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Professor Keith Andrew Wesnes

Professor Keith Andrew Wesnes

Professor of Cognitive Neuroscience

South Cloisters 2.40

Keith is Professor of Cognitive Neuroscience and a member of the REACH research group. Since 1973 he has specialized in the measurement of changes to human cognitive function in clinical trials. His PhD into the cholinergic bases of human attention led him to computerize tests of major aspects of cognition in order to detect subtle changes in function produced by nicotine and scopolamine in healthy volunteers. In the early 1980s he developed the CDR System, a computerized set of tests to assess cognitive function in clinical trials with volunteers and virtually any clinical population. From 1986 until 2009 the CDR System was provided to the pharmaceutical and nutraceutical industries as a scientific service by his privately held company, Cognitive Drug Research Ltd. During this time the CDR System was used in over 1000 clinical trials and became the most widely used system of its type in worldwide research. The company grew to 95 employees, had offices in Goring, Chicago and Melbourne, and was twice awarded the most prestigious accolade for businesses in the United Kingdom, the Queen's Award for Enterprise; in 2002 for International Trade, and in 2003 for Innovation. In 2009 the company was sold and the CDR System is now provided to the clinical trial industry by Bracket Global.

Keith runs Wesnes Cognition Ltd, and has developed CogTrackTM, an internet based cognitive assessment system. The CogTrackTM System is being used in a variety of studies worldwide, including the 10 year PROTECT study (www.protectstudy.org.uk) in which over 16,000 adults, aged 50 to 96, performed the tests during the first year of the study.

Keith holds Visiting Professorships at the Department of Psychology, Northumbria University (since 1997), the Centre for Human Psychopharmacology, Swinburne University, Melbourne (since 2007), and the Medicinal Plant Research Group, University of Newcastle (since 2015). Previous academic positions have been held at Indiana University, Reading University, Guy’s Hospital Medical School, the University of East London and Bristol University. He has authored just under 300 peer-reviewed papers and chapters. Nine students have received PhDs under his supervision. 

Qualifications

  • BSc in Experimental Psychology, Reading University, 1973
  • PhD in Psychopharmacology, Reading University, 1979
  • FSS, 1983
  • CPsychol, 1988
  • FBPsS, 1989

Research

Research interests

My research interest is the quality of cognitive function over the lifespan, and the factors which influence it. I firmly believe that properly developed automated tests provide the most sensitive and appropriate assessments of change in cognitive function in clinical research. Recently, the opportunity to test individuals online has enabled research to be conducted without the need for laboratory visits. To this end, I have developed the internet based CogTrack System to pursue these interests, for example into the factors determining cognitive ageing, both in traditional laboratory studies as well as large, remotely conducted, long-term population programmes.

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Wesnes KA, Gommoll C, Chen C, Sambunaris A, McIntyre RS, Harvey PD (2017). Effects of levomilnacipran extended-release on major depressive disorder patients with cognitive impairments: post-hoc analysis of a phase III study. Int Clin Psychopharmacol, 32(2), 72-79. Abstract.  Author URL.
Wesnes KA, Brooker H, Watson AW, Bal W, Okello E (2017). Effects of the Red Bull energy drink on cognitive function and mood in healthy young volunteers. J Psychopharmacol, 31(2), 211-221. Abstract.  Author URL.
Harrison SL, de Craen AJM, Kerse N, Teh R, Granic A, Davies K, Wesnes KA, den Elzen WPJ, Gussekloo J, Kirkwood TBL, et al (2017). Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: the Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers. J Am Geriatr Soc, 65(2), 381-389. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry Abstract.  Author URL.  Full text.
Meador KJ, Yang H, Piña-Garza JE, Laurenza A, Kumar D, Wesnes KA (2016). Cognitive effects of adjunctive perampanel for partial-onset seizures: a randomized trial. Epilepsia, 57(2), 243-251. Abstract.  Author URL.
Wesnes KA, Hopkins SC, Brooker HJ, Koblan KS (2016). Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder. CNS Spectr, 21(5), 379-384. Abstract.  Author URL.
Wesnes KA, McNamara C, Annas P (2016). Norms for healthy adults aged 18-87 years for the Cognitive Drug Research System: an automated set of tests of attention, information processing and memory for use in clinical trials. J Psychopharmacol, 30(3), 263-272. Abstract.  Author URL.
Kure CE, Rosenfeldt FL, Scholey AB, Pipingas A, Kaye DM, Bergin PJ, Croft KD, Wesnes KA, Myers SP, Stough C, et al (2016). Relationships Among Cognitive Function and Cerebral Blood Flow, Oxidative Stress, and Inflammation in Older Heart Failure Patients. J Card Fail, 22(7), 548-559. Abstract.  Author URL.
Katz DA, Locke C, Liu W, Zhang J, Achari R, Wesnes KA, Tracy KA (2016). Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers. Alcohol Clin Exp Res, 40(4), 838-845. Abstract.  Author URL.
Harrison SL, Stephan BCM, Siervo M, Granic A, Davies K, Wesnes KA, Kirkwood TBL, Robinson L, Jagger C (2015). Is there an association between metabolic syndrome and cognitive function in very old adults? the Newcastle 85+ Study. J Am Geriatr Soc, 63(4), 667-675. Abstract.  Author URL.
Wesnes KA, Aarsland D, Ballard C, Londos E (2015). Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies. Int J Geriatr Psychiatry, 30(1), 46-54. Abstract.  Author URL.
Goldberg TE, Harvey PD, Wesnes KA, Snyder PJ, Schneider LS (2015). Practice effects due to serial cognitive assessment: Implications for preclinical Alzheimer's disease randomized controlled trials. Alzheimers Dement (Amst), 1(1), 103-111. Abstract.  Author URL.
Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, et al (2015). Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study. Eur J Neurol, 22(1), 106-e7. Abstract.  Author URL.
de Jager CA, Dye L, de Bruin EA, Butler L, Fletcher J, Lamport DJ, Latulippe ME, Spencer JPE, Wesnes K (2014). Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutrition Reviews, 72(3), 162-179.
Smith MA, Else JE, Paul L, Foster JK, Walker M, Wesnes KA, Riby LM (2014). Functional Living in Older Adults with Type 2 Diabetes: Executive Functioning, Dual Task Performance, and the Impact on Postural Stability and Motor Control. J Aging Health, 26(5), 841-859. Abstract.  Author URL.
Wesnes KA (2014). Moving beyond the pros and cons of automating cognitive testing in pathological aging and dementia: the case for equal opportunity. Alzheimers Res Ther, 6(5). Abstract.  Author URL.
Wesnes KA, Annas P, Basun H, Edgar C, Blennow K (2014). Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels. Alzheimers Res Ther, 6(2). Abstract.  Author URL.
Wesnes KA, Edgar CJ (2014). The role of human cognitive neuroscience in drug discovery for the dementias. Curr Opin Pharmacol, 14, 62-73. Abstract.  Author URL.
Wesnes KA, Barrett ML, Udani JK (2013). An evaluation of the cognitive and mood effects of an energy shot over a 6h period in volunteers: a randomized, double-blind, placebo controlled, cross-over study. Appetite, 67, 105-113. Abstract.  Author URL.
Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, et al (2013). Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD Study. Neurology, 82(4), 308-316.
Wesnes KA, Barrett ML, Udani JK (2013). Corrigendum to "An evaluation of the cognitive and mood effects of an energy shot over a 6 h period in volunteers. A randomized, double-blind, placebo controlled, cross-over study" [Appetite 67 (2013) 105-113] (DOI:10.1016/j.appet.2013.04.005). Appetite
Wesnes KA, Edgar CJ, Kezic I, Salih HM, de Boer P (2013). Effects of nicotine withdrawal on cognition in a clinical trial setting. Psychopharmacology (Berl), 229(1), 133-140. Abstract.  Author URL.
Jones EK, Sünram-Lea SI, Wesnes KA (2012). Acute ingestion of different macronutrients differentially enhances aspects of memory and attention in healthy young adults. Biol Psychol, 89(2), 477-486. Abstract.  Author URL.
Wesnes KA, Pincock C, Scholey A (2012). Breakfast is associated with enhanced cognitive function in schoolchildren. An internet based study. Appetite, 59(3), 646-649. Abstract.  Author URL.
Biegstraaten M, Wesnes KA, Luzy C, Petakov M, Mrsic M, Niederau C, Giraldo P, Hughes D, Mehta A, Mengel K-E, et al (2012). The cognitive profile of type 1 Gaucher disease patients. J Inherit Metab Dis, 35(6), 1093-1099. Abstract.  Author URL.
Taib MNM, Shariff ZM, Wesnes KA, Saad HA, Sariman S (2012). The effect of high lactose-isomaltulose on cognitive performance of young children. A double blind cross-over design study. Appetite, 58(1), 81-87. Abstract.  Author URL.
Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ (2011). The effects of acute tryptophan depletion on neuropsychological function, mood and movement in the healthy elderly. J Psychopharmacol, 25(10), 1337-1343. Abstract.  Author URL.
Moss L, Rouse M, Wesnes KA, Moss M (2010). Differential effects of the aromas of Salvia species on memory and mood. Hum Psychopharmacol, 25(5), 388-396. Abstract.  Author URL.
Gidron Y, Hall P, Wesnes KA, Bucks RS (2010). Does a neuropsychological index of hemispheric lateralization predict onset of upper respiratory tract infectious symptoms?. Br J Health Psychol, 15(Pt 3), 469-477. Abstract.  Author URL.
Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ (2010). Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson's disease. J Psychopharmacol, 24(10), 1465-1472. Abstract.  Author URL.
Harvey PD, Ferris SH, Cummings JL, Wesnes KA, Hsu C, Lane RM, Tekin S (2010). Evaluation of dementia rating scales in Parkinson's disease dementia. Am J Alzheimers Dis Other Demen, 25(2), 142-148. Abstract.  Author URL.
Wesnes KA (2010). Evaluation of techniques to identify beneficial effects of nutrition and natural products on cognitive function. Nutr Rev, 68 Suppl 1, S22-S28. Abstract.  Author URL.
Hudson G, Stutt A, Eccles M, Robinson L, Allcock LM, Wesnes KA, Chinnery PF, Burn DJ (2010). Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease. Neurosci Lett, 479(2), 123-125. Abstract.  Author URL.
Pase MP, Pipingas A, Kras M, Nolidin K, Gibbs AL, Wesnes KA, Scholey AB, Stough C (2010). Healthy middle-aged individuals are vulnerable to cognitive deficits as a result of increased arterial stiffness. J Hypertens, 28(8), 1724-1729. Abstract.  Author URL.
Wesnes KA, Annas P, Edgar CJ, Deeprose C, Karlsten R, Philipp A, Kalliomäki J, Segerdahl M (2010). Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers. J Psychopharmacol, 24(11), 1659-1669. Abstract.  Author URL.
Edgar CJ, Pace-Schott EF, Wesnes KA (2009). Approaches to measuring the effects of wake-promoting drugs: a focus on cognitive function. Hum Psychopharmacol, 24(5), 371-389. Abstract.  Author URL.
Czeisler CA, Walsh JK, Wesnes KA, Arora S, Roth T (2009). Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clinic Proceedings, 84(11), 958-972. Abstract.
Czeisler CA, Walsh JK, Wesnes KA, Arora S, Roth T (2009). Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clin Proc, 84(11), 958-972. Abstract.  Author URL.
Wesnes KA, Edgar C, Tretter RN, Bolodeoku J (2009). Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg. Expert Opin Drug Saf, 8(6), 615-626. Abstract.  Author URL.
Ellis JR, Nathan PJ, Villemagne VL, Mulligan RS, Saunder T, Young K, Smith CL, Welch J, Woodward M, Wesnes KA, et al (2009). Galantamine-induced improvements in cognitive function are not related to alterations in alpha(4)beta (2) nicotinic receptors in early Alzheimer's disease as measured in vivo by 2-[18F]fluoro-A-85380 PET. Psychopharmacology (Berl), 202(1-3), 79-91. Abstract.  Author URL.
Wesnes KA, Edgar C, Dean ADP, Wroe SJ (2009). The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy. Epilepsy Behav, 14(3), 522-528. Abstract.  Author URL.
Kohli S, Fisher SG, Tra Y, Adams MJ, Mapstone ME, Wesnes KA, Roscoe JA, Morrow GR (2009). The effect of modafinil on cognitive function in breast cancer survivors. Cancer, 115(12), 2605-2616. Abstract.  Author URL.
Scholey AB, Tildesley NTJ, Ballard CG, Wesnes KA, Tasker A, Perry EK, Kennedy DO (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berl), 198(1), 127-139. Abstract.  Author URL.
Wesnes KA (2008). Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system. Neurodegener Dis, 5(3-4), 261-263. Abstract.  Author URL.
Saxby BK, Harrington F, Wesnes KA, McKeith IG, Ford GA (2008). Candesartan and cognitive decline in older patients with hypertension: a substudy of the SCOPE trial. Neurology, 70(19 Pt 2), 1858-1866. Abstract.  Author URL.
Edgar CJ, Wesnes KA (2008). Cognition assessment in paediatric clinical trials. Drug Discov Today, 13(1-2), 79-85. Abstract.  Author URL.
Bartholomeusz CF, Wesnes KA, Kulkarni J, Vitetta L, Croft RJ, Nathan PJ (2008). Estradiol treatment and its interaction with the cholinergic system: effects on cognitive function in healthy young women. Horm Behav, 54(5), 684-693. Abstract.  Author URL.
van den Goor JM, Saxby BK, Tijssen JG, Wesnes KA, de Mol BA, Nieuwland R (2008). Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures. Perfusion, 23(5), 267-273. Abstract.
Ellis JR, Villemagne VL, Nathan PJ, Mulligan RS, Gong SJ, Chan JG, Sachinidis J, O'Keefe GJ, Pathmaraj K, Wesnes KA, et al (2008). Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study. Neurobiol Learn Mem, 90(2), 404-412. Abstract.  Author URL.
Bucks RS, Gidron Y, Harris P, Teeling J, Wesnes KA, Perry VH (2008). Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study. Brain Behav Immun, 22(3), 399-407. Abstract.  Author URL.
Palmer C, Ellis KA, O'Neill BV, Croft RJ, Leung S, Oliver C, Wesnes KA, Nathan PJ (2008). The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls. Hum Psychopharmacol, 23(2), 151-159. Abstract.  Author URL.
Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 77(2), 113-122. Abstract.  Author URL.
Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. J Psychopharmacol, 21(1), 65-70. Abstract.  Author URL.
Ingwersen J, Defeyter MA, Kennedy DO, Wesnes KA, Scholey AB (2007). A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning. Appetite, 49(1), 240-244. Abstract.  Author URL.
Wesnes KA (2006). Cognitive function testing: the case for standardization and automation. J Br Menopause Soc, 12(4), 158-163. Abstract.  Author URL.
Roth T, White D, Schmidt-Nowara W, Wesnes KA, Niebler G, Arora S, Black J (2006). Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults. Clin Ther, 28(5), 689-706. Abstract.  Author URL.
Shah J, Wesnes KA, Kovelesky RA, Henney HR (2006). Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. Clin Ther, 28(9), 1308-1317. Abstract.  Author URL.
Ellis JR, Ellis KA, Bartholomeusz CF, Harrison BJ, Wesnes KA, Erskine FF, Vitetta L, Nathan PJ (2006). Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans. Int J Neuropsychopharmacol, 9(2), 175-189. Abstract.  Author URL.
Allcock LM, Kenny RA, Mosimann UP, Tordoff S, Wesnes KA, Hildreth AJ, Burn DJ (2006). Orthostatic hypotension in Parkinson's disease: association with cognitive decline?. Int J Geriatr Psychiatry, 21(8), 778-783. Abstract.  Author URL.
Harsh JR, Hayduk R, Rosenberg R, Wesnes KA, Walsh JK, Arora S, Niebler GE, Roth T (2006). The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Curr Med Res Opin, 22(4), 761-774. Abstract.  Author URL.
Wesnes KA, McKeith I, Edgar C, Emre M, Lane R (2005). Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology, 65(10), 1654-1656. Abstract.  Author URL.
Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005). Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl), 179(4), 813-825. Abstract.  Author URL.
Ellis KA, Mehta MA, Wesnes KA, Armstrong S, Nathan PJ (2005). Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans. Psychopharmacology (Berl), 181(4), 771-780. Abstract.  Author URL.
Kay GG, Wesnes KA (2005). Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers. BJU Int, 96(7), 1055-1062. Abstract.  Author URL.
Tildesley NTJ, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB (2005). Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav, 83(5), 699-709. Abstract.  Author URL.
Schiff R, Bulpitt CJ, Wesnes KA, Rajkumar C (2005). Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study. Psychoneuroendocrinology, 30(4), 309-315. Abstract.  Author URL.
Sünram-Lea SI, Birchall RJ, Wesnes KA, Petrini O (2005). The effect of acute administration of 400mg of Panax ginseng on cognitive performance and mood in healthy young volunteers. Current Topics in Nutraceutical Research, 3(1), 65-74. Abstract.
Pomara N, Willoughby LM, Sidtis JJ, Doraiswamy PM, Wesnes KA, Cooper TB, Greenblatt DJ (2004). Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly. Neurochem Res, 29(12), 2311-2315. Abstract.  Author URL.
Blacker CVR, Greenwood DT, Wesnes KA, Wilson R, Woodward C, Howe I, Ali T (2004). Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. JAMA, 292(10), 1195-1204. Abstract.  Author URL.
McKeith IG, Wesnes KA, Perry E, Ferrara R (2004). Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies. Dement Geriatr Cogn Disord, 18(1), 94-100. Abstract.  Author URL.
Kennedy DO, Haskell CF, Wesnes KA, Scholey AB (2004). Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav, 79(3), 401-411. Abstract.  Author URL.
Harrison BJ, Olver JS, Norman TR, Burrows GD, Wesnes KA, Nathan PJ (2004). Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. J Psychopharmacol, 18(1), 32-40. Abstract.  Author URL.
Matrenza C, Hughes J-M, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ (2004). Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. J Psychopharmacol, 18(1), 21-31. Abstract.  Author URL.
Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG (2004). Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology, 63(11), 2091-2096. Abstract.  Author URL.
Wesnes KA, Pincock C, Richardson D, Helm G, Hails S (2003). Breakfast reduces declines in attention and memory over the morning in schoolchildren. Appetite, 41(3), 329-331. Abstract.  Author URL.
Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA, Scholey AB (2003). Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology, 28(10), 1871-1881. Abstract.  Author URL.
Ferguson JM, Wesnes KA, Schwartz GE (2003). Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients. Int Clin Psychopharmacol, 18(1), 9-14. Abstract.  Author URL.
Kitagawa H, Takenouchi T, Azuma R, Wesnes KA, Kramer WG, Clody DE, Burnett AL (2003). Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology, 28(3), 542-551. Abstract.  Author URL.
Tildesley NTJ, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey AB (2003). Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav, 75(3), 669-674. Abstract.  Author URL.
Wesnes KA, Harrison JE (2003). The evaluation of cognitive function in the dementias: methodological and regulatory considerations. Dialogues Clin Neurosci, 5(1), 77-88. Abstract.  Author URL.
Girdler NM, Fairbrother KJ, Lyne JP, Neave N, Scholey A, Hargaden N, Wesnes KA, Engler J, Rotherham NA (2002). A randomised crossover trial of post-operative cognitive and psychomotor recovery from benzodiazepine sedation: effects of reversal with flumazenil over a prolonged recovery period. Br Dent J, 192(6), 335-339. Abstract.  Author URL.
Girdler NM, Lyne JP, Wallace R, Neave N, Scholey A, Wesnes KA, Herman C (2002). A randomised, controlled trial of cognitive and psychomotor recovery from midazolam sedation following reversal with oral flumazenil. Anaesthesia, 57(9), 868-876. Abstract.  Author URL.
Seed JA, McCue PM, Wesnes KA, Dahabra S, Young AH (2002). Basal activity of the HPA axis and cognitive function in anorexia nervosa. Int J Neuropsychopharmacol, 5(1), 17-25. Abstract.  Author URL.
Wesnes KA, McKeith IG, Ferrara R, Emre M, Del Ser T, Spano PF, Cicin-Sain A, Anand R, Spiegel R (2002). Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system. Dement Geriatr Cogn Disord, 13(3), 183-192. Abstract.  Author URL.
Forton DM, Thomas HC, Murphy CA, Allsop JM, Foster GR, Main J, Wesnes KA, Taylor-Robinson SD (2002). Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease. Hepatology, 35(2), 433-439. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2002). Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav, 75(5), 739-751. Abstract.  Author URL.
Kennedy DO, Scholey AB, Tildesley NTJ, Perry EK, Wesnes KA (2002). Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav, 72(4), 953-964. Abstract.  Author URL.
Ford C, Scholey A, Ayre G, Wesnes KA (2002). The effect of glucose administration and the emotional content of words on heart rate and memory. Journal of Psychopharmacology, 16(3), 241-244. Abstract.
McCue P, Scholey AB, Herman C, Wesnes KA (2002). Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome. J Telemed Telecare, 8(6), 337-343. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2001). Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr Neurosci, 4(5), 399-412. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2001). Dose dependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutr Neurosci, 4(4), 295-310. Abstract.  Author URL.
Wesnes KA (2001). The assessment of cognitive function in clinical trials. Good Clinical Practice Journal, 8(8), 10-14.
Wesnes KA, Bullock R (2001). The emerging importance of attention and the speed of cognitive function in ageing and dementia research. CPD Bulletin Old Age Psychiatry, 3(1), 11-15. Abstract.
Neave N, Scholey AB, Emmett JR, Moss M, Kennedy DO, Wesnes KA (2001). Water ingestion improves subjective alertness, but has no effect on cognitive performance in dehydrated healthy young volunteers. Appetite, 37(3), 255-256. Author URL.
Wesnes KA, Garratt C, Wickens M, Gudgeon A, Oliver S (2000). Effects of sibutramine alone and with alcohol on cognitive function in healthy volunteers. Br J Clin Pharmacol, 49(2), 110-117. Abstract.  Author URL.
Legangneux E, McEwen J, Wesnes KA, Bergougnan L, Miget N, Canal M, L'Heritier C, Pinquier JL, Rosenzweig P (2000). The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers. J Psychopharmacol, 14(2), 164-171. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2000). The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology (Berl), 151(4), 416-423. Abstract.  Author URL.
Wesnes KA, Ward T, McGinty A, Petrini O (2000). The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl), 152(4), 353-361. Abstract.  Author URL.
Wesnes KA (2000). The value of assessing cognitive function in drug development. Dialogues Clin Neurosci, 2(3), 183-202. Abstract.  Author URL.
Hearing SD, Wesnes KA, Bowman CE (1999). Beta blockers and cognitive function in elderly hypertensive patients: Withdrawal and consequences of ACE inhibitor substitution. International Journal of Geriatric Psychopharmacology, 2(1), 13-17. Abstract.
Woodruff-Pak DS, Jaeger ME, Gorman C, Wesnes KA (1999). Relationships among age, conditioned stimulus-unconditioned stimulus interval, and neuropsychological test performance. Neuropsychology, 13(1), 90-102. Abstract.  Author URL.
Ebert U, Oertel R, Wesnes KA, Kirch W (1998). Effects of physostigmine on scopolamine-induced changes in quantitative electroencephalogram and cognitive performance. Human Psychopharmacology, 13(3), 199-210. Abstract.
Ebert U, Siepmann M, Oertel R, Wesnes KA, Kirch W (1998). Pharmacokinetics and pharmacodynamics of scopolamine after subcutaneous administration. J Clin Pharmacol, 38(8), 720-726. Abstract.  Author URL.
Preece AW, Wesnes KA, Iwi GR (1998). The effect of a 50 Hz magnetic field on cognitive function in humans. Int J Radiat Biol, 74(4), 463-470. Abstract.  Author URL.
Keith MS, Stanislav SW, Wesnes KA (1998). Validity of a cognitive computerized assessment system in brain-injured patients. Brain Inj, 12(12), 1037-1043. Abstract.  Author URL.
Wesnes KA, Walker MB, Walker LG, Heys SD, White L, Warren R, Eremin O (1997). Cognitive performance and mood after a weekend on call in a surgical unit. Br J Surg, 84(4), 493-495. Abstract.  Author URL.
Wesnes KA, Faleni RA, Hefting NR, Hoogsteen G, Houben JJ, Jenkins E, Jonkman JH, Leonard J, Petrini O, van Lier JJ, et al (1997). The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacol Bull, 33(4), 677-683. Abstract.  Author URL.
Nicholl CG, Lynch S, Kelly CA, White L, Simpson PM, Wesnes KA, Pitt BMN (1995). The cognitive drug research computerized assessment system in the evaluation of early dementia‐is speed of the essence?. International Journal of Geriatric Psychiatry, 10(3), 199-206. Abstract.
Wesnes KA, Simpson PM, White L, Pinker S, Knibbs A (1992). Automated microcomputerized cognitive evaluation of the elderly and demented: utility, validity, relevance to everyday behaviour and drug sensitivity. European Neuropsychopharmacology, 2(3).
Rai GS, Shovlin C, Wesnes KA (1991). A double-blind, placebo controlled study of Ginkgo biloba extract ('tanakan') in elderly outpatients with mild to moderate memory impairment. Curr Med Res Opin, 12(6), 350-355. Abstract.  Author URL.
Wesnes KA, Simpson PM, White L, Pinker S, Jertz G, Murphy M, Siegfried K (1991). Cholinesterase inhibition in the scopolamine model of dementia. Ann N Y Acad Sci, 640, 268-271. Abstract.  Author URL.
Jones RW, Wesnes KA, Kirby J (1991). Effects of NMDA modulation in scopolamine dementia. Ann N Y Acad Sci, 640, 241-244. Abstract.  Author URL.
Simpson PM, Surmon DJ, Wesnes KA, Wilcock GK (1991). The cognitive drug research computerized assessment system for demented patients: a validation study. International Journal of Geriatric Psychiatry, 6(2), 95-102. Abstract.
Anand R, Wesnes KA (1990). Cognition-enhancing effects of moclobemide, a reversible MAO inhibitor, in humans. Adv Neurol, 51, 261-268. Author URL.
Wesnes KA, Simpson PM, Christmas L, Anand R, McClelland GR (1989). The effects of moclobemide on cognition. J Neural Transm Suppl, 28, 91-102. Abstract.  Author URL.

Chapters

Zangara A, Wesnes KA (2012). Herbal cognitive enhancers: New developments and challenges for therapeutic applications. In  (Ed) Brain Aging and Therapeutic Interventions, 267-289.  Abstract.

Conferences

Wesnes KA (2005). An automated system for assessing cognitive function in any environment.

Publications by year


2017

Wesnes KA, Gommoll C, Chen C, Sambunaris A, McIntyre RS, Harvey PD (2017). Effects of levomilnacipran extended-release on major depressive disorder patients with cognitive impairments: post-hoc analysis of a phase III study. Int Clin Psychopharmacol, 32(2), 72-79. Abstract.  Author URL.
Wesnes KA, Brooker H, Watson AW, Bal W, Okello E (2017). Effects of the Red Bull energy drink on cognitive function and mood in healthy young volunteers. J Psychopharmacol, 31(2), 211-221. Abstract.  Author URL.
Harrison SL, de Craen AJM, Kerse N, Teh R, Granic A, Davies K, Wesnes KA, den Elzen WPJ, Gussekloo J, Kirkwood TBL, et al (2017). Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: the Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers. J Am Geriatr Soc, 65(2), 381-389. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry Abstract.  Author URL.  Full text.

2016

Meador KJ, Yang H, Piña-Garza JE, Laurenza A, Kumar D, Wesnes KA (2016). Cognitive effects of adjunctive perampanel for partial-onset seizures: a randomized trial. Epilepsia, 57(2), 243-251. Abstract.  Author URL.
Wesnes KA, Hopkins SC, Brooker HJ, Koblan KS (2016). Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder. CNS Spectr, 21(5), 379-384. Abstract.  Author URL.
Wesnes KA, McNamara C, Annas P (2016). Norms for healthy adults aged 18-87 years for the Cognitive Drug Research System: an automated set of tests of attention, information processing and memory for use in clinical trials. J Psychopharmacol, 30(3), 263-272. Abstract.  Author URL.
Kure CE, Rosenfeldt FL, Scholey AB, Pipingas A, Kaye DM, Bergin PJ, Croft KD, Wesnes KA, Myers SP, Stough C, et al (2016). Relationships Among Cognitive Function and Cerebral Blood Flow, Oxidative Stress, and Inflammation in Older Heart Failure Patients. J Card Fail, 22(7), 548-559. Abstract.  Author URL.
Katz DA, Locke C, Liu W, Zhang J, Achari R, Wesnes KA, Tracy KA (2016). Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers. Alcohol Clin Exp Res, 40(4), 838-845. Abstract.  Author URL.

2015

Harrison SL, Stephan BCM, Siervo M, Granic A, Davies K, Wesnes KA, Kirkwood TBL, Robinson L, Jagger C (2015). Is there an association between metabolic syndrome and cognitive function in very old adults? the Newcastle 85+ Study. J Am Geriatr Soc, 63(4), 667-675. Abstract.  Author URL.
Wesnes KA, Aarsland D, Ballard C, Londos E (2015). Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies. Int J Geriatr Psychiatry, 30(1), 46-54. Abstract.  Author URL.
Goldberg TE, Harvey PD, Wesnes KA, Snyder PJ, Schneider LS (2015). Practice effects due to serial cognitive assessment: Implications for preclinical Alzheimer's disease randomized controlled trials. Alzheimers Dement (Amst), 1(1), 103-111. Abstract.  Author URL.
Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, et al (2015). Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study. Eur J Neurol, 22(1), 106-e7. Abstract.  Author URL.

2014

de Jager CA, Dye L, de Bruin EA, Butler L, Fletcher J, Lamport DJ, Latulippe ME, Spencer JPE, Wesnes K (2014). Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutrition Reviews, 72(3), 162-179.
Smith MA, Else JE, Paul L, Foster JK, Walker M, Wesnes KA, Riby LM (2014). Functional Living in Older Adults with Type 2 Diabetes: Executive Functioning, Dual Task Performance, and the Impact on Postural Stability and Motor Control. J Aging Health, 26(5), 841-859. Abstract.  Author URL.
Wesnes KA (2014). Moving beyond the pros and cons of automating cognitive testing in pathological aging and dementia: the case for equal opportunity. Alzheimers Res Ther, 6(5). Abstract.  Author URL.
Wesnes KA, Annas P, Basun H, Edgar C, Blennow K (2014). Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels. Alzheimers Res Ther, 6(2). Abstract.  Author URL.
Wesnes KA, Edgar CJ (2014). The role of human cognitive neuroscience in drug discovery for the dementias. Curr Opin Pharmacol, 14, 62-73. Abstract.  Author URL.

2013

Wesnes KA, Barrett ML, Udani JK (2013). An evaluation of the cognitive and mood effects of an energy shot over a 6h period in volunteers: a randomized, double-blind, placebo controlled, cross-over study. Appetite, 67, 105-113. Abstract.  Author URL.
Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, et al (2013). Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD Study. Neurology, 82(4), 308-316.
Wesnes KA, Barrett ML, Udani JK (2013). Corrigendum to "An evaluation of the cognitive and mood effects of an energy shot over a 6 h period in volunteers. A randomized, double-blind, placebo controlled, cross-over study" [Appetite 67 (2013) 105-113] (DOI:10.1016/j.appet.2013.04.005). Appetite
Wesnes KA, Edgar CJ, Kezic I, Salih HM, de Boer P (2013). Effects of nicotine withdrawal on cognition in a clinical trial setting. Psychopharmacology (Berl), 229(1), 133-140. Abstract.  Author URL.

2012

Jones EK, Sünram-Lea SI, Wesnes KA (2012). Acute ingestion of different macronutrients differentially enhances aspects of memory and attention in healthy young adults. Biol Psychol, 89(2), 477-486. Abstract.  Author URL.
Wesnes KA, Pincock C, Scholey A (2012). Breakfast is associated with enhanced cognitive function in schoolchildren. An internet based study. Appetite, 59(3), 646-649. Abstract.  Author URL.
Zangara A, Wesnes KA (2012). Herbal cognitive enhancers: New developments and challenges for therapeutic applications. In  (Ed) Brain Aging and Therapeutic Interventions, 267-289.  Abstract.
Biegstraaten M, Wesnes KA, Luzy C, Petakov M, Mrsic M, Niederau C, Giraldo P, Hughes D, Mehta A, Mengel K-E, et al (2012). The cognitive profile of type 1 Gaucher disease patients. J Inherit Metab Dis, 35(6), 1093-1099. Abstract.  Author URL.
Taib MNM, Shariff ZM, Wesnes KA, Saad HA, Sariman S (2012). The effect of high lactose-isomaltulose on cognitive performance of young children. A double blind cross-over design study. Appetite, 58(1), 81-87. Abstract.  Author URL.

2011

Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ (2011). The effects of acute tryptophan depletion on neuropsychological function, mood and movement in the healthy elderly. J Psychopharmacol, 25(10), 1337-1343. Abstract.  Author URL.

2010

Moss L, Rouse M, Wesnes KA, Moss M (2010). Differential effects of the aromas of Salvia species on memory and mood. Hum Psychopharmacol, 25(5), 388-396. Abstract.  Author URL.
Gidron Y, Hall P, Wesnes KA, Bucks RS (2010). Does a neuropsychological index of hemispheric lateralization predict onset of upper respiratory tract infectious symptoms?. Br J Health Psychol, 15(Pt 3), 469-477. Abstract.  Author URL.
Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ (2010). Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson's disease. J Psychopharmacol, 24(10), 1465-1472. Abstract.  Author URL.
Harvey PD, Ferris SH, Cummings JL, Wesnes KA, Hsu C, Lane RM, Tekin S (2010). Evaluation of dementia rating scales in Parkinson's disease dementia. Am J Alzheimers Dis Other Demen, 25(2), 142-148. Abstract.  Author URL.
Wesnes KA (2010). Evaluation of techniques to identify beneficial effects of nutrition and natural products on cognitive function. Nutr Rev, 68 Suppl 1, S22-S28. Abstract.  Author URL.
Hudson G, Stutt A, Eccles M, Robinson L, Allcock LM, Wesnes KA, Chinnery PF, Burn DJ (2010). Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease. Neurosci Lett, 479(2), 123-125. Abstract.  Author URL.
Pase MP, Pipingas A, Kras M, Nolidin K, Gibbs AL, Wesnes KA, Scholey AB, Stough C (2010). Healthy middle-aged individuals are vulnerable to cognitive deficits as a result of increased arterial stiffness. J Hypertens, 28(8), 1724-1729. Abstract.  Author URL.
Wesnes KA, Annas P, Edgar CJ, Deeprose C, Karlsten R, Philipp A, Kalliomäki J, Segerdahl M (2010). Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers. J Psychopharmacol, 24(11), 1659-1669. Abstract.  Author URL.

2009

Edgar CJ, Pace-Schott EF, Wesnes KA (2009). Approaches to measuring the effects of wake-promoting drugs: a focus on cognitive function. Hum Psychopharmacol, 24(5), 371-389. Abstract.  Author URL.
Czeisler CA, Walsh JK, Wesnes KA, Arora S, Roth T (2009). Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clinic Proceedings, 84(11), 958-972. Abstract.
Czeisler CA, Walsh JK, Wesnes KA, Arora S, Roth T (2009). Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clin Proc, 84(11), 958-972. Abstract.  Author URL.
Wesnes KA, Edgar C, Tretter RN, Bolodeoku J (2009). Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg. Expert Opin Drug Saf, 8(6), 615-626. Abstract.  Author URL.
Ellis JR, Nathan PJ, Villemagne VL, Mulligan RS, Saunder T, Young K, Smith CL, Welch J, Woodward M, Wesnes KA, et al (2009). Galantamine-induced improvements in cognitive function are not related to alterations in alpha(4)beta (2) nicotinic receptors in early Alzheimer's disease as measured in vivo by 2-[18F]fluoro-A-85380 PET. Psychopharmacology (Berl), 202(1-3), 79-91. Abstract.  Author URL.
Wesnes KA, Edgar C, Dean ADP, Wroe SJ (2009). The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy. Epilepsy Behav, 14(3), 522-528. Abstract.  Author URL.
Kohli S, Fisher SG, Tra Y, Adams MJ, Mapstone ME, Wesnes KA, Roscoe JA, Morrow GR (2009). The effect of modafinil on cognitive function in breast cancer survivors. Cancer, 115(12), 2605-2616. Abstract.  Author URL.

2008

Scholey AB, Tildesley NTJ, Ballard CG, Wesnes KA, Tasker A, Perry EK, Kennedy DO (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berl), 198(1), 127-139. Abstract.  Author URL.
Wesnes KA (2008). Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system. Neurodegener Dis, 5(3-4), 261-263. Abstract.  Author URL.
Saxby BK, Harrington F, Wesnes KA, McKeith IG, Ford GA (2008). Candesartan and cognitive decline in older patients with hypertension: a substudy of the SCOPE trial. Neurology, 70(19 Pt 2), 1858-1866. Abstract.  Author URL.
Edgar CJ, Wesnes KA (2008). Cognition assessment in paediatric clinical trials. Drug Discov Today, 13(1-2), 79-85. Abstract.  Author URL.
Bartholomeusz CF, Wesnes KA, Kulkarni J, Vitetta L, Croft RJ, Nathan PJ (2008). Estradiol treatment and its interaction with the cholinergic system: effects on cognitive function in healthy young women. Horm Behav, 54(5), 684-693. Abstract.  Author URL.
van den Goor JM, Saxby BK, Tijssen JG, Wesnes KA, de Mol BA, Nieuwland R (2008). Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures. Perfusion, 23(5), 267-273. Abstract.
Ellis JR, Villemagne VL, Nathan PJ, Mulligan RS, Gong SJ, Chan JG, Sachinidis J, O'Keefe GJ, Pathmaraj K, Wesnes KA, et al (2008). Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study. Neurobiol Learn Mem, 90(2), 404-412. Abstract.  Author URL.
Bucks RS, Gidron Y, Harris P, Teeling J, Wesnes KA, Perry VH (2008). Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study. Brain Behav Immun, 22(3), 399-407. Abstract.  Author URL.
Palmer C, Ellis KA, O'Neill BV, Croft RJ, Leung S, Oliver C, Wesnes KA, Nathan PJ (2008). The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls. Hum Psychopharmacol, 23(2), 151-159. Abstract.  Author URL.
Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 77(2), 113-122. Abstract.  Author URL.

2007

Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. J Psychopharmacol, 21(1), 65-70. Abstract.  Author URL.
Ingwersen J, Defeyter MA, Kennedy DO, Wesnes KA, Scholey AB (2007). A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning. Appetite, 49(1), 240-244. Abstract.  Author URL.

2006

Wesnes KA (2006). Cognitive function testing: the case for standardization and automation. J Br Menopause Soc, 12(4), 158-163. Abstract.  Author URL.
Roth T, White D, Schmidt-Nowara W, Wesnes KA, Niebler G, Arora S, Black J (2006). Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults. Clin Ther, 28(5), 689-706. Abstract.  Author URL.
Shah J, Wesnes KA, Kovelesky RA, Henney HR (2006). Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. Clin Ther, 28(9), 1308-1317. Abstract.  Author URL.
Ellis JR, Ellis KA, Bartholomeusz CF, Harrison BJ, Wesnes KA, Erskine FF, Vitetta L, Nathan PJ (2006). Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans. Int J Neuropsychopharmacol, 9(2), 175-189. Abstract.  Author URL.
Allcock LM, Kenny RA, Mosimann UP, Tordoff S, Wesnes KA, Hildreth AJ, Burn DJ (2006). Orthostatic hypotension in Parkinson's disease: association with cognitive decline?. Int J Geriatr Psychiatry, 21(8), 778-783. Abstract.  Author URL.
Harsh JR, Hayduk R, Rosenberg R, Wesnes KA, Walsh JK, Arora S, Niebler GE, Roth T (2006). The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Curr Med Res Opin, 22(4), 761-774. Abstract.  Author URL.

2005

Wesnes KA (2005). An automated system for assessing cognitive function in any environment.
Wesnes KA, McKeith I, Edgar C, Emre M, Lane R (2005). Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology, 65(10), 1654-1656. Abstract.  Author URL.
Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005). Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl), 179(4), 813-825. Abstract.  Author URL.
Ellis KA, Mehta MA, Wesnes KA, Armstrong S, Nathan PJ (2005). Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans. Psychopharmacology (Berl), 181(4), 771-780. Abstract.  Author URL.
Kay GG, Wesnes KA (2005). Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers. BJU Int, 96(7), 1055-1062. Abstract.  Author URL.
Tildesley NTJ, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB (2005). Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav, 83(5), 699-709. Abstract.  Author URL.
Schiff R, Bulpitt CJ, Wesnes KA, Rajkumar C (2005). Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study. Psychoneuroendocrinology, 30(4), 309-315. Abstract.  Author URL.
Sünram-Lea SI, Birchall RJ, Wesnes KA, Petrini O (2005). The effect of acute administration of 400mg of Panax ginseng on cognitive performance and mood in healthy young volunteers. Current Topics in Nutraceutical Research, 3(1), 65-74. Abstract.

2004

Pomara N, Willoughby LM, Sidtis JJ, Doraiswamy PM, Wesnes KA, Cooper TB, Greenblatt DJ (2004). Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly. Neurochem Res, 29(12), 2311-2315. Abstract.  Author URL.
Blacker CVR, Greenwood DT, Wesnes KA, Wilson R, Woodward C, Howe I, Ali T (2004). Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. JAMA, 292(10), 1195-1204. Abstract.  Author URL.
McKeith IG, Wesnes KA, Perry E, Ferrara R (2004). Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies. Dement Geriatr Cogn Disord, 18(1), 94-100. Abstract.  Author URL.
Kennedy DO, Haskell CF, Wesnes KA, Scholey AB (2004). Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav, 79(3), 401-411. Abstract.  Author URL.
Harrison BJ, Olver JS, Norman TR, Burrows GD, Wesnes KA, Nathan PJ (2004). Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. J Psychopharmacol, 18(1), 32-40. Abstract.  Author URL.
Matrenza C, Hughes J-M, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ (2004). Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. J Psychopharmacol, 18(1), 21-31. Abstract.  Author URL.
Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG (2004). Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology, 63(11), 2091-2096. Abstract.  Author URL.

2003

Wesnes KA, Pincock C, Richardson D, Helm G, Hails S (2003). Breakfast reduces declines in attention and memory over the morning in schoolchildren. Appetite, 41(3), 329-331. Abstract.  Author URL.
Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA, Scholey AB (2003). Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology, 28(10), 1871-1881. Abstract.  Author URL.
Ferguson JM, Wesnes KA, Schwartz GE (2003). Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients. Int Clin Psychopharmacol, 18(1), 9-14. Abstract.  Author URL.
Kitagawa H, Takenouchi T, Azuma R, Wesnes KA, Kramer WG, Clody DE, Burnett AL (2003). Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology, 28(3), 542-551. Abstract.  Author URL.
Tildesley NTJ, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey AB (2003). Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav, 75(3), 669-674. Abstract.  Author URL.
Wesnes KA, Harrison JE (2003). The evaluation of cognitive function in the dementias: methodological and regulatory considerations. Dialogues Clin Neurosci, 5(1), 77-88. Abstract.  Author URL.

2002

Girdler NM, Fairbrother KJ, Lyne JP, Neave N, Scholey A, Hargaden N, Wesnes KA, Engler J, Rotherham NA (2002). A randomised crossover trial of post-operative cognitive and psychomotor recovery from benzodiazepine sedation: effects of reversal with flumazenil over a prolonged recovery period. Br Dent J, 192(6), 335-339. Abstract.  Author URL.
Girdler NM, Lyne JP, Wallace R, Neave N, Scholey A, Wesnes KA, Herman C (2002). A randomised, controlled trial of cognitive and psychomotor recovery from midazolam sedation following reversal with oral flumazenil. Anaesthesia, 57(9), 868-876. Abstract.  Author URL.
Seed JA, McCue PM, Wesnes KA, Dahabra S, Young AH (2002). Basal activity of the HPA axis and cognitive function in anorexia nervosa. Int J Neuropsychopharmacol, 5(1), 17-25. Abstract.  Author URL.
Wesnes KA, McKeith IG, Ferrara R, Emre M, Del Ser T, Spano PF, Cicin-Sain A, Anand R, Spiegel R (2002). Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system. Dement Geriatr Cogn Disord, 13(3), 183-192. Abstract.  Author URL.
Forton DM, Thomas HC, Murphy CA, Allsop JM, Foster GR, Main J, Wesnes KA, Taylor-Robinson SD (2002). Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease. Hepatology, 35(2), 433-439. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2002). Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav, 75(5), 739-751. Abstract.  Author URL.
Kennedy DO, Scholey AB, Tildesley NTJ, Perry EK, Wesnes KA (2002). Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav, 72(4), 953-964. Abstract.  Author URL.
Ford C, Scholey A, Ayre G, Wesnes KA (2002). The effect of glucose administration and the emotional content of words on heart rate and memory. Journal of Psychopharmacology, 16(3), 241-244. Abstract.
McCue P, Scholey AB, Herman C, Wesnes KA (2002). Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome. J Telemed Telecare, 8(6), 337-343. Abstract.  Author URL.

2001

Kennedy DO, Scholey AB, Wesnes KA (2001). Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr Neurosci, 4(5), 399-412. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2001). Dose dependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutr Neurosci, 4(4), 295-310. Abstract.  Author URL.
Wesnes KA (2001). The assessment of cognitive function in clinical trials. Good Clinical Practice Journal, 8(8), 10-14.
Wesnes KA, Bullock R (2001). The emerging importance of attention and the speed of cognitive function in ageing and dementia research. CPD Bulletin Old Age Psychiatry, 3(1), 11-15. Abstract.
Neave N, Scholey AB, Emmett JR, Moss M, Kennedy DO, Wesnes KA (2001). Water ingestion improves subjective alertness, but has no effect on cognitive performance in dehydrated healthy young volunteers. Appetite, 37(3), 255-256. Author URL.

2000

Wesnes KA, Garratt C, Wickens M, Gudgeon A, Oliver S (2000). Effects of sibutramine alone and with alcohol on cognitive function in healthy volunteers. Br J Clin Pharmacol, 49(2), 110-117. Abstract.  Author URL.
Legangneux E, McEwen J, Wesnes KA, Bergougnan L, Miget N, Canal M, L'Heritier C, Pinquier JL, Rosenzweig P (2000). The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers. J Psychopharmacol, 14(2), 164-171. Abstract.  Author URL.
Kennedy DO, Scholey AB, Wesnes KA (2000). The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology (Berl), 151(4), 416-423. Abstract.  Author URL.
Wesnes KA, Ward T, McGinty A, Petrini O (2000). The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl), 152(4), 353-361. Abstract.  Author URL.
Wesnes KA (2000). The value of assessing cognitive function in drug development. Dialogues Clin Neurosci, 2(3), 183-202. Abstract.  Author URL.

1999

Hearing SD, Wesnes KA, Bowman CE (1999). Beta blockers and cognitive function in elderly hypertensive patients: Withdrawal and consequences of ACE inhibitor substitution. International Journal of Geriatric Psychopharmacology, 2(1), 13-17. Abstract.
Woodruff-Pak DS, Jaeger ME, Gorman C, Wesnes KA (1999). Relationships among age, conditioned stimulus-unconditioned stimulus interval, and neuropsychological test performance. Neuropsychology, 13(1), 90-102. Abstract.  Author URL.

1998

Ebert U, Oertel R, Wesnes KA, Kirch W (1998). Effects of physostigmine on scopolamine-induced changes in quantitative electroencephalogram and cognitive performance. Human Psychopharmacology, 13(3), 199-210. Abstract.
Ebert U, Siepmann M, Oertel R, Wesnes KA, Kirch W (1998). Pharmacokinetics and pharmacodynamics of scopolamine after subcutaneous administration. J Clin Pharmacol, 38(8), 720-726. Abstract.  Author URL.
Preece AW, Wesnes KA, Iwi GR (1998). The effect of a 50 Hz magnetic field on cognitive function in humans. Int J Radiat Biol, 74(4), 463-470. Abstract.  Author URL.
Keith MS, Stanislav SW, Wesnes KA (1998). Validity of a cognitive computerized assessment system in brain-injured patients. Brain Inj, 12(12), 1037-1043. Abstract.  Author URL.

1997

Wesnes KA, Walker MB, Walker LG, Heys SD, White L, Warren R, Eremin O (1997). Cognitive performance and mood after a weekend on call in a surgical unit. Br J Surg, 84(4), 493-495. Abstract.  Author URL.
Wesnes KA, Faleni RA, Hefting NR, Hoogsteen G, Houben JJ, Jenkins E, Jonkman JH, Leonard J, Petrini O, van Lier JJ, et al (1997). The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacol Bull, 33(4), 677-683. Abstract.  Author URL.

1995

Nicholl CG, Lynch S, Kelly CA, White L, Simpson PM, Wesnes KA, Pitt BMN (1995). The cognitive drug research computerized assessment system in the evaluation of early dementia‐is speed of the essence?. International Journal of Geriatric Psychiatry, 10(3), 199-206. Abstract.

1992

Wesnes KA, Simpson PM, White L, Pinker S, Knibbs A (1992). Automated microcomputerized cognitive evaluation of the elderly and demented: utility, validity, relevance to everyday behaviour and drug sensitivity. European Neuropsychopharmacology, 2(3).

1991

Rai GS, Shovlin C, Wesnes KA (1991). A double-blind, placebo controlled study of Ginkgo biloba extract ('tanakan') in elderly outpatients with mild to moderate memory impairment. Curr Med Res Opin, 12(6), 350-355. Abstract.  Author URL.
Wesnes KA, Simpson PM, White L, Pinker S, Jertz G, Murphy M, Siegfried K (1991). Cholinesterase inhibition in the scopolamine model of dementia. Ann N Y Acad Sci, 640, 268-271. Abstract.  Author URL.
Jones RW, Wesnes KA, Kirby J (1991). Effects of NMDA modulation in scopolamine dementia. Ann N Y Acad Sci, 640, 241-244. Abstract.  Author URL.
Simpson PM, Surmon DJ, Wesnes KA, Wilcock GK (1991). The cognitive drug research computerized assessment system for demented patients: a validation study. International Journal of Geriatric Psychiatry, 6(2), 95-102. Abstract.

1990

Anand R, Wesnes KA (1990). Cognition-enhancing effects of moclobemide, a reversible MAO inhibitor, in humans. Adv Neurol, 51, 261-268. Author URL.

1989

Wesnes KA, Simpson PM, Christmas L, Anand R, McClelland GR (1989). The effects of moclobemide on cognition. J Neural Transm Suppl, 28, 91-102. Abstract.  Author URL.

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