COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Kunihiko Aizawa

Dr Kunihiko Aizawa

Research Fellow

 Diabetes and Vascular Research Centre 

Overview

Kuni obtained PhD in Kinesiology from The University of Western Ontario, Canada. He subsequently joined the NIHR Exeter Clinical Research Facility and Diabetes and Vascular Medicine Research Centre, where he is the lead researcher for the ultrasound-based macrovascular investigation. His main research interest is large artery structure and its function. He utilizes non-invasive techniques such as carotid artery ultrasound, brachial artery flow-mediated dilatation and applanation tonometry to investigate large artery stiffness, carotid plaque characteristics and endothelial function in healthy as well as clinical populations. Kuni has been working on international clinical studies including SUMMIT (SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools), REMOVAL (REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes) and BEAt-DKD (Biomarker Enterprise to Attack Diabetic Kidney Disease).

Qualifications

  • PhD (The University of Western Ontario, Canada)
  • MSc (The University of Western Ontario, Canada)
  • BPE (Juntendo University, Japan)

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, et al (In Press). Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. BMC Cardiovasc Disord, 16(1). Abstract.  Author URL.  Full text.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (In Press). Brachial artery vasodilatory response and wall shear rate determined by multigate Doppler in a healthy young cohort. J Appl Physiol (1985), 124(1), 150-159. Abstract.  Author URL.  Full text.
Gurung A, Gates PE, Mazzaro L, Fulford J, Zhang F, Barker AJ, Hertzberg J, Aizawa K, Strain WD, Elyas S, et al (In Press). Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging. Ultrasound Med Biol, 43(8), 1618-1627. Abstract.  Author URL.
Gates PE, Gurung A, Mazzaro L, Aizawa K, Elyas S, Strain WD, Shore AC, Shandas R (In Press). Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry. Ultrasound Med Biol, 44(7), 1392-1401. Abstract.  Author URL.
Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, et al (In Press). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovasc Diabetol, 16(1). Abstract.  Author URL.  Full text.
Weir-McCall JR, Brown L, Summersgill J, Talarczyk P, Bonnici-Mallia M, Chin SC, Khan F, Struthers AD, Sullivan F, Colhoun HM, et al (2018). Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: a TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture. Hypertension, 71(5), 937-945. Abstract.  Author URL.  Full text.
Petrie JR, Chaturvedi N, Ford I, Brouwers MCGJ, Greenlaw N, Tillin T, Hramiak I, Hughes AD, Jenkins AJ, Klein BEK, et al (2017). Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. The Lancet Diabetes & Endocrinology, 5(8), 597-609.
Petrie JR, Chaturvedi N, Ford I, Hramiak I, Hughes AD, Jenkins AJ, E. Klein B, Klein R, Ooi TC, Rossing P, et al (2017). Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): an international multicentre trial. Diabetes, Obesity and Metabolism, 19(4), 509-516.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.  Full text.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.  Full text.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Journal of Internal Medicine, 278(3), 291-302. Abstract.
Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N (2013). Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med, 60, 89-97. Abstract.  Author URL.  Full text.

Conferences

Segers P, O'Rourke MF, Parker K, Westerhof N, Hughes A, Aguado-Sierra J, Aizawa K, Alastruey J, Allen J, Avolio A, et al (2017). Towards a consensus on the understanding and analysis of the pulse waveform: Results from the 2016 Workshop on Arterial Hemodynamics: Past, present and future.  Abstract.
Ramalli A, Byra M, Dallai A, Palombo C, Aizawa K, Sbragi S, Shore A, Tortoli P, IEEE (2015). A Multiparametric Approach Integrating Vessel Diameter, Wall Shear Rate and Physiologic Signals for Optimized Flow Mediated Dilation Studies.  Author URL.

Publications by year


In Press

Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, et al (In Press). Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. BMC Cardiovasc Disord, 16(1). Abstract.  Author URL.  Full text.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (In Press). Brachial artery vasodilatory response and wall shear rate determined by multigate Doppler in a healthy young cohort. J Appl Physiol (1985), 124(1), 150-159. Abstract.  Author URL.  Full text.
Gurung A, Gates PE, Mazzaro L, Fulford J, Zhang F, Barker AJ, Hertzberg J, Aizawa K, Strain WD, Elyas S, et al (In Press). Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging. Ultrasound Med Biol, 43(8), 1618-1627. Abstract.  Author URL.
Gates PE, Gurung A, Mazzaro L, Aizawa K, Elyas S, Strain WD, Shore AC, Shandas R (In Press). Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry. Ultrasound Med Biol, 44(7), 1392-1401. Abstract.  Author URL.
Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, et al (In Press). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovasc Diabetol, 16(1). Abstract.  Author URL.  Full text.

2018

Weir-McCall JR, Brown L, Summersgill J, Talarczyk P, Bonnici-Mallia M, Chin SC, Khan F, Struthers AD, Sullivan F, Colhoun HM, et al (2018). Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: a TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture. Hypertension, 71(5), 937-945. Abstract.  Author URL.  Full text.

2017

Petrie JR, Chaturvedi N, Ford I, Brouwers MCGJ, Greenlaw N, Tillin T, Hramiak I, Hughes AD, Jenkins AJ, Klein BEK, et al (2017). Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. The Lancet Diabetes & Endocrinology, 5(8), 597-609.
Petrie JR, Chaturvedi N, Ford I, Hramiak I, Hughes AD, Jenkins AJ, E. Klein B, Klein R, Ooi TC, Rossing P, et al (2017). Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): an international multicentre trial. Diabetes, Obesity and Metabolism, 19(4), 509-516.
Segers P, O'Rourke MF, Parker K, Westerhof N, Hughes A, Aguado-Sierra J, Aizawa K, Alastruey J, Allen J, Avolio A, et al (2017). Towards a consensus on the understanding and analysis of the pulse waveform: Results from the 2016 Workshop on Arterial Hemodynamics: Past, present and future.  Abstract.

2016

Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.  Full text.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.  Full text.

2015

Ramalli A, Byra M, Dallai A, Palombo C, Aizawa K, Sbragi S, Shore A, Tortoli P, IEEE (2015). A Multiparametric Approach Integrating Vessel Diameter, Wall Shear Rate and Physiologic Signals for Optimized Flow Mediated Dilation Studies.  Author URL.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Journal of Internal Medicine, 278(3), 291-302. Abstract.

2013

Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N (2013). Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med, 60, 89-97. Abstract.  Author URL.  Full text.

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