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Dr Jonathan Brown

Dr Jonathan Brown

Senior Lecturer

5504

Hatherly D1

Dr Jon Brown is a neurophysiologist with an interest in how neuronal function is affected in neurological and psychiatric disease. In his group, they use electrophysiological approaches to explore synaptic and intrinsic excitability changes in models of diseases such as Alzheimer’s disease, frontotemporal dementia and schizophrenia.

Dr Brown graduated from University of Manchester with a BSc (1st class) in Neuroscience and then an MRes in Biological Sciences (specializing in neurosciences). Subsequently, he obtained a PhD from the University of Bristol, whilst based in the Neurology Centre of Excellence for Drug Discovery at GlaxoSmithKline. He went on to take up postdoctoral positions both at GSK and University of Bristol before being appointed Senior Research Fellow and then Senior Lecturer at the University of Exeter Medical School.

Broad research specialisms

  • Models of dementia and psychiatric disease
  • In vitro brain slice electrophysiology
  • In vivo electrophysiology
  • Synaptic and intrinsic neurophysiology

Qualifications

  • PhD, 2004, University of Bristol
  • MRes, 2000, University of Manchester
  • BSc Neuroscience (1st class), 1999, University of Manchester

Research

Research interests

Cognitive dysfunction in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia arise from changes to neuronal networks. For example, in late-stage AD, there is substantial neurodegeneration which alters the integrity of the surviving network. Furthermore, there is increasing evidence that more subtle changes to synaptic circuits may underlie the cognitive deficits that occur earlier on in the disease, prior to detectable neuronal loss.

Dr Brown and his colleagues aim to characterize these changes in neuronal networks at multiple levels of complexity, using mouse models of dementia and schizophrenia. They make whole-cell recordings from neurons in brain areas known to be affected in these diseases, such as the hippocampus, entorhinal cortex and prefrontal cortex. They use these approaches to explore the synaptic and intrinsic properties of these neurons. More recently they have been using recording techniques that allow them to record network activity from multiple brain regions simultaneously, to explore the impact of cellular level changes on larger scale network interactions.

Research projects

  • Neuronal network disruptions in a model of tauopathy
  • Altered intrinsic excitability in mouse models of Alzheimer’s disease associated amyloidopathy
  • Synaptic and intrinsic deficits in mice expressing mutant DISC1

Grants/Funding

In total Dr Brown holds or has held >£2m of grant funding either as PI or Co-I

  • MRC Case award: Intrinsic Neuronal Plasticity in rodent models of Neurological Disease (Co-I; Sep 2009-Sep 2013 £76k)
  • Pfizer Research Contract. (Co-I; Dec 2009-Dec 2012 ~£650k)
  • MRC Case award: Synaptic and intrinsic deficits in genetic models of psychiatric disease (Co-I; Sep 2010-Sep 2014 £76k)
  • University of Bristol Research Committee Strategy Fund Award (pilot grant). Neurobiology of normal ageing. (Co-I; £16k)
  • MRC Project grant: Altered intrinsic excitability in mouse models of Alzheimer’s disease associated amyloidopathy (Co-I; Apr 2012-Apr 2015, £713k)
  • ARUK Senior Research Fellowship: Neuronal network disruptions in a model of tauopathy (PI; Jan 2013-Jan 2016, £319k)
  • Eli Lilly studentships (Co-I; Oct 2013-Oct 2017, £240k)

Key publications | Publications by category | Publications by year

Key publications


Martin HGS, Lassalle O, Brown JT, Manzoni OJ (2016). Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome. Cereb Cortex, 26(5), 2084-2092. Abstract.  Author URL.  Full text.
Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.  Full text.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.  Full text.
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract.  Author URL.  Full text.
Witton J, Staniaszek LE, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. The Journal of Physiology, 594(16), 4615-4630. Full text.
Banks PJ, Burroughs AC, Barker GRI, Brown JT, Warburton EC, Bashir ZI (2015). Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission. Proc Natl Acad Sci U S A, 112(35), 11096-11101. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Walsh DA, Brown JT, Randall AD (2017). In vitro. characterisation of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice. The Journal of Physiology Full text.
Martin HGS, Lassalle O, Brown JT, Manzoni OJ (2016). Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome. Cereb Cortex, 26(5), 2084-2092. Abstract.  Author URL.  Full text.
Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.  Full text.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.  Full text.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract.  Author URL.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, et al (2016). Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. J Physiol, 594(22), 6583-6594. Abstract.  Author URL.
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract.  Author URL.  Full text.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Witton J, Staniaszek LE, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. The Journal of Physiology, 594(16), 4615-4630. Full text.
Banks PJ, Burroughs AC, Barker GRI, Brown JT, Warburton EC, Bashir ZI (2015). Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission. Proc Natl Acad Sci U S A, 112(35), 11096-11101. Abstract.  Author URL.  Full text.
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Church TW, Weatherall KL, Corrêa SAL, Prole DL, Brown JT, Marrion NV (2015). Preferential assembly of heteromeric small conductance calcium-activated potassium channels. Eur J Neurosci, 41(3), 305-315. Abstract.  Author URL.
Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.
Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract.  Author URL.
Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract.  Author URL.
Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract.  Author URL.
Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract.  Author URL.
Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract.  Author URL.
Brown JT, Chin J, Leiser SC, Pangalos MN, Randall AD (2011). Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging, 32(11), 2109.e1-2109.14. Abstract.  Author URL.
McMillan LE, Brown JT, Henley JM, Cimarosti H (2011). Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neurosci Lett, 502(3), 201-208. Abstract.  Author URL.
Brown JT, Booth CA, Randall AD (2011). Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci, 33(5), 879-889. Abstract.  Author URL.
Sitzia F, Brown JT, Randall AD, Dunlop J (2011). Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol, 2 Abstract.  Author URL.  Full text.
Witton J, Brown JT, Jones MW, Randall AD (2010). Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain, 3 Abstract.  Author URL.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology, 59(4-5), 243-267. Abstract.  Author URL.
Brown JT, Weatherall KL, Corria LR, Chater TE, Isaac JT, Marrion NV (2010). Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft. Front Synaptic Neurosci, 2 Abstract.  Author URL.
Chater TE, Henley JM, Brown JT, Randall AD (2010). Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods, 193(1), 7-13. Abstract.  Author URL.
Brown JT, Randall AD (2009). Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol, 587(Pt 6), 1265-1281. Abstract.  Author URL.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract.  Author URL.
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB, Wilde JI, Scott L, et al (2009). Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. Journal of Immunology, 183, 3454-62. Abstract.
Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VAH, Hagan JJ, Herdon HJ, et al (2008). Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol, 154(5), 1104-1115. Abstract.  Author URL.
Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL (2008). The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs. Neuropharmacology, 55(4), 459-463. Abstract.  Author URL.
Brown JT, Davies CH, Randall AD (2007). Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci, 25(10), 2982-2990. Abstract.  Author URL.
Brown JT, Teriakidis A, Randall AD (2006). A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations. Neuropharmacology, 50(1), 47-56. Abstract.  Author URL.
Teriakidis A, Brown JT, Randall A (2006). Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants. Pharmacol Rep, 58(6), 859-869. Abstract.  Author URL.
Gill CH, Brown JT, Shivji N, Lappin SC, Farmer C, Randall A, McNaughton NCL, Cobb SR, Davies CH (2006). Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. Synapse, 59(5), 308-316. Abstract.  Author URL.
Piccinin S, Randall AD, Brown JT (2006). KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. J Neurophysiol, 95(5), 3105-3112. Abstract.  Author URL.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, et al (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26(3), 179-198. Abstract.  Author URL.
Lappin SC, Dale TJ, Brown JT, Trezise DJ, Davies CH (2005). Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons. Brain research, 1065, 37-46. Abstract.
Brown JT, Randall A (2005). Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro. Synapse, 55(4), 262-269. Abstract.  Author URL.
Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH (2005). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit. Epilepsy Res, 65(1-2), 41-51. Abstract.  Author URL.
Brown JT, Richardson JC, Collingridge GL, Randall AD, Davies CH (2005). Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 15(1), 110-117. Abstract.  Author URL.
Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD (2004). Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. Neuroscience, 129(1), 49-54. Abstract.  Author URL.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JHL, Topps S, Medhurst AD, et al (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol, 68(8), 1655-1666. Abstract.  Author URL.
Harrison S, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24, 1170-1179. Abstract.
Harrison SM, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24(4), 1170-1179.
Brown JT, Gill CH, Farmer CE, Lanneau C, Randall AD, Pangalos MN, Collingridge GL, Davies CH (2003). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res, 57(2-3), 121-136. Abstract.  Author URL.
Reed HE, Cutler DJ, Brown TM, Brown JT, Coen CW, Piggins HD (2002). Effects of Vasoactive Intestinal Polypeptide on Neurones of the Rat Suprachiasmatic Nuclei in Vitro. Journal of Neuroendocrinology, 14, 639-646.
Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, Charles KJ, Wood M, Davies CH, Pangalos MN, et al (2001). Gabapentin is not a GABA B receptor agonist. , 41, 965-975.

Conferences

Molnar E, Spittle A, Brown J (2015). Signalling and crosstalk of AMPA/Kainate, mGlu5 and GABA(B) receptors in oligodendrocyte precursor cells.  Author URL.
Church T, Brown J, Marrion N (2013). B-Adrenergic Receptor-Mediated Suppression of the Medium After hyperpolarization in Rat Hippocampal Neurons Maintained in Culture.  Author URL.
Randall A, Brown J (2008). mGluR1-mediated long-lasting intrinsic plasticity in hippocampal CA3 pyramidal cells.  Author URL.

Publications by year


2017

Walsh DA, Brown JT, Randall AD (2017). In vitro. characterisation of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice. The Journal of Physiology Full text.

2016

Martin HGS, Lassalle O, Brown JT, Manzoni OJ (2016). Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome. Cereb Cortex, 26(5), 2084-2092. Abstract.  Author URL.  Full text.
Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.  Full text.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.  Full text.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract.  Author URL.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, et al (2016). Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. J Physiol, 594(22), 6583-6594. Abstract.  Author URL.

2015

Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract.  Author URL.  Full text.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Witton J, Staniaszek LE, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. The Journal of Physiology, 594(16), 4615-4630. Full text.
Banks PJ, Burroughs AC, Barker GRI, Brown JT, Warburton EC, Bashir ZI (2015). Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission. Proc Natl Acad Sci U S A, 112(35), 11096-11101. Abstract.  Author URL.  Full text.
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Church TW, Weatherall KL, Corrêa SAL, Prole DL, Brown JT, Marrion NV (2015). Preferential assembly of heteromeric small conductance calcium-activated potassium channels. Eur J Neurosci, 41(3), 305-315. Abstract.  Author URL.
Molnar E, Spittle A, Brown J (2015). Signalling and crosstalk of AMPA/Kainate, mGlu5 and GABA(B) receptors in oligodendrocyte precursor cells.  Author URL.

2014

Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.
Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract.  Author URL.

2013

Church T, Brown J, Marrion N (2013). B-Adrenergic Receptor-Mediated Suppression of the Medium After hyperpolarization in Rat Hippocampal Neurons Maintained in Culture.  Author URL.
Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract.  Author URL.

2012

Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract.  Author URL.
Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract.  Author URL.

2011

Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract.  Author URL.
Brown JT, Chin J, Leiser SC, Pangalos MN, Randall AD (2011). Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging, 32(11), 2109.e1-2109.14. Abstract.  Author URL.
McMillan LE, Brown JT, Henley JM, Cimarosti H (2011). Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neurosci Lett, 502(3), 201-208. Abstract.  Author URL.
Brown JT, Booth CA, Randall AD (2011). Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci, 33(5), 879-889. Abstract.  Author URL.
Sitzia F, Brown JT, Randall AD, Dunlop J (2011). Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol, 2 Abstract.  Author URL.  Full text.

2010

Witton J, Brown JT, Jones MW, Randall AD (2010). Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain, 3 Abstract.  Author URL.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology, 59(4-5), 243-267. Abstract.  Author URL.
Brown JT, Weatherall KL, Corria LR, Chater TE, Isaac JT, Marrion NV (2010). Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft. Front Synaptic Neurosci, 2 Abstract.  Author URL.
Chater TE, Henley JM, Brown JT, Randall AD (2010). Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods, 193(1), 7-13. Abstract.  Author URL.

2009

Brown JT, Randall AD (2009). Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol, 587(Pt 6), 1265-1281. Abstract.  Author URL.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract.  Author URL.
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB, Wilde JI, Scott L, et al (2009). Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. Journal of Immunology, 183, 3454-62. Abstract.

2008

Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VAH, Hagan JJ, Herdon HJ, et al (2008). Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol, 154(5), 1104-1115. Abstract.  Author URL.
Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL (2008). The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs. Neuropharmacology, 55(4), 459-463. Abstract.  Author URL.
Randall A, Brown J (2008). mGluR1-mediated long-lasting intrinsic plasticity in hippocampal CA3 pyramidal cells.  Author URL.

2007

Brown JT, Davies CH, Randall AD (2007). Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci, 25(10), 2982-2990. Abstract.  Author URL.

2006

Brown JT, Teriakidis A, Randall AD (2006). A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations. Neuropharmacology, 50(1), 47-56. Abstract.  Author URL.
Teriakidis A, Brown JT, Randall A (2006). Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants. Pharmacol Rep, 58(6), 859-869. Abstract.  Author URL.
Gill CH, Brown JT, Shivji N, Lappin SC, Farmer C, Randall A, McNaughton NCL, Cobb SR, Davies CH (2006). Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. Synapse, 59(5), 308-316. Abstract.  Author URL.
Piccinin S, Randall AD, Brown JT (2006). KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. J Neurophysiol, 95(5), 3105-3112. Abstract.  Author URL.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, et al (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26(3), 179-198. Abstract.  Author URL.

2005

Lappin SC, Dale TJ, Brown JT, Trezise DJ, Davies CH (2005). Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons. Brain research, 1065, 37-46. Abstract.
Brown JT, Randall A (2005). Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro. Synapse, 55(4), 262-269. Abstract.  Author URL.
Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH (2005). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit. Epilepsy Res, 65(1-2), 41-51. Abstract.  Author URL.
Brown JT, Richardson JC, Collingridge GL, Randall AD, Davies CH (2005). Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 15(1), 110-117. Abstract.  Author URL.

2004

Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD (2004). Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. Neuroscience, 129(1), 49-54. Abstract.  Author URL.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JHL, Topps S, Medhurst AD, et al (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol, 68(8), 1655-1666. Abstract.  Author URL.

2003

Harrison S, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24, 1170-1179. Abstract.
Harrison SM, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24(4), 1170-1179.
Brown JT, Gill CH, Farmer CE, Lanneau C, Randall AD, Pangalos MN, Collingridge GL, Davies CH (2003). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res, 57(2-3), 121-136. Abstract.  Author URL.

2002

Reed HE, Cutler DJ, Brown TM, Brown JT, Coen CW, Piggins HD (2002). Effects of Vasoactive Intestinal Polypeptide on Neurones of the Rat Suprachiasmatic Nuclei in Vitro. Journal of Neuroendocrinology, 14, 639-646.

2001

Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, Charles KJ, Wood M, Davies CH, Pangalos MN, et al (2001). Gabapentin is not a GABA B receptor agonist. , 41, 965-975.

Editorial responsibilities

Academic editor for PLoS One


Invited lectures

Wyeth Pharmaceuticals

GlaxoSmithKline

Eisai

University of Auckland

University of Manchester

Imperial College London

BSc Medical Sciences:

  • Module Lead for CSC2006: Foundations in Neuroscience
  • Academic Tutor Group facilitator

BMBS:

  • LSRC facilitator

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