Senior Lecturer (E&R)
01392 72 6014
Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
The main focus of my research focuses on the investigation of cardiovascular and renal physiology on a whole-organ level and over time in both health and disease. I have extensive experience with various pre-clinical models of pathological conditions, including; hypertension, chronic kidney disease, diabetes, and ischemia/hypoxia. My ambitions are inherently multidisciplinary and involve physiology, bioengineering, electrochemistry, pharmacology and nephrology.
- MSc (Utrecht, the Netherlands)
- PhD (Utrecht, the Netherlands)
My current research is funded by an Intermediate Basic Research Fellowship and a Project Grant, both from the British Heart Foundation. I aim to map the time course of events during progression of cardiovascular and kidney disease by identifying the mediators/controllers of long-term regulation of tissue oxygenation, blood flow and sympathetic nerve activity and how these relate to the genesis of hypertension. If we understand more about long-term regulation and the sequence of events leading to hypoxia, hypoperfusion and coincident elevation of sympathetic nervous system activity, we might be able to intervene earlier and change the progression of cardiovascular and kidney disease.
I aim to identify, quantify and validate novel metabolic targets to screen new drugs, improve diagnosis and ultimately improve the management and outcome for cardiovascular and kidney disease patients. I believe this will have a major impact in clinical practice which is something I strive for.
- Carotid Body-Renal Interactions in Renovascular Hypertension
- Examining the role of intra-renal hypoxia in chronic kidney disease
- Cardio renal paradigms elucidated through an international exchange scheme (www.bristol.ac.uk/carpediem)
- The role of the glycocalyx in chronic kidney disease
- Pre-clinical evaluation of novel sulfide-releasing drugs for the treatment of chronic or diabetic kidney disease
- 2019 BHF Research Project
Carotid Body-Renal Interactions in Renovascular Hypertension (PI; 2016-2019, £265k).
- 2018 BHF Intermediate Research Fellowship
Examining the role of intra-renal hypoxia in chronic kidney disease (PI; 2014-2018, £471k).
- 2017 Austin Medical Research Foundation
A breath of fresh air: measuring oxygen in diseased kidneys (PI; 2014-2017, £80k).
- 2017 Marie Curie, IRSES
Cardio Renal Paradigms ElucidateD through an International Exchange scheMe (CARPEDIEM) (CI; 2013-2017, £244k).
- 2015 Royal Society Project Grant
Prolonged recording of blood pressure and renal blood flow in a clinically relevant model of chronic kidney disease (PI; 2015, £15k).
- 2014 Marie Curie, IOF
Rechargeable Telemetry-Based Electrochemical Sensors: Kidney Oxygenation and health (ReTeBESKO) (PI; 2011-2014, £238k).
- 2009 Innovative Pilot Research Grant, Dutch Diabetes Foundation
Role of nNOS derived nitric oxide in the onset of hyperfiltration in diabetes (PI; 2008-2009, £45k).
Publications by category
Publications by year
External Engagement and Impact
- Guest Editor - Frontiers in Integrative Physiology http://journal.frontiersin.org/researchtopic/4264/hypoxia-in-kidney-disease
- “The role of the glycocalyx in chronic kidney disease” Bristol (2017).
- “Investigating the long term control of renal oxygenation, blood flow and mitochondrial hydrogen sulfide in renal and cardiovascular disease” Uppsala (June 2017)
- “SNAPshot: ME A breath of fresh air: measuring oxygen in diseased kidneys” Bristol (May 2016)
- “Tissue oxygen and blood flow in conscious rats: a telemetric approach” The 3rd Conference of the Hypoxia Research Association, Tokyo (July 2015).
- “CARPEDIEM: update & future” International Symposium on Oxygen Biology, Tokyo (July 2015).
- “Examining the role of intra-renal hypoxia in chronic kidney disease” Bristol Renal Unit (September 2014).
- “Direct measurement of intrarenal oxygen in vivo” European Renal Association – European Dialysis and Transplant Association Congress; (June 2014).
- “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Maastricht (May 2014).
- “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Bristol (April 2014).
- “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” Groningen (December 2013).
- “Measuring oxygen in the diseased kidney “Dutch Physiology Society Symposium (July 2013).
- “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” St John’s, Newfoundland, Canada, (November 2013).
- “A breath of fresh air: Measuring Oxygen in Diseased Kidneys” University of Bristol, England (May 2013).
- “Measuring oxygen in diseased kidneys” Graduate school of Life Sciences, UCARE meeting, University of Utrecht, the Netherlands (May 2013).
- “Telemetry and cardiovascular research” Maastricht University, the Netherlands (April 2013).
- “Rechargeable telemetry-Based Electrochemical Sensors: Kidney Oxygenation” University Medical Centre Utrecht, The Netherlands (April 2013).
- “Telemetry-based oxygen sensing in kidney tissue with Carbon Paste Electrodes: Progress and challenges” National University of Ireland, Maynooth, Ireland (May 2012).
- “Renal disease development: from hereditary hypertension to acquired chronic kidney disease” Monash University, Melbourne Australia (August 2011).
- “Life as a postdoc at the UMCU” Dutch Nephrology Days, The Netherlands (April 2009).
- “Blood Pressure, Renal Salt Handling and Autoregulation in Streptozotocin-Diabetic Rats” University of Victoria, Canada (May 2008).
- “2K1C, is there an interaction between hypertension and diabetes type 1?” University of Calgary, Canada Dec 2007).