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Professor Mitra Tavakoli

Associate Professor in Medicine (E&R)

+44 (0)1392 403089

Diabetes and Vascular Research Centre

Overview

Professor Mitra Tavakoli is Associate Professor of Medicine at the University of Exeter and is distinguished for her significant contribution for our understanding of the small fibre neuropathy at diabetes and establishing the technique of “Corneal Confocal Microscopy”. Her recent work elucidated the role of intervention for the regeneration of nerves at type 1 and type 2 diabetes. Her earlier work showed for the first time that CCM could be used to quantify early small nerve fibre damage with good sensitivity and specificity. Her ongoing research into understanding the role of novel intervention at rare models of neuropathies, which initiated a new direction of research. In addition, she is widely respected for training scientists across the world. She spearheads new technologies and contributes to the major UK and international collaborations.

Qualifications

2019 Fellowship Higher Education Academy (FHEA)
2016 Member College of Optometrists (MCOptom)
2010 Fellowship, American Academy of Optometry (FAAO)
2009 Fellowship, British Contact Lens Association (FBCLA)
2008 PhD (Medicine), School of Medicine, University of Manchester
2003 MSc, Optometry, University of Bradford
2000 BSc (Hons) (Distinction), Optometry, Mashad University of Medical Sciences

Research group links

Research

Research interests

The primary focus of my work is based on the assessment of corneal nerve morphology using a relatively new technique of in vivo corneal confocal microscopy as a valid surrogate endpoint for human diabetic neuropathy and in a range of other peripheral neuropathies.

Based on the contributions my colleagues and I have made to this field, we have pioneered the use of In Vivo Corneal Confocal Microscopy (IVCCM or CCM) as an ideal non-invasive surrogate marker for diabetic neuropathy (Tavakoli et al. 2010) and a range of other neuropathies including Idiopathic small fibre neuropathy with focusing on Impaired glucose tolerance (Tavakoli et al. 2011), Fabry disease (Tavakoli et al. 2009) and Charcot-Marie-Tooth disease (Tavakoli et al. 2012). In parallel, we showed for the first time a strong correlation between invasive and none-invasive methods of measuring corneal sensitivity in diabetic patients, which also correlated with the severity of neuropathy (Tavakoli et al. 2007). We showed for the first time that CCM could be used to quantify early small nerve fibre damage with good sensitivity and specificity (Tavakoli et al. 2010). Moreover, we have shown that corneal nerve damage assessed using CCM relates to the severity of intraepidermal nerve fibre loss (the gold standard for small fibre damage) in foot skin biopsies (Quattrini et al. 2007; Chen et al. 2015).

Of significant therapeutic potential we have shown that CCM detects nerve fibre regeneration within six months of pancreas transplantation in type 1 diabetic patients (Mehra et al. 2007; Tavakoli et al. 2013).

Furthermore, in type 2 diabetes, we have demonstrated an improvement in corneal nerve fibre density after improvement in glycaemic control, blood pressure and lipids (Tavakoli et al. 2011). More recently we showed normalizing HbA1c by extensive glycaemic control in type 2 diabetes improves microvascular complications including neuropathy and nephropathy more effectively than standard care, but not retinopathy (Ishibashi et al. 2019). The critical findings of this study impact the standard care of patients.

In a large scale international collaborative project, we established a normative range for corneal nerve parameters ( Tavakoli et al. 2015). This was a milestone at the development of CCM for Clinical use and now widely applies globally.

One of the latest development in my research was assessing the implementation of this clinical technique and to primary care for screening diabetic neuropathy which has been done for the first time worldwide. In this exciting project that was funded by NIHR, CLAHRC, and Industry (Heidelberg Engineering), we assessed the feasibility and acceptability of CCM for patients and practitioners for screening diabetic neuropathy alongside retinopathy program ( Tavakoli et al. 2016).

Currently, the focus of the research is on investigating the longitudinal changes in corneal nerves in diabetic neuropathy that can be detected earlier by CCM. We also investigate the potential application of CCM in a range of other neuropathies.

This translational research represents a huge leap forward in terms of our ability to diagnose, follow the progression and assess therapeutic response in patients with diabetic neuropathy and other peripheral neuropathies and will have an immediate diagnostic impact on patients but also longer-term implications with the development of a novel surrogate marker for assessing new therapies.

Research projects

The Ophthalmic-Vascular lab at the University of Exeter Medical School provides state-of the art clinical research facility for investigating the structural and functional performance of the neural and microvascular structures as a diagnostic and research based model. These ophthalmic markers uses in a range of systemic and vascular conditions in particular diabetes mellitus.

The lab is based at NIHR Exeter Clinical Research Facility at Research, Innovation, Learning and Development (RILD) building.

Grants

Multinational Collaborative Evaluation of Corneal Confocal Microscopy as a Surrogate Endpoint for the Identification and Prediction of Diabetic Neuropathy in Type 1 Diabetes. Funding body: NIH, Role: PI Manchester, the Consortium’s Topic Expert on the CCM procedure; Duration: 2015-2018
Implementation of Corneal Confocal Microscopy to Primary Care optometry practices for Screening Diabetic Neuropathy. Funding body: CLAHRC-NIHR; Role: PI; Duration: 2014-2015
Developing corneal confocal microscopy of human diabetic neuropathy. Funding Body: JDRF; Role: Co-PI; Duration 2008-2012
Corneal Confocal Microscopy: a non-invasive surrogate for diabetic neuropathy; Funding body: NIH; Role: Co-investigator; Duration: 2008-2013

Publications

Key publications | Publications by category | Publications by year

Key publications

Tavakoli M, Ishibashi F (2018). Impact of normoglycaemia in reducing microvascular complications in patients with type 2 diabetes. Author URL.

Ishibashi F, Tavakoli M (2018). Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study. Frontiers in Endocrinology, 9(MAR).

© 2018 Ishibashi and Tavakoli. Aims: Hyperglycemia is associated with an increased risk of microvascular complications in patients with type 2 diabetes. The aim of the present study was to investigate whether the reduction of the levels of HbA1c by tight glycemic control (GC) decreases the rate of microvascular complications and improves the neurological measures in patients with type 2 diabetes. Methods: Detailed clinical and neurological examinations including corneal confocal microscopy (CCM) were performed in 141 Japanese patients with type 2 diabetes and 60 age-matched control subjects at baseline and follow-up with GC for 4 years. Patients were stratified according to the mean HbA1c level during follow-up into good (HbA1c < 53.0 mmol/mol, mean; 47.5 mmol/mol), fair (53.0 mmol/mol ≤ HbA1c < 58.5 mmol/mol, mean; 55.6 mmol/mol), and poor (HbA1c ≥ 58.5 mmol/mol, mean; 68.9 mmol/mol) GC groups with similar HbA1c levels at baseline (84.5-88.2 mmol/mol). Results: at baseline, CCM revealed significant nerve fiber damage in all patients compared to that in controls. The interval changes in most corneal nerve fiber (CNF) parameters and neurophysiological functions were significantly related with the mean HbA1c levels during follow-up. Interestingly, the baseline HbA1c level did not impact on neurological functions at follow-up. Interval changes in neuropathy outcomes were associated with mean clinical factors during follow-up and hypoglycemic strategies. Good GC improved all nerve functions, including CNF branch density and bead, but not the length and main fiber density. Fair GC deteriorated some nerve functions. Poor GC compromised all neuropathy outcomes. Irrespective of GC levels, retinopathy increased after follow-up period, while nephropathy decreased. Conclusion: This study showed that tight GC was beneficial just for nephropathy among microvascular complications. Despite strict GC, the retinopathy progressed in patients with type 2 diabetes. Glucose control did not improve neurophysiological and corneal nerve measurements unless near-normoglycemia was reached.

Abstract.

Tavakoli M, Ferdousi M, Petropoulos IN, Morris J, Pritchard N, Zhivov A, Ziegler D, Pacaud D, Romanchuk K, Perkins BA, et al (2015). Normative Values for Corneal Nerve Morphology Assessed Using Corneal Confocal Microscopy: a Multinational Normative Data Set. Diabetes Care, 38(5), 838-843.

Asghar O, Petropoulos IN, Alam U, Jones W, Jeziorska M, Marshall A, Ponirakis G, Fadavi H, Boulton AJM, Tavakoli M, et al (2014). Corneal Confocal Microscopy Detects Neuropathy in Subjects with Impaired Glucose Tolerance: Figure 1. Diabetes Care, 37(9), 2643-2646.

Tavakoli M, Mitu-Pretorian M, Petropoulos IN, Fadavi H, Asghar O, Alam U, Ponirakis G, Jeziorska M, Marshall A, Efron N, et al (2012). Corneal Confocal Microscopy Detects Early Nerve Regeneration in Diabetic Neuropathy After Simultaneous Pancreas and Kidney Transplantation. Diabetes, 62(1), 254-260.

Tavakoli M, Marshall A, Banka S, Petropoulos IN, Fadavi H, Kingston H, Malik RA (2012). Corneal confocal microscopy detects small-fiber neuropathy in Charcot-Marie-Tooth disease type 1A patients. Muscle & Nerve, 46(5), 698-704.

Publications by category

Journal articles

Lewis EJH, Lovblom LE, Ferdousi M, Halpern EM, Jeziorska M, Pacaud D, Pritchard N, Dehghani C, Edwards K, Srinivasan S, et al (2020). Rapid Corneal Nerve Fiber Loss: a Marker of Diabetic Neuropathy Onset and Progression. Diabetes Care, 43(8), 1829-1835.

Ishibashi F, Tavakoli M (2020). Thinning of Macular Neuroretinal Layers Contributes to Sleep Disorder in Patients with Type 2 Diabetes Without Clinical Evidences of Neuropathy and Retinopathy. Frontiers in Endocrinology, 11

Ishibashi F, Taniguchi M, Kosaka A, Uetake H, Tavakoli M (2019). Improvement in Neuropathy Outcomes with Normalizing HbA1c in Patients with Type 2 Diabetes. Diabetes Care, 42(1), 110-118. Abstract. Author URL.

Perkins BA, Lovblom LE, Bril V, Scarr D, Ostrovski I, Orszag A, Edwards K, Pritchard N, Russell A, Dehghani C, et al (2018). Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study. Diabetologia, 61(8), 1856-1861. Abstract.

Fadavi H, Tavakoli M, Foden P, Ferdousi M, Petropoulos IN, Jeziorska M, Chaturvedi N, Boulton AJM, Malik RA, Abbott CA, et al (2018). Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK. Diabetes Metab Res Rev, 34(7). Abstract. Author URL.

Ishibashi F, Tavakoli M (2018). Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study. Frontiers in Endocrinology, 9(MAR).

Abstract.

Tavakoli M, Yavuz DG, Tahrani AA, Selvarajah D, Bowling FL, Fadavi H (2017). Diabetic Neuropathy: Current Status and Future Prospects. JOURNAL OF DIABETES RESEARCH, 2017 Author URL.

Alam U, Jeziorska M, Petropoulos IN, Asghar O, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Efron N, et al (2017). Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. PLoS One, 12(7). Abstract. Author URL.

Alahmar AT, Petropoulos IN, Ferdousi M, Jones W, Fadavi H, Azmi S, Alam U, Asghar O, Meskiri A, Kheyami A, et al (2017). Expression of skin Glyoxalase-I, advanced glycation end products (AGEs) and receptor (RAGE) in patients with long term type 1 diabetes and diabetic neuropathy. Brunei International Medical Journal, 13(6), 180-193.

Background: Certain group of diabetic patients have been shown to remain free of diabetic complications despite having had diabetes for longer periods. Advanced glycation end products (AGEs), their receptor (RAGE) and Glyoxalase-I (GLO-I) have been implicated in the development of diabetic neuropathy. Objective: to assess the effect of long term type 1 diabetes mellitus on skin distribution and expression of AGEs, RAGE and GLO-I and to correlate these expressions with measures of small and large nerve fibre damage. Methods: Sixty-seven patients with type 1 diabetes mellitus of shorter ( < 15 years, n=20), intermediate (15-40 years, n=25) and longer ( > 40 years, n=22) duration and 34 non-diabetic controls underwent diabetic neuropathy assessment: Neuropathy disability score (NDS), quantitative sensory testing (QST) including vibration pressure and thermal thresholds, nerve conduction studies (NCS), deep breathing heart rate variability (DB-HRV), corneal confocal microscopy (CCM) and intraepidermal nerve fibre density (IENFD) and AGEs, RAGE and GLO-I expression in foot skin biopsies. Results: Compared to controls, type 1 diabetes mellitus patients showed progressively increased skin expression of AGEs, RAGE but progressively lower GLO-I expression with increasing duration of diabetes. Thus patients with longerduration diabetes demonstrated significantly higher skin AGEs and RAGE but lower GLO-I expression than both shorter and intermediate duration diabetic groups. In patients with longer duration diabetes who developed diabetic neuropathy, the skin expression of AGEs and RAGE were significantly higher but GLO-I were significantly lower than those who did not develop diabetic neuropathy. These expressions also correlated with IENFD, CCM and NCS measures. Conclusion: Patients with type 1 diabetes mellitus showed progressively increased skin expression of AGEs, RAGE but progressively lower GLO-I expression with increasing duration of diabetes. Patients with longer duration diabetes who developed diabetic neuropathy have significantly higher skin AGEs and RAGE and decreased GLO-I expression suggesting a potential role for these macromolecules as aetiological, marker of the disease as well as therapeutic target for diabetic neuropathy.

Abstract.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, et al (2017). Network topology of NaV1.7 mutations in sodium channel-related painful disorders. BMC Systems Biology, 11(1).

Azmi S, Ferdousi M, Alam U, Petropoulos IN, Ponirakis G, Marshall A, Asghar O, Fadavi H, Jones W, Tavakoli M, et al (2017). Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study. Diabetologia, 60(6), 1094-1101. Abstract. Author URL.

Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, et al (2017). Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Diabetes, 66(5), 1380-1390. Abstract. Author URL.

Tavakoli M, Fukashi Ishibashi, Rie Kojima, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, Mitra Tavakoli (2017). The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy. Journal of Diabetes Research

Tavakoli M, Chen X, Graham J, Petropoulos I, Malik R (2016). An Automatic Tool for Quantification of Nerve Fibres in Corneal Confocal Microscopy Images. IEEE Trans Biomed Eng, 64, 786-794. Full text.

Ponirakis G, Odriozola MN, Odriozola S, Petropoulos IN, Azmi S, Ferdousi M, Fadavi H, Alam U, Marshall A, Jeziorska M, et al (2016). NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes. Diabetes Technol Ther, 18(12), 800-805. Abstract. Author URL.

Perini I, Tavakoli M, Marshall A, Minde J, Morrison I (2016). Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation. J Neurophysiol, 116(2), 425-430. Abstract. Author URL.

Alahmar A, Petropoulos I, Ferdousi M, Jones W, Fadavi H, Azmi S, Alam U, Asghar O, Meskiri A, Kheyami A, et al (2016). Skin Expression of Advanced Glycation end Products (AGEs), Their Receptor (RAGE) and Glyoxalase-I (GLO-I) in Patients with Diabetic Neuropathy. British Journal of Medicine and Medical Research, 12(5), 1-13.

Ishibashi F, Kojima R, Taniguchi M, Kosaka A, Uetake H, Tavakoli M (2016). The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus. J Diabetes Res, 2016 Abstract. Author URL. Full text.

Tavakoli M, Malik R (2015). 8. The Acceptability and Feasibility of Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children: a Pilot Study (632-P). Nederlands Tijdschrift voor Diabetologie, 13(3), 61-62.

Ponirakis G, Fadavi H, Petropoulos IN, Azmi S, Ferdousi M, Dabbah MA, Kheyami A, Alam U, Asghar O, Marshall A, et al (2015). Automated Quantification of Neuropad Improves its Diagnostic Ability in Patients with Diabetic Neuropathy. Journal of Diabetes Research, 2015, 1-7. Abstract. Full text.

Bagheri A, Borhani M, Salehirad S, Yazdani S, Tavakoli M (2015). Blepharoptosis Associated with Third Cranial Nerve Palsy. Ophthalmic Plastic and Reconstructive Surgery, 31(5), 357-360.

Petropoulos IN, Green P, Chan AWS, Alam U, Fadavi H, Marshall A, Asghar O, Efron N, Tavakoli M, Malik RA, et al (2015). Corneal Confocal Microscopy Detects Neuropathy in Patients with Type 1 Diabetes without Retinopathy or Microalbuminuria. PLOS ONE, 10(4), e0123517-e0123517. Full text.

Ferdousi M, Azmi S, Petropoulos IN, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Malik I, Mansoor W, Malik RA, et al (2015). Corneal Confocal Microscopy Detects Small Fibre Neuropathy in Patients with Upper Gastrointestinal Cancer and Nerve Regeneration in Chemotherapy Induced Peripheral Neuropathy. PLOS ONE, 10(10), e0139394-e0139394. Full text.

Azmi S, Ferdousi M, Petropoulos IN, Ponirakis G, Alam U, Fadavi H, Asghar O, Marshall A, Atkinson AJ, Jones W, et al (2015). Corneal Confocal Microscopy Identifies Small-Fiber Neuropathy in Subjects with Impaired Glucose Tolerance Who Develop Type 2 Diabetes. Diabetes Care, 38(8), 1502-1508.

Tavakoli M, Begum P, McLaughlin J, Malik RA (2015). Corneal confocal microscopy for the diagnosis of diabetic autonomic neuropathy. Muscle & Nerve, 52(3), 363-370.

Alam U, Asghar O, Petropoulos IN, Jeziorska M, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Efron N, et al (2015). Erratum. Small Fiber Neuropathy in Patients with Latent Autoimmune Diabetes in Adults. Diabetes Care 2015;38:e102–e103. Diabetes Care, 38(10), 1992.2-1992.

Lagali N, Poletti E, Patel DV, McGhee CNJ, Hamrah P, Kheirkhah A, Tavakoli M, Petropoulos IN, Malik RA, Utheim TP, et al (2015). Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves. Investigative Opthalmology & Visual Science, 56(9), 5102-5102.

Petropoulos IN, Tavakoli M, Marshall A, Malik RA (2015). Response to Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208. Diabetes, 64(2), e2-e3.

Alam U, Asghar O, Petropoulos IN, Jeziorska M, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Efron N, et al (2015). Small Fiber Neuropathy in Patients with Latent Autoimmune Diabetes in Adults: Table 1. Diabetes Care, 38(7), e102-e103.

Chen X, Graham J, Dabbah MA, Petropoulos IN, Ponirakis G, Asghar O, Alam U, Marshall A, Fadavi H, Ferdousi M, et al (2015). Small Nerve Fiber Quantification in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Comparing Corneal Confocal Microscopy with Intraepidermal Nerve Fiber Density. Diabetes Care, 38(6), 1138-1144.

Kass-Iliyya L, Javed S, Gosal D, Kobylecki C, Marshall A, Petropoulos IN, Ponirakis G, Tavakoli M, Ferdousi M, Chaudhuri KR, et al (2015). Small fiber neuropathy in Parkinson's disease: a clinical, pathological and corneal confocal microscopy study. Parkinsonism & Related Disorders, 21(12), 1454-1460.

Petropoulos IN, Ferdousi M, Marshall A, Alam U, Ponirakis G, Azmi S, Fadavi H, Efron N, Tavakoli M, Malik RA, et al (2015). The Inferior Whorl for Detecting Diabetic Peripheral Neuropathy Using Corneal Confocal Microscopy. Investigative Opthalmology & Visual Science, 56(4), 2498-2498.

Pacaud D, Romanchuk KG, Tavakoli M, Gougeon C, Virtanen H, Ferdousi M, Nettel-Aguirre A, Mah JK, Malik RA (2015). The Reliability and Reproducibility of Corneal Confocal Microscopy in Children. Investigative Opthalmology & Visual Science, 56(9), 5636-5636.

Javed S, Petropoulos IN, Tavakoli M, Malik RA (2014). Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy. Handb Clin Neurol, 126, 275-290. Abstract. Author URL.

Azmi S, Ferdousi M, Petropoulos IN, Ponirakis G, Fadavi H, Tavakoli M, Alam U, Jones W, Marshall A, Jeziorska M, et al (2014). Corneal Confocal Microscopy Shows an Improvement in Small-Fiber Neuropathy in Subjects with Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Compared with Multiple Daily Injection: Table 1. Diabetes Care, 38(1), e3-e4.

Pritchard N, Edwards K, Dehghani C, Fadavi H, Jeziorska M, Marshall A, Petropoulos IN, Ponirakis G, Russell AW, Sampson GP, et al (2014). Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark): Study design and baseline characteristics. Diabetes Research and Clinical Practice, 104(2), 248-256.

Petropoulos IN, Alam U, Fadavi H, Marshall A, Asghar O, Dabbah MA, Chen X, Graham J, Ponirakis G, Boulton AJM, et al (2014). Rapid Automated Diagnosis of Diabetic Peripheral Neuropathy with in Vivo Corneal Confocal Microscopy. Investigative Opthalmology & Visual Science, 55(4), 2071-2071.

Ponirakis G, Petropoulos IN, Fadavi H, Alam U, Asghar O, Marshall A, Tavakoli M, Malik RA (2014). The diagnostic accuracy of Neuropad®for assessing large and small fibre diabetic neuropathy. Diabetic Medicine, 31(12), 1673-1680.

Petropoulos IN, Alam U, Fadavi H, Asghar O, Green P, Ponirakis G, Marshall A, Boulton AJM, Tavakoli M, Malik RA, et al (2013). Corneal Nerve Loss Detected with Corneal Confocal Microscopy is Symmetrical and Related to the Severity of Diabetic Polyneuropathy. Diabetes Care, 36(11), 3646-3651.

Tavakoli M, Petropoulos IN, Malik RA (2013). Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot. J Diabetes Sci Technol, 7(5), 1179-1189. Abstract. Author URL.

Tavakoli M (2013). Corneal confocal microscopy: Beyond corneal defects! Translational studies in diabetes and neurology. Contact Lens and Anterior Eye, 36, e1-e1.

Petropoulos IN, Manzoor T, Morgan P, Fadavi H, Asghar O, Alam U, Ponirakis G, Dabbah MA, Chen X, Graham J, et al (2013). Repeatability of in Vivo Corneal Confocal Microscopy to Quantify Corneal Nerve Morphology. Cornea, 32(5), e83-e89.

Safiarian R, Amini P, Moez EK, Mohammadzadeh F, Tavakoli M, Zayeri F (2013). Risk group classification for bleeding after coronary artery bypass graft surgery: a comparison of the logistic regression with decision tree models. TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 21(3), 574-580. Author URL.

Sellers EAC, Clark I, Tavakoli M, Dean HJ, McGavock J, Malik RA (2013). The acceptability and feasibility of corneal confocal microscopy to detect early diabetic neuropathy in children: a pilot study. Diabetic Medicine, 30(5), 630-631.

Tavakoli M, Petropoulos IN, Malik RA (2012). Assessing corneal nerve structure and function in diabetic neuropathy. Clinical and Experimental Optometry, 95(3), 338-347.

Razmju H, Akhlaghi MR, Tavakoli M (2012). Evaluation of intravitreal injection of bevacizumab (Avastin) in treatment of diabetic macular edema in patients referring to Feiz Eye Hospital, Isfahan, Iran. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 17, S79-S82. Author URL.

Dabbah MA, Graham J, Petropoulos IN, Tavakoli M, Malik RA (2011). Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Medical Image Analysis, 15(5), 738-747.

Tavakoli M, Malik RA (2011). Corneal Confocal Microscopy: a Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies. Journal of Visualized Experiments(47).

Tavakoli M, Kallinikos P, Iqbal A, Herbert A, Fadavi H, Efron N, Boulton AJM, a Malik R (2011). Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabetic Medicine, 28(10), 1261-1267.

Tavakoli M, Boulton AJM, Efron N, Malik RA (2011). Increased Langerhan cell density and corneal nerve damage in diabetic patients: Role of immune mechanisms in human diabetic neuropathy. Contact Lens and Anterior Eye, 34(1), 7-11.

Zhivov A, Stachs O (2011). Re: “Increased Langerhan cell density and corneal nerve damage in diabetic patients: Role of immune mechanisms in human diabetic neuropathy” by Tavakoli et al. Contact Lens and Anterior Eye, 34(2), 98-98.

Efron N, Tavakoli M, Boulton AJM, Malik R (2011). Reply to letter from Dr Zhivov and Dr Stachs. Contact Lens and Anterior Eye, 34(2), 99-99.

Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Marshall A, Finnigan J, Morgan P, Efron N, Boulton AJM, Malik RA, et al (2010). Corneal Confocal Microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care, 33(8), 1792-1797.

Tavakoli M, Marshall A, Pitceathly R, Fadavi H, Gow D, Roberts ME, Efron N, Boulton AJM, Malik RA (2010). Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy. EXPERIMENTAL NEUROLOGY, 223(1), 245-250. Author URL.

Petropoulos I, Fadavi H, Asghar O, Alam U, Ponirakis G, Tavakoli M, Malik R (2010). Diabetic neuropathy: Review of diagnosis and management. Diabetes and Primary Care, 12(3), 165-174. Abstract.

Dabbah MA, Graham J, Petropoulos I, Tavakoli M, Malik RA (2010). Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Med Image Comput Comput Assist Interv, 13(Pt 1), 300-307. Abstract. Author URL.

Tavakoli M, Asghar O, Alam U, Petropoulos IN, Fadavi H, Malik RA (2010). Review: Novel insights on diagnosis, cause and treatment of diabetic neuropathy: focus on painful diabetic neuropathy. Therapeutic Advances in Endocrinology and Metabolism, 1(2), 69-88.

Patel DV, Tavakoli M, Craig JP, Efron N, McGhee CNJ (2009). Corneal Sensitivity and Slit Scanning in Vivo Confocal Microscopy of the Subbasal Nerve Plexus of the Normal Central and Peripheral Human Cornea. Cornea, 28(7), 735-740.

Tavakoli M, Marshall A, Thompson L, Kenny M, Waldek S, Efron N, Malik RA (2009). Corneal confocal microscopy: a novel noninvasive means to diagnose neuropathy in patients with fabry disease. Muscle & Nerve, 40(6), 976-984.

Tavakoli M, Fadavi H, Malik RA (2008). Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy. European Endocrinology, 4, 48-48. Abstract.

Tavakoli M, Malik RA (2008). Management of painful diabetic neuropathy. Expert Opin Pharmacother, 9(17), 2969-2978. Abstract. Author URL.

Tavakoli M, Mojaddidi M, Fadavi H, Malik RA (2008). Pathophysiology and treatment of painful diabetic neuropathy. Current Pain and Headache Reports, 12(3), 192-197.

Quattrini C, Jeziorska M, Tavakoli M, Begum P, Boulton AJM, Malik RA (2008). The Neuropad test: a visual indicator test for human diabetic neuropathy. Diabetologia, 51(6), 1046-1050.

Mehra S, Tavakoli M, Kallinikos PA, Efron N, Boulton AJM, Augustine T, Malik RA (2007). Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation in Patients with Type 1 Diabetes. Diabetes Care, 30(10), 2608-2612.

Tavakoli M, Kallinikos PA, Efron N, Boulton AJM, Malik RA (2007). Corneal Sensitivity is Reduced and Relates to the Severity of Neuropathy in Patients with Diabetes. Diabetes Care, 30(7), 1895-1897.

Dash SK (2007). Corneal Sensitivity is Reduced and Relates to the Severity of Neuropathy in Patients with Diabetes: Response to Tavakoli et al. Diabetes Care, 30(12), e142-e142.

Tavakoli M, Kallinikos PA, Efron N, Boulton AJM, Malik RA (2007). Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes: Response to Dash [16]. Diabetes Care, 30(12).

Greenstein A, Tavakoli M, Mojaddidi M, Al-Sunni A, Matfin G, Malik RA (2007). Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development. British Journal of Diabetes and Vascular Disease, 7(4), 166-171. Abstract.

Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J, Marshall A, Boulton AJM, Efron N, Malik RA, et al (2007). Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy. Diabetes, 56(8), 2148-2154.

Mojaddidi M, Quattrini C, Tavakoli M, Malik RA (2005). Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy. Current Diabetes Reports, 5(6), 417-422.

Tavakoli M (2001). Yekta AA, Tavakoli M, Study of the prevalence of types and amounts of refractive errors in different ages among patients examined at the department of optometry, Mashad University of Medical Sciences, Iranian J. Basic Medical Sciences 2001; 4: 106-115. Iranian J. Basic Medical Sciences, 4, 106-115.

Chapters

Javed S, Petropoulos IN, Tavakoli. M, Malik RA, Tavakoli M (2014). Chapter 20: Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy. In (Ed) Handbook of Clinical Neurology Diabetes and the Nervous System, Elsevier B.V, 275-290.

Tavakoli M (2014). Chapter 3: Neuropatia de fibra fina: novas abordagens diagnósticas. In Hermelinda C. Pedrosa, Lucio Vilar, Andrew J. M. Boulton (Eds.) Neuropatias e Pé Diabético. Abstract.

Tavakoli M, Fadavi H, Malik RA (2014). Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy. In (Ed) Studies in Diabetes, Springer Science & Business Media, 93-105. Abstract.

Tavakoli M, Mojaddidi M, Fadavi H, Malik RA (2009). Chapter 2 Pathogenesis of human diabetic neuropathy. In (Ed) Diabetic Neuropathy, Oxford University Press.

Tavakoli M (2009). Pathogenesis of Human Diabetic Neuropathy. In (Ed) Diabetic Neuropathy, Oxford University Press, USA. Abstract.

Conferences

Tavakoli M, Ishibashi F (2019). Impact of normalised HbA1c on diabetic neuropathy and other microvascular complications in Type 2 diabetes. Author URL.

Tavakoli M, Ishibashi F (2018). Impact of normoglycaemia in reducing microvascular complications in patients with type 2 diabetes. Author URL.

Tavakoli M, Ishibashi F (2018). The Impact of Normoglycemia in Reducing Microvascular Complications in Patients with Type 2 Diabetes-A Follow-Up Study. Author URL.

Lewis EJH, Tavakoli M, Lovblom LE, Halpern EM, Jeziorska M, Pacaud D, Pritchard N, Shtein RM, Efron N, Bril V, et al (2018). The Reference Distribution of Annual Change in Corneal Nerve Fibre Length in Diabetes Mellitus. Author URL.

Osigian CJ, Grace S, Cavuoto KM, Feuer WJ, Tavakoli M, Capo H, Lam BL (2017). Comparison of Non-Sedated Cone Flicker ERG Screening Test and Sedated Conventional ERG in Children. Author URL.

Perkins BA, Lovblom LE, Bril V, Edwards K, Pritchard N, Russell A, Pacaud D, Romanchuk K, Mah J, Boulton AJM, et al (2017). Concurrent Diagnostic Validity of in Vivo Corneal Confocal Microscopy for the Diagnosis of Diabetic Polyneuropathy (DPN): a Pooled Multinational Analysis. Author URL.

Alam U, Petropoulos IN, Fadavi H, Asghar O, Marshall A, Jeziorska M, Azmi S, Pritchard N, Ponirakis G, Edwards K, et al (2017). Corneal Confocal Microscopy Detects a Small-Fibre Neuropathy in Patients with LADA. Author URL.

Tavakoli M, Soiland-Reyes C, Spencer R, Howard S, Boaden R (2017). Corneal Confocal Microscopy for Early Detection of Diabetic Neuropathy in Newly Diagnosed Patients with Type 2 Diabetes Mellitus. Author URL.

Azmi S, Alam U, Ferdousi M, Petropoulos IN, Ponirakis G, Fadavi H, Asghar O, Marshall A, Jones W, Tavakoli M, et al (2017). Corneal Confocal Microscopy: a Viable Surrogate Endpoint for Neuropathy following Simultaneous Pancreas Kidney Transplant. Author URL.

Alam U, Petropoulos IN, Fadavi H, Asghar O, Ponirakis G, Jeziorska M, Marshall A, Tavakoli M, Boulton AJM, Efron N, et al (2017). Corneal confocal microscopy detects improvements in small nerve fibres in subjects with latent autoimmune diabetes in adults with enhanced glycaemic control. Author URL.

Tavakoli M (2017). Evaluation of clinical diagnostic markers for early detection of diabetic neuropathy. Author URL.

Tavakoli M, Howard S, Soiland-Reyes C, Spencer R, Cotterill S, Perry C, Boaden R (2017). IMPLEMENTATION OF CORNEAL CONFOCAL MICROSCOPY FOR SCREENING DIABETIC NEUROPATHY IN PRIMARY CARE: a FEASIBILITY AND ACCEPTABILITY STUDY. Author URL.

Tavakoli M, Manchester E-CG (2017). Screening and Early Detection of Diabetic Neuropathy in Newly Diagnosed Type 2 Diabetes Mellitus. Author URL.

Azmi S, Jeziorska M, Ferdousi M, Petropoulos I, Ponirakis G, Marshall A, Alam U, Fadavi H, Tavakoli M, Asghar O, et al (2017). Simultaneous pancreas kidney transplantation in type 1 diabetes is associated with an early improvement in small fibres. Author URL.

Sankar A, Fadavi H, Ferdousi M, Marshall A, Azmi S, Tavakoli M, Boulton AJM, Malik RA (2016). Corneal Confocal Microscopy Distinguishes between Painful and Painless Diabetic Peripheral Neuropathy. Author URL.

Sankar A, Fadavi H, Ferdousi M, Marshall A, Azmi S, Tavakoli M, Boulton AJM, Malik RA (2016). Corneal confocal microscopy differentiates patients with painful from painless diabetic neuropathy. Author URL.

Tavakoli M, Ferdousi M, Petropoulos L, Morris J, Pritchard N, Romanchuk K, Pacaud D, Perkins BA, Brill V, Ziegler D, et al (2015). A Multinational Normative Dataset for Corneal Nerve Morphology Assessed Using Corneal Confocal Microscopy. Author URL.

Tavakoli M, Ferdousi M, Petropoulos I, Morris J, Pritchard N, Zhivov A, Ziegler D, Pacaud D, Romanchuk K, Perkins B, et al (2015). A multi-national normative dataset for corneal nerve morphological parameters with using corneal confocal microscopy for early diagnosing diabetic neuropathy. Author URL.

Javed S, Ponirakis G, Ferdousi M, Azmi S, Petropoulos I, Tavakoli M, Jeziorska M, Gosal D, Malik RA (2015). Corneal confocal microscopy detects small-fibre damage, particularly in patients with sensory and autonomic ISFN. Author URL.

Tavakoli M, Ferdousi M, Petropoulos I, Fadavi H, Boulton AJM, Malik R (2015). NEURO - DEGENERATION OF CORNEA AND RETINA IN PATIENTS WITH TYPE 1 DIABETES WITHOUT CLINICAL EVIDENCE OF DIABETIC RETINOPATHY AND NEUROPATHY. Author URL.

Azmi S, Ferdousi M, Ponirakis G, Alam U, Petropoulos I, Marshall A, Tavakoli M, Ammori B, Soran H, Malik R, et al (2015). Obesity related neuropathy and the effects of bariatric surgery. Author URL.

Azmi S, Ferdousi M, Ponirakis G, Petropoulos I, Schofield J, Fadavi H, Tavakoli M, Soran H, Malik RA (2015). Obesity related neuropathy and the effects of bariatric surgery. Author URL.

Azmi S, Ferdousi M, Ponirakis G, Petropoulos IN, Alam U, Tavakoli M, Fadavi H, Schofield J, Siahmansur T, Marshall A, et al (2015). Obesity-related Neuropathy and the Effects of Bariatric Surgery. Author URL.

Tavakoli M, Malik R (2015). The Acceptability and Feasibility of Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children: a Pilot Study. Author URL.

Ponirakis G, Odriozola M, Petropoulos IN, Azmi S, Ferdousi M, Fadavi H, Alam U, Asghar O, Mashall A, Tavakoli M, et al (2015). The Diagnostic Validity of Nervecheck: from Functional and Structural Damage of Small and Large Nerve Fibres to Neuropathic Pain. Author URL.

Azmi S, Ponirakis G, Ferdousi M, Petropoulos IN, Alam U, Marshall A, Kheyami A, Fadavi H, Tavakoli M, Boulton AJM, et al (2014). Corneal Confocal Microscopy (CCM) Detects an Improvement in Small Fibre Neuropathy in Subjects with Type 1 Diabetes Mellitus (T1DM) on Continuous Subcutaneous Insulin Infusion (CSII). Author URL.

Alam U, Azmi S, Ferdousi M, Petropoulos IN, Ponirakis G, Fadavi H, Tavakoli M, Marshall A, Boulton AJM, Malik RA, et al (2014). Corneal Confocal Microscopy (CCM) Identifies Early Small Fibre Neuropathy and Predicts the Development of Microalbuminuria in Type 1 Diabetes (T1DM). Author URL.

Tavakoli M, Begum P, Malik RA, Mclaughlin J (2014). Corneal Confocal Microscopy for the Diagnosis of Autonomic Neuropathy in Diabetic Gastroenteropathy. Author URL.

Pacaud D, Romanchuk K, Tavakoli M, Gougeon C, Ferdousi M, Mah JK, Nettel-Aguirre A, Malik RA (2014). Corneal Confocal Microscopy in Children with Type 1 Diabetes: Interobserver Agreement and Repeatability of Nerve Fiber Length Measurements. Author URL.

Azmi S, Petropoulos I, Ferdousi MF, Ponirakis G, Alam U, Fadavi HF, Tavakoli M, Kheyami A, Jeziorska M, Malik RA, et al (2014). Corneal confocal microscopy detects early nerve damage in subjects with impaired glucose tolerance and predicts progression to diabetes. Author URL.

Ponirakis G, Petropoulos I, Fadavi HF, Uazman AU, Asghar OA, Jeziorska M, Ferdousi MF, Marshall AM, Tavakoli M, Malik RAM, et al (2014). Corneal confocal microscopy: a prognostic test for the development of diabetic neuropathy. Author URL.

Alam U, Petropoulos IN, Asghar O, Azmi S, Fadavi H, Marshall A, Tavakoli M, Boulton AJM, Efron N, Malik RA, et al (2014). Diabetic Neuropathy in Patients with Latent Autoimmune Diabetes in Adults (LADA). Author URL.

Tavakoli M, Ferdousi M, Petropoulos IN, Fadavi H, Marshall A, Boulton AJM, Malik RA (2014). Ophthalmic biomarkers of diabetic neuropathy: does neural dysfunction precede vascular changes?. Author URL.

Tavakoli M, Ferdousi M, Petropoulos I, Malik R (2014). Retinal and Corneal neural dysfunction precedes retinopathy and correlates with peripheral neuropathy in patients with Type 1 diabetes. Author URL.

Alahmar A, Fadavi H, Alam U, Asghar O, Petropoulos IN, Ferdousi M, Ponirakis G, Meskiri A, Jones W, Azmi S, et al (2014). Skin AGE/RAGE Expression is Related to the Severity of Diabetic Neuropathy. Author URL.

Alam U, Petropoulos IN, Fadavi H, Asghar O, Marshall A, Ponirakis G, Al-Ahmar A, Kheyami A, Ferdousi M, Azmi S, et al (2013). Corneal Confocal Microscopy is as Proficient as Electrophysiology and Skin Biopsy in Detecting Neuropathy in Subjects with Type 1 Diabetes Mellitus. Author URL.

Tavakoli M, Malik R (2013). Corneal Confocal Microscopy detects neuropathy before retinopathy and nephropathy in children with Type 1 Diabetes: a Preliminary Study. Author URL.

Petropoulos IN, Asghar O, Alam U, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Malik RA (2013). Corneal confocal microscopy detects and tracks progression of neuropathy in subjects with impaired glucose tolerance. Author URL.

Tavakoli M, Mitu-Pretorian M, Petropoulos IN, Fadavi H, Asghar O, Alam U, Ponirakis G, Jeziorska M, Marshall A, Boulton AJM, et al (2013). Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy following simultaneous pancreas and kidney transplantation. Author URL.

Tavakoli M, Malik RA (2013). Corneal confocal microscopy detects neuropathy before retinopathy and nephropathy in children with type 1 diabetes: a preliminary study. Author URL.

Ponirakis G, Petropoulos IP, Fadavi H, Alam UA, Asghar OA, Tavakoli M, Malik RAM (2013). Diagnostic performance of Neuropad response. Author URL.

Azmi S, Alam U, Fadavi H, Asghar O, Petropoulos IN, Ponirakis G, Marshall A, Ferdousi M, Kheyami A, Alahmar A, et al (2013). Early Non-Progressive Small Fibre Neuropathy in Type 2 Diabetes. Author URL.

Efron N, Pritchard N, Edwards K, Sampson G, Russell A, Petropoulos I, Alam U, Fadavi H, Tavakoli M, Malik R, et al (2013). Longitudinal Assessment of Neuropathy in Diabetes using novel ophthalmic MARKers (LANDMark): Baseline findings. Author URL.

Khambalia H, Tavakoli M, Moinuddin Z, van Dellen D, Malik R, Augustine T (2013). Simultaneous Pancreas and Kidney Transplantation leads to Early Nerve Regeneration, as Evaluated by Corneal Confocal Microscopy. Author URL.

Alam U, Petropoulos I, Fadavi H, Asghar O, Marshall A, Ponirakis G, Tavakoli M, Boulton AJ, Malik R (2012). Small Fibre Dysfunction and Vitamin D Deficiency Underlie Painful Diabetic Neuropathy. Author URL.

Tavakoli M, Toosi MHB, Pourreza R, Banaee T, Pourreza HR, IEEE (2011). Automated Optic Nerve Head Detection in Fluorescein Angiography Fundus Images. Author URL.

Asghar O, Petropoulos IN, Alam U, Ponirakis G, Fadavi H, Marshall A, Tavakoli M, Boulton AJM, Malik RA (2011). Corneal Confocal Microscopy Detects Neuropathy in Impaired Glucose Tolerance. Author URL.

Tavakoli M, Petropoulos I, Fadavi H, Alam U, Asghar O, Ponirakis G, Boulton AJM, Malik RA (2011). Corneal nerve fibre damage defined using corneal confocal microscopy in relation to tear film proteomics. Author URL.

Fadavi H, Tavakoli M, Petropolous IN, Caturvedi N, Jeziorska M, Boulton AJM, Malik RA, Abbott CA (2011). Potential explanation for lower incidence of foot ulceration in Asian compared to European patients with type 2 diabetes. Author URL.

Alam U, Fadavi H, Petropoulos I, Ponirakis G, Asghar O, Marshall A, Tavakoli M, Boulton AJM, Malik RA (2011). Protection from Neuropathy: Lessons from Patients with Long Duration Type 1 Diabetes. Author URL.

Quattrini C, Tavakoli M, Kallinikos P, Marshall A, Efron N, Boulton AJM, Malik RA (2010). Comparing skin biopsy with corneal confocal microscopy: diagnostic yield of nerve fiber density. Author URL.

Petropoulos IN, Asghar O, Alam U, Fadavi H, Dabbah MA, Marshall A, Tavakoli M, Boulton AJM, Malik RA (2010). Corneal Confocal Microscopy Detects Neuropathy in Subjects with Impaired Glucose Tolerance. Author URL.

Dabbah MA, Graham J, Petropoulos I, Tavakoli M, Malik RA (2010). Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Abstract.

Tavakoli M, Quattrini C, Begum P, Fadavi H, Boulton AJM, Malik RA (2010). Neuropad and corneal confocal microscopy: new indicators for human diabetic neuropathy. Author URL.

Fadavi H, Tavakoli M, Petropoulos I, Chaturvedi N, Boulton AJM, Malik R, Abbott CA (2010). Predisposing Risk Factors Underlying the Reduced Risk of Foot Ulceration in South Asian Compared to European Patient with Diabetes. Author URL.

Fadavi H, Tavakoli M, Finnigan J, Doyle S, Chaturvedi N, Boulton AJM, Malik RA, Abbott CA (2009). Reduced Small Nerve Fibre Damage May Underlie a Lower Incidence of Foot Ulceration in Asian Compared to European Patients with Diabetes. Author URL.

Tavakoli M, Mehra S, Boulton AJ, Augustine T-T, Malik RA (2008). Corneal confocal microscopy detects early nerve regeneration in type 1 diabetic patients undergoing combined pancreas/kidney transplantation. Author URL.

Pitceathly RDS, Tavakoli M, Marshall A, Roberts ME, Gow D, Efron N, Malik RA (2008). Corneal confocal microscopy to diagnose idiopathic small fibre neuropathy. Author URL.

Tavakoli M, Marshall A, Roberts ME, Malik RA (2008). Corneal diabetic neuropathy: a new hallmark of peripheral diabetic neuropathy. Author URL.

Mehra S, Tavakoli M, Tavakoli A, Malik R, Parajasingam R, Parrott NR, Augustine TA (2007). Corneal confocal microscopy detects early neural regeneration in type 1 diabetics after pancreas transplantation. Author URL.

Tavakoli M, Mehra S, Augustine T, Malik RA (2006). Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation. Author URL.

Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Tomlinson D, Efron N, Boulton AJM, Malik RA (2006). Corneal confocal microscopy is a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Author URL.

Quattrini C, Kallinikos P, Tavakoli M, Jeziorska M, Sheard A, Finnigan J, Boulton A, Efron N, Malik R (2005). Corneal confocal microscopy is superior to skin biopsy as a surrogate marker of human diabetic neuropathy. Author URL.

Publications by year

2020

2019

Tavakoli M, Ishibashi F (2019). Impact of normalised HbA1c on diabetic neuropathy and other microvascular complications in Type 2 diabetes. Author URL.

2018

Tavakoli M, Ishibashi F (2018). Impact of normoglycaemia in reducing microvascular complications in patients with type 2 diabetes. Author URL.

Ishibashi F, Tavakoli M (2018). Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study. Frontiers in Endocrinology, 9(MAR).

Abstract.

Tavakoli M, Ishibashi F (2018). The Impact of Normoglycemia in Reducing Microvascular Complications in Patients with Type 2 Diabetes-A Follow-Up Study. Author URL.

2017

Osigian CJ, Grace S, Cavuoto KM, Feuer WJ, Tavakoli M, Capo H, Lam BL (2017). Comparison of Non-Sedated Cone Flicker ERG Screening Test and Sedated Conventional ERG in Children. Author URL.

Tavakoli M, Yavuz DG, Tahrani AA, Selvarajah D, Bowling FL, Fadavi H (2017). Diabetic Neuropathy: Current Status and Future Prospects. JOURNAL OF DIABETES RESEARCH, 2017 Author URL.

Tavakoli M (2017). Evaluation of clinical diagnostic markers for early detection of diabetic neuropathy. Author URL.

Abstract.

Tavakoli M, Manchester E-CG (2017). Screening and Early Detection of Diabetic Neuropathy in Newly Diagnosed Type 2 Diabetes Mellitus. Author URL.

2016

2015

Bagheri A, Borhani M, Salehirad S, Yazdani S, Tavakoli M (2015). Blepharoptosis Associated with Third Cranial Nerve Palsy. Ophthalmic Plastic and Reconstructive Surgery, 31(5), 357-360.

Tavakoli M, Begum P, McLaughlin J, Malik RA (2015). Corneal confocal microscopy for the diagnosis of diabetic autonomic neuropathy. Muscle & Nerve, 52(3), 363-370.

Azmi S, Ferdousi M, Ponirakis G, Petropoulos I, Schofield J, Fadavi H, Tavakoli M, Soran H, Malik RA (2015). Obesity related neuropathy and the effects of bariatric surgery. Author URL.

Tavakoli M, Malik R (2015). The Acceptability and Feasibility of Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children: a Pilot Study. Author URL.

2014

Javed S, Petropoulos IN, Tavakoli M, Malik RA (2014). Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy. Handb Clin Neurol, 126, 275-290. Abstract. Author URL.

Tavakoli M, Begum P, Malik RA, Mclaughlin J (2014). Corneal Confocal Microscopy for the Diagnosis of Autonomic Neuropathy in Diabetic Gastroenteropathy. Author URL.

Tavakoli M, Fadavi H, Malik RA (2014). Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy. In (Ed) Studies in Diabetes, Springer Science & Business Media, 93-105. Abstract.

2013

Tavakoli M, Malik R (2013). Corneal Confocal Microscopy detects neuropathy before retinopathy and nephropathy in children with Type 1 Diabetes: a Preliminary Study. Author URL.

Tavakoli M, Malik RA (2013). Corneal confocal microscopy detects neuropathy before retinopathy and nephropathy in children with type 1 diabetes: a preliminary study. Author URL.

Tavakoli M, Petropoulos IN, Malik RA (2013). Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot. J Diabetes Sci Technol, 7(5), 1179-1189. Abstract. Author URL.

Tavakoli M (2013). Corneal confocal microscopy: Beyond corneal defects! Translational studies in diabetes and neurology. Contact Lens and Anterior Eye, 36, e1-e1.

Ponirakis G, Petropoulos IP, Fadavi H, Alam UA, Asghar OA, Tavakoli M, Malik RAM (2013). Diagnostic performance of Neuropad response. Author URL.

2012

Tavakoli M, Petropoulos IN, Malik RA (2012). Assessing corneal nerve structure and function in diabetic neuropathy. Clinical and Experimental Optometry, 95(3), 338-347.

2011

Tavakoli M, Toosi MHB, Pourreza R, Banaee T, Pourreza HR, IEEE (2011). Automated Optic Nerve Head Detection in Fluorescein Angiography Fundus Images. Author URL.

Tavakoli M, Malik RA (2011). Corneal Confocal Microscopy: a Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies. Journal of Visualized Experiments(47).

Efron N, Tavakoli M, Boulton AJM, Malik R (2011). Reply to letter from Dr Zhivov and Dr Stachs. Contact Lens and Anterior Eye, 34(2), 99-99.

2010

Petropoulos I, Fadavi H, Asghar O, Alam U, Ponirakis G, Tavakoli M, Malik R (2010). Diabetic neuropathy: Review of diagnosis and management. Diabetes and Primary Care, 12(3), 165-174. Abstract.

Dabbah MA, Graham J, Petropoulos I, Tavakoli M, Malik RA (2010). Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Abstract.

Tavakoli M, Quattrini C, Begum P, Fadavi H, Boulton AJM, Malik RA (2010). Neuropad and corneal confocal microscopy: new indicators for human diabetic neuropathy. Author URL.

2009

Tavakoli M, Mojaddidi M, Fadavi H, Malik RA (2009). Chapter 2 Pathogenesis of human diabetic neuropathy. In (Ed) Diabetic Neuropathy, Oxford University Press.

Tavakoli M (2009). Pathogenesis of Human Diabetic Neuropathy. In (Ed) Diabetic Neuropathy, Oxford University Press, USA. Abstract.

2008

Tavakoli M, Fadavi H, Malik RA (2008). Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy. European Endocrinology, 4, 48-48. Abstract.

Pitceathly RDS, Tavakoli M, Marshall A, Roberts ME, Gow D, Efron N, Malik RA (2008). Corneal confocal microscopy to diagnose idiopathic small fibre neuropathy. Author URL.

Tavakoli M, Marshall A, Roberts ME, Malik RA (2008). Corneal diabetic neuropathy: a new hallmark of peripheral diabetic neuropathy. Author URL.

Tavakoli M, Malik RA (2008). Management of painful diabetic neuropathy. Expert Opin Pharmacother, 9(17), 2969-2978. Abstract. Author URL.

Tavakoli M, Mojaddidi M, Fadavi H, Malik RA (2008). Pathophysiology and treatment of painful diabetic neuropathy. Current Pain and Headache Reports, 12(3), 192-197.

Quattrini C, Jeziorska M, Tavakoli M, Begum P, Boulton AJM, Malik RA (2008). The Neuropad test: a visual indicator test for human diabetic neuropathy. Diabetologia, 51(6), 1046-1050.

2007

Dash SK (2007). Corneal Sensitivity is Reduced and Relates to the Severity of Neuropathy in Patients with Diabetes: Response to Tavakoli et al. Diabetes Care, 30(12), e142-e142.

2006

Tavakoli M, Mehra S, Augustine T, Malik RA (2006). Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation. Author URL.

2005

Mojaddidi M, Quattrini C, Tavakoli M, Malik RA (2005). Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy. Current Diabetes Reports, 5(6), 417-422.

2001

Mitra_Tavakoli Details from cache as at 2020-12-05 02:46:45

Refresh publications

External Engagement and Impact

Awards

2013 Irving Fatt Memorial Award Lecture – British Contact Lens Association (BCLA)
2011 Clinical Science Prize for the Neuropathy study group of the European association for the study of diabetes (EASD)
2008 Best Graduate Student of the year- School of Clinical and Laboratory Sciences-University of Manchester
2006 Best PhD Medical Essay- University of Manchester
2001 Exemplary Researcher of Medical Sciences, Mashad University of Medical Sciences, Ferdowsi Scientific Festival

Editorial responsibilities

2012-date: Associate Editor, Cornea: BMC Ophthalmology
2015-date: Editorial Board “Journal of Neurology, Neurological Science and Disorders”
2014-date: Editorial Board “International Journal of Ophthalmology & Eye Science (IJOES)”
2016-date: Associate Editor for Diabetes in:
- Frontiers in Neuroscience
- Frontiers in Endocrinology
- Frontiers in Public Health
2016-date: Associate Editor, Diabetes and Metabolism; BMC Endocrine Disorders

Invited lectures

Selected:

Mitra Tavakoli, Corneal Confocal Microscopy: A New way of Screening & Early Detection of DN; , Keynote Speaker, British Association of Retinal Screening, September 2018, Bristol, UK
Mitra Tavakoli, July 2016, Modern Approach of Diabetic Neuropathy, Summer School of Diabetic Neuropathy, Neurodiab, Romania
Mitra Tavakoli, July 2016, Lessons from studies in Diabetic Neuropathy, Summer School of Diabetic Neuropathy, Siana, Romania
Mitra Tavakoli, Corneal Confocal Microscopy: A Diagnostic test for early detection Diabetic Neuropathy; April 2015, University of Rostock, Germany
Mitra Tavakoli, ‘Corneal Confocal Microscopy: A new way of detecting Diabetic Neuropathy, Bucharest, Romania, Invited by Romanian Society for Diabetic Neuropathy, October 2014
Mitra Tavakoli, Corneal Physiology: Applications of Corneal Confocal microscopy in Optometry & Ophthalmology, Optometrie’14 conference, Koln, Germany, 28th March 2014
Mitra Tavakoli, BCLA Irving Fatt Lecture 2013- Manchester – Corneal confocal microscopy: Beyond corneal defects! Translational studies in Diabetes and Neurology- 6th June 2013, Manchester Central.
Mitra Tavakoli, Corneal Confocal microscopy: A new way of detecting peripheral neuropathy, University of Flinders, Adelaide, Australia, August 2012
Mitra Tavakoli, Advances in diagnosis of diabetic neuropathy, Endocrine Group, University of Marmara, March 2012- Istanbul, Turkey
Mitra Tavakoli, Corneal Confocal microscopy: A new way of detecting peripheral neuropathy, Young Investigator Clinical Prize talk- Neurodiab meeting- September 2011- Porto- Portugal.
Mitra Tavakoli, “New insights into Diagnosis of Diabetic Neuropathy” – JDRF Research Meeting- Cork (Ireland) - Invited by JDRF & Diabetes Ireland Research Alliance– March 2011.
Mitra Tavakoli, "Interactions of Langerhans cells with the subbasal nerve layer in diabetic neuropathy". Invited by Prof. Nathan Efron to visit and give a talk in Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, Australia, July 2010.
Mitra Tavakoli, “Corneal confocal microscopy: a non- invasive surrogate for diabetic retinopathy”. University of Cardiff, School of Optometry & Vision Sciences. June 2010.
Mitra Tavakoli, New advances in diagnosis of diabetic neuropathy, International Congress in Diabetes and its Complications (ICDC), May 2009, Yazd, Iran.
Mitra Tavakoli, Early detection of nerve fibre repair using corneal Confocal microscopy following pancreas transplantation in diabetic patients with severe neuropathy; BCLA conference, June 2007, Manchester
Mitra Tavakoli, Corneal confocal microscopy: A novel non-invasive surrogate marker of diabetic neuropathy; EASD 11th Oxford Workshop: Regeneration in Diabetes Complications, July 2006, Oxford, UK.
Mitra Tavakoli, Corneal confocal microscopy: A novel non-invasive surrogate marker of diabetic neuropathy. Representing the University of Manchester in “The 3rd International Best PhD Medical Essays” Hradovec Kralovec, Czech Republic, 29 November- December 2006.

Other

Link to Google Scholar
Link to ORCiD

Teaching

Diabetes Microvascular Complications
Ophthalmic Imaging
Translational Research

Medical Sciences (BSc)

CSC1001; CSC2001; CSC4001; Integrated Clinical Science (ICS 1, 2, 4)
CSC4002- Project Supervisior- Expanding Horizons 4
CSC2006- Lecturer- Vision- Foundations in Neuroscience
CSC4019 - Lecturer- Translational Medical Sciences
CSC4008- Lecturer- Vision - Frontiers in Neuroscience
Professional Training Year provider ( Supervisior)
Academic Tutor

Medicine (BMBS)

PBL
LSRC

Postgraduate

PhD/MPhil supervisor

Supervision / Group

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Profile

Professor Mitra Tavakoli

Associate Professor in Medicine (E&R)

Overview

Qualifications

Links

Research group links

Research

Research interests

Research projects

Links

Publications

Key publications

Abstract:Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

Publications by category

Journal articles

Abstract:Improvement in Neuropathy Outcomes with Normalizing HbA1c in Patients with Type 2 Diabetes.

Abstract:Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study

Abstract:Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.

Abstract:Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

Abstract:Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy.

Abstract:Expression of skin Glyoxalase-I, advanced glycation end products (AGEs) and receptor (RAGE) in patients with long term type 1 diabetes and diabetic neuropathy

Abstract:Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study.

Abstract:Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.

Abstract:NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes.

Abstract:Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation.

Abstract:The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus.

Abstract:Automated Quantification of Neuropad Improves its Diagnostic Ability in Patients with Diabetic Neuropathy

Abstract:Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy.

Abstract:Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot.

Abstract:Diabetic neuropathy: Review of diagnosis and management

Abstract:Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images.

Abstract:Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy

Abstract:Management of painful diabetic neuropathy.

Abstract:Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

Chapters

Abstract:Chapter 3: Neuropatia de fibra fina: novas abordagens diagnósticas

Abstract:Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy.

Abstract:Pathogenesis of Human Diabetic Neuropathy

Conferences

Abstract:Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images

Publications by year

2020

2019

Abstract:Improvement in Neuropathy Outcomes with Normalizing HbA1c in Patients with Type 2 Diabetes.

2018

Abstract:Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study

Abstract:Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.

Abstract:Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

2017

Abstract:Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy.

Abstract:Expression of skin Glyoxalase-I, advanced glycation end products (AGEs) and receptor (RAGE) in patients with long term type 1 diabetes and diabetic neuropathy

Abstract:Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study.

Abstract:Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.

2016

Abstract:NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes.

Abstract:Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation.

Abstract:The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus.

2015

Abstract:Automated Quantification of Neuropad Improves its Diagnostic Ability in Patients with Diabetic Neuropathy

2014

Abstract:Chapter 3: Neuropatia de fibra fina: novas abordagens diagnósticas

Abstract:Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy.

Abstract:Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy.

2013

Abstract:Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot.

2012

2011

2010

Abstract:Diabetic neuropathy: Review of diagnosis and management

Abstract:Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images

Abstract:Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images.

2009

Abstract:Pathogenesis of Human Diabetic Neuropathy

2008

Abstract:Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy

Abstract:Management of painful diabetic neuropathy.

2007

Abstract:Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

2006

Abstract:
Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

Abstract:
Improvement in Neuropathy Outcomes with Normalizing HbA1c in Patients with Type 2 Diabetes.

Abstract:
Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study

Abstract:
Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.

Abstract:
Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

Abstract:
Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy.

Abstract:
Expression of skin Glyoxalase-I, advanced glycation end products (AGEs) and receptor (RAGE) in patients with long term type 1 diabetes and diabetic neuropathy

Abstract:
Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study.

Abstract:
Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.

Abstract:
NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes.

Abstract:
Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation.

Abstract:
The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus.

Abstract:
Automated Quantification of Neuropad Improves its Diagnostic Ability in Patients with Diabetic Neuropathy

Abstract:
Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy.

Abstract:
Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot.

Abstract:
Diabetic neuropathy: Review of diagnosis and management

Abstract:
Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images.

Abstract:
Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy

Abstract:
Management of painful diabetic neuropathy.

Abstract:
Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

Abstract:
Chapter 3: Neuropatia de fibra fina: novas abordagens diagnósticas

Abstract:
Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy.

Abstract:
Pathogenesis of Human Diabetic Neuropathy

Abstract:
Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images

Abstract:
Improvement in Neuropathy Outcomes with Normalizing HbA1c in Patients with Type 2 Diabetes.

Abstract:
Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study

Abstract:
Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.

Abstract:
Impact of normoglycemia in reducing microvascular complications in patients with type 2 diabetes: a follow-up study

Abstract:
Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy.

Abstract:
Expression of skin Glyoxalase-I, advanced glycation end products (AGEs) and receptor (RAGE) in patients with long term type 1 diabetes and diabetic neuropathy

Abstract:
Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study.

Abstract:
Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.

Abstract:
NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes.

Abstract:
Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation.

Abstract:
The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus.

Abstract:
Automated Quantification of Neuropad Improves its Diagnostic Ability in Patients with Diabetic Neuropathy

Abstract:
Chapter 3: Neuropatia de fibra fina: novas abordagens diagnósticas

Abstract:
Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy.

Abstract:
Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy.

Abstract:
Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot.

Abstract:
Diabetic neuropathy: Review of diagnosis and management

Abstract:
Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images

Abstract:
Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images.

Abstract:
Pathogenesis of Human Diabetic Neuropathy

Abstract:
Advances in the Diagnosis and Treatment of Painful Diabetic Neuropathy

Abstract:
Management of painful diabetic neuropathy.

Abstract:
Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development