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Dr Katie Lunnon

Dr Katie Lunnon

Senior Lecturer in Epigenetics

01392 408298

RILD Building 04.05

Katie is a Senior Lecturer in Epigenetics at the University of Exeter Medical School, with a particular interest in dementia. Katie graduated with a BSc Honours degree in Biochemistry & Pharmacology (1st Class) from the University of Southampton in 2004. It was during this Batchelor's degree that Katie became fascinated by dementia, which naturally led on to her PhD studies in the CNS Inflammation Group at the University of Southampton under the supervision of Professor Hugh Perry. During her PhD she investigated the effect that systemic inflammation has on the brain, particularly in dementia.

In 2008 Katie started a post-doctoral research position in the Department of Old Age Psychiatry in King's College London. In this role she identified peripheral changes that occur in the blood of people with Alzheimer's disease. Subsequently in 2011 Katie moved to the Social, Genetic and Developmental Psychiatry (SGDP) Centre also within King's College London to work in the Psychiatric Epigenetics Group. Here she combined techniques she had previously acquired, with cutting-edge methylomics technology to investigate the role of DNA methylation in late-onset Alzheimer's disease aetiology. This work represented the first high-throughput, genome-wide, cross-tissue methylomic study in Alzheimer's disease.

Katie was appointed as a Lecturer at the University of Exeter Medical School, in June 2013, and became a Senior Lecturer in September 2015. Here the focus of her research surrounds investigating epigenetic mechanisms in dementia.

Broad research specialisms

  • The role of epigenetics (DNA methylation) in dementia
  • Biomarkers for early dementia
  • Mitochondrial dysfunction in dementia
  • Neuroinflammation in dementia

Qualifications

  • BSc Biochemistry & Pharmacology (1st Hons) (2004, Southampton)
  • PhD Neuroscience (2008, Southampton)
  • PGCAP (2010, King’s College London)

Research

Research interests

Katie’s key research interests focus on the role of epigenetics in dementia. The scope of her research ranges from identifying new epigenetic biomarkers for Alzheimer’s disease, to identifying novel epigenetic marks in Alzheimer’s brain

Research projects

  • Cross-tissue methylomic profiling in Alzheimer’s disease
  • Mitochondrial DNA methylation
  • Cell-specific methylomic profiles in normal brain
  • The prevalence of alternative DNA modifications in Alzheimer’s disease
  • Methylation Quantitative Trait Loci (mQTL) analyses

Research grants

  • 2016 Medical Research Council
    MRC grant as part of collaborative JPND project to study 5hmC in brain stem
  • 2015 GW4
    GW4 Accelerator Grant "Characterization of novel epigenetic dysfunction in Alzheimer's Disease"
  • 2015 Alzheimers Society
    Alzheimer's Society Major Project Grant "The contribution of epigenetic phenomena to Alzheimer�s disease: an integrated genetic-epigenetic analysis"
  • 2014 Royal Society
    Royal Society Project Grant "Highly parallel bisulfite-sequencing analysis of the ANK1 gene in Alzheimer�s disease"
  • 2014 BRACE
    BRACE PhD studentship "Functional characterisation of ANK1, a novel gene implicated in Alzheimer�s Disease"
  • 2014 Alzheimer Research UK
    "Alzheimer�s Research UK Network South West"
  • 2014 Alzheimer Association
    Alzheimer's Association New Investigator Research Grant "The role of 5-hydroxymethylation in Alzheimer�s disease brain"
  • 2013 ARUK
    Alzheimer's Research UK Pilot Grant "The role of mitochondrial epigenetics in Alzheimer's disease"

Links


Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr
Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2016). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract.  Author URL.  Full text.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.10. Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16 Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12.
Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kloszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract.
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract.
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol Aging, 35(2), 279-290. Abstract.  Author URL.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiology of Aging, 35(10). Abstract.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging, 35(10), 2422.e13-2422.e16. Abstract.  Author URL.  Full text.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, Destefano AL, Kara E, Bras J, Sharma M, et al (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics, 46(9), 989-993. Abstract.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's and Dementia, 10(6), 799-807. Abstract.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement, 10(6), 799-807.e2. Abstract.  Author URL.  Full text.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.
Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, et al (2013). A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis, 33(3), 737-753. Abstract.  Author URL.  Full text.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Lunnon K, Mill J (2013). Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 162(8), 789-799. Abstract.  Full text.
Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, et al (2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2012). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry Abstract.  Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, et al (2012). Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet, 21(16), 3719-3726. Abstract.  Author URL.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kloszewska I, et al (2012). Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis, 30(3), 685-710. Abstract.  Author URL.  Full text.
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, et al (2012). Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One, 7(9). Abstract.  Author URL.  Full text.
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, et al (2011). Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry, 16(11), 1130-1138. Abstract.  Author URL.
Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. J Immunol, 186(12), 7215-7224. Abstract.  Author URL.
Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V (2010). Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165(3), 662-674. Abstract.  Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract.  Author URL.  Full text.
Cunningham C, Campion S, Lunnon K, Murray CL, Woods JFC, Deacon RMJ, Rawlins JNP, Perry VH (2009). Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease. BIOLOGICAL PSYCHIATRY, 65(4), 304-312. Author URL.
Teeling JL, Lunnon KS, Glennie MJ, Perry VH (2008). Systemic inflammation modulates Fc receptor expression on microglia in a mouse model of chronic neurodegeneration: Implications for immunotherapy. JOURNAL OF NEUROIMMUNOLOGY, 203(2), 197-197. Author URL.
Perry VH, Lunnon K, Relton J, Szak S (2007). Innate inflammation in chronic neurodegeneration and the impact of systemic inflammation. NEURON GLIA BIOLOGY, 2, S64-S64. Author URL.
Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005). Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci, 25(40), 9275-9284. Abstract.  Author URL.  Full text.

Conferences

Rutten B, Vermetten E, Vinkers C, Pishva E, Kenis G, de Nijs L, Eijssen L, Viechtbauer W, van den Hove D, Schraut K, et al (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results from a Dutch Prospective Military Cohort Study.  Author URL.
Teeling JL, Lunnon KS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia in a mouse model of chronic neurodegeneration: implications for immunotherapy.  Author URL.
Lunnon K, Teeling J, Szak S, Relton J, Glennic M, Perry VH (2008). Innate Inflammation's contribution to chronic neurodegeneration: microglia phenotype "switching".  Author URL.
Cunningham C, Campion S, Lunnon K, Deacon RMJ, Rawlins INR, Perry VH (2008). Systemic inflammation superimposed on chronic neurodegeneration induces acute behavioural and cognitive changes and accelerates neurological decline.  Author URL.
Teeling JL, Lunnon KS, Cunningham C, Newman T, Perry VH (2008). The role of cytokines in immune-to-brain communication following immune stimulation.  Author URL.

Publications by year


In Press

Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr

2016

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2016). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract.  Author URL.  Full text.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.10. Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16 Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Rutten B, Vermetten E, Vinkers C, Pishva E, Kenis G, de Nijs L, Eijssen L, Viechtbauer W, van den Hove D, Schraut K, et al (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results from a Dutch Prospective Military Cohort Study.  Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12.
Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kloszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract.

2014

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract.
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol Aging, 35(2), 279-290. Abstract.  Author URL.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiology of Aging, 35(10). Abstract.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging, 35(10), 2422.e13-2422.e16. Abstract.  Author URL.  Full text.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, Destefano AL, Kara E, Bras J, Sharma M, et al (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics, 46(9), 989-993. Abstract.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's and Dementia, 10(6), 799-807. Abstract.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement, 10(6), 799-807.e2. Abstract.  Author URL.  Full text.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.

2013

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, et al (2013). A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis, 33(3), 737-753. Abstract.  Author URL.  Full text.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Lunnon K, Mill J (2013). Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 162(8), 789-799. Abstract.  Full text.
Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, et al (2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One, 8(6). Abstract.  Author URL.  Full text.

2012

Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2012). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry Abstract.  Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, et al (2012). Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet, 21(16), 3719-3726. Abstract.  Author URL.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kloszewska I, et al (2012). Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis, 30(3), 685-710. Abstract.  Author URL.  Full text.
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, et al (2012). Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One, 7(9). Abstract.  Author URL.  Full text.

2011

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, et al (2011). Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry, 16(11), 1130-1138. Abstract.  Author URL.
Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. J Immunol, 186(12), 7215-7224. Abstract.  Author URL.
Teeling JL, Lunnon KS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia in a mouse model of chronic neurodegeneration: implications for immunotherapy.  Author URL.

2010

Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V (2010). Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165(3), 662-674. Abstract.  Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract.  Author URL.  Full text.

2009

Cunningham C, Campion S, Lunnon K, Murray CL, Woods JFC, Deacon RMJ, Rawlins JNP, Perry VH (2009). Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease. BIOLOGICAL PSYCHIATRY, 65(4), 304-312. Author URL.

2008

Lunnon K, Teeling J, Szak S, Relton J, Glennic M, Perry VH (2008). Innate Inflammation's contribution to chronic neurodegeneration: microglia phenotype "switching".  Author URL.
Teeling JL, Lunnon KS, Glennie MJ, Perry VH (2008). Systemic inflammation modulates Fc receptor expression on microglia in a mouse model of chronic neurodegeneration: Implications for immunotherapy. JOURNAL OF NEUROIMMUNOLOGY, 203(2), 197-197. Author URL.
Cunningham C, Campion S, Lunnon K, Deacon RMJ, Rawlins INR, Perry VH (2008). Systemic inflammation superimposed on chronic neurodegeneration induces acute behavioural and cognitive changes and accelerates neurological decline.  Author URL.
Teeling JL, Lunnon KS, Cunningham C, Newman T, Perry VH (2008). The role of cytokines in immune-to-brain communication following immune stimulation.  Author URL.

2007

Perry VH, Lunnon K, Relton J, Szak S (2007). Innate inflammation in chronic neurodegeneration and the impact of systemic inflammation. NEURON GLIA BIOLOGY, 2, S64-S64. Author URL.

2005

Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005). Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci, 25(40), 9275-9284. Abstract.  Author URL.  Full text.

Grant Review Boards:

  • GW4 review panel for accelerator and initiator grant funding
  • grant review board for Alzheimer’s Research UK.

Editorial Positions

  • editorial board member for  the Elsevier journal “Neuroepigenetics”.

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