Journal articles
Wakeling M, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, Flaxman CS, Wyatt RC, Hewat TI, Hopkins JJ, et al (In Press). A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1.
Nature Genetics Abstract.
De Franco E, Owens N, Hattersley A, Flanagan S, Wakeling M, Johnson M, Wright C (In Press). Primate-specific ZNF808 is essential for pancreatic development in humans. Nature Genetics
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, et al (2023). Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR.
Nat Commun,
14(1).
Author URL.
Davies J, Franklin A, Walker E, Owens N, Bray N, Bamford RA, Commin G, Chioza B, Burrage J, Dempster E, et al (2022). 1. DEVELOPMENTAL TRAJECTORIES OF DNA METHYLATION IN NEURAL CELL POPULATIONS IN HUMAN CORTEX AND LINKS TO NEURODEVELOPMENTAL DISORDERS. European Neuropsychopharmacology, 63
Owens NDL, Flanagan SE (2022). Disrupted β-cell-specific gene silencing causes congenital hyperinsulinism.
NATURE GENETICS,
54(11), 1597-1598.
Author URL.
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, et al (2022). Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR.
Nat Commun,
13(1).
Abstract.
Author URL.
Bernard LD, Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, Tachtsidi A, Gil N, Owens N, Bates LE, et al (2022). OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
NUCLEIC ACIDS RESEARCH,
50(13), 7367-7379.
Author URL.
Festuccia N, Owens N, Chervova A, Dubois A, Navarro P (2021). The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.
Development,
148(17).
Abstract.
Coux RX, Owens NDL, Navarro P (2020). Chromatin accessibility and transcription factor binding through the perspective of mitosis.
Transcription,
11(5), 236-240.
Abstract.
Raveux A, Stedman A, Coqueran S, Vandormael-Pournin S, Owens N, Romagnolo B, Cohen-Tannoudji M (2020). Compensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium.
Cell Death Differ,
27(10), 2872-2887.
Abstract.
Author URL.
Owens NDL, De Domenico E, Gilchrist MJ (2019). An RNA-seq protocol for differential expression analysis.
Cold Spring Harbor Protocols,
2019(6), 498-506.
Abstract.
Owens N, Papadopoulou T, Festuccia N, Tachtsidi A, Gonzalez I, Dubois A, Vandormael-Pournin S, Nora EP, Bruneau BG, Cohen-Tannoudji M, et al (2019). CTCF confers local nucleosome resiliency after DNA replication and during mitosis.
Elife,
8 Abstract.
Author URL.
Gentsch GE, Spruce T, Owens NDL, Smith JC (2019). Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals.
Nat Commun,
10(1).
Abstract.
Author URL.
Gentsch GE, Spruce T, Owens NDL, Monteiro RS, Smith JC (2019). The Innate Immune Response of Frog Embryos to Antisense Morpholino Oligomers Depends on Developmental Stage, GC Content and Dose.
Dev Cell,
49(4), 506-507.
Author URL.
Gentsch GE, Owens NDL, Smith JC (2019). The Spatiotemporal Control of Zygotic Genome Activation.
iScience,
16, 485-498.
Abstract.
Author URL.
Heurtier V, Owens N, Gonzalez I, Mueller F, Proux C, Mornico D, Clerc P, Dubois A, Navarro P (2019). The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.
Nat Commun,
10(1).
Abstract.
Author URL.
Festuccia N, Owens N, Papadopoulou T, Gonzalez I, Tachtsidi A, Vandoermel-Pournin S, Gallego E, Gutierrez N, Dubois A, Cohen-Tannoudji M, et al (2019). Transcription factor activity and nucleosome organization in mitosis.
Genome Res,
29(2), 250-260.
Abstract.
Author URL.
Festuccia N, Owens N, Navarro P (2018). Esrrb, an estrogen-related receptor involved in early development, pluripotency, and reprogramming.
FEBS Lett,
592(6), 852-877.
Abstract.
Author URL.
Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC (2018). Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus.
Dev Cell,
44(5), 597-610.e10.
Abstract.
Author URL.
Forouzmand E, Owens NDL, Blitz IL, Paraiso KD, Khokha MK, Gilchrist MJ, Xie X, Cho KWY (2017). Developmentally regulated long non-coding RNAs in Xenopus tropicalis.
Developmental Biology,
426(2), 401-408.
Abstract.
Festuccia N, Gonzalez I, Owens N, Navarro P (2017). Mitotic bookmarking in development and stem cells.
Development,
144(20), 3633-3645.
Abstract.
Author URL.
Robson A, Owens NDL, Baserga SJ, Khokha MK, Griffin JN (2016). Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis.
BMC Dev Biol,
16(1).
Abstract.
Author URL.
Owens NDL, Blitz IL, Lane MA, Patrushev I, Overton JD, Gilchrist MJ, Cho KWY, Khokha MK (2016). Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development.
Cell Reports,
14(3), 632-647.
Abstract.
De Domenico E, Owens NDL, Grant IM, Gomes-Faria R, Gilchrist MJ (2015). Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing.
Developmental Biology,
408(2), 252-268.
Abstract.
DiMeglio P, Duarte JH, Ahlfors H, Owens NDL, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, et al (2014). Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.
Immunity,
40(6), 989-1001.
Abstract.
Collart C, Owens NDL, Bhaw-Rosun L, Cooper B, De Domenico E, Patrushev I, Sesay AK, Smith JN, Smith JC, Gilchrist MJ, et al (2014). High-resolution analysis of gene activity during the Xenopus mid-blastula transition.
Development (Cambridge),
141(9), 1927-1939.
Abstract.
Bewick AJ, Chain FJJ, Zimmerman LB, Sesay A, Gilchrist MJ, Owens NDL, Seifertova E, Krylov V, Macha J, Tlapakova T, et al (2013). A large pseudoautosomal region on the Sex chromosomes of the frog Silurana tropicalis.
Genome Biology and Evolution,
5(6), 1087-1098.
Abstract.
Seifertova E, Zimmerman LB, Gilchrist MJ, Macha J, Kubickova S, Cernohorska H, Zarsky V, Owens NDL, Sesay AK, Tlapakova T, et al (2013). Efficient high-throughput sequencing of a laser microdissected chromosome arm.
BMC Genomics,
14(1).
Abstract.
Gentsch GE, Owens NDL, Martin SR, Piccinelli P, Faial T, Trotter MWB, Gilchrist MJ, Smith JC (2013). InVivo T-Box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuromesodermal Bipotency.
Cell Reports,
4(6), 1185-1196.
Abstract.
Owens NDL, Greensted A, Timmis J, Tyrrell A (2013). The Receptor Density Algorithm.
THEORETICAL COMPUTER SCIENCE,
481, 51-73.
Author URL.
Hilder JA, Owens NDL, Neal MJ, Hickey PJ, Cairns SN, Kilgour DPA, Timmis J, Tyrrell AM (2012). Chemical Detection Using the Receptor Density Algorithm.
IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS,
42(6), 1730-1741.
Author URL.
Owens NDL, Timmis J, Greensted A, Tyrrell A (2010). Elucidation of T cell signalling models.
J Theor Biol,
262(3), 452-470.
Abstract.
Author URL.
Owens N, Stepney S (2010). Investigations of Game of Life Cellular Automata Rules on Penrose Tilings: Lifetime, Ash, and Oscillator Statistics.
JOURNAL OF CELLULAR AUTOMATA,
5(3), 207-225.
Author URL.
Conferences
Gentsch G, Spruce T, Owens N, Smith J (2017). Genome activation in <i>Xenopus tropicalis</i>.
Author URL.
Di Meglio P, Duarte JH, Ahlfors H, Owens NDL, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, et al (2014). Environmental factors transmitted by the aryl hydrocarbon receptor influence the severity of psoriatic inflammation.
Author URL.
Hilder JA, Owens NDL, Hickey PJ, Cairns SN, Kilgour DPA, Timmis J, Tyrrell A (2011). Parameter optimisation in the receptor density algorithm.
Abstract.
Owens NDL, Greensted A, Timmis J, Tyrrell A (2009). T Cell Receptor Signalling Inspired Kernel Density Estimation and Anomaly Detection.
Author URL.
Timmis J, Andrews P, Owens N, Clark E (2008). Immune systems and computation: an interdisciplinary adventure.
Author URL.
Owens NDL, Timmis J, Greensted A, Tyrrell A (2008). Modelling the tunability of early T cell signalling events.
Author URL.
Tyrrell AM, Timmis J, Greensted AJ, Owens ND (2007). Evolvable hardware, a fundamental technology for homeostasis.
Author URL.
Owens ND, Timmis J, Greensted AJ, Tyrell AM (2007). On immune inspired homeostasis for electronic systems.
Author URL.