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 Maarten Koeners

Maarten Koeners

Research Fellow

01392 72 6014

Hatherly D3

The main focus of my research focuses on the investigation of cardiovascular and renal physiology on a whole-organ level and over time in both health and disease. I have extensive experience with various pre-clinical models of pathological conditions, including; hypertension, chronic kidney disease, diabetes, and ischemia/hypoxia. My ambitions are inherently multidisciplinary and involve physiology, bioengineering, electrochemistry, pharmacology and nephrology.

 

Qualifications

  • MSc (Utrecht, the Netherlands)
  • PhD (Utrecht, the Netherlands)

Research

Research interests

My current research is funded by an Intermediate Basic Research Fellowship and a Project Grant, both from the British Heart Foundation. I aim to map the time course of events during progression of cardiovascular and kidney disease by identifying the mediators/controllers of long-term regulation of tissue oxygenation, blood flow and sympathetic nerve activity and how these relate to the genesis of hypertension. If we understand more about long-term regulation and the sequence of events leading to hypoxia, hypoperfusion and coincident elevation of sympathetic nervous system activity, we might be able to intervene earlier and change the progression of cardiovascular and kidney disease.

I aim to identify, quantify and validate novel metabolic targets to screen new drugs, improve diagnosis and ultimately improve the management and outcome for cardiovascular and kidney disease patients. I believe this will have a major impact in clinical practice which is something I strive for.

 

Research projects

  • Carotid Body-Renal Interactions in Renovascular Hypertension
  • Examining the role of intra-renal hypoxia in chronic kidney disease
  • Cardio renal paradigms elucidated through an international exchange scheme (www.bristol.ac.uk/carpediem)
  • The role of the glycocalyx in chronic kidney disease
  • Pre-clinical evaluation of novel sulfide-releasing drugs for the treatment of chronic or diabetic kidney disease

Research grants

  • 2019 BHF Research Project
    Carotid Body-Renal Interactions in Renovascular Hypertension (PI; 2016-2019, £265k).
  • 2018 BHF Intermediate Research Fellowship
    Examining the role of intra-renal hypoxia in chronic kidney disease (PI; 2014-2018, £471k).
  • 2017 Austin Medical Research Foundation
    A breath of fresh air: measuring oxygen in diseased kidneys (PI; 2014-2017, £80k).
  • 2017 Marie Curie, IRSES
    Cardio Renal Paradigms ElucidateD through an International Exchange scheMe (CARPEDIEM) (CI; 2013-2017, £244k).
  • 2015 Royal Society Project Grant
    Prolonged recording of blood pressure and renal blood flow in a clinically relevant model of chronic kidney disease (PI; 2015, £15k).
  • 2014 Marie Curie, IOF
    Rechargeable Telemetry-Based Electrochemical Sensors: Kidney Oxygenation and health (ReTeBESKO) (PI; 2011-2014, £238k).
  • 2009 Innovative Pilot Research Grant, Dutch Diabetes Foundation
    Role of nNOS derived nitric oxide in the onset of hyperfiltration in diabetes (PI; 2008-2009, £45k).

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Koeners MPM, Patinha D, Pijacka W, Paton JFR (In Press). Cooperative oxygen sensing by the kidney and carotid body in blood pressure control. Frontiers in Physiology Full text.
Koeners MP, Lewis KE, Ford AP, Paton JF (In Press). Hypertension: a problem of organ blood flow supply-demand mismatch. Future Cardiol, 12(3), 339-349. Abstract.  Author URL.
Adamovich Y, Ladeuix B, Golik M, Koeners MP, Asher G (2017). Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α. Cell Metab, 25(1), 93-101. Abstract.  Author URL.
Emans TW, Janssen BJ, Pinkham MI, Ow CPC, Evans RG, Joles JA, Malpas SC, Krediet CTP, Koeners MP (2016). Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow. J Physiol, 594(21), 6287-6300. Abstract.  Author URL.
Koeners MP, Wesseling S, Sánchez M, Braam B, Joles JA (2016). Perinatal Inhibition of NF-KappaB Has Long-Term Antihypertensive and Renoprotective Effects in Fawn-Hooded Hypertensive Rats. Am J Hypertens, 29(1), 123-131. Abstract.  Author URL.
Koeners MP, Ow CPC, Russell DM, Evans RG, Malpas SC (2016). Prolonged and Continuous Measurement of Kidney Oxygenation in Conscious Rats. Methods Mol Biol, 1397, 93-111. Abstract.  Author URL.
Gerritsen KGF, Bovenschen N, Nguyen TQ, Sprengers D, Koeners MP, van Koppen AN, Joles JA, Goldschmeding R, Kok RJ (2016). Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis. J Cell Commun Signal, 10(4), 295-303. Abstract.  Author URL.
Gerritsen KGF, Leeuwis JW, Koeners MP, Bakker SJL, van Oeveren W, Aten J, Tarnow L, Rossing P, Wetzels JFM, Joles JA, et al (2015). Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy is Caused by Local Production and Tubular Dysfunction. J Diabetes Res, 2015 Abstract.  Author URL.
Koeners MP, Braam B, Joles JA (2014). Blood pressure follows the kidney. Organogenesis, 4(3), 153-157.
Papazova DA, van Koppen A, Koeners MP, Bleys RL, Verhaar MC, Joles JA (2014). Maintenance of hypertensive hemodynamics does not depend on ROS in established experimental chronic kidney disease. PLoS One, 9(2). Abstract.  Author URL.
Koeners MP, Vink EE, Kuijper A, Gadellaa N, Rosenberger C, Mathia S, van den Meiracker AH, Garrelds IM, Blankestijn PJ, Joles JA, et al (2014). Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension. J Hypertens, 32(3), 587-597. Abstract.  Author URL.
Koeners MP, Ow CPC, Russell DM, Abdelkader A, Eppel GA, Ludbrook J, Malpas SC, Evans RG (2013). Telemetry-based oxygen sensor for continuous monitoring of kidney oxygenation in conscious rats. Am J Physiol Renal Physiol, 304(12), F1471-F1480. Abstract.  Author URL.
Gerritsen KG, Abrahams AC, Peters HP, Nguyen TQ, Koeners MP, den Hoedt CH, Dendooven A, van den Dorpel MA, Blankestijn PJ, Wetzels JF, et al (2012). Effect of GFR on plasma N-terminal connective tissue growth factor (CTGF) concentrations. Am J Kidney Dis, 59(5), 619-627. Abstract.  Author URL.
Sima CA, Koeners MP, Joles JA, Braam B, Magil AB, Cupples WA (2012). Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake. Diabetologia, 55(8), 2246-2255. Abstract.  Author URL.
Wesseling S, Essers PB, Koeners MP, Pereboom TC, Braam B, van Faassen EE, Macinnes AW, Joles JA (2011). Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life. Front Genet, 2 Abstract.  Author URL.
Koeners MP, Braam B, Joles JA (2011). Perinatal inhibition of NF-kappaB has long-term antihypertensive effects in spontaneously hypertensive rats. J Hypertens, 29(6), 1160-1166. Abstract.  Author URL.
Wesseling S, Koeners MP, Joles JA (2011). Salt sensitivity of blood pressure: developmental and sex-related effects. Am J Clin Nutr, 94(6 Suppl), 1928S-1932S. Abstract.  Author URL.
Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA (2011). Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab, 300(4), E691-E698. Abstract.  Author URL.
Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA (2010). Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. Am J Hypertens, 23(7), 802-808. Abstract.  Author URL.
Gerritsen KG, Peters HP, Nguyen TQ, Koeners MP, Wetzels JF, Joles JA, Christensen EI, Verroust PJ, Li D, Oliver N, et al (2010). Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. Am J Physiol Renal Physiol, 298(6), F1457-F1464. Abstract.  Author URL.
Wesseling S, Koeners MP, Kantouh F, Joles JA, Braam B (2009). Consequences of perinatal treatment with L-arginine and antioxidants for the renal transcriptome in spontaneously hypertensive rats. Pflugers Arch, 458(3), 513-524. Abstract.  Author URL.
Wesseling S, Koeners MP, Joles JA (2009). Taurine: red bull or red herring?. Hypertension, 53(6), 909-911. Author URL.
Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA (2008). A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats. Am J Physiol Regul Integr Comp Physiol, 294(6), R1847-R1855. Abstract.  Author URL.
Koeners MP, Braam B, Joles JA (2008). Blood pressure follows the kidney: Perinatal influences on hereditary hypertension. Organogenesis, 4(3), 153-157. Abstract.  Author URL.
van Faassen EE, Koeners MP, Joles JA, Vanin AF (2008). Detection of basal NO production in rat tissues using iron-dithiocarbamate complexes. Nitric Oxide, 18(4), 279-286. Abstract.  Author URL.
Koeners MP, Joles JA (2007). A fat chance of renal injury. Kidney Int, 72(3), 232-234. Abstract.  Author URL.
Koeners MP, van Faassen EE, Wesseling S, de Sain-van der Velden M, Koomans HA, Braam B, Joles JA (2007). Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects. Hypertension, 50(6), 1077-1084. Abstract.  Author URL.
Koeners MP, Racasan S, Koomans HA, Joles JA, Braam B (2007). Nitric oxide, superoxide and renal blood flow autoregulation in SHR after perinatal L-arginine and antioxidants. Acta Physiol (Oxf), 190(4), 329-338. Abstract.  Author URL.
Hillebrand JJG, Koeners MP, de Rijke CE, Kas MJH, Adan RAH (2005). Leptin treatment in activity-based anorexia. Biol Psychiatry, 58(2), 165-171. Abstract.  Author URL.

Publications by year


In Press

Koeners MPM, Patinha D, Pijacka W, Paton JFR (In Press). Cooperative oxygen sensing by the kidney and carotid body in blood pressure control. Frontiers in Physiology Full text.
Koeners MP, Lewis KE, Ford AP, Paton JF (In Press). Hypertension: a problem of organ blood flow supply-demand mismatch. Future Cardiol, 12(3), 339-349. Abstract.  Author URL.

2017

Adamovich Y, Ladeuix B, Golik M, Koeners MP, Asher G (2017). Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α. Cell Metab, 25(1), 93-101. Abstract.  Author URL.

2016

Emans TW, Janssen BJ, Pinkham MI, Ow CPC, Evans RG, Joles JA, Malpas SC, Krediet CTP, Koeners MP (2016). Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow. J Physiol, 594(21), 6287-6300. Abstract.  Author URL.
Koeners MP, Wesseling S, Sánchez M, Braam B, Joles JA (2016). Perinatal Inhibition of NF-KappaB Has Long-Term Antihypertensive and Renoprotective Effects in Fawn-Hooded Hypertensive Rats. Am J Hypertens, 29(1), 123-131. Abstract.  Author URL.
Koeners MP, Ow CPC, Russell DM, Evans RG, Malpas SC (2016). Prolonged and Continuous Measurement of Kidney Oxygenation in Conscious Rats. Methods Mol Biol, 1397, 93-111. Abstract.  Author URL.
Gerritsen KGF, Bovenschen N, Nguyen TQ, Sprengers D, Koeners MP, van Koppen AN, Joles JA, Goldschmeding R, Kok RJ (2016). Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis. J Cell Commun Signal, 10(4), 295-303. Abstract.  Author URL.

2015

Gerritsen KGF, Leeuwis JW, Koeners MP, Bakker SJL, van Oeveren W, Aten J, Tarnow L, Rossing P, Wetzels JFM, Joles JA, et al (2015). Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy is Caused by Local Production and Tubular Dysfunction. J Diabetes Res, 2015 Abstract.  Author URL.

2014

Koeners MP, Braam B, Joles JA (2014). Blood pressure follows the kidney. Organogenesis, 4(3), 153-157.
Papazova DA, van Koppen A, Koeners MP, Bleys RL, Verhaar MC, Joles JA (2014). Maintenance of hypertensive hemodynamics does not depend on ROS in established experimental chronic kidney disease. PLoS One, 9(2). Abstract.  Author URL.
Koeners MP, Vink EE, Kuijper A, Gadellaa N, Rosenberger C, Mathia S, van den Meiracker AH, Garrelds IM, Blankestijn PJ, Joles JA, et al (2014). Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension. J Hypertens, 32(3), 587-597. Abstract.  Author URL.

2013

Koeners MP, Ow CPC, Russell DM, Abdelkader A, Eppel GA, Ludbrook J, Malpas SC, Evans RG (2013). Telemetry-based oxygen sensor for continuous monitoring of kidney oxygenation in conscious rats. Am J Physiol Renal Physiol, 304(12), F1471-F1480. Abstract.  Author URL.

2012

Gerritsen KG, Abrahams AC, Peters HP, Nguyen TQ, Koeners MP, den Hoedt CH, Dendooven A, van den Dorpel MA, Blankestijn PJ, Wetzels JF, et al (2012). Effect of GFR on plasma N-terminal connective tissue growth factor (CTGF) concentrations. Am J Kidney Dis, 59(5), 619-627. Abstract.  Author URL.
Sima CA, Koeners MP, Joles JA, Braam B, Magil AB, Cupples WA (2012). Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake. Diabetologia, 55(8), 2246-2255. Abstract.  Author URL.

2011

Wesseling S, Essers PB, Koeners MP, Pereboom TC, Braam B, van Faassen EE, Macinnes AW, Joles JA (2011). Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life. Front Genet, 2 Abstract.  Author URL.
Koeners MP, Braam B, Joles JA (2011). Perinatal inhibition of NF-kappaB has long-term antihypertensive effects in spontaneously hypertensive rats. J Hypertens, 29(6), 1160-1166. Abstract.  Author URL.
Wesseling S, Koeners MP, Joles JA (2011). Salt sensitivity of blood pressure: developmental and sex-related effects. Am J Clin Nutr, 94(6 Suppl), 1928S-1932S. Abstract.  Author URL.
Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA (2011). Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab, 300(4), E691-E698. Abstract.  Author URL.

2010

Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA (2010). Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. Am J Hypertens, 23(7), 802-808. Abstract.  Author URL.
Gerritsen KG, Peters HP, Nguyen TQ, Koeners MP, Wetzels JF, Joles JA, Christensen EI, Verroust PJ, Li D, Oliver N, et al (2010). Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. Am J Physiol Renal Physiol, 298(6), F1457-F1464. Abstract.  Author URL.

2009

Wesseling S, Koeners MP, Kantouh F, Joles JA, Braam B (2009). Consequences of perinatal treatment with L-arginine and antioxidants for the renal transcriptome in spontaneously hypertensive rats. Pflugers Arch, 458(3), 513-524. Abstract.  Author URL.
Wesseling S, Koeners MP, Joles JA (2009). Taurine: red bull or red herring?. Hypertension, 53(6), 909-911. Author URL.

2008

Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA (2008). A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats. Am J Physiol Regul Integr Comp Physiol, 294(6), R1847-R1855. Abstract.  Author URL.
Koeners MP, Braam B, Joles JA (2008). Blood pressure follows the kidney: Perinatal influences on hereditary hypertension. Organogenesis, 4(3), 153-157. Abstract.  Author URL.
van Faassen EE, Koeners MP, Joles JA, Vanin AF (2008). Detection of basal NO production in rat tissues using iron-dithiocarbamate complexes. Nitric Oxide, 18(4), 279-286. Abstract.  Author URL.

2007

Koeners MP, Joles JA (2007). A fat chance of renal injury. Kidney Int, 72(3), 232-234. Abstract.  Author URL.
Koeners MP, van Faassen EE, Wesseling S, de Sain-van der Velden M, Koomans HA, Braam B, Joles JA (2007). Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects. Hypertension, 50(6), 1077-1084. Abstract.  Author URL.
Koeners MP, Racasan S, Koomans HA, Joles JA, Braam B (2007). Nitric oxide, superoxide and renal blood flow autoregulation in SHR after perinatal L-arginine and antioxidants. Acta Physiol (Oxf), 190(4), 329-338. Abstract.  Author URL.

2005

Hillebrand JJG, Koeners MP, de Rijke CE, Kas MJH, Adan RAH (2005). Leptin treatment in activity-based anorexia. Biol Psychiatry, 58(2), 165-171. Abstract.  Author URL.

Editorial responsibilities


Invited lectures

2017

  • “The role of the glycocalyx in chronic kidney disease” Bristol (2017).
  • “Investigating the long term control of renal oxygenation, blood flow and mitochondrial hydrogen sulfide in renal and cardiovascular disease” Uppsala (June 2017)

2016

  • “SNAPshot: ME A breath of fresh air: measuring oxygen in diseased kidneys” Bristol (May 2016)

2015

  • “Tissue oxygen and blood flow in conscious rats: a telemetric approach” The 3rd Conference of the Hypoxia Research Association, Tokyo (July 2015).
  • “CARPEDIEM: update & future” International Symposium on Oxygen Biology, Tokyo (July 2015).

2014

  • “Examining the role of intra-renal hypoxia in chronic kidney disease” Bristol Renal Unit (September 2014).
  • “Direct measurement of intrarenal oxygen in vivo” European Renal Association – European Dialysis and Transplant Association Congress; (June 2014).
  • “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Maastricht (May 2014).
  • “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Bristol (April 2014).

2013

  • “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Groningen (December 2013).
  • “Measuring oxygen in the diseased kidney “Dutch Physiology Society Symposium (July 2013).
  • “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” St John’s, Newfoundland, Canada, (November 2013).
  • “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” University of Bristol, England (May 2013).
  • “Measuring oxygen in diseased kidneys” Graduate school of Life Sciences, UCARE meeting, University of Utrecht, the Netherlands (May 2013).
  • “Telemetry and cardiovascular research” Maastricht University, the Netherlands (April 2013).
  • “Rechargeable telemetry-Based Electrochemical Sensors: Kidney Oxygenation” University Medical Centre Utrecht, The Netherlands (April 2013).

2007-2012

  • “Telemetry-based oxygen sensing in kidney tissue with Carbon Paste Electrodes: Progress and challenges” National University of Ireland, Maynooth, Ireland (May 2012).
  •  “Renal disease development: from hereditary hypertension to acquired chronic kidney disease” Monash University, Melbourne Australia (August 2011).
  • “Life as a postdoc at the UMCU” Dutch Nephrology Days, The Netherlands (April 2009).
  • “Blood Pressure, Renal Salt Handling and Autoregulation in Streptozotocin-Diabetic Rats” University of Victoria, Canada (May 2008).
  • “2K1C, is there an interaction between hypertension and diabetes type 1?” University of Calgary, Canada Dec 2007).

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