Loading content
Dr Katarina Kos

Dr Katarina Kos

Senior Lecturer (E&R) (Clinical)

01392 406761

RILD Building L3/21

Dr Katarina Kos has a key interest in the field of Type 2 diabetes and its link with obesity and its complications. She is passionate about prevention of diabetes and obesity and collaborates with many teams across disciplines in studies surrounding healthy lifestyle in obesogenic and adverse environments.

She also leads the adipose tissue biology group at the University of Exeter with a special interest in adipose tissue physiology and obesity-related disorders.

Kataria's was more recent interview by the BBC World Service in 'The Forum', a discussion programme, which brings together prominent thinkers from different disciplines with the aim of creating stimulating discussion informed by highly distinct academic, artistic, and cultural perspectives. This prompted a blog with the title: THE BIRTHDAY CAKE DILEMMA in which she reflects on psychological and cultural factors which drive our eating behaviour and the 'emotional crutch' food provides to many.

Qualifications

Ludwing Maximilians University of Munich, MBBS equivalent

MD Ludwig Maximillian University, Munich

PhD at the University of Warwick with the title: Adipose tissue crosstalk with the brain

Masters in Medical Education, University of Warwick

Career

Katarina joined the University of Exeter in 2009 after having worked in Liverpool as Clinical Lecturer and completion on clinical specialist training. 

Links

Research

Research interests

Current research interests of Katarina are to increase the understanding of the extracellular matrix proteins and their regulators which influence the healthy expansion of fat tissue. She is curious of whether dysfuntional fat changes such as fibrosis are reversible. She hopes to identify physiological barriers which stop us from losing weight and which can be modified. She is also interested in how fat dysfunction contributes to ill health such as diabetes.

Energy surplus leads to deposition of superfluous energy as fat/ triglycerides in fat/adipose tissue. Katarina believes that this is the most physiological and healthy way to deal with surplus calories. With time and due to a variety of predisposing factors adipose tissue can become stressed. Fat cells expand to the limits of their ability and new fat cells fail to be formed. The emerging dysfunction is characterised by inflammation of fat by infiltration of immune cells such as macrophages. The structural network of connective tissue into which fat cells are embedded also changes with obesity. It becomes rigid and scarred (fibrosed) not allowing fat cells to grow and expand. In the last few years it was demonstrated very convincingly that this process can potentially be reversed. This is very important in light of the improvement of diabetes with weight loss.

 

Research projects

Effect of yo-yo dieting on fat tissue dysfunction

Macrophage co-culture with adipose tissue explants and the effect on insulin on extracellular matrix regulators

Sedentary behaviour and impairement in glucose tolerance

Effect of GLP-1 analogues on fat tissue dysfunction

Research networks

Katarina has close collaborations with the vascular team, biophysics group, functional genomics team and has an interest in the cross talk of adipose tissue with insulin producing beta cells. Besides laboratory based studies she undertakes projects within the translational medicine framework supported and part of the Exeter NIHR clinical research facility (CRF). She is also working on exploring psychological issues of eating behaviour.

Key publications | Publications by category | Publications by year

Key publications


Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH, Pinkney JH (2010). In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1. Diabetes Obes Metab, 12(4), 360-363. Abstract.  Author URL.
Kos K, Baker AR, Jernas M, Harte AL, Clapham JC, O'Hare JP, Carlsson L, Kumar S, McTernan PG (2009). DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue. Diabetes Obes Metab, 11(4), 285-292. Abstract.  Author URL.
Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C (2009). Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology, 150(4), 1688-1696. Abstract.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlosson LM, Randeva HS, et al (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin and glucose. Diabetes, 8(58), 1780-1788.

Publications by category


Journal articles

Tarrant M, Khan S, Farrow C, Shah P, Daly M, Kos K (In Press). Creating and nurturing social identities in the delivery of healthcare: Patient experiences of a group-based weight-management programme for people with morbid obesity. British Journal of Health Psychology Full text.
Thorn CE, Knight B, Pastel E, McCulloch LJ, Patel B, Shore AC, Kos K (2017). Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity. Diabetes Metab, 43(3), 240-247. Abstract.  Author URL.
Pastel E, McCulloch LJ, Ward R, Joshi S, Gooding KM, Shore AC, Kos K (2017). GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction. Clin Sci (Lond), 131(5), 343-353. Abstract.  Author URL.
Tarrant M, Khan SS, Farrow CV, Shah P, Daly M, Kos K (2017). Patient experiences of a bariatric group programme for managing obesity: a qualitative interview study. Br J Health Psychol, 22(1), 77-93. Abstract.  Author URL.  Full text.
Pastel E, Joshi S, Knight B, Liversedge N, Ward R, Kos K (2016). Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling. Nutr Diabetes, 6(12). Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Pulsford R, Blackwell J, Hillsdon M, Kos K (2016). Intermittent walking, but not standing, improves postprandial insulin and glucose relative to sustained sitting: a randomised cross-over study in middle-aged men. Journal of Science and Medicine in Sport Full text.
Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (2016). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR, Kuller LH, Langa KM, et al (2016). Vitamin D and Risk of Neuroimaging Abnormalities. PLoS One, 11(5). Abstract.  Author URL.  Full text.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.
McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract.
McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract.  Author URL.  Full text.
Aung MM, Gooding KM, Kos K, Shore AC (2015). Human, in vivo, microvascular actions of glucagon-like peptide 1 (GLP-1) and its analogues in health, obesity and well controlled Type 2 diabetes. DIABETIC MEDICINE, 32, 99-99. Author URL.
Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuźma E, Kos K, Llewellyn DJ (2015). Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS One, 10(5). Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.
Lawrence NS, O'Sullivan J, Parslow D, Javaid M, Adams RC, Chambers CD, Kos K, Verbruggen F (2015). Training response inhibition to food is associated with weight loss and reduced energy intake. Appetite, 95, 17-28. Abstract.  Full text.
Aung MM, Gooding KM, Haynes LJ, Kos K, Shore AC (2014). Do glucagon like peptide-1 analogues alter microvascular function in healthy lean individuals?. DIABETIC MEDICINE, 31, 52-52. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract.  Author URL.  Full text.
Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Weedon MN, Ellard S, Prindle MJ, Caswell R, Allen HL, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nature Genetics, 45(8), 947-950. Abstract.
Weedon MN, Ellard S, Prindle MJ, Caswell R, Lango Allen H, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet, 45(8), 947-950. Abstract.  Author URL.  Full text.
Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL.
Alkhouli N, Mansfield J, Green E, Bell J, Knight B, Liversedge N, Tham JC, Welbourn R, Shore AC, Kos K, et al (2013). The mechanical properties of human adipose tissues and their relationships to the structure and composition of the extracellular matrix. Am J Physiol Endocrinol Metab, 305(12), E1427-E1435. Abstract.  Author URL.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.
Kos K, Wong S, Tan BK, Kerrigan D, Randeva HS, Pinkney JH, Wilding JPH (2011). Human RBP4 adipose tissue expression is gender specific and influenced by leptin. Clin Endocrinol (Oxf), 74(2), 197-205. Abstract.  Author URL.
Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-639. Abstract.  Author URL.
Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH, Pinkney JH (2010). In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1. Diabetes Obes Metab, 12(4), 360-363. Abstract.  Author URL.
Kos K, Wilding JPH (2010). SPARC: a key player in the pathologies associated with obesity and diabetes. Nat Rev Endocrinol, 6(4), 225-235. Abstract.  Author URL.
Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P, Bing C (2010). The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf), 72(3), 334-341. Abstract.  Author URL.
Kos K, Wilding JPH (2009). Adipokines: emerging therapeutic targets. Curr Opin Investig Drugs, 10(10), 1061-1068. Abstract.  Author URL.
Kos K, Baker AR, Jernas M, Harte AL, Clapham JC, O'Hare JP, Carlsson L, Kumar S, McTernan PG (2009). DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue. Diabetes Obes Metab, 11(4), 285-292. Abstract.  Author URL.
Kos K, Harte AL, O'Hare PJ, Kumar S, McTernan PG (2009). Ghrelin and the differential regulation of des-acyl (DSG) and oct-anoyl ghrelin (OTG) in human adipose tissue (AT). Clin Endocrinol (Oxf), 70(3), 383-389. Abstract.  Author URL.
Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C (2009). Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology, 150(4), 1688-1696. Abstract.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlosson LM, Randeva HS, et al (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin and glucose. Diabetes, 8(58), 1780-1788.
Kos K, Wong S, Kerrigan D, Wilding JPH, Pinkney JH (2008). Adipose tissue derived SPARC and obesity related inflammation in healthy. DIABETOLOGIA, 51, S330-S331. Author URL.
Kos K, Syn W-K, Lewandowski KC, Bennett J, Nwokolo CU, O'Hare JP, Randeva H (2008). Comparison of maternal ghrelin and leptin in healthy mothers and mothers with Type 1 diabetes. Diabet Med, 25(12), 1400-1405. Abstract.  Author URL.
Pinkney JH, Wong SPY, Kerrigan D, Kos K, Wilding JPH (2008). Distribution and characteristics of adiponectin R1 and R2 receptor in RNA gene expression in human visceral and subcutaneous adipose tissue. DIABETOLOGIA, 51, S90-S90. Author URL.
Kos K, Harte AL, da Silva NF, Tonchev A, Chaldakov G, James S, Snead DR, Hoggart B, O'Hare JP, McTernan PG, et al (2007). Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab, 92(3), 1129-1136. Abstract.  Author URL.
Kusminski CM, McTernan PG, Schraw T, Kos K, O'Hare JP, Ahima R, Kumar S, Scherer PE (2007). Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia, 50(3), 634-642. Abstract.  Author URL.
Kos K, Baker A, Harte A, O'Hare JP, McTernan P, Kumar S (2007). DPP IV in human adipose tissue may regulate adipose tissue mass through modulation of NPY. DIABETIC MEDICINE, 24, 35-35. Author URL.
Kos K, Harte AL, James S, Snead DR, O'Hare JP, McTernan PG, Kumar S (2007). Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. Am J Physiol Endocrinol Metab, 293(5), E1335-E1340. Abstract.  Author URL.

Chapters

Kos K (2015). Inability to lose weight. In  (Ed) Endocrinology and Diabetes: Case Studies, Questions and Commentaries, 183-190.  Abstract.
Kos K, Wilding JPH (2008). Diet, exercise and lifestyles. In Barnett AH (Ed) Management of type 2 diabetes, Oxford University Press.

Conferences

Kos K, McCulloch LJ, Ward R, Joshi S, Sjoholm K, Pitt A, Gooding KM, Shore AC, Carlsson LMS (2015). Adipose tissue response to GLP-1 analogue-induced weight loss.  Author URL.
Gooding K, Aung MM, Kos K, Shore A (2015). MICROVASCULAR ACTIONS OF GLUCAGON-LIKE PEPTIDE-1 AND ITS ANALOGUES IN LEAN AND OBESE PARTICIPANTS AND PARTICIPANTS WITH TYPE 2 DIABETES.  Author URL.
Thorn CE, Knight B, Laura MJ, Patel B, Shore A, Kos K (2015). OBSTRUCTIVE SLEEP APNOEA SYNDROME AFFECTS BLOOD FLOW AND OXYGENATION OF ADIPOSE TISSUE.  Author URL.
McCulloch LJ, Rawling TJ, Price EJ, Knight B, Liversedge NH, Kos K (2013). Collagen VI mRNA expression is regulated by leptin: a potential physiological feedback mechanism regulating adipose tissue expandability.  Author URL.
Kos K, Franck N, Jernas M, Nystrom FH, Carlsson LMS (2011). Nutritional reversibility of human adipose tissue hypoxia and fibrosis.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS, Randeva H, et al (2009). Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS, Randeva HS, et al (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose.  Abstract.  Author URL.  Full text.
Kos KT, Wong S, Jernas M, Kerrigan D, Carlsson L, Wilding JPH, Pinkney JH (2009). The human adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1.  Author URL.
Kos K, Wong S, Kerrigan D, Pinkney JH, Wilding JP (2008). Depot specific expression of SPARC in human adipose tissue, relation with adipokines and insulin resistance.  Author URL.
Kos K, Wong S, Kerrigan D, Wilding JPH, Pinkney JH (2008). Gender differences of RBP4 expression, relation of plasma, VAT and SCAT expression and its relation with insulin resistance and inflammation.  Author URL.
Kos K, Baker AR, Harte AL, O'Hare JP, McTernan PG, Kumar S (2007). DPP-IV inhibitors influence fat metabolism through modulation of NPY's paracrine antilipolytic action in adipose tissue.  Author URL.
Goodyear SJ, Da Silva NF, Kos K, Harte AL, Sung E, Wong LS, O'hare JP, Kumar S, Nwokolo CU, Mcternan PG, et al (2007). The peripheral actions of the des-acyl and octanoylated gherlin on leptin in human abdominal subcutaneous adipocytes.  Author URL.
Goodyear SJ, da Silva NF, Kos K, Harte AL, Sung E, Wong LS, O'Hare JP, Kumar S, Nwokolo C, McTernan PG, et al (2007). The peripheral role of ghrelin: suppression of leptin secretion in human subcutaneous adipocytes.  Author URL.

Internet publications

Kos K, Wilding JPH (2008). New treatments for type 2 diabetes.

Publications by year


In Press

Tarrant M, Khan S, Farrow C, Shah P, Daly M, Kos K (In Press). Creating and nurturing social identities in the delivery of healthcare: Patient experiences of a group-based weight-management programme for people with morbid obesity. British Journal of Health Psychology Full text.

2017

Thorn CE, Knight B, Pastel E, McCulloch LJ, Patel B, Shore AC, Kos K (2017). Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity. Diabetes Metab, 43(3), 240-247. Abstract.  Author URL.
Pastel E, McCulloch LJ, Ward R, Joshi S, Gooding KM, Shore AC, Kos K (2017). GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction. Clin Sci (Lond), 131(5), 343-353. Abstract.  Author URL.
Tarrant M, Khan SS, Farrow CV, Shah P, Daly M, Kos K (2017). Patient experiences of a bariatric group programme for managing obesity: a qualitative interview study. Br J Health Psychol, 22(1), 77-93. Abstract.  Author URL.  Full text.

2016

Pastel E, Joshi S, Knight B, Liversedge N, Ward R, Kos K (2016). Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling. Nutr Diabetes, 6(12). Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Pulsford R, Blackwell J, Hillsdon M, Kos K (2016). Intermittent walking, but not standing, improves postprandial insulin and glucose relative to sustained sitting: a randomised cross-over study in middle-aged men. Journal of Science and Medicine in Sport Full text.
Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (2016). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR, Kuller LH, Langa KM, et al (2016). Vitamin D and Risk of Neuroimaging Abnormalities. PLoS One, 11(5). Abstract.  Author URL.  Full text.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.

2015

Kos K, McCulloch LJ, Ward R, Joshi S, Sjoholm K, Pitt A, Gooding KM, Shore AC, Carlsson LMS (2015). Adipose tissue response to GLP-1 analogue-induced weight loss.  Author URL.
McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract.
McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract.  Author URL.  Full text.
Aung MM, Gooding KM, Kos K, Shore AC (2015). Human, in vivo, microvascular actions of glucagon-like peptide 1 (GLP-1) and its analogues in health, obesity and well controlled Type 2 diabetes. DIABETIC MEDICINE, 32, 99-99. Author URL.
Kos K (2015). Inability to lose weight. In  (Ed) Endocrinology and Diabetes: Case Studies, Questions and Commentaries, 183-190.  Abstract.
Gooding K, Aung MM, Kos K, Shore A (2015). MICROVASCULAR ACTIONS OF GLUCAGON-LIKE PEPTIDE-1 AND ITS ANALOGUES IN LEAN AND OBESE PARTICIPANTS AND PARTICIPANTS WITH TYPE 2 DIABETES.  Author URL.
Thorn CE, Knight B, Laura MJ, Patel B, Shore A, Kos K (2015). OBSTRUCTIVE SLEEP APNOEA SYNDROME AFFECTS BLOOD FLOW AND OXYGENATION OF ADIPOSE TISSUE.  Author URL.
Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuźma E, Kos K, Llewellyn DJ (2015). Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS One, 10(5). Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.
Lawrence NS, O'Sullivan J, Parslow D, Javaid M, Adams RC, Chambers CD, Kos K, Verbruggen F (2015). Training response inhibition to food is associated with weight loss and reduced energy intake. Appetite, 95, 17-28. Abstract.  Full text.

2014

Aung MM, Gooding KM, Haynes LJ, Kos K, Shore AC (2014). Do glucagon like peptide-1 analogues alter microvascular function in healthy lean individuals?. DIABETIC MEDICINE, 31, 52-52. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract.  Author URL.  Full text.

2013

Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Weedon MN, Ellard S, Prindle MJ, Caswell R, Allen HL, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nature Genetics, 45(8), 947-950. Abstract.
Weedon MN, Ellard S, Prindle MJ, Caswell R, Lango Allen H, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet, 45(8), 947-950. Abstract.  Author URL.  Full text.
McCulloch LJ, Rawling TJ, Price EJ, Knight B, Liversedge NH, Kos K (2013). Collagen VI mRNA expression is regulated by leptin: a potential physiological feedback mechanism regulating adipose tissue expandability.  Author URL.
Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL.
Alkhouli N, Mansfield J, Green E, Bell J, Knight B, Liversedge N, Tham JC, Welbourn R, Shore AC, Kos K, et al (2013). The mechanical properties of human adipose tissues and their relationships to the structure and composition of the extracellular matrix. Am J Physiol Endocrinol Metab, 305(12), E1427-E1435. Abstract.  Author URL.

2012

Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.

2011

Kos K, Wong S, Tan BK, Kerrigan D, Randeva HS, Pinkney JH, Wilding JPH (2011). Human RBP4 adipose tissue expression is gender specific and influenced by leptin. Clin Endocrinol (Oxf), 74(2), 197-205. Abstract.  Author URL.
Kos K, Franck N, Jernas M, Nystrom FH, Carlsson LMS (2011). Nutritional reversibility of human adipose tissue hypoxia and fibrosis.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-639. Abstract.  Author URL.

2010

Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH, Pinkney JH (2010). In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1. Diabetes Obes Metab, 12(4), 360-363. Abstract.  Author URL.
Kos K, Wilding JPH (2010). SPARC: a key player in the pathologies associated with obesity and diabetes. Nat Rev Endocrinol, 6(4), 225-235. Abstract.  Author URL.
Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P, Bing C (2010). The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf), 72(3), 334-341. Abstract.  Author URL.

2009

Kos K, Wilding JPH (2009). Adipokines: emerging therapeutic targets. Curr Opin Investig Drugs, 10(10), 1061-1068. Abstract.  Author URL.
Kos K, Baker AR, Jernas M, Harte AL, Clapham JC, O'Hare JP, Carlsson L, Kumar S, McTernan PG (2009). DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue. Diabetes Obes Metab, 11(4), 285-292. Abstract.  Author URL.
Kos K, Harte AL, O'Hare PJ, Kumar S, McTernan PG (2009). Ghrelin and the differential regulation of des-acyl (DSG) and oct-anoyl ghrelin (OTG) in human adipose tissue (AT). Clin Endocrinol (Oxf), 70(3), 383-389. Abstract.  Author URL.
Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C (2009). Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology, 150(4), 1688-1696. Abstract.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS, Randeva H, et al (2009). Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue.  Author URL.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlosson LM, Randeva HS, et al (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin and glucose. Diabetes, 8(58), 1780-1788.
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS, Randeva HS, et al (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose.  Abstract.  Author URL.  Full text.
Kos KT, Wong S, Jernas M, Kerrigan D, Carlsson L, Wilding JPH, Pinkney JH (2009). The human adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1.  Author URL.

2008

Kos K, Wong S, Kerrigan D, Wilding JPH, Pinkney JH (2008). Adipose tissue derived SPARC and obesity related inflammation in healthy. DIABETOLOGIA, 51, S330-S331. Author URL.
Kos K, Syn W-K, Lewandowski KC, Bennett J, Nwokolo CU, O'Hare JP, Randeva H (2008). Comparison of maternal ghrelin and leptin in healthy mothers and mothers with Type 1 diabetes. Diabet Med, 25(12), 1400-1405. Abstract.  Author URL.
Kos K, Wong S, Kerrigan D, Pinkney JH, Wilding JP (2008). Depot specific expression of SPARC in human adipose tissue, relation with adipokines and insulin resistance.  Author URL.
Kos K, Wilding JPH (2008). Diet, exercise and lifestyles. In Barnett AH (Ed) Management of type 2 diabetes, Oxford University Press.
Pinkney JH, Wong SPY, Kerrigan D, Kos K, Wilding JPH (2008). Distribution and characteristics of adiponectin R1 and R2 receptor in RNA gene expression in human visceral and subcutaneous adipose tissue. DIABETOLOGIA, 51, S90-S90. Author URL.
Kos K, Wong S, Kerrigan D, Wilding JPH, Pinkney JH (2008). Gender differences of RBP4 expression, relation of plasma, VAT and SCAT expression and its relation with insulin resistance and inflammation.  Author URL.
Kos K, Wilding JPH (2008). New treatments for type 2 diabetes.

2007

Kos K, Harte AL, da Silva NF, Tonchev A, Chaldakov G, James S, Snead DR, Hoggart B, O'Hare JP, McTernan PG, et al (2007). Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab, 92(3), 1129-1136. Abstract.  Author URL.
Kusminski CM, McTernan PG, Schraw T, Kos K, O'Hare JP, Ahima R, Kumar S, Scherer PE (2007). Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia, 50(3), 634-642. Abstract.  Author URL.
Kos K, Baker A, Harte A, O'Hare JP, McTernan P, Kumar S (2007). DPP IV in human adipose tissue may regulate adipose tissue mass through modulation of NPY. DIABETIC MEDICINE, 24, 35-35. Author URL.
Kos K, Baker AR, Harte AL, O'Hare JP, McTernan PG, Kumar S (2007). DPP-IV inhibitors influence fat metabolism through modulation of NPY's paracrine antilipolytic action in adipose tissue.  Author URL.
Kos K, Harte AL, James S, Snead DR, O'Hare JP, McTernan PG, Kumar S (2007). Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. Am J Physiol Endocrinol Metab, 293(5), E1335-E1340. Abstract.  Author URL.
Goodyear SJ, Da Silva NF, Kos K, Harte AL, Sung E, Wong LS, O'hare JP, Kumar S, Nwokolo CU, Mcternan PG, et al (2007). The peripheral actions of the des-acyl and octanoylated gherlin on leptin in human abdominal subcutaneous adipocytes.  Author URL.
Goodyear SJ, da Silva NF, Kos K, Harte AL, Sung E, Wong LS, O'Hare JP, Kumar S, Nwokolo C, McTernan PG, et al (2007). The peripheral role of ghrelin: suppression of leptin secretion in human subcutaneous adipocytes.  Author URL.

Dr Kos is lecturing in Diabetes and Obesity and associated conditions and supervises BClin Sciences student in their practical assignments, has master and PhD students, supervises project students in molecular biology and teaches medical students on research methodology and clinical aspects of diabetes and endocrinology.

She (co-)supervised many successful interdisciplinary PhD students 

Dr Natalia Alkhouli/Hammad, with physics and microvascular biology

Dr Richard Pulsford, with sport sciences, now Lecturer at the University of Exeter

Dr Myo Myo Aung, with microvascular biology

Dr Alexander Bowen, ilset tissue biology

Dr Thomas Littlejohn, with epidemiology, now postdoctoral fellow at the University of Oxford

Katarina led the Exeter Grand Challenge theme: The Obesity Crisis, which was a great success and with more than 60 students one of the best atttended challenges. Many enthusiastic students produced outputs ranging from videos in how to tackle stigma to development of a peer-supported student aclivity and running clubs and healthy eating and lifestyle forums. See more on: http://www.exeter.ac.uk/grandchallenges/challenges2015/obesitycrisis/.

Back | Edit Profile