COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Mark Russell

Dr Mark Russell

Lecturer

 01392 408282

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Qualifications

  • Bsc (Hons) Biological Sciences
  • MRes Marine Biology
  • PhD

Career

My BSc and MRes were conducted at the University of Plymouth, the latter in conjuction with the Marine Biological Association of the UK where I studies plankton during my research project. Although this was facinating, I moved from Marine Biology to Human Health in 2005 when I joined Prof. Noel Morgan's Islet Biology Team as a lab technician at the then Peninsula Medical School. Since that time I have completed my PhD under the guidance of Prof. Morgan,  was then funded as a post-doc in the team thereafter. I was appointed to a tenured E & R Lecturer position at the University of Exeter Medical School in 2019.

 

Research group links

Research

Research interests

My research interests centre around the study of the JAK/STAT signal transduction cascade in pancreatic islet cells, both in the context of health and disease, particularly diabetes. These pathways are activated by an array of differential cytokines, growth factors and hormones, and culminate in either beneficial and detrimental effects cells depending on the identity of the initial stimuli. I have studied the impact of a number of the soluble factors which stimulate this pathway on measurements of beta-cell health and function (e.g. viability, insulin secretion or proliferation), and examined the role of JAK/STAT signaling in these responses. Furthermore, I study how these pathways become disregulated in diabetes.

Whilst the majority of these studies are performed in rodent or human clonal beta-cell lines (e.g. INS-1E or EndoC-bH1 cells), where possible they are replicated in human islets. Furthermore, we also have access to the Exeter Archival Diabetes Biobank, a rare collection of post-mortem pancreas samples from individuals with diabetes (https://foulis.vub.ac.be/). This resource is used validate results generated from in vitro study of cell lines, and to explore how key JAK/STAT pathway components are altered in diabetes.

Research grants

  • 2021 European Foundation for the Study of Diabetes
    JAKMIP1: Putting the brakes on islet HLA class I hyperexpression in type 1 diabetes?
  • 2020 Diabetes Research and Wellness Foundation
    Is mitochondrial STAT3 a novel regulator of insulin secretion?
  • 2019 Society for Endocrinology
    Early career research grant. ‘Does the loss of STAT6 contribute to islet HLA class I hyper-expression in type 1 diabetes?’
  • 2015 EFSD
    Subcellular localisation of cell cycle regulatory proteins in human beta-cells: is the current paradigm correct?

Publications

Key publications | Publications by category | Publications by year

Key publications


Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.

Publications by category


Journal articles

Russell MA, PIgors M, Houssen M, Manson A, Kelsell D, Longhurst H, Morgan NG (In Press). A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID). Clinical Immunology Full text.
Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemburg MK, et al (In Press). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes Full text.
Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik D, Morgan N, et al (In Press). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia Full text.
Russell M, Leete P (2019). Glucocorticoids: novel agents to stimulate beta-cell neogenesis?. Annals of Translational Medicine, 7(8). Full text.
Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al (2019). HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells from Donors with Type 1 Diabetes. Diabetes, 68(5), 988-1001. Abstract.  Author URL.  Full text.
King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ (2019). Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass. Nutrients, 11(3). Abstract.  Author URL.
Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2019). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes. Diabetologia, 62(1), 87-98. Abstract.  Author URL.  Full text.
Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, et al (2018). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Abstract.  Author URL.  Full text.
Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, et al (2018). Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Neurol Genet, 4(2). Abstract.  Author URL.  Full text.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, et al (2017). Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain, 140(11), 2838-2850. Abstract.  Author URL.
Hodik M, Anagandula M, Fuxe J, Krogvold L, Dahl-Jørgensen K, Hyöty H, Sarmiento L, Frisk G, Atkinson M, Pugliese A, et al (2016). Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. BMJ Open Diabetes Research and Care, 4(1). Abstract.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Nisr RB, Russell MA, Chrachri A, Moody AJ, Gilpin ML (2011). Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic beta-cells. FEMS Immunol Med Microbiol, 63, 217-227. Abstract.  Author URL.
Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK. ISLETS, 2(4), 236-239. Author URL.
Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.
Taylor AR, Russell MA, Harper GM, Collins TFT, Brownlee C (2007). Dynamics of formation and secretion of heterococcoliths by Coccolithus pelagicus ssp braarudii. European Journal of Phycology, 42, 125-136. Abstract.

Publications by year


In Press

Russell MA, PIgors M, Houssen M, Manson A, Kelsell D, Longhurst H, Morgan NG (In Press). A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID). Clinical Immunology Full text.
Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemburg MK, et al (In Press). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes Full text.
Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik D, Morgan N, et al (In Press). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia Full text.

2019

Russell M, Leete P (2019). Glucocorticoids: novel agents to stimulate beta-cell neogenesis?. Annals of Translational Medicine, 7(8). Full text.
Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al (2019). HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells from Donors with Type 1 Diabetes. Diabetes, 68(5), 988-1001. Abstract.  Author URL.  Full text.
King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ (2019). Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass. Nutrients, 11(3). Abstract.  Author URL.
Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2019). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes. Diabetologia, 62(1), 87-98. Abstract.  Author URL.  Full text.

2018

Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, et al (2018). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Abstract.  Author URL.  Full text.
Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, et al (2018). Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Neurol Genet, 4(2). Abstract.  Author URL.  Full text.

2017

Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.  Full text.
Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, et al (2017). Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain, 140(11), 2838-2850. Abstract.  Author URL.

2016

Hodik M, Anagandula M, Fuxe J, Krogvold L, Dahl-Jørgensen K, Hyöty H, Sarmiento L, Frisk G, Atkinson M, Pugliese A, et al (2016). Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes. BMJ Open Diabetes Research and Care, 4(1). Abstract.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.

2015

Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.

2014

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Author URL.  Full text.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.

2013

Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.

2011

Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Nisr RB, Russell MA, Chrachri A, Moody AJ, Gilpin ML (2011). Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic beta-cells. FEMS Immunol Med Microbiol, 63, 217-227. Abstract.  Author URL.

2010

Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK. ISLETS, 2(4), 236-239. Author URL.

2009

Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.

2007

Taylor AR, Russell MA, Harper GM, Collins TFT, Brownlee C (2007). Dynamics of formation and secretion of heterococcoliths by Coccolithus pelagicus ssp braarudii. European Journal of Phycology, 42, 125-136. Abstract.

Mark_Russell Details from cache as at 2021-04-18 20:42:58

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Teaching

Involved in the teaching activities of several modules from the Medical Sciences and Medicine degree programmes:

Problem Based Learning group facilitator [Year 1; Medicine]

Provider of Life Science Resouce Centre education sessions [Year 1 & 2; Medicine]

Special study unit group facilitator [Year 1; Medicine]

Translational Medical Sciences group provider [Year 3; Medical Science]

Group provider on Fundamental Skills for Medical Scientists module [Year 1; Medical Sciences]

Group facilitator on Medical Genetics module [Year 2; Medical Sciences]

Marker on Disease, Diagnostics & Therapeutics module [Year 2; Medical Sciences]

Research relevant

Provider of Final Year Projects and Professional Training Year oppertunities. 

Supervision / Group

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