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Dr Kashyap Patel

Academic Clinical Lecturer

+44 1392 408226

RILD Building 

Research

Research interests

Dr Patel presents his research into identifying new genes that can cause young onset monogenic diabetes (diabetes caused by a defect in a single gene) in the video below. This talk was recorded at the Living Systems Institute Research Symposium in March 2016.

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Patel KA, Kettunen J, Laakso M, Stančáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, et al (In Press). Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Laver TW, Colclough K, Shepherd M, Patel K, Houghton JAL, Dusatkova P, Pruhova S, Morris AD, Palmer CN, McCarthy MI, et al (In Press). The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes. Diabetes, 65(10), 3212-3217. Abstract.  Author URL.  Full text.
Day JO, Flanagan SE, Shepherd MH, Patrick AW, Abid N, Torrens L, Zeman AJ, Patel KA, Hattersley AT (2017). Hyperglycaemia-related complications at the time of diagnosis can cause permanent neurological disability in children with neonatal diabetes. Diabetic Medicine, 34(7), 1000-1004. Full text.
Patel KA, Warren R, Brooke A, Aziz A, Avades T, Poyner R, Vaidya B (2017). Interpretation of thyroid scintigraphy is inconsistent among endocrinologists. J Endocrinol Invest, 40(10), 1155-1157. Author URL.  Full text.
Hattersley AT, Patel KA (2017). Precision diabetes: learning from monogenic diabetes. Diabetologia, 60(5), 769-777. Abstract.  Author URL.  Full text.
Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, Hattersley AT, Weedon MN (2016). A Type 1 Diabetes Genetic Risk Score can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care, 39(3), 337-344. Abstract.  Author URL.  Full text.
Fendler W, Madzio J, Kozinski K, Patel K, Janikiewicz J, Szopa M, Tracz A, Borowiec M, Jarosz-Chobot P, Mysliwiec M, et al (2016). Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors. Diabetologia, 59(7), 1463-1473. Abstract.  Author URL.  Full text.
Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, et al (2016). Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(8), 1412-1422.
Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, et al (2016). Prospective functional classification of all possible missense variants in PPARG. Nat Genet, 48(12), 1570-1575. Abstract.  Author URL.
Babiker T, Vedovato N, Patel K, Thomas N, Finn R, Männikkö R, Chakera AJ, Flanagan SE, Shepherd MH, Ellard S, et al (2016). Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia, 59(6), 1162-1166. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT (2016). Type 1 Diabetes Genetic Risk Score: a Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes, 65(7), 2094-2099. Full text.
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, et al (2014). The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications, 5 Full text.
von Wilamowitz-Moellendorff A, Hunter RW, Garcia-Rocha M, Kang L, Lopez-Soldado I, Lantier L, Patel K, Peggie MW, Martinez-Pons C, Voss M, et al (2013). Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082.
Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang H-H, Xue L, Jiang H, et al (2012). Cellular Responses to the Metal-Binding Properties of Metformin. Diabetes, 61(6), 1423-1433.
Henriksson E, Jones H, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O (2012). The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes. Biochemical Journal, 444(3), 503-514.
Gajjar K, Patel K, Rao CA (2011). Thyroid disease in pregnancy. The Obstetrician & Gynaecologist, 11(2), 150-151.

Conferences

Johnson MB, Patel KA, De Franco E, Flanagan SE, Ellard S, Hattersley AT (2017). A type 1 diabetes genetic risk score discriminatesmonogenic autoimmune diabetes from polygenic clustering of diabetes and autoimmunity.  Author URL.
Grubb AL, Patel KA, Oram RA, Hill AV, Angwin C, McDonald TJ, Weedon MN, Hattersley AT, Shields BV, Jones AG, et al (2017). Development of a risk calculator to identify patients with Type 1 diabetes who will require early insulin therapy.  Author URL.
Patel KA, Sheppard M, Lockett H, Hattersley AT, Walker JN (2017). Insulin pump therapy: a clinically and cost effective alternative for a patient with severe insulin resistance and minimal endogenous insulin secretion.  Author URL.
Bowman P, Shepherd MH, Babiker T, Flanagan SE, Houghton JAL, Mathews F, Patel KA, Thomas NJ, Ellard S, Hattersley AT, et al (2017). Sulphonylureas are a highly effective long-term treatment for KCNJ11 neonatal diabetes: the first 10 year follow-up study of a large international cohort.  Author URL.
Patel KA, Hill A, Shields BM, Oram RA, Jones A, Hattersley AT (2017). Type 2 diabetes and severe insulin deficiency.  Author URL.
Patel KA, Oram RA, Mcdonald TJ, Hudson M, Colclough K, Ellard S, Weedon MN, Pearson EZ, Hattersley AT (2016). Classifying the unclassified using Type 1 diabetes genetic risk score: patients with young onset diabetes who are islet autoantibody negative and have preserved c-peptide.  Author URL.
Patel KA, Laver T, Johnson M, Sanders T, Shepherd M, Ellard S, Flanagan S, Hattersley AT, Weedon MN (2016). RFX6 is a new MODY gene.  Author URL.
Weedon MN, Hill AV, McDonald TJ, Patel KA, Jones A, Hattersley AT, Oram R (2015). A novel inexpensive test can discriminate between Type 1 and Type 2 diabetes.  Author URL.
Babiker T, Patel KA, Chakera AJ, Houghton J, Shepherd MH, Ellard S, Hattersley AT (2015). Predicting successful transfer to sulphonylureas in neonatal diabetes caused by KCNJ11 mutations.  Author URL.
Patel KA, Weedon MN, Ellard S, Hattersley AT, Oram RA (2015). Type 1 diabetes genetic risk score: a novel tool to differentiate monogenic diabetes from Type 1 diabetes.  Author URL.

Publications by year


In Press

Patel KA, Kettunen J, Laakso M, Stančáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, et al (In Press). Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Laver TW, Colclough K, Shepherd M, Patel K, Houghton JAL, Dusatkova P, Pruhova S, Morris AD, Palmer CN, McCarthy MI, et al (In Press). The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes. Diabetes, 65(10), 3212-3217. Abstract.  Author URL.  Full text.

2017

Johnson MB, Patel KA, De Franco E, Flanagan SE, Ellard S, Hattersley AT (2017). A type 1 diabetes genetic risk score discriminatesmonogenic autoimmune diabetes from polygenic clustering of diabetes and autoimmunity.  Author URL.
Grubb AL, Patel KA, Oram RA, Hill AV, Angwin C, McDonald TJ, Weedon MN, Hattersley AT, Shields BV, Jones AG, et al (2017). Development of a risk calculator to identify patients with Type 1 diabetes who will require early insulin therapy.  Author URL.
Day JO, Flanagan SE, Shepherd MH, Patrick AW, Abid N, Torrens L, Zeman AJ, Patel KA, Hattersley AT (2017). Hyperglycaemia-related complications at the time of diagnosis can cause permanent neurological disability in children with neonatal diabetes. Diabetic Medicine, 34(7), 1000-1004. Full text.
Patel KA, Sheppard M, Lockett H, Hattersley AT, Walker JN (2017). Insulin pump therapy: a clinically and cost effective alternative for a patient with severe insulin resistance and minimal endogenous insulin secretion.  Author URL.
Patel KA, Warren R, Brooke A, Aziz A, Avades T, Poyner R, Vaidya B (2017). Interpretation of thyroid scintigraphy is inconsistent among endocrinologists. J Endocrinol Invest, 40(10), 1155-1157. Author URL.  Full text.
Hattersley AT, Patel KA (2017). Precision diabetes: learning from monogenic diabetes. Diabetologia, 60(5), 769-777. Abstract.  Author URL.  Full text.
Bowman P, Shepherd MH, Babiker T, Flanagan SE, Houghton JAL, Mathews F, Patel KA, Thomas NJ, Ellard S, Hattersley AT, et al (2017). Sulphonylureas are a highly effective long-term treatment for KCNJ11 neonatal diabetes: the first 10 year follow-up study of a large international cohort.  Author URL.
Patel KA, Hill A, Shields BM, Oram RA, Jones A, Hattersley AT (2017). Type 2 diabetes and severe insulin deficiency.  Author URL.

2016

Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, Hattersley AT, Weedon MN (2016). A Type 1 Diabetes Genetic Risk Score can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care, 39(3), 337-344. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Mcdonald TJ, Hudson M, Colclough K, Ellard S, Weedon MN, Pearson EZ, Hattersley AT (2016). Classifying the unclassified using Type 1 diabetes genetic risk score: patients with young onset diabetes who are islet autoantibody negative and have preserved c-peptide.  Author URL.
Fendler W, Madzio J, Kozinski K, Patel K, Janikiewicz J, Szopa M, Tracz A, Borowiec M, Jarosz-Chobot P, Mysliwiec M, et al (2016). Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors. Diabetologia, 59(7), 1463-1473. Abstract.  Author URL.  Full text.
Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, et al (2016). Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(8), 1412-1422.
Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, et al (2016). Prospective functional classification of all possible missense variants in PPARG. Nat Genet, 48(12), 1570-1575. Abstract.  Author URL.
Patel KA, Laver T, Johnson M, Sanders T, Shepherd M, Ellard S, Flanagan S, Hattersley AT, Weedon MN (2016). RFX6 is a new MODY gene.  Author URL.
Babiker T, Vedovato N, Patel K, Thomas N, Finn R, Männikkö R, Chakera AJ, Flanagan SE, Shepherd MH, Ellard S, et al (2016). Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia, 59(6), 1162-1166. Abstract.  Author URL.  Full text.
Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT (2016). Type 1 Diabetes Genetic Risk Score: a Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes, 65(7), 2094-2099. Full text.

2015

Weedon MN, Hill AV, McDonald TJ, Patel KA, Jones A, Hattersley AT, Oram R (2015). A novel inexpensive test can discriminate between Type 1 and Type 2 diabetes.  Author URL.
Babiker T, Patel KA, Chakera AJ, Houghton J, Shepherd MH, Ellard S, Hattersley AT (2015). Predicting successful transfer to sulphonylureas in neonatal diabetes caused by KCNJ11 mutations.  Author URL.
Patel KA, Weedon MN, Ellard S, Hattersley AT, Oram RA (2015). Type 1 diabetes genetic risk score: a novel tool to differentiate monogenic diabetes from Type 1 diabetes.  Author URL.

2014

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, et al (2014). The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications, 5 Full text.

2013

von Wilamowitz-Moellendorff A, Hunter RW, Garcia-Rocha M, Kang L, Lopez-Soldado I, Lantier L, Patel K, Peggie MW, Martinez-Pons C, Voss M, et al (2013). Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082.

2012

Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang H-H, Xue L, Jiang H, et al (2012). Cellular Responses to the Metal-Binding Properties of Metformin. Diabetes, 61(6), 1423-1433.
Henriksson E, Jones H, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O (2012). The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes. Biochemical Journal, 444(3), 503-514.

2011

Gajjar K, Patel K, Rao CA (2011). Thyroid disease in pregnancy. The Obstetrician & Gynaecologist, 11(2), 150-151.

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