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Associate Professor Lorna Harries

Associate Professor Lorna Harries

Associate Professor in Molecular Genetics

+44 (0) 1392 406773

RILD Building L3/32

Professor Harries gained her PhD from University College London in November 1994 and has since worked at several institutions including the Biomedical Research Centre at the University of Dundee, the MRC Cell Mutation Unit at the University of Brighton and the Institute of Biomedical and Clinical Sciences at the University of Exeter Medical School working with Professor Andrew Hattersley and Professor Sian Ellard. Following the award of an RCUK fellowship in 2006, She is now an Associate Professor in Molecular Genetics at UEMS.

Lorna has developed an interest in gene regulation and alternative messenger RNA processing in endocrine disease and human ageing. She now heads the ‘RNA-mediated mechanisms of disease’ group at UEMS. She has written over 90 peer-reviewed articles and was awarded the Diabetes UK RD Lawrence Prize Lectureship in 2011. She is co-ordinator of the annual UEMS ‘Men in White’ school outreach with Dr, John Chilton. This event brings in year 9 students from schools stretching from South Devon to North Somerset and gives them hands-on experience of work in a research laboratory. Lorna is a STEMnet ambassador and also an Exeter Catalyst Champion for Public Engagement.

Broad research specialisms

Her current work focuses on the role of alternative messenger RNA processing and small RNA regulation of genes involved in ageing and conmmon chronic disease.

Qualifications

  • BSc Genetics
  • PhD Genetics
  • FHEA

Links

Research

Research interests

Prof Harries has interests in -omics approaches to the study of normal physiology or on disease processes in man. Her specific focus is on the impact of alternative messenger RNA processing or small RNA gene regulation, with particular reference to diabetes and metabolism, human ageing and endocrine disrupting chemicals.

Research projects

  • Determinants of beta cell differentiation status in type 2 diabetes.
  • The role of age-associated inflammation on moderation of alternative splicing and its impact on age-related disease.
  • Messenger RNA analysis of genes implicated in susceptibility to type 2 diabetes.
  • Mechanistic study of disrupted alternative splicing in human ageing
  • Analysis of the effects of endocrine disrupting chemicals (BPA, Perfluoroalkyl chemicals) on gene expression and human disease.

Grants/Funding

Current funding

  • DMT Research Grant: Harries (PI). The role of age-associated inflammation in moderation of alternative splicing and its impact on age-related disease.14.09.15 - 13.09.18
  • Dr Hadwen Trust PhD studentship: Harries (PI).Determinants of beta cell differentiation status in type 2 diabetes.15.09.15 - 30.9.18
  • Wellcome Trust People Award: Harries (PI).Death by Rubber Duck.01.09.14 - 31.6.17
  • MRC Project grant: Harries (Co-I).Genetic and environmental influences on ageing well in the UK Biobank. 01.11.15 - 31.12.18

Completed funding (past 5 years)

  • Wellcome Trust Seed Corn Fund. David Melzer, Lorna Harries and Jonathan Mill. Genomic markers of biological age in human in-vivo blood leucocytes. March 2013 - March 2014.
  • MRC Research Grant: Harries (PI). Messenger RNA analysis of genes implicated in susceptibility to type 2 diabetes.01.08.12 - 30.09.15
  • Research Grant: Diabetes Research and Wellness Foundation. Katarina Kos (PI), Lorna Harries (Co-I) and David Melzer (Co-I). Which human SPARC isoforms are suitable peripheral makers of diabetes and obesity-related complications. 01/06/11 - 01/06/12
  • Project grant. Wellcome Trust. Harries (PI) with Prof G.A.Rutter. Can Genetic Variation in microRNA sequences impact on the normal function of the pancreatic beta cell? 01/02/10 - 31/07/12
  • Project grant . Wellcome Trust. Harries (PI) Alternate mRNA processing and mRNA surveillance of key pancreatic transcription factors in monogenic diabetes. 03/01/06 - 02/01/11.
  • Project grant. Fidelity Foundation. David Melzer PI, Harries (Co-I), Murray (Co-I) and Llewellyn (Co-I). Gene expression and cognitive decline in older adults: the GEECOG study 01.01.10 - 01.07.11.
  • Small Grant. Harries (PI). Northcott Devon Medical Foundation. Expression of susceptibility genes in cancer of the prostate. 01/07/09 - 01/03/10

Key publications | Publications by category | Publications by year

Key publications


Locke JM, da Silva Xavier G, Rutter, GA, Harries LW (In Press). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia Abstract.  Full text.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW (2015). A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia, 58(4), 745-748. Abstract.  Full text.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.  Full text.
Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Abstract.  Full text.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.

Publications by category


Journal articles

Locke JM, da Silva Xavier G, Rutter, GA, Harries LW (In Press). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia Abstract.  Full text.
Harries LW, Melzer D, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (In Press). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 12(119), 1788-1793. Abstract.
Flanagan SE, Dũng VC, Houghton JAL, De Franco E, Ngoc CTB, Damhuis A, Ashcroft FM, Harries LW, Ellard S (2017). An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression. J Clin Res Pediatr Endocrinol, 9(3), 260-264. Abstract.  Author URL.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.
Latorre E, Harries LW (2017). Splicing regulatory factors, ageing and age-related disease. Ageing Res Rev, 36, 165-170. Abstract.  Author URL.  Full text.
Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, et al (2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Sci Rep, 7(1). Abstract.  Author URL.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract.  Author URL.  Full text.
Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, et al (2016). Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine, 8, 103-116. Abstract.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Chen BH, Hivert M-F, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, et al (2016). Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes, 65(12), 3794-3804. Abstract.  Author URL.
Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R (2016). Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia, 59(1), 161-169. Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Abstract.  Author URL.  Full text.
Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW (2015). A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia, 58(4), 745-748. Abstract.  Full text.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract.  Author URL.  Full text.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract.  Author URL.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.  Full text.
Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M, Leung HY, Robson CN, et al (2015). The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. Oncoscience, 2(9), 755-764. Abstract.  Author URL.  Full text.
Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, et al (2015). The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget, 6(33), 34358-34374. Abstract.  Author URL.  Full text.
Locke JM, Lango Allen H, Harries LW (2014). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetologica, 51(2), 325-329. Abstract.  Full text.
Locke JM, Lango Allen H, Harries LW (2014). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol, 51(2), 325-329. Abstract.  Author URL.  Full text.
Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Abstract.  Author URL.
Hogg DR, Harries LW (2014). Human genetic variation and its effect on miRNA biogenesis, activity and function. Biochem Soc Trans, 42(4), 1184-1189. Abstract.  Author URL.
Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Abstract.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Harries LW (2014). MicroRNAs as Mediators of the Ageing Process. Genes (Basel), 5(3), 656-670. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Abstract.  Author URL.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract.  Author URL.
Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2013). Microarray-based whole transcriptome expression profiling as a tool to understand human ageing. , 209-220. Abstract.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.  Full text.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mechanisms of Ageing and Development, 133(8), 556-562. Abstract.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Abstract.  Author URL.  Full text.
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract.  Author URL.  Full text.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Abstract.  Author URL.
Locke JM, Harries LW (2012). MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls. Biochem Soc Trans, 40(4), 800-803. Abstract.  Author URL.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.  Full text.
Garin I, de Nanclares GP, Gastaldo E, Harries LW, Rubio-Cabezas O, Castaño L (2012). Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene. PLoS ONE, 7(1). Abstract.  Full text.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Pilling L, Bandinelli S, Guralnik JM, Singleton A, Hernandez D, Ferrucci L (2011). CONFIRMATION OF MOUSE MODEL OF SARCOPENIA BY GENOME WIDE EXPRESSION STUDY IN HUMANS. GERONTOLOGIST, 51, 506-507. Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CCA, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, et al (2011). Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet, 43(2), 117-120. Abstract.  Author URL.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum to: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia, 1-1.
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum to: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia, 54(12).
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes (Diabetologia DOI: 10.1007/s00125-011-2290-6). Diabetologia, 54(12).
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Harries LW (2011). Messenger RNA processing and its role in diabetes. Diabet Med, 28(9), 1010-1017. Abstract.  Author URL.
Assam EE, Rhodes A, Ladomery M, Harries L, Sohail M (2011). Novel Alternative Splice Variants of HER2 in Invasive Breast Cancer. CANCER RESEARCH, 71 Author URL.
Morrison FS, Johnstone KA, Harries LW (2011). Physiological effects of type 2 diabetes on mRNA processing and gene expression. Expert Review of Endocrinology and Metabolism, 6(2), 255-267. Abstract.
Harries LW, Perry JRB, McCullagh P, Crundwell M (2010). Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer. BMC Cancer, 10 Abstract.  Author URL.  Full text.
Alexander HM, Young E, Harries LW, Joyner M, Newman P, Sarsfield P (2010). An unusual case of cyclin-D1-positive peripheral T cell lymphoma with a 11:14 translocation. Journal of Hematopathology, 3(2), 77-81. Abstract.
Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.
Tarr JM, Winyard PG, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin accumulates in the joints of rheumatoid arthritis patients and inhibits FasL (CD95L) mediated apoptosis of T cells. Arthritis and Rheumatism, 62(10), 2919-2929. Full text.
Wirsing A, Johnstone KA, Harries LW, Ellard S, Ryffel GU, Stanik J, Gasperikova D, Klimes I, Murphy R (2010). Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro. Diabetic Medicine, 27(6), 631-635.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.
Hanlon K, Harries LW, Ellard S, Rudin CE (2009). Evaluation of 13q14 status in multiple myeloma by digital single nucleotide polymorphism technology. J Mol Diagn, 11(5), 450-457. Abstract.  Author URL.
Hanlon K, Ellard S, Rudin CE, Thorne S, Davies T, Harries LW (2009). Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques. J Mol Diagn, 11(4), 298-305. Abstract.  Author URL.
Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, et al (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol, 20(5), 1123-1131. Abstract.  Author URL.
Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, et al (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. PEDIATRIC NEPHROLOGY, 24(4), 885-885. Author URL.
Hanlon K, Rudin CE, Harries LW (2009). Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One, 4(9). Abstract.  Author URL.  Full text.
Harries LW, Brown JE, Gloyn AL (2009). Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Flanagan SE, Clauin S, Bellanné-Chantelot C, de Lonlay P, Harries LW, Gloyn AL, Ellard S (2009). Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat, 30(2), 170-180. Abstract.  Author URL.
Locke JM, Ellard S, Norwood VF, Harries LW (2009). Variants in the isoform-specific coding regions of the HNF1A, HNF4A and HNF1B genes are not a common cause of familial, young-onset diabetes or renal cysts and diabetes (RCAD). DIABETIC MEDICINE, 26(5), 570-570. Author URL.
Harries LW, Sloman MJ, Sellers EA, Hattersley AT, Ellard S (2008). DIABETES SUSCEPTIBILITY IN THE CANADIAN OJI-CREE POPULATION IS MODERATED BY ABNORMAL mRNA PROCESSING OF HNF1A G319S TRANSCRIPTS. Diabetes Abstract.
Harries LW, Sloman MJ, Sellers EAC, Hattersley AT, Ellard S (2008). Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts. DIABETES, 57(7), 1978-1982. Author URL.
Edghill EL, Oram RA, Owens M, Stals KL, Harries LW, Hattersley AT, Ellard S, Bingham C (2008). Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease. Nephrol Dial Transplant, 23(2), 627-635. Abstract.  Author URL.
Shield JPH, Flanagan SE, Mackay DJ, Harries LW, Proks P, Girard C, Ashcroft FM, Temple IK, Ellard S (2008). Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy. Diabetes, 57(1), 255-258. Abstract.  Author URL.
Locke JM, Harries LW (2008). RNA processing and mRNA surveillance in monogenic diabetes. Gene Regul Syst Bio, 2, 203-212. Abstract.  Author URL.  Full text.
Murphy R, Baptista J, Holly J, Umpleby AM, Ellard S, Harries LW, Crolla J, Cundy T, Hattersley AT (2008). Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene. J Clin Endocrinol Metab, 93(11), 4373-4380. Abstract.  Author URL.
Harries LW, Locke JM, Shields B, Hanley NA, Hanley KP, Steele A, Njølstad PR, Ellard S, Hattersley AT (2008). The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes, 57(6), 1745-1752. Abstract.  Author URL.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Wolstencroft EC, Hanlon K, Harries LW, Standen GR, Sternberg A, Ellard S (2007). Development of a quantitative real-time polymerase chain reaction assay for the detection of the JAK2 V617F mutation. J Mol Diagn, 9(1), 42-46. Abstract.  Author URL.
Locke JM, Harries LW, Sloman MJ, Sellers EA, Hattersley AT, Ellard S (2007). Diabetes susceptibility in the Canadian Oji-Cree population may be moderated by abnormal mRNA processing of HNFIA G319S transcripts. DIABETIC MEDICINE, 24, 36-36. Author URL.
Singh R, Edghill E, Bingham C, Ellard S, Hattersley AT, Harries LW (2007). Low prevalence of mitochondrial DNA 3243A>G point mutation in Caucasians with unexplained renal disease. Diabet Med, 24(7), 804-806. Author URL.
Edghill EL, Gloyn AL, Goriely A, Harries LW, Flanagan SE, Rankin J, Hattersley AT, Ellard S (2007). Origin of de novo KCNJ11 mutations and risk of neonatal diabetes for subsequent siblings. J Clin Endocrinol Metab, 92(5), 1773-1777. Abstract.  Author URL.
Ellard S, Thomas K, Edghill EL, Owens M, Ambye L, Cropper J, Little J, Strachan M, Stride A, Ersoy B, et al (2007). Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young. Diabetologia, 50(11), 2313-2317. Abstract.  Author URL.
Ellard S, Flanagan SE, Girard CA, Patch A-M, Harries LW, Parrish A, Edghill EL, Mackay DJG, Proks P, Shimomura K, et al (2007). Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. Am J Hum Genet, 81(2), 375-382. Abstract.  Author URL.
Singh R, Hattersley AT, Harries LW (2007). Reduced peripheral blood mitochondrial DNA content is not a risk factor for Type 2 diabetes. Diabet Med, 24(7), 784-787. Abstract.  Author URL.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, et al (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science, 316(5829), 1336-1341. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Wickham CL, Harries LW, Sarsfield P, Joyner MV, Ellard S (2006). Large variation in t(11;14)(q13;q32) and t(14;18)(q32;q21) translocation product size is confirmed by sequence analysis of PCR products. Clin Lab Haematol, 28(4), 248-253. Abstract.  Author URL.
Singh R, Ellard S, Hattersley A, Harries LW (2006). Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation. J Mol Diagn, 8(2), 225-230. Abstract.  Author URL.
Harries LW, Wickham CL, Evans JC, Rule SA, Joyner MV, Ellard S (2005). Analysis of haematopoietic chimaerism by quantitative real-time polymerase chain reaction. Bone Marrow Transplant, 35(3), 283-290. Abstract.  Author URL.
Harries LW, Bingham C, Bellanne-Chantelot C, Hattersley AT, Ellard S (2005). The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay. Hum Genet, 118(2), 214-224. Abstract.  Author URL.
Theron T, Fousteri MI, Volker M, Harries LW, Botta E, Stefanini M, Fujimoto M, Andressoo J-O, Mitchell J, Jaspers NGJ, et al (2005). Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome. Mol Cell Biol, 25(18), 8368-8378. Abstract.  Author URL.
Harries LW, Ellard S, Jones RWA, Hattersley AT, Bingham C (2004). Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome. Diabetologia, 47(5), 937-942. Abstract.  Author URL.
Harries LW, Hattersley AT, Ellard S (2004). Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay. Diabetes, 53(2), 500-504. Abstract.  Author URL.
Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, Temple IK, Hattersley AT, Ellard S (2004). Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab, 89(8), 3932-3935. Abstract.  Author URL.
Bulman MP, Harries LW, Hansen T, Shepherd M, Kelly WF, Hattersley AT, Ellard S (2002). Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young. Diabetologia, 45(10), 1463-1467. Abstract.  Author URL.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica, 28(12), 1129-1165. Author URL.
Matthias C, Bockmühl U, Jahnke V, Harries LW, Wolf CR, Jones PW, Alldersea J, Worrall SF, Hand P, Fryer AA, et al (1998). The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. Pharmacogenetics, 8(1), 1-6. Abstract.  Author URL.
Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, Wolf CR, Ogreid D, Ulvik A, Vu P, Haugen A, et al (1997). Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis, 18(7), 1285-1289. Abstract.  Author URL.
Harries LW, Stubbins MJ, Forman D, Howard GC, Wolf CR (1997). Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis, 18(4), 641-644. Abstract.  Author URL.
Stubbins MJ, Harries LW, Smith G, Tarbit MH, Wolf CR (1996). Genetic analysis of the human cytochrome P450 CYP2C9 locus. Pharmacogenetics, 6(5), 429-439. Abstract.  Author URL.
Abbott C, Malas S, Pilz A, Pate L, Ali R, Peters J (1994). Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2. Genomics, 20(1), 94-98. Abstract.  Author URL.

Chapters

Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.

Conferences

Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS.  Author URL.
Ellard S, Edghill EL, Locke J, Flanagan SE, Patch AM, Harries LW, Hattersley AT (2008). Both recessive and dominant INS gene mutations are a common cause of neonatal diabetes.  Author URL.
Edghill EL, Locke J, Flanagan SE, Patch A-M, Harries LW, Ellard S, Hattersley AT (2008). Recessive mutations in the INS gene; a novel common cause of permanent neonatal diabetes in consanguineous pedigrees.  Author URL.
Hanlon K, Harries LW, Ellard S, Rudin CE (2007). A novel application of digital single nucleotide polymorphism (dSNP) technology to the identification of chromosome 13q deletions in multiple myeloma and chronic lymphocytic leukaemia.  Author URL.
Harries LW, Shields B, Ellard S, Hattersley AT (2007). Expression profiling and genotype: phenotype analysis of naturally occurring HNF4A mutations suggest a role for fetally expressed P1 transcripts in normal beta-cell function.  Author URL.
Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus.  Author URL.
Wolstencroft E, Hanlon K, Harries L, Sternberg A, Ellard S (2006). Development of a quantitative real-time PCR assay for the detection of the JAK2 V617F mutation in myeloproliferative disorders.  Author URL.
Owens M, Edghill EL, Harries LW, Bingham C, Oram R, Hattersley AT, Ellard S (2006). Hepatocyte nuclear factor-1beta gene deletions are common in subjects with unexplained renal disease and diabetes.  Author URL.
Sloman M, Harries L, Ellard S (2005). A real-time PCR two-step reflex test for the detection of HFE gene mutations causing haemochromatosis.  Author URL.
Harries LW, Wickham CL, Rule SA, Joyner MV, Ellard S (2004). Improved quantitation of haematopoietic chimaerism by real-time polymerase chain reaction.  Author URL.
Wickham CL, Harries LW, Sarsfield P, Joyner MV, Ellard S (2004). Improving the accuracy of detection of t(11;14)(q13;q32) and t(14;18)(q32;q21) chromosomal translocations by PCR.  Author URL.

Publications by year


In Press

Locke JM, da Silva Xavier G, Rutter, GA, Harries LW (In Press). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia Abstract.  Full text.
Harries LW, Melzer D, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (In Press). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 12(119), 1788-1793. Abstract.

2017

Flanagan SE, Dũng VC, Houghton JAL, De Franco E, Ngoc CTB, Damhuis A, Ashcroft FM, Harries LW, Ellard S (2017). An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression. J Clin Res Pediatr Endocrinol, 9(3), 260-264. Abstract.  Author URL.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.
Latorre E, Harries LW (2017). Splicing regulatory factors, ageing and age-related disease. Ageing Res Rev, 36, 165-170. Abstract.  Author URL.  Full text.
Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, et al (2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Sci Rep, 7(1). Abstract.  Author URL.

2016

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract.  Author URL.  Full text.
Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, et al (2016). Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine, 8, 103-116. Abstract.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Chen BH, Hivert M-F, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, et al (2016). Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes, 65(12), 3794-3804. Abstract.  Author URL.
Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R (2016). Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia, 59(1), 161-169. Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Abstract.  Author URL.  Full text.

2015

Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW (2015). A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia, 58(4), 745-748. Abstract.  Full text.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract.  Author URL.  Full text.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract.  Author URL.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.  Full text.
Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M, Leung HY, Robson CN, et al (2015). The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. Oncoscience, 2(9), 755-764. Abstract.  Author URL.  Full text.
Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, et al (2015). The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget, 6(33), 34358-34374. Abstract.  Author URL.  Full text.

2014

Locke JM, Lango Allen H, Harries LW (2014). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetologica, 51(2), 325-329. Abstract.  Full text.
Locke JM, Lango Allen H, Harries LW (2014). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol, 51(2), 325-329. Abstract.  Author URL.  Full text.
Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Abstract.  Author URL.
Hogg DR, Harries LW (2014). Human genetic variation and its effect on miRNA biogenesis, activity and function. Biochem Soc Trans, 42(4), 1184-1189. Abstract.  Author URL.
Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Abstract.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Harries LW (2014). MicroRNAs as Mediators of the Ageing Process. Genes (Basel), 5(3), 656-670. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.

2013

Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Abstract.  Author URL.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract.  Author URL.
Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2013). Microarray-based whole transcriptome expression profiling as a tool to understand human ageing. , 209-220. Abstract.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.  Full text.

2012

Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mechanisms of Ageing and Development, 133(8), 556-562. Abstract.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Abstract.  Author URL.  Full text.
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract.  Author URL.  Full text.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Abstract.  Author URL.
Locke JM, Harries LW (2012). MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls. Biochem Soc Trans, 40(4), 800-803. Abstract.  Author URL.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.  Full text.
Garin I, de Nanclares GP, Gastaldo E, Harries LW, Rubio-Cabezas O, Castaño L (2012). Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene. PLoS ONE, 7(1). Abstract.  Full text.

2011

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Pilling L, Bandinelli S, Guralnik JM, Singleton A, Hernandez D, Ferrucci L (2011). CONFIRMATION OF MOUSE MODEL OF SARCOPENIA BY GENOME WIDE EXPRESSION STUDY IN HUMANS. GERONTOLOGIST, 51, 506-507. Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CCA, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, et al (2011). Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet, 43(2), 117-120. Abstract.  Author URL.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum to: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia, 1-1.
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum to: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia, 54(12).
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes (Diabetologia DOI: 10.1007/s00125-011-2290-6). Diabetologia, 54(12).
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Harries LW (2011). Messenger RNA processing and its role in diabetes. Diabet Med, 28(9), 1010-1017. Abstract.  Author URL.
Assam EE, Rhodes A, Ladomery M, Harries L, Sohail M (2011). Novel Alternative Splice Variants of HER2 in Invasive Breast Cancer. CANCER RESEARCH, 71 Author URL.
Morrison FS, Johnstone KA, Harries LW (2011). Physiological effects of type 2 diabetes on mRNA processing and gene expression. Expert Review of Endocrinology and Metabolism, 6(2), 255-267. Abstract.

2010

Harries LW, Perry JRB, McCullagh P, Crundwell M (2010). Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer. BMC Cancer, 10 Abstract.  Author URL.  Full text.
Alexander HM, Young E, Harries LW, Joyner M, Newman P, Sarsfield P (2010). An unusual case of cyclin-D1-positive peripheral T cell lymphoma with a 11:14 translocation. Journal of Hematopathology, 3(2), 77-81. Abstract.
Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.
Tarr JM, Winyard PG, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin accumulates in the joints of rheumatoid arthritis patients and inhibits FasL (CD95L) mediated apoptosis of T cells. Arthritis and Rheumatism, 62(10), 2919-2929. Full text.
Wirsing A, Johnstone KA, Harries LW, Ellard S, Ryffel GU, Stanik J, Gasperikova D, Klimes I, Murphy R (2010). Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro. Diabetic Medicine, 27(6), 631-635.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.

2009

Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS.  Author URL.
Hanlon K, Harries LW, Ellard S, Rudin CE (2009). Evaluation of 13q14 status in multiple myeloma by digital single nucleotide polymorphism technology. J Mol Diagn, 11(5), 450-457. Abstract.  Author URL.
Hanlon K, Ellard S, Rudin CE, Thorne S, Davies T, Harries LW (2009). Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques. J Mol Diagn, 11(4), 298-305. Abstract.  Author URL.
Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, et al (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol, 20(5), 1123-1131. Abstract.  Author URL.
Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, et al (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. PEDIATRIC NEPHROLOGY, 24(4), 885-885. Author URL.
Hanlon K, Rudin CE, Harries LW (2009). Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One, 4(9). Abstract.  Author URL.  Full text.
Harries LW, Brown JE, Gloyn AL (2009). Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Flanagan SE, Clauin S, Bellanné-Chantelot C, de Lonlay P, Harries LW, Gloyn AL, Ellard S (2009). Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat, 30(2), 170-180. Abstract.  Author URL.
Locke JM, Ellard S, Norwood VF, Harries LW (2009). Variants in the isoform-specific coding regions of the HNF1A, HNF4A and HNF1B genes are not a common cause of familial, young-onset diabetes or renal cysts and diabetes (RCAD). DIABETIC MEDICINE, 26(5), 570-570. Author URL.

2008

Ellard S, Edghill EL, Locke J, Flanagan SE, Patch AM, Harries LW, Hattersley AT (2008). Both recessive and dominant INS gene mutations are a common cause of neonatal diabetes.  Author URL.
Harries LW, Sloman MJ, Sellers EA, Hattersley AT, Ellard S (2008). DIABETES SUSCEPTIBILITY IN THE CANADIAN OJI-CREE POPULATION IS MODERATED BY ABNORMAL mRNA PROCESSING OF HNF1A G319S TRANSCRIPTS. Diabetes Abstract.
Harries LW, Sloman MJ, Sellers EAC, Hattersley AT, Ellard S (2008). Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts. DIABETES, 57(7), 1978-1982. Author URL.
Edghill EL, Oram RA, Owens M, Stals KL, Harries LW, Hattersley AT, Ellard S, Bingham C (2008). Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease. Nephrol Dial Transplant, 23(2), 627-635. Abstract.  Author URL.
Shield JPH, Flanagan SE, Mackay DJ, Harries LW, Proks P, Girard C, Ashcroft FM, Temple IK, Ellard S (2008). Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy. Diabetes, 57(1), 255-258. Abstract.  Author URL.
Locke JM, Harries LW (2008). RNA processing and mRNA surveillance in monogenic diabetes. Gene Regul Syst Bio, 2, 203-212. Abstract.  Author URL.  Full text.
Edghill EL, Locke J, Flanagan SE, Patch A-M, Harries LW, Ellard S, Hattersley AT (2008). Recessive mutations in the INS gene; a novel common cause of permanent neonatal diabetes in consanguineous pedigrees.  Author URL.
Murphy R, Baptista J, Holly J, Umpleby AM, Ellard S, Harries LW, Crolla J, Cundy T, Hattersley AT (2008). Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene. J Clin Endocrinol Metab, 93(11), 4373-4380. Abstract.  Author URL.
Harries LW, Locke JM, Shields B, Hanley NA, Hanley KP, Steele A, Njølstad PR, Ellard S, Hattersley AT (2008). The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes, 57(6), 1745-1752. Abstract.  Author URL.

2007

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Hanlon K, Harries LW, Ellard S, Rudin CE (2007). A novel application of digital single nucleotide polymorphism (dSNP) technology to the identification of chromosome 13q deletions in multiple myeloma and chronic lymphocytic leukaemia.  Author URL.
Wolstencroft EC, Hanlon K, Harries LW, Standen GR, Sternberg A, Ellard S (2007). Development of a quantitative real-time polymerase chain reaction assay for the detection of the JAK2 V617F mutation. J Mol Diagn, 9(1), 42-46. Abstract.  Author URL.
Locke JM, Harries LW, Sloman MJ, Sellers EA, Hattersley AT, Ellard S (2007). Diabetes susceptibility in the Canadian Oji-Cree population may be moderated by abnormal mRNA processing of HNFIA G319S transcripts. DIABETIC MEDICINE, 24, 36-36. Author URL.
Harries LW, Shields B, Ellard S, Hattersley AT (2007). Expression profiling and genotype: phenotype analysis of naturally occurring HNF4A mutations suggest a role for fetally expressed P1 transcripts in normal beta-cell function.  Author URL.
Singh R, Edghill E, Bingham C, Ellard S, Hattersley AT, Harries LW (2007). Low prevalence of mitochondrial DNA 3243A>G point mutation in Caucasians with unexplained renal disease. Diabet Med, 24(7), 804-806. Author URL.
Edghill EL, Gloyn AL, Goriely A, Harries LW, Flanagan SE, Rankin J, Hattersley AT, Ellard S (2007). Origin of de novo KCNJ11 mutations and risk of neonatal diabetes for subsequent siblings. J Clin Endocrinol Metab, 92(5), 1773-1777. Abstract.  Author URL.
Ellard S, Thomas K, Edghill EL, Owens M, Ambye L, Cropper J, Little J, Strachan M, Stride A, Ersoy B, et al (2007). Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young. Diabetologia, 50(11), 2313-2317. Abstract.  Author URL.
Ellard S, Flanagan SE, Girard CA, Patch A-M, Harries LW, Parrish A, Edghill EL, Mackay DJG, Proks P, Shimomura K, et al (2007). Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. Am J Hum Genet, 81(2), 375-382. Abstract.  Author URL.
Singh R, Hattersley AT, Harries LW (2007). Reduced peripheral blood mitochondrial DNA content is not a risk factor for Type 2 diabetes. Diabet Med, 24(7), 784-787. Abstract.  Author URL.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, et al (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science, 316(5829), 1336-1341. Abstract.  Author URL.

2006

Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
Wolstencroft E, Hanlon K, Harries L, Sternberg A, Ellard S (2006). Development of a quantitative real-time PCR assay for the detection of the JAK2 V617F mutation in myeloproliferative disorders.  Author URL.
Owens M, Edghill EL, Harries LW, Bingham C, Oram R, Hattersley AT, Ellard S (2006). Hepatocyte nuclear factor-1beta gene deletions are common in subjects with unexplained renal disease and diabetes.  Author URL.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Wickham CL, Harries LW, Sarsfield P, Joyner MV, Ellard S (2006). Large variation in t(11;14)(q13;q32) and t(14;18)(q32;q21) translocation product size is confirmed by sequence analysis of PCR products. Clin Lab Haematol, 28(4), 248-253. Abstract.  Author URL.
Singh R, Ellard S, Hattersley A, Harries LW (2006). Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation. J Mol Diagn, 8(2), 225-230. Abstract.  Author URL.

2005

Sloman M, Harries L, Ellard S (2005). A real-time PCR two-step reflex test for the detection of HFE gene mutations causing haemochromatosis.  Author URL.
Harries LW, Wickham CL, Evans JC, Rule SA, Joyner MV, Ellard S (2005). Analysis of haematopoietic chimaerism by quantitative real-time polymerase chain reaction. Bone Marrow Transplant, 35(3), 283-290. Abstract.  Author URL.
Harries LW, Bingham C, Bellanne-Chantelot C, Hattersley AT, Ellard S (2005). The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay. Hum Genet, 118(2), 214-224. Abstract.  Author URL.
Theron T, Fousteri MI, Volker M, Harries LW, Botta E, Stefanini M, Fujimoto M, Andressoo J-O, Mitchell J, Jaspers NGJ, et al (2005). Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome. Mol Cell Biol, 25(18), 8368-8378. Abstract.  Author URL.

2004

Harries LW, Ellard S, Jones RWA, Hattersley AT, Bingham C (2004). Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome. Diabetologia, 47(5), 937-942. Abstract.  Author URL.
Harries LW, Wickham CL, Rule SA, Joyner MV, Ellard S (2004). Improved quantitation of haematopoietic chimaerism by real-time polymerase chain reaction.  Author URL.
Wickham CL, Harries LW, Sarsfield P, Joyner MV, Ellard S (2004). Improving the accuracy of detection of t(11;14)(q13;q32) and t(14;18)(q32;q21) chromosomal translocations by PCR.  Author URL.
Harries LW, Hattersley AT, Ellard S (2004). Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay. Diabetes, 53(2), 500-504. Abstract.  Author URL.
Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, Temple IK, Hattersley AT, Ellard S (2004). Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab, 89(8), 3932-3935. Abstract.  Author URL.

2002

Bulman MP, Harries LW, Hansen T, Shepherd M, Kelly WF, Hattersley AT, Ellard S (2002). Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young. Diabetologia, 45(10), 1463-1467. Abstract.  Author URL.

1998

Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica, 28(12), 1129-1165. Author URL.
Matthias C, Bockmühl U, Jahnke V, Harries LW, Wolf CR, Jones PW, Alldersea J, Worrall SF, Hand P, Fryer AA, et al (1998). The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. Pharmacogenetics, 8(1), 1-6. Abstract.  Author URL.

1997

Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, Wolf CR, Ogreid D, Ulvik A, Vu P, Haugen A, et al (1997). Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis, 18(7), 1285-1289. Abstract.  Author URL.
Harries LW, Stubbins MJ, Forman D, Howard GC, Wolf CR (1997). Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis, 18(4), 641-644. Abstract.  Author URL.

1996

Stubbins MJ, Harries LW, Smith G, Tarbit MH, Wolf CR (1996). Genetic analysis of the human cytochrome P450 CYP2C9 locus. Pharmacogenetics, 6(5), 429-439. Abstract.  Author URL.

1994

Abbott C, Malas S, Pilz A, Pate L, Ali R, Peters J (1994). Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2. Genomics, 20(1), 94-98. Abstract.  Author URL.

Awards

Diabetes UK RD Lawrence lectureship 2011


Committee/panel activities

Member of Diabetes UK

Member of BRSA Executive committee (Hon General Secretary)

Member of the UK Environmental mutagens society (UKEMS)


Invited lectures

Liverpool University 2015

Bristol University 2010

Cardiff University 2011

RD Lawrence Lecture, Diabetes UK 2011

Babraham institute 2012

Aston University 2013

Newcastle University 2015

Undergraduate Teaching Responsibilities

  • Small group facilitator
  • Medical Genetics Module lead
  • Adolescence PBL case manager
  • Project student supervision

Postgraduate responsiblilites

  • PhD supervisor
  • Research Degrees committee member
  • PGA-QC committee member
  • Fellow of the Higher Education Academy

Other

  • Men in White co-coordinator
  • Genetic Modification Safety Committee member
  • STEMnet ambassador
  • Exeter Catalyst champion for Public Outreach
  • Elected member of BRSA Executive committee

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