COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Mark Russell

Dr Mark Russell

Research Fellow

 01392 408224

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Qualifications

  • Bsc (Hons) Biological Sciences
  • MRes Marine Biology
  • PhD

Research

Research grants

  • 2015 EFSD
    Subcellular localisation of cell cycle regulatory proteins in human beta-cells: is the current paradigm correct?

Publications

Key publications | Publications by category | Publications by year

Key publications


Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (In Press). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.

Publications by category


Journal articles

Russell MA, PIgors M, Houssen M, Manson A, Kelsell D, Longhurst H, Morgan NG (In Press). A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID). Clinical Immunology Full text.
Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, et al (In Press). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Abstract.  Author URL.  Full text.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (In Press). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (In Press). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemburg MK, et al (In Press). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes Full text.
Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2018). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes. Diabetologia Abstract.  Author URL.
Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, et al (2018). Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Neurol Genet, 4(2). Abstract.  Author URL.  Full text.
Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, et al (2017). Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain, 140(11), 2838-2850. Abstract.  Author URL.
Hodik M, Anagandula M, Fuxe J, Krogvold L, Dahl-Jørgensen K, Hyöty H, Sarmiento L, Frisk G, Atkinson M, Pugliese A, et al (2016). Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. BMJ Open Diabetes Research and Care, 4(1). Abstract.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Nisr RB, Russell MA, Chrachri A, Moody AJ, Gilpin ML (2011). Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic beta-cells. FEMS Immunol Med Microbiol, 63, 217-227. Abstract.  Author URL.
Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK. ISLETS, 2(4), 236-239. Author URL.
Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.
Taylor AR, Russell MA, Harper GM, Collins TFT, Brownlee C (2007). Dynamics of formation and secretion of heterococcoliths by Coccolithus pelagicus ssp braarudii. European Journal of Phycology, 42, 125-136. Abstract.

Publications by year


In Press

Russell MA, PIgors M, Houssen M, Manson A, Kelsell D, Longhurst H, Morgan NG (In Press). A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID). Clinical Immunology Full text.
Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, et al (In Press). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Abstract.  Author URL.  Full text.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (In Press). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (In Press). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemburg MK, et al (In Press). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes Full text.

2018

Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2018). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes. Diabetologia Abstract.  Author URL.
Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, et al (2018). Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Neurol Genet, 4(2). Abstract.  Author URL.  Full text.

2017

Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, et al (2017). Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain, 140(11), 2838-2850. Abstract.  Author URL.

2016

Hodik M, Anagandula M, Fuxe J, Krogvold L, Dahl-Jørgensen K, Hyöty H, Sarmiento L, Frisk G, Atkinson M, Pugliese A, et al (2016). Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. BMJ Open Diabetes Research and Care, 4(1). Abstract.

2015

Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.

2014

Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.

2013

Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.

2011

Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Nisr RB, Russell MA, Chrachri A, Moody AJ, Gilpin ML (2011). Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic beta-cells. FEMS Immunol Med Microbiol, 63, 217-227. Abstract.  Author URL.

2010

Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK. ISLETS, 2(4), 236-239. Author URL.

2009

Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.

2007

Taylor AR, Russell MA, Harper GM, Collins TFT, Brownlee C (2007). Dynamics of formation and secretion of heterococcoliths by Coccolithus pelagicus ssp braarudii. European Journal of Phycology, 42, 125-136. Abstract.

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