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Dr Kashyap Patel

Academic Clinical Lecturer

+44 1392 408226

RILD Building 

Research

Research interests

Dr Patel presents his research into identifying new genes that can cause young onset monogenic diabetes (diabetes caused by a defect in a single gene) in the video below. This talk was recorded at the Living Systems Institute Research Symposium in March 2016.

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, Hattersley AT, Weedon MN (2016). A Type 1 Diabetes Genetic Risk Score can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care, 39(3), 337-344. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Mcdonald TJ, Hudson M, Colclough K, Ellard S, Weedon MN, Pearson EZ, Hattersley AT (2016). Classifying the unclassified using Type 1 diabetes genetic risk score: patients with young onset diabetes who are islet autoantibody negative and have preserved c-peptide. DIABETIC MEDICINE, 33, 188-189. Author URL.
Fendler W, Madzio J, Kozinski K, Patel K, Janikiewicz J, Szopa M, Tracz A, Borowiec M, Jarosz-Chobot P, Mysliwiec M, et al (2016). Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors. Diabetologia, 59(7), 1463-1473. Abstract.  Author URL.  Full text.
Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, et al (2016). Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(8), 1412-1422.
Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, et al (2016). Prospective functional classification of all possible missense variants in PPARG. Nat Genet, 48(12), 1570-1575. Abstract.  Author URL.
Patel KA, Laver T, Johnson M, Sanders T, Shepherd M, Ellard S, Flanagan S, Hattersley AT, Weedon MN (2016). RFX6 is a new MODY gene. DIABETIC MEDICINE, 33, 33-33. Author URL.
Babiker T, Vedovato N, Patel K, Thomas N, Finn R, Männikkö R, Chakera AJ, Flanagan SE, Shepherd MH, Ellard S, et al (2016). Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia, 59(6), 1162-1166. Abstract.  Author URL.  Full text.
Laver TW, Colclough K, Shepherd M, Patel K, Houghton JAL, Dusatkova P, Pruhova S, Morris AD, Palmer CN, McCarthy MI, et al (2016). The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes. Diabetes, 65(10), 3212-3217. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT (2016). Type 1 Diabetes Genetic Risk Score: a Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes, 65(7), 2094-2099. Full text.
Babiker T, Patel KA, Chakera AJ, Houghton J, Shepherd MH, Ellard S, Hattersley AT (2015). Predicting successful transfer to sulphonylureas in neonatal diabetes caused by KCNJ11 mutations. DIABETIC MEDICINE, 32, 19-20. Author URL.
Patel KA, Weedon MN, Ellard S, Hattersley AT, Oram RA (2015). Type 1 diabetes genetic risk score: a novel tool to differentiate monogenic diabetes from Type 1 diabetes. DIABETIC MEDICINE, 32, 21-22. Author URL.
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, et al (2014). The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications, 5
von Wilamowitz-Moellendorff A, Hunter RW, Garcia-Rocha M, Kang L, Lopez-Soldado I, Lantier L, Patel K, Peggie MW, Martinez-Pons C, Voss M, et al (2013). Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082.
Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang H-H, Xue L, Jiang H, et al (2012). Cellular Responses to the Metal-Binding Properties of Metformin. Diabetes, 61(6), 1423-1433.
Henriksson E, Jones HA, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O (2012). The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes. Biochemical Journal, 444(3), 503-514.
Gajjar K, Patel K, Rao CA (2011). Thyroid disease in pregnancy. The Obstetrician & Gynaecologist, 11(2), 150-151.

Conferences

Weedon MN, Hill AV, McDonald TJ, Patel KA, Jones A, Hattersley AT, Oram R (2015). A novel inexpensive test can discriminate between Type 1 and Type 2 diabetes.  Author URL.

Publications by year


2016

Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, Hattersley AT, Weedon MN (2016). A Type 1 Diabetes Genetic Risk Score can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care, 39(3), 337-344. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Mcdonald TJ, Hudson M, Colclough K, Ellard S, Weedon MN, Pearson EZ, Hattersley AT (2016). Classifying the unclassified using Type 1 diabetes genetic risk score: patients with young onset diabetes who are islet autoantibody negative and have preserved c-peptide. DIABETIC MEDICINE, 33, 188-189. Author URL.
Fendler W, Madzio J, Kozinski K, Patel K, Janikiewicz J, Szopa M, Tracz A, Borowiec M, Jarosz-Chobot P, Mysliwiec M, et al (2016). Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors. Diabetologia, 59(7), 1463-1473. Abstract.  Author URL.  Full text.
Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, et al (2016). Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(8), 1412-1422.
Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, et al (2016). Prospective functional classification of all possible missense variants in PPARG. Nat Genet, 48(12), 1570-1575. Abstract.  Author URL.
Patel KA, Laver T, Johnson M, Sanders T, Shepherd M, Ellard S, Flanagan S, Hattersley AT, Weedon MN (2016). RFX6 is a new MODY gene. DIABETIC MEDICINE, 33, 33-33. Author URL.
Babiker T, Vedovato N, Patel K, Thomas N, Finn R, Männikkö R, Chakera AJ, Flanagan SE, Shepherd MH, Ellard S, et al (2016). Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia, 59(6), 1162-1166. Abstract.  Author URL.  Full text.
Laver TW, Colclough K, Shepherd M, Patel K, Houghton JAL, Dusatkova P, Pruhova S, Morris AD, Palmer CN, McCarthy MI, et al (2016). The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes. Diabetes, 65(10), 3212-3217. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT (2016). Type 1 Diabetes Genetic Risk Score: a Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes, 65(7), 2094-2099. Full text.

2015

Weedon MN, Hill AV, McDonald TJ, Patel KA, Jones A, Hattersley AT, Oram R (2015). A novel inexpensive test can discriminate between Type 1 and Type 2 diabetes.  Author URL.
Babiker T, Patel KA, Chakera AJ, Houghton J, Shepherd MH, Ellard S, Hattersley AT (2015). Predicting successful transfer to sulphonylureas in neonatal diabetes caused by KCNJ11 mutations. DIABETIC MEDICINE, 32, 19-20. Author URL.
Patel KA, Weedon MN, Ellard S, Hattersley AT, Oram RA (2015). Type 1 diabetes genetic risk score: a novel tool to differentiate monogenic diabetes from Type 1 diabetes. DIABETIC MEDICINE, 32, 21-22. Author URL.

2014

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, et al (2014). The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications, 5

2013

von Wilamowitz-Moellendorff A, Hunter RW, Garcia-Rocha M, Kang L, Lopez-Soldado I, Lantier L, Patel K, Peggie MW, Martinez-Pons C, Voss M, et al (2013). Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082.

2012

Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang H-H, Xue L, Jiang H, et al (2012). Cellular Responses to the Metal-Binding Properties of Metformin. Diabetes, 61(6), 1423-1433.
Henriksson E, Jones HA, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O (2012). The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes. Biochemical Journal, 444(3), 503-514.

2011

Gajjar K, Patel K, Rao CA (2011). Thyroid disease in pregnancy. The Obstetrician & Gynaecologist, 11(2), 150-151.

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