COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Kim Gooding

Dr Kim Gooding

Postdoctoral Research Fellow

 01392 403088

 Diabetes and Vascular Research Centre 

Overview

Dr Kim Gooding graduated with a degree in Biomedical Science and was awarded a PhD in Medical Sciences from the University of Exeter. Kim is a senior member of the Diabetes and Vascular Medicine Research team within the NIHR Exeter Clinical Research Facility. In addition to her research

Kim’s research is primarily focused on examining the relationship between microvascular endothelial function and the vascular complications associated with type 2 diabetes and prediabetes. She also works closely with the Patient Public Involvement groups within the NIHR Exeter Clinical Research Facility.

Qualifications

  • PhD in Medical Science
  • BSc (Hons) in Biomedical Science

Research

Research interests

Kim’s research interests are to develop, lead and collaborate on a programme of work to examine the relationship between microvascular function and the vascular complications associated with type 2 diabetes and prediabetes, with particular interests in (1) the underlying pathogenesis of diabetic retinopathy and nephropathy, and whether novel imaging biomarkers may help identify individuals at risk of these complications and (2) the vascular actions of incretin based therapies.

Recent research activities have included being the co-lead on the multi-centre Diabetic Retinopathy imaging study that forms part of the Innovative Medicines Initiative (IMI) funded SUMMIT consortium. She also actively contributes to the development and management of multi-centre study funded by IMI investigating prognostic imaging biomarkers for diabetic kidney disease.

Her programme of studies examining the microvascular actions of incretin based medications, including the DPP-IV inhibitors and  GLP-1 receptor agonists, has been funded by Diabetes UK and has utilised a multi-disciplinary approach using in vitro, ex vivo and clinical studies approaches.

Research projects

Current Projects:

  • The vascular actions of glucagon-like peptide-1 analogues and its mediators in people with type 2 diabetes and diabetic retinopathy (VIBE study).
  • Examining the relationship between blood vessel health and kidney function in people with and without diabetes (BEAT-DKD Exeter).
  • The role of SGLT-2 co-transporter inhibitors on metabolite utilisation in people with type 2 diabetes (DAMES study).
  • An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature.
  • Is the glycocalyx marker, hyaluronic acid, associated with early signs of diabetic retinopathy, macular thickening and albuminuria?
  • Examining whether subtle changes in the retina are associated with vascular complications in people with type 2 diabetes.

Grants/Funding:

  • Diabetes UK: The vascular actions of glucagon-like peptide-1 analogues and its mediators in people with type 2 diabetes and diabetic retinopathy (VIBE study).
  • Innovative Medicines Initiative (IMI): Examining the relationship between blood vessel health and kidney function in people with and without diabetes (BEAT-DKD Exeter).
  • Astra Zeneca: The role of SGLT-2 co-transporter inhibitors on metabolite utilisation in people with type 2 diabetes (DAMES study).
  • Diabetes UK: An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature.
  • Northcott Devon Medical Foundation: Is the glycocalyx marker, hyaluronic acid, associated with early signs of diabetic retinopathy, macular thickening and albuminuria?

Papers

Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study. Natali A, Nesti L, Venturi E, Shore AC, Khan F, Gooding K, Gates PE, Looker HC, Dove F, Goncalves I, Persson M, Nilsson J; SUMMIT consortium. Diabetes Obes Metab. 2018 Sep 3. doi: 10.1111/dom.13519.

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study. Shore AC, Colhoun HM, Natali A, Palombo C, Khan F, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, Gates PE, Looker H, Dove F, Belch J, Pinnola S, Venturi E, Kozakova M, Goncalves I, Kravic J, Björkbacka H, Nilsson J; SUMMIT Consortium. Diabetes Care. 2018;41(10):2212-2219.

The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, Littleford RC, Gilchrist M, Colhoun HM, Shore AC, Khan F, Strain WD. Cardiovasc Diabetol. 2017;16(1):114. doi: 10.1186/s12933-017-0594-7.

GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction. Pastel E, McCulloch LJ, Ward R, Joshi S, Gooding KM, Shore AC, Kos K. Clin Sci (Lond). 2017;131(5):343-353.

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Gates P, Khan F, Looker HC, Adams F, Belch J, Pinnola S, Venturi E, Kozakova M, Gan LM, Schnecke V, Nilsson J; SUMMIT consortium. BMC Cardiovasc Disord. 2016 ;16(1):171. doi: 10.1186/s12872-016-0346-8

Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE. Physiol Rep. 2016 Jun;4(12). pii: e12808. doi: 10.14814/phy2.12808.

Red Blood Cell Susceptibility to Pneumolysin: correlation with membrane biochemical and physical properties. Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, Winlove CP. J Biol Chem. 2016;291(19):10210-27.

Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE. Ultrasound Med Biol. 2016 ;42(5):1130-7.

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Strain D, Khan F, Looker HC, Adams F, Belch J, Pinnoli S, Venturi E, Kozakova M, Gan LM, Schnecke V, Nilsson J; SUMMIT Consortium. Arterioscler Thromb Vasc Biol. 2015;35(7):1723-31.

Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, Gates PE, Khan F, Looker HC, Adams F, Belch J, Pinnoli S, Venturi E, Morizzo C, Goncalves I, Ladenvall C, Nilsson J; SUMMIT consortium. J Intern Med. 2015;278(3):291-302.

Blood Oxygen Saturation After Ischemia is Altered With Abnormal Microvascular Reperfusion. Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW. Microcirculation. 2015;22(4):294-305.

Ethnic differences in microvascular function in apparently healthy South African men and women. Pienaar PR, Micklesfield LK, Gill JM, Shore AC, Gooding KM, Levitt NS, Lambert EV. Exp Physiol. 2014;99(7):985-94.

Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG. Ann N Y Acad Sci. 2010;1203:146-50.

Capillary pressure may predict preclinical changes in the eye. Gooding KM, Tooke JE, von Lany H, Mitra M, Ling R, Ball CI, Mawson D, Skinner K, Shore AC. Diabetologia. 2010;53(9):2029-35.

Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC.Diabetologia. 2010;53(8):1722-6.

Variability in sublingual microvessel density and flow measurements in healthy volunteers. Hubble SM, Kyte HL, Gooding K, Shore AC. Microcirculation. 2009;16(2):183-91.

The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Tooke JE, Elston LM, Gooding KM, Ball CI, Mawson DM, Piper J, Sriraman R, Urquhart R, Shore AC. Diabetologia. 2006;49(5):1064-70.

Maximum skin hyperaemia induced by local heating: possible mechanisms. Gooding KM, Hannemann MM, Tooke JE, Clough GF, Shore AC. J Vasc Res. 2006;43(3):270-7.

Impact of hormone replacement therapy on microvascular function in healthy and Type 2 diabetic postmenopausal women. Gooding KM, MacLeod KM, Spyer G, Ewings P, Tooke JE, Shore AC. Diabet Med. 2005;22(5):536-42.

Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene. Stride A, Pearson ER, Brown A, Gooding K, Castleden HA, Hattersley AT. Diabet Med. 2004;21(8):928-30.

Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC. Hypertension. 2003;41(5):1111-7.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Gooding KM, Shore AC, Mawson D, Ball CI, Pitt A, Aizawa K, Strain WD (2013). A pilot study investigating whether dipeptidyl peptidase-IV inhibition alters vascular function in obese men. DIABETIC MEDICINE, 30, E8-E9. Author URL.
Ball CI, Pitt AJ, Shore AC, Kyte HL, Gooding KM (2013). Does the Finnish diabetes risk score simplify recruitment of research participants at a raised risk of diabetes?. DIABETIC MEDICINE, 30, 77-77. Author URL.
Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity. Heart, 96(4), e8-e8.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract.  Author URL.
Gooding KM, Tooke JE, von Lany H, Mitra M, Ling R, Ball CI, Mawson D, Skinner K, Shore AC (2010). Capillary pressure may predict preclinical changes in the eye. Diabetologia, 53(9), 2029-2035. Abstract.  Author URL.
Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG (2010). Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci, 1203, 146-150. Abstract.  Author URL.
Gooding KM, Spyer G, Tooke JE, MacLeod KM (2007). Alteration of oestradiol, testosterone, gonadotrophins and SHBG by type 2 diabetes in postmenopausal women: Clinical implications for the incidence of breast cancer, and cardiovascular risk in diabetic women?. Practical Diabetes International, 24(9), 465-470. Abstract.
Gooding KM, Hannemann MM, Tooke JE, Clough GF, Shore AC (2006). Maximum skin hyperaemia induced by local heating: possible mechanisms. J Vasc Res, 43(3), 270-277. Abstract.  Author URL.
JTooke, Ball C, Elston L, Gooding K (2006). The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia, 49(5), 1064-1070.
Tooke JE, Elston LM, Gooding KM, Ball CI, Mawson DM, Piper J, Sriraman R, Urquhart R, Shore AC (2006). The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia, 49(5), 1064-1070. Abstract.  Author URL.
Gooding KM, MacLeod KM, Spyer G, Ewings P, Tooke JE, Shore AC (2005). Impact of hormone replacement therapy on microvascular function in healthy and Type 2 diabetic postmenopausal women. Diabet Med, 22(5), 536-542. Abstract.  Author URL.
AShore, Fegan P, Gooding K, Tooke J (2003). Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertension, 41(5), 1111-1117.
Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC (2003). Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertension, 41(5), 1111-1117. Abstract.  Author URL.
Gooding KM, Tooke JE, Shore AC (2002). Assessment of microvascular filtration coefficent during early and late phase of the menstrual cycle in females not taking the oral contraceptive pill. JOURNAL OF PHYSIOLOGY-LONDON, 539, 85P-86P. Author URL.
Gooding KM, Shore AC (2000). The role of prostaglandins in the skin hyperaemic response during local heating. JOURNAL OF PHYSIOLOGY-LONDON, 525, 21P-21P. Author URL.
Gooding KM, Tooke JE, Shore AC (1999). The time course of the skin hyperaemic response during local heating. JOURNAL OF VASCULAR RESEARCH, 36(4), 332-332. Author URL.

Conferences

Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY.  Author URL.
Gooding KM, Tooke JE, Ling R, von Lany H, Mitra M, Ball C, Mawson D, Shore AC (2008). Fovea thickness and capillary pressure in non-diabetic individuals.  Author URL.
Gorshunska MY, Gooding KM, Mawson DM, Ball CI, Piper J, Tooke JE, Shore AC (2006). Microvascular distensibility in Type 2 diabetic patients: Relationship to hypertension and insulin resistance.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Tooke JE, Shore AC (2006). Microvascular function is altered by polymorphisms in the promoter region of the aldose reductase gene in healthy subjects.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Jarvis D, Tooke JE, Shore AC (2006). The impact of polymorphisms in the promoter region of the aldose reductase gene on microvascular function in healthy subjects.  Author URL.
Urquhart R, Gooding KM, Elston LM, Sriraman R, Shore AC, Tooke JE (2005). Effect of pioglitazone on microcirculation parameters in patients with type 2 diabetes treated with insulin.  Author URL.
Urquhart R, Elston LM, Gooding KM, Sriraman R, Shore AC, Tooke JE (2005). The effect of pioglitazone on inflammatory markers in patients with type 2 diabetes treated with insulin.  Author URL.
Gooding KM, Spyer G, MacLeod KM, Shore AC (2003). The effect of hormone replacement therapy on microvascular function in type 2 diabetic and healthy postmenopausal women.  Author URL.

Publications by year


2013

Gooding KM, Shore AC, Mawson D, Ball CI, Pitt A, Aizawa K, Strain WD (2013). A pilot study investigating whether dipeptidyl peptidase-IV inhibition alters vascular function in obese men. DIABETIC MEDICINE, 30, E8-E9. Author URL.
Ball CI, Pitt AJ, Shore AC, Kyte HL, Gooding KM (2013). Does the Finnish diabetes risk score simplify recruitment of research participants at a raised risk of diabetes?. DIABETIC MEDICINE, 30, 77-77. Author URL.

2010

Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity. Heart, 96(4), e8-e8.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract.  Author URL.
Gooding KM, Tooke JE, von Lany H, Mitra M, Ling R, Ball CI, Mawson D, Skinner K, Shore AC (2010). Capillary pressure may predict preclinical changes in the eye. Diabetologia, 53(9), 2029-2035. Abstract.  Author URL.
Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG (2010). Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci, 1203, 146-150. Abstract.  Author URL.

2009

Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY.  Author URL.

2008

Gooding KM, Tooke JE, Ling R, von Lany H, Mitra M, Ball C, Mawson D, Shore AC (2008). Fovea thickness and capillary pressure in non-diabetic individuals.  Author URL.

2007

Gooding KM, Spyer G, Tooke JE, MacLeod KM (2007). Alteration of oestradiol, testosterone, gonadotrophins and SHBG by type 2 diabetes in postmenopausal women: Clinical implications for the incidence of breast cancer, and cardiovascular risk in diabetic women?. Practical Diabetes International, 24(9), 465-470. Abstract.

2006

Gooding KM, Hannemann MM, Tooke JE, Clough GF, Shore AC (2006). Maximum skin hyperaemia induced by local heating: possible mechanisms. J Vasc Res, 43(3), 270-277. Abstract.  Author URL.
Gorshunska MY, Gooding KM, Mawson DM, Ball CI, Piper J, Tooke JE, Shore AC (2006). Microvascular distensibility in Type 2 diabetic patients: Relationship to hypertension and insulin resistance.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Tooke JE, Shore AC (2006). Microvascular function is altered by polymorphisms in the promoter region of the aldose reductase gene in healthy subjects.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Jarvis D, Tooke JE, Shore AC (2006). The impact of polymorphisms in the promoter region of the aldose reductase gene on microvascular function in healthy subjects.  Author URL.
JTooke, Ball C, Elston L, Gooding K (2006). The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia, 49(5), 1064-1070.
Tooke JE, Elston LM, Gooding KM, Ball CI, Mawson DM, Piper J, Sriraman R, Urquhart R, Shore AC (2006). The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia, 49(5), 1064-1070. Abstract.  Author URL.

2005

Urquhart R, Gooding KM, Elston LM, Sriraman R, Shore AC, Tooke JE (2005). Effect of pioglitazone on microcirculation parameters in patients with type 2 diabetes treated with insulin.  Author URL.
Gooding KM, MacLeod KM, Spyer G, Ewings P, Tooke JE, Shore AC (2005). Impact of hormone replacement therapy on microvascular function in healthy and Type 2 diabetic postmenopausal women. Diabet Med, 22(5), 536-542. Abstract.  Author URL.
Urquhart R, Elston LM, Gooding KM, Sriraman R, Shore AC, Tooke JE (2005). The effect of pioglitazone on inflammatory markers in patients with type 2 diabetes treated with insulin.  Author URL.

2003

AShore, Fegan P, Gooding K, Tooke J (2003). Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertension, 41(5), 1111-1117.
Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC (2003). Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Hypertension, 41(5), 1111-1117. Abstract.  Author URL.
Gooding KM, Spyer G, MacLeod KM, Shore AC (2003). The effect of hormone replacement therapy on microvascular function in type 2 diabetic and healthy postmenopausal women.  Author URL.

2002

Gooding KM, Tooke JE, Shore AC (2002). Assessment of microvascular filtration coefficent during early and late phase of the menstrual cycle in females not taking the oral contraceptive pill. JOURNAL OF PHYSIOLOGY-LONDON, 539, 85P-86P. Author URL.

2000

Gooding KM, Shore AC (2000). The role of prostaglandins in the skin hyperaemic response during local heating. JOURNAL OF PHYSIOLOGY-LONDON, 525, 21P-21P. Author URL.

1999

Gooding KM, Tooke JE, Shore AC (1999). The time course of the skin hyperaemic response during local heating. JOURNAL OF VASCULAR RESEARCH, 36(4), 332-332. Author URL.

Kim_Gooding Details from cache as at 2018-12-17 10:07:05

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External Engagment and Impact

Awards

  • British Microcirculation Society Poster Award 2009

Committee/panel activities

Kim is an active member of national and European societies for the microcirculation. Her involvement in the British Microcirculation Society includes:

  • Membership Secretary for the British Microcirculation Society (2014-2018)
  • Organising committee for the annual Society meetings in 2010 and 2019.
  • Chairing sessions and acting as poster judge at the annual meetings.

Kim is also a member of the Diabetes UK and the European Association for the Study of Diabetes.

Teaching

Teaching responsibilities: (Undergraduate, Postgraduate)

Current postgraduate supervision

Andrew Forbes Brown (Thesis title: Cross-sectional analysis of microvascular health in type 2 diabetic patients at differing stages of kidney function).

Natalia Rolinska (Thesis title: Examining whether subtle changes in the retina are associated with vascular complications in people with type 2 diabetes).

Leighton Freeman (Thesis title: An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature).

Undergraduate teaching responsibilities

BSc Medical Sciences

Academic tutor

Final year project provider

Professional training year supervisor

BMBS Medicine

Research in action special study unit provider

 

Supervision / Group

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