COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Professor Katie Lunnon

Professor Katie Lunnon

Professor of Dementia Genomics

 01392 406758

 RILD Building 03.27

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Katie is Professor of Dementia Genomics at the University of Exeter Medical School, with a particular interest in dementia. Katie graduated with a BSc Honours degree in Biochemistry & Pharmacology (1st Class) from the University of Southampton in 2004. It was during this Batchelor's degree that Katie became fascinated by dementia, which naturally led on to her PhD studies in the CNS Inflammation Group at the University of Southampton under the supervision of Professor Hugh Perry. During her PhD she investigated the effect that systemic inflammation has on the brain, particularly in dementia.

In 2008 Katie started a post-doctoral research position in the Department of Old Age Psychiatry in King's College London. In this role she identified peripheral changes that occur in the blood of people with Alzheimer's disease. Subsequently in 2011 Katie moved to the Social, Genetic and Developmental Psychiatry (SGDP) Centre also within King's College London to work in the Psychiatric Epigenetics Group. Here she combined techniques she had previously acquired, with cutting-edge methylomics technology to investigate the role of DNA methylation in late-onset Alzheimer's disease aetiology. This work represented the first high-throughput, genome-wide, cross-tissue methylomic study in Alzheimer's disease.

Katie was appointed as a Lecturer at the University of Exeter Medical School, in June 2013, became a Senior Lecturer in September 2015, an Associate Professor in  April 2017 and Professor in July 2019. Here the focus of her research surrounds investigating genomic mechanisms in dementia.

Broad research specialisms

  • The role of epigenetics (DNA methylation) in dementia
  • Biomarkers for early dementia
  • Mitochondrial dysfunction in dementia
  • Neuroinflammation in dementia

Qualifications

  • BSc Biochemistry & Pharmacology (1st Class Hons) (2004, Southampton)
  • PhD Neuroscience (2008, Southampton)
  • PGCAP (2010, King’s College London)

Research group links

Research

Research interests

Katie’s key research interests focus on the role of epigenetics in dementia. The scope of her research ranges from identifying new epigenetic biomarkers for Alzheimer’s disease, to identifying novel epigenetic marks in Alzheimer’s brain

Research projects

  • Epigenomic profiling in dementia brain samples
  • Biomarkers for dementia
  • Multi-omic analyses in dementia
  • Mitochondrial DNA methylation
  • Cell-specific epigenetic profiles
  • The role of inflammation and other risk factors in dementia
  • Methylation Quantitative Trait Loci (mQTL) analyses

Research grants

  • 2017 Alzheimer Research UK
    Alzheimer’s Research UK Young Investigator of the Year
  • 2017 Alzheimer Research UK
    An integrated "omics" analysis to elucidate the role of miRNAs in Alzheimer's disease.
  • 2017 Alzheimer Research UK
    Alzheimer's Research UK South West Network 2017-18
  • 2017 Alzheimers Society
    Molecular characterisation of the role of systemic infections in Alzheimer's disease brain”
  • 2016 Medical Research Council
    MRC grant as part of collaborative JPND project to study 5hmC in brain stem
  • 2016 Alzheimer Research UK
    Determining the potential utility of epigenetic modulators to treat Alzheimer’s disease: A collaboration between Exeter and Oxford ARUK Network Centres and the Oxford DDI
  • 2015 GW4
    GW4 Accelerator Grant "Characterization of novel epigenetic dysfunction in Alzheimer's Disease"
  • 2015 Alzheimers Society
    Alzheimer's Society Major Project Grant "The contribution of epigenetic phenomena to Alzheimer�s disease: an integrated genetic-epigenetic analysis"
  • 2014 Royal Society
    Royal Society Project Grant "Highly parallel bisulfite-sequencing analysis of the ANK1 gene in Alzheimer�s disease"
  • 2014 BRACE
    BRACE PhD studentship "Functional characterisation of ANK1, a novel gene implicated in Alzheimer�s Disease"
  • 2014 Alzheimer Research UK
    "Alzheimer�s Research UK Network South West"
  • 2014 Alzheimer Association
    Alzheimer's Association New Investigator Research Grant "The role of 5-hydroxymethylation in Alzheimer�s disease brain"
  • 2013 ARUK
    Alzheimer's Research UK Pilot Grant "The role of mitochondrial epigenetics in Alzheimer's disease"

Links


Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience Full text.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex.  Abstract.
Dabin LC, Guntoro F, Campbell T, Belicard T, Smith AR, Smith RG, Raubould R, Schott JM, Lunnon K, Sarkies P, et al (In Press). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease.  Abstract.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (In Press). Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex.  Abstract.
Higham JP, Malik BR, Buhl E, Dawson J, Ogier AS, Lunnon K, Hodge JJL (In Press). Mis-expression of the Alzheimer’s disease associated gene Ankyrin causes memory loss and shortened lifespan in Drosophila.  Abstract.
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging Full text.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (In Press). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex.  Abstract.
Smith AR, Wheildon G, Lunnon K (2020). A 5‐year update on epigenome‐wide association studies of DNA modifications in Alzheimer’s disease: progress, practicalities and promise. Neuropathology and Applied Neurobiology
C. Dabin L, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, et al (2020). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease. Acta Neuropathologica Abstract.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract.  Author URL.  Full text.
Schrauben M, Dempster E, Lunnon K (2020). Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease. Brain Pathology
Chouliaras L, Kumar GS, Thomas AJ, Lunnon K, Chinnery PF, O'Brien JT (2020). Epigenetic regulation in the pathophysiology of Lewy body dementia. Prog Neurobiol, 192 Abstract.  Author URL.
Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, et al (2020). Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology. Alzheimers Dement, 16(9), 1213-1223. Abstract.  Author URL.
Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Abstract.  Author URL.  Full text.
Smith AR, Mill J, Lunnon K (2020). The Molecular Etiology of Alzheimer’s disease. Brain Pathology
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.
Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW (2020). circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. Geroscience, 42(1), 183-199. Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K, et al (2019). A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging, 74, 70-76. Abstract.
Higham JP, Malik BR, Buhl E, Dawson JM, Ogier AS, Lunnon K, Hodge JJL (2019). Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila. FRONTIERS IN CELLULAR NEUROSCIENCE, 13 Author URL.  Full text.
Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, et al (2019). Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood. Clin Epigenetics, 11(1). Abstract.  Author URL.
Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Abstract.  Author URL.  Full text.
Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Hum Mol Genet, 28(16), 2763-2774. Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2019). Corrigendum to "miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways" [Exp. Cell Res. 29 (2019) 111559]. Exp Cell Res, 385(1). Author URL.
Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128 Abstract.  Author URL.  Full text.
Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Abstract.  Full text.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract.  Author URL.
Harries LW (2019). RNA Biology Provides New Therapeutic Targets for Human Disease. FRONTIERS IN GENETICS, 10 Author URL.  Full text.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.  Full text.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Jeffery N, Harries LW (2019). miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Exp Cell Res, 384(1). Abstract.  Author URL.  Full text.
Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742. Full text.
Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2018). Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 13(1). Abstract.  Author URL.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract.  Author URL.  Full text.
Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, et al (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry, 23(5), 1145-1156. Abstract.  Author URL.  Full text.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2018). Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging, 66, 179.e17-179.e29. Abstract.  Full text.
Lardenoije R, Pishva E, Lunnon K, van den Hove DL (2018). Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders. , 158, 49-82. Abstract.
Chouliaras L, Pishva E, Haapakoski R, Zsoldos E, Mahmood A, Filippini N, Burrage J, Mill J, Kivimäki M, Lunnon K, et al (2018). Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. Epigenomics, 10(5), 585-595. Abstract.  Author URL.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.  Full text.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract.  Author URL.  Full text.
Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2017). ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 12(7). Abstract.  Author URL.  Full text.
Haque S, Harries LW (2017). Circular RNAs (circRNAs) in Health and Disease. Genes (Basel), 8(12). Abstract.  Author URL.  Full text.
Smith RG, Lunnon K (2017). DNA Modifications and Alzheimer's Disease. Adv Exp Med Biol, 978, 303-319. Abstract.  Author URL.  Full text.
Iatrou A, Kenis G, Rutten BPF, Lunnon K, van den Hove DLA (2017). Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?. Cell Mol Life Sci, 74(3), 509-523. Abstract.  Author URL.  Full text.
Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K (2017). Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. J Neurochem, 143(2), 158-170. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract.  Author URL.  Full text.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.
Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, et al (2017). Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiology of Aging, 53, 36-47. Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.  Full text.
Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2016). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract.  Author URL.  Full text.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging, 46, 235.e1-235.e9. Abstract.  Author URL.  Full text.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Smith AR, Mill J, Smith RG, Lunnon K (2016). Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies. Neuroepigenetics, 6, 32-50. Abstract.  Full text.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.e10. Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. PLoS One, 11(6). Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Abstract.  Author URL.  Full text.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16 Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12.
Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kłoszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging, 35(10), 2422.e13-2422.e16. Abstract.  Author URL.  Full text.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, Destefano AL, Kara E, Bras J, Sharma M, et al (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics, 46(9), 989-993. Abstract.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Harries LW (2014). MicroRNAs as Mediators of the Ageing Process. Genes (Basel), 5(3), 656-670. Abstract.  Author URL.  Full text.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's and Dementia, 10(6), 799-807.e2. Abstract.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement, 10(6), 799-807.e2. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.
Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, et al (2013). A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis, 33(3), 737-753. Abstract.  Author URL.  Full text.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Lunnon K, Mill J (2013). Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 162(8), 789-799. Abstract.  Full text.
Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, et al (2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2012). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry Abstract.  Author URL.  Full text.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, et al (2012). Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet, 21(16), 3719-3726. Abstract.  Author URL.
Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Abstract.  Author URL.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, et al (2012). Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis, 30(3), 685-710. Abstract.  Author URL.  Full text.
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, et al (2012). Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One, 7(9). Abstract.  Author URL.  Full text.
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, et al (2011). Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry, 16(11), 1130-1138. Abstract.  Author URL.
Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. J Immunol, 186(12), 7215-7224. Abstract.  Author URL.
Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V (2010). Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165(3), 662-674. Abstract.  Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract.  Author URL.  Full text.
Hanlon K, Harries LW, Ellard S, Rudin CE (2009). Evaluation of 13q14 status in multiple myeloma by digital single nucleotide polymorphism technology. J Mol Diagn, 11(5), 450-457. Abstract.  Author URL.
Hanlon K, Ellard S, Rudin CE, Thorne S, Davies T, Harries LW (2009). Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques. J Mol Diagn, 11(4), 298-305. Abstract.  Author URL.
Hanlon K, Rudin CE, Harries LW (2009). Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One, 4(9). Abstract.  Author URL.  Full text.
Cunningham C, Campion S, Lunnon K, Murray CL, Woods JFC, Deacon RMJ, Rawlins JNP, Perry VH (2009). Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease. BIOLOGICAL PSYCHIATRY, 65(4), 304-312. Author URL.  Full text.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Wolstencroft EC, Hanlon K, Harries LW, Standen GR, Sternberg A, Ellard S (2007). Development of a quantitative real-time polymerase chain reaction assay for the detection of the JAK2 V617F mutation. J Mol Diagn, 9(1), 42-46. Abstract.  Author URL.
Harries LW (2006). Alternate mRNA processing of the hepatocyte nuclear factor genes and its role in monogenic diabetes. Expert Rev Endocrinol Metab, 1(6), 715-726. Abstract.  Author URL.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Singh R, Ellard S, Hattersley A, Harries LW (2006). Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation. J Mol Diagn, 8(2), 225-230. Abstract.  Author URL.
Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005). Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci, 25(40), 9275-9284. Abstract.  Author URL.  Full text.
Harries LW, Hattersley AT, Ellard S (2004). Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay. Diabetes, 53(2), 500-504. Abstract.  Author URL.
Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, Temple IK, Hattersley AT, Ellard S (2004). Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab, 89(8), 3932-3935. Abstract.  Author URL.

Conferences

Rutten B, Vermetten E, Vinkers C, Pishva E, Kenis G, de Nijs L, Eijssen L, Viechtbauer W, van den Hove D, Schraut K, et al (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results from a Dutch Prospective Military Cohort Study.  Author URL.
Teeling JL, Lunnon KS, Cunningham C, Newman T, Perry VH (2008). The role of cytokines in immune-to-brain communication following immune stimulation.  Author URL.

Publications by year


In Press

Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience Full text.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex.  Abstract.
Dabin LC, Guntoro F, Campbell T, Belicard T, Smith AR, Smith RG, Raubould R, Schott JM, Lunnon K, Sarkies P, et al (In Press). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease.  Abstract.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (In Press). Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex.  Abstract.
Higham JP, Malik BR, Buhl E, Dawson J, Ogier AS, Lunnon K, Hodge JJL (In Press). Mis-expression of the Alzheimer’s disease associated gene Ankyrin causes memory loss and shortened lifespan in Drosophila.  Abstract.
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging Full text.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (In Press). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex.  Abstract.

2020

Smith AR, Wheildon G, Lunnon K (2020). A 5‐year update on epigenome‐wide association studies of DNA modifications in Alzheimer’s disease: progress, practicalities and promise. Neuropathology and Applied Neurobiology
C. Dabin L, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, et al (2020). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease. Acta Neuropathologica Abstract.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract.  Author URL.  Full text.
Schrauben M, Dempster E, Lunnon K (2020). Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease. Brain Pathology
Chouliaras L, Kumar GS, Thomas AJ, Lunnon K, Chinnery PF, O'Brien JT (2020). Epigenetic regulation in the pathophysiology of Lewy body dementia. Prog Neurobiol, 192 Abstract.  Author URL.
Imm J (2020). Exploring the Epigenome of Neurons and Glia in Vitro to Determine their Utility as a Model for Alzheimer's Disease.  Abstract.  Full text.
Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, et al (2020). Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology. Alzheimers Dement, 16(9), 1213-1223. Abstract.  Author URL.
Tam HT (2020). Investigating APOE DNA methylation in Alzheimer's disease and its relationship to APOE ε4 genotype.  Abstract.  Full text.
Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Abstract.  Author URL.  Full text.
Smith AR, Mill J, Lunnon K (2020). The Molecular Etiology of Alzheimer’s disease. Brain Pathology
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.
Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW (2020). circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. Geroscience, 42(1), 183-199. Abstract.  Author URL.  Full text.

2019

Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K, et al (2019). A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging, 74, 70-76. Abstract.
Higham JP, Malik BR, Buhl E, Dawson JM, Ogier AS, Lunnon K, Hodge JJL (2019). Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila. FRONTIERS IN CELLULAR NEUROSCIENCE, 13 Author URL.  Full text.
Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, et al (2019). Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood. Clin Epigenetics, 11(1). Abstract.  Author URL.
Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Abstract.  Author URL.  Full text.
Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Hum Mol Genet, 28(16), 2763-2774. Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2019). Corrigendum to "miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways" [Exp. Cell Res. 29 (2019) 111559]. Exp Cell Res, 385(1). Author URL.
Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128 Abstract.  Author URL.  Full text.
Castanho I (2019). Functional genomic characterisation of animal models of AD: relevance to human dementia.  Abstract.  Full text.
Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Abstract.  Full text.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract.  Author URL.
Harries LW (2019). RNA Biology Provides New Therapeutic Targets for Human Disease. FRONTIERS IN GENETICS, 10 Author URL.  Full text.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.  Full text.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Jeffery N, Harries LW (2019). miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Exp Cell Res, 384(1). Abstract.  Author URL.  Full text.

2018

Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742. Full text.
Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2018). Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 13(1). Abstract.  Author URL.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract.  Author URL.  Full text.
Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, et al (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry, 23(5), 1145-1156. Abstract.  Author URL.  Full text.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2018). Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging, 66, 179.e17-179.e29. Abstract.  Full text.
Lardenoije R, Pishva E, Lunnon K, van den Hove DL (2018). Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders. , 158, 49-82. Abstract.
Chouliaras L, Pishva E, Haapakoski R, Zsoldos E, Mahmood A, Filippini N, Burrage J, Mill J, Kivimäki M, Lunnon K, et al (2018). Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. Epigenomics, 10(5), 585-595. Abstract.  Author URL.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.  Full text.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract.  Author URL.  Full text.

2017

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2017). ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 12(7). Abstract.  Author URL.  Full text.
Haque S, Harries LW (2017). Circular RNAs (circRNAs) in Health and Disease. Genes (Basel), 8(12). Abstract.  Author URL.  Full text.
Smith RG, Lunnon K (2017). DNA Modifications and Alzheimer's Disease. Adv Exp Med Biol, 978, 303-319. Abstract.  Author URL.  Full text.
Iatrou A, Kenis G, Rutten BPF, Lunnon K, van den Hove DLA (2017). Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?. Cell Mol Life Sci, 74(3), 509-523. Abstract.  Author URL.  Full text.
Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K (2017). Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. J Neurochem, 143(2), 158-170. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract.  Author URL.  Full text.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.
Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, et al (2017). Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiology of Aging, 53, 36-47. Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.  Full text.

2016

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2016). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract.  Author URL.  Full text.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging, 46, 235.e1-235.e9. Abstract.  Author URL.  Full text.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Smith AR, Mill J, Smith RG, Lunnon K (2016). Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies. Neuroepigenetics, 6, 32-50. Abstract.  Full text.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.e10. Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. PLoS One, 11(6). Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Abstract.  Author URL.  Full text.

2015

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16 Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Rutten B, Vermetten E, Vinkers C, Pishva E, Kenis G, de Nijs L, Eijssen L, Viechtbauer W, van den Hove D, Schraut K, et al (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results from a Dutch Prospective Military Cohort Study.  Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12.
Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.

2014

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kłoszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging, 35(10), 2422.e13-2422.e16. Abstract.  Author URL.  Full text.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, Destefano AL, Kara E, Bras J, Sharma M, et al (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics, 46(9), 989-993. Abstract.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Harries LW (2014). MicroRNAs as Mediators of the Ageing Process. Genes (Basel), 5(3), 656-670. Abstract.  Author URL.  Full text.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's and Dementia, 10(6), 799-807.e2. Abstract.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement, 10(6), 799-807.e2. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.

2013

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, et al (2013). A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis, 33(3), 737-753. Abstract.  Author URL.  Full text.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Lunnon K, Mill J (2013). Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 162(8), 789-799. Abstract.  Full text.
Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, et al (2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One, 8(6). Abstract.  Author URL.  Full text.

2012

Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2012). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry Abstract.  Author URL.  Full text.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, et al (2012). Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet, 21(16), 3719-3726. Abstract.  Author URL.
Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Abstract.  Author URL.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, et al (2012). Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis, 30(3), 685-710. Abstract.  Author URL.  Full text.
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, et al (2012). Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One, 7(9). Abstract.  Author URL.  Full text.

2011

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, et al (2011). Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry, 16(11), 1130-1138. Abstract.  Author URL.
Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. J Immunol, 186(12), 7215-7224. Abstract.  Author URL.

2010

Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V (2010). Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165(3), 662-674. Abstract.  Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract.  Author URL.  Full text.

2009

Hanlon K, Harries LW, Ellard S, Rudin CE (2009). Evaluation of 13q14 status in multiple myeloma by digital single nucleotide polymorphism technology. J Mol Diagn, 11(5), 450-457. Abstract.  Author URL.
Hanlon K, Ellard S, Rudin CE, Thorne S, Davies T, Harries LW (2009). Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques. J Mol Diagn, 11(4), 298-305. Abstract.  Author URL.
Hanlon K, Rudin CE, Harries LW (2009). Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One, 4(9). Abstract.  Author URL.  Full text.
Cunningham C, Campion S, Lunnon K, Murray CL, Woods JFC, Deacon RMJ, Rawlins JNP, Perry VH (2009). Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease. BIOLOGICAL PSYCHIATRY, 65(4), 304-312. Author URL.  Full text.

2008

Teeling JL, Lunnon KS, Cunningham C, Newman T, Perry VH (2008). The role of cytokines in immune-to-brain communication following immune stimulation.  Author URL.

2007

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Wolstencroft EC, Hanlon K, Harries LW, Standen GR, Sternberg A, Ellard S (2007). Development of a quantitative real-time polymerase chain reaction assay for the detection of the JAK2 V617F mutation. J Mol Diagn, 9(1), 42-46. Abstract.  Author URL.

2006

Harries LW (2006). Alternate mRNA processing of the hepatocyte nuclear factor genes and its role in monogenic diabetes. Expert Rev Endocrinol Metab, 1(6), 715-726. Abstract.  Author URL.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Singh R, Ellard S, Hattersley A, Harries LW (2006). Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation. J Mol Diagn, 8(2), 225-230. Abstract.  Author URL.

2005

Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005). Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci, 25(40), 9275-9284. Abstract.  Author URL.  Full text.

2004

Harries LW, Hattersley AT, Ellard S (2004). Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay. Diabetes, 53(2), 500-504. Abstract.  Author URL.
Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, Temple IK, Hattersley AT, Ellard S (2004). Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab, 89(8), 3932-3935. Abstract.  Author URL.

Katie_Lunnon Details from cache as at 2020-10-31 04:57:37

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External Engagement and Impact

Grant Review Boards:

  • Grant review board for Alzheimer’s Research UK.
  • GW4 review panel for accelerator and initiator grant funding

 

Teaching

Modules

2020/21


Supervision / Group

Postdoctoral researchers

  • Ehsan Pishva
  • Rebecca Smith
  • Adam Smith
  • Darren Soanes

Postgraduate researchers

  • Josh Harvey
  • Jennifer Imm
  • Lachlan MacBean
  • Janou Roubroeks
  • Michael Schrauben
  • Greg Wheildon

Alumni

  • Matthew Devall
  • Adam Smith
  • Hau Tak Tam

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