Mecosan, 20(79), 9-22. Abstract.
Armeni P, Ciani O, Vella VA, Cavallo MC, Tarricone R (2011). Medical devices in Italy: One sector, many markets. Mecosan, 19(76), 23-40. Abstract.
Ciani O, Taylor RS (2011). SURROGATE END POINT SCRUTINY a more evidence based approach to the use of surrogate end points in policy making. BMJ-BRITISH MEDICAL JOURNAL, 343 Author URL.
Ciani O, Taylor RS (2011). Surrogate end point scrutiny: a more evidence based approach to the use of surrogate end points in policy making. BMJ (Online), 343(7829).
Ciani O, Taylor RS (2011). Treatment effect bias in randomised controlled trials using surrogate outcomes: a preliminary cohort study analysis. Trials, 12(S1).

2010

Cavallo MC, Ciani O, Gugiatti A, Jommi C, Tarricone R (2010). Management of technological innovations in health care: Analysis and comparison of some regional policies in Italy. Mecosan, 19(74), 37-65. Abstract.

2009

Andreoni G, Mazzola M, Ciani O, Zambetti M, Romero M, Costa F, Preatoni E (2009). Method for Movement and Gesture Assessment (MMGA) in Ergonomics.  Author URL.

2008

Ciani O, Piccini L, Parini S, Rullo A, Bagnoli F, Marti P, Andreoni G (2008). Pervasive technology in Neonatal Intensive Care Unit: a prototype for newborns unobtrusive monitoring.  Abstract.  Author URL.

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