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Dr Joel Tabak

Dr Joel Tabak

Senior Lecturer (E&R)

3903

Hatherly 

Research

Research interests

Dr Tabak gives an overview of his research into understanding hormone regulation in the video below, filmed at the Living Systems Institute Symposium 2016.

Research grants

  • 2015 Wellcome Trust
    ISSF2 Seed Corn Funding

Key publications | Publications by category | Publications by year

Key publications


Fletcher P, Bertram R, Tabak J (In Press). From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability. J Comput Neurosci, 40(3), 331-345. Abstract.  Author URL.
Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ (2016). Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs. Endocrinology, 157(8), 3108-3121. Abstract.  Author URL.
Vo T, Tabak J, Bertram R, Wechselberger M (2014). A geometric understanding of how fast activating potassium channels promote bursting in pituitary cells. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 36(2), 259-278. Author URL.
Tabak J, Tomaiuolo M, Gonzalez-Iglesias AE, Milescu LS, Bertram R (2011). Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study. J Neurosci, 31(46), 16855-16863. Abstract.  Author URL.  Full text.
Tabak J, Rinzel J, Bertram R (2011). Quantifying the relative contributions of divisive and subtractive feedback to rhythm generation. PLoS Comput Biol, 7(4). Abstract.  Author URL.  Full text.
Tomaiuolo M, Bertram R, Gonzalez-Iglesias AE, Tabak J (2010). Investigating heterogeneity of intracellular calcium dynamics in anterior pituitary lactotrophs using a combined modelling/experimental approach. J Neuroendocrinol, 22(12), 1279-1289. Abstract.  Author URL.

Publications by category


Journal articles

Fletcher P, Bertram R, Tabak J (In Press). From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability. J Comput Neurosci, 40(3), 331-345. Abstract.  Author URL.
Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ (2016). Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs. Endocrinology, 157(8), 3108-3121. Abstract.  Author URL.
Tagliavini A, Tabak J, Bertram R, Pedersen MG (2016). Is bursting more effective than spiking in evoking pituitary hormone secretion? a spatiotemporal simulation study of calcium and granule dynamics. American Journal of Physiology - Endocrinology and Metabolism, 310(7), E515-E525. Full text.
Gonzalez-Iglesias AE, Fletcher PA, Arias-Cristancho JA, Cristancho-Gordo R, Helena CV, Bertram R, Tabak J (2015). Direct Stimulatory Effects of Oxytocin in Female Rat Gonadotrophs and Somatotrophs in Vitro: Comparison with Lactotrophs. Endocrinology, 156(2), 600-612.
Duncan PJ, Senguel S, Tabak J, Ruth P, Bertram R, Shipston MJ (2015). Large conductance Ca2+-activated K+ (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs. JOURNAL OF PHYSIOLOGY-LONDON, 593(5), 1197-1211. Author URL.  Full text.
Vo T, Tabak J, Bertram R, Wechselberger M (2014). A geometric understanding of how fast activating potassium channels promote bursting in pituitary cells. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 36(2), 259-278. Author URL.
Sengül S, Clewley R, Bertram R, Tabak J (2014). Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model. J Comput Neurosci, 37(3), 403-415. Abstract.  Author URL.
Fletcher PA, Clément F, Vidal A, Tabak J, Bertram R (2014). Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs. PLoS One, 9(4). Abstract.  Author URL.  Full text.
Tomaiuolo M, Bertram R, Leng G, Tabak J (2012). Models of electrical activity: calibration and prediction testing on the same cell. Biophys J, 103(9), 2021-2032. Abstract.  Author URL.
Teka W, Tabak J, Bertram R (2012). The relationship between two fast/slow analysis techniques for bursting oscillations. Chaos, 22(4). Abstract.  Author URL.
Tabak J, Tomaiuolo M, Gonzalez-Iglesias AE, Milescu LS, Bertram R (2011). Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study. J Neurosci, 31(46), 16855-16863. Abstract.  Author URL.  Full text.
Teka W, Tsaneva-Atanasova K, Bertram R, Tabak J (2011). From plateau to pseudo-plateau bursting: making the transition. Bull Math Biol, 73(6), 1292-1311. Abstract.  Author URL.
Watts M, Tabak J, Bertram R (2011). Mathematical modeling demonstrates how multiple slow processes can provide adjustable control of islet bursting. Islets, 3(6), 320-326. Abstract.  Author URL.
Tabak J, Rinzel J, Bertram R (2011). Quantifying the relative contributions of divisive and subtractive feedback to rhythm generation. PLoS Comput Biol, 7(4). Abstract.  Author URL.  Full text.
Watts M, Tabak J, Zimliki C, Sherman A, Bertram R (2011). Slow variable dominance and phase resetting in phantom bursting. J Theor Biol, 276(1), 218-228. Abstract.  Author URL.
Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Tabak J, Bertram R, Freeman ME (2011). Systemic oxytocin induces a prolactin secretory rhythm via the pelvic nerve in ovariectomized rats. Am J Physiol Regul Integr Comp Physiol, 301(3), R676-R681. Abstract.  Author URL.
Teka W, Tabak J, Vo T, Wechselberger M, Bertram R (2011). The dynamics underlying pseudo-plateau bursting in a pituitary cell model. J Math Neurosci, 1(12). Abstract.  Author URL.  Full text.
Bertram R, Helena CV, Gonzalez-Iglesias AE, Tabak J, Freeman ME (2010). A tale of two rhythms: the emerging roles of oxytocin in rhythmic prolactin release. J Neuroendocrinol, 22(7), 778-784. Abstract.  Author URL.
Tomaiuolo M, Bertram R, Gonzalez-Iglesias AE, Tabak J (2010). Investigating heterogeneity of intracellular calcium dynamics in anterior pituitary lactotrophs using a combined modelling/experimental approach. J Neuroendocrinol, 22(12), 1279-1289. Abstract.  Author URL.
Stojilkovic SS, Tabak J, Bertram R (2010). Ion Channels and Signaling in the Pituitary Gland. ENDOCRINE REVIEWS, 31(6), 845-915. Author URL.
Tabak J, Mascagni M, Bertram R (2010). Mechanism for the universal pattern of activity in developing neuronal networks. J Neurophysiol, 103(4), 2208-2221. Abstract.  Author URL.
Vo T, Bertram R, Tabak J, Wechselberger M (2010). Mixed mode oscillations as a mechanism for pseudo-plateau bursting. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 28(3), 443-458. Author URL.
Tsaneva-Atanasova K, Osinga HM, Tabak J, Pedersen MG (2010). Modeling mechanisms of cell secretion. Acta Biotheor, 58(4), 315-327. Abstract.  Author URL.
Tabak J, Shermann A, Leng G (2010). The Modern Box and Arrow Diagram. JOURNAL OF NEUROENDOCRINOLOGY, 22(12), 1215-1216. Author URL.
Tabak J, Gonzalez-Iglesias AE, Toporikova N, Bertram R, Freeman ME (2010). Variations in the response of pituitary lactotrophs to oxytocin during the rat estrous cycle. Endocrinology, 151(4), 1806-1813. Abstract.  Author URL.
Tomaiuolo M, Tabak J, Bertram R (2009). Correlation analysis a tool for comparing relaxation-type models to experimental data. Methods Enzymol, 467, 1-22. Abstract.  Author URL.
Toporikova N, Tabak J, Freeman ME, Bertram R (2008). A-type K(+) current can act as a trigger for bursting in the absence of a slow variable. Neural Comput, 20(2), 436-451. Abstract.  Author URL.
Vladimirski BB, Tabak J, O'Donovan MJ, Rinzel J (2008). Episodic activity in a heterogeneous excitatory network, from spiking neurons to mean field. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 25(1), 39-63. Author URL.
Tabak J, Toporikova N, Freeman ME, Bertram R (2007). Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents. J Comput Neurosci, 22(2), 211-222. Abstract.  Author URL.
Tabak J, O'Donovan MJ, Rinzel J (2006). Differential control of active and silent phases in relaxation models of neuronal rhythms. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 21(3), 307-328. Author URL.
Bertram R, Tabak J, Toporikova N, Freeman ME (2006). Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Sci STKE, 2006(321). Abstract.  Author URL.
Marchetti C, Tabak J, Chub N, O'Donovan MJ, Rinzel J (2005). Modeling spontaneous activity in the developing spinal cord using activity-dependent variations of intracellular chloride. JOURNAL OF NEUROSCIENCE, 25(14), 3601-3612. Author URL.
Tabak J, Latham PE (2003). Analysis of spontaneous bursting activity in random neural networks. NEUROREPORT, 14(11), 1445-1449. Author URL.
Tabak J, Rinzel J, O'Donovan MJ (2001). The role of activity-dependent network depression in the expression and self-regulation of spontaneous activity in the developing spinal cord. JOURNAL OF NEUROSCIENCE, 21(22), 8966-8978. Author URL.
Tabak J, Senn W, O'Donovan MJ, Rinzel J (2000). Modeling of spontaneous activity in developing spinal cord using activity-dependent depression in an excitatory network. JOURNAL OF NEUROSCIENCE, 20(8), 3041-3056. Author URL.
Tabak J, Murphey CR, Moore LE (2000). Parameter estimation methods for single neuron models. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 9(3), 215-236. Author URL.
Tabak J, Senn W, O'Donovan MJ, Rinzel J (1999). Comparison of two models for pattern generation based on synaptic depression. NEUROCOMPUTING, 26-7, 551-556. Author URL.
Moore LE, Chub N, Tabak J, O'Donovan M (1999). NMDA-induced dendritic oscillations during a soma voltage clamp of chick spinal neurons. JOURNAL OF NEUROSCIENCE, 19(19), 8271-8280. Author URL.
Fedirchuk B, Wenner P, Whelan PJ, Ho S, Tabak J, O'Donovan MJ (1999). Spontaneous network activity transiently depresses synaptic transmission in the embryonic chick spinal cord. JOURNAL OF NEUROSCIENCE, 19(6), 2102-2112. Author URL.
Tabak J, Moore LE (1998). Simulation and parameter estimation study of a simple neuronal model of rhythm generation: role of NMDA and non-NMDA receptors. J Comput Neurosci, 5(2), 209-235. Abstract.  Author URL.

Conferences

Tabak J, Senn W, O'Donovan MJ, Rinzel J (1999). Comparison of two models for pattern generation based on synaptic depression.  Author URL.
O'Donovan MJ, Wenner P, Chub N, Tabak J, Rinzel J (1998). Mechanisms of spontaneous activity in the developing spinal cord and their relevance to locomotion.  Author URL.
Tabak J, O'Donovan MJ (1998). Statistical analysis and intersegmental delays reveal possible roles of network depression in the generation of spontaneous activity in the chick embryo spinal cord.  Author URL.

Publications by year


In Press

Fletcher P, Bertram R, Tabak J (In Press). From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability. J Comput Neurosci, 40(3), 331-345. Abstract.  Author URL.

2016

Duncan PJ, Tabak J, Ruth P, Bertram R, Shipston MJ (2016). Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs. Endocrinology, 157(8), 3108-3121. Abstract.  Author URL.
Tagliavini A, Tabak J, Bertram R, Pedersen MG (2016). Is bursting more effective than spiking in evoking pituitary hormone secretion? a spatiotemporal simulation study of calcium and granule dynamics. American Journal of Physiology - Endocrinology and Metabolism, 310(7), E515-E525. Full text.

2015

Gonzalez-Iglesias AE, Fletcher PA, Arias-Cristancho JA, Cristancho-Gordo R, Helena CV, Bertram R, Tabak J (2015). Direct Stimulatory Effects of Oxytocin in Female Rat Gonadotrophs and Somatotrophs in Vitro: Comparison with Lactotrophs. Endocrinology, 156(2), 600-612.
Duncan PJ, Senguel S, Tabak J, Ruth P, Bertram R, Shipston MJ (2015). Large conductance Ca2+-activated K+ (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs. JOURNAL OF PHYSIOLOGY-LONDON, 593(5), 1197-1211. Author URL.  Full text.

2014

Vo T, Tabak J, Bertram R, Wechselberger M (2014). A geometric understanding of how fast activating potassium channels promote bursting in pituitary cells. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 36(2), 259-278. Author URL.
Sengül S, Clewley R, Bertram R, Tabak J (2014). Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model. J Comput Neurosci, 37(3), 403-415. Abstract.  Author URL.
Fletcher PA, Clément F, Vidal A, Tabak J, Bertram R (2014). Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs. PLoS One, 9(4). Abstract.  Author URL.  Full text.

2012

Tomaiuolo M, Bertram R, Leng G, Tabak J (2012). Models of electrical activity: calibration and prediction testing on the same cell. Biophys J, 103(9), 2021-2032. Abstract.  Author URL.
Teka W, Tabak J, Bertram R (2012). The relationship between two fast/slow analysis techniques for bursting oscillations. Chaos, 22(4). Abstract.  Author URL.

2011

Tabak J, Tomaiuolo M, Gonzalez-Iglesias AE, Milescu LS, Bertram R (2011). Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study. J Neurosci, 31(46), 16855-16863. Abstract.  Author URL.  Full text.
Teka W, Tsaneva-Atanasova K, Bertram R, Tabak J (2011). From plateau to pseudo-plateau bursting: making the transition. Bull Math Biol, 73(6), 1292-1311. Abstract.  Author URL.
Watts M, Tabak J, Bertram R (2011). Mathematical modeling demonstrates how multiple slow processes can provide adjustable control of islet bursting. Islets, 3(6), 320-326. Abstract.  Author URL.
Tabak J, Rinzel J, Bertram R (2011). Quantifying the relative contributions of divisive and subtractive feedback to rhythm generation. PLoS Comput Biol, 7(4). Abstract.  Author URL.  Full text.
Watts M, Tabak J, Zimliki C, Sherman A, Bertram R (2011). Slow variable dominance and phase resetting in phantom bursting. J Theor Biol, 276(1), 218-228. Abstract.  Author URL.
Helena CV, Cristancho-Gordo R, Gonzalez-Iglesias AE, Tabak J, Bertram R, Freeman ME (2011). Systemic oxytocin induces a prolactin secretory rhythm via the pelvic nerve in ovariectomized rats. Am J Physiol Regul Integr Comp Physiol, 301(3), R676-R681. Abstract.  Author URL.
Teka W, Tabak J, Vo T, Wechselberger M, Bertram R (2011). The dynamics underlying pseudo-plateau bursting in a pituitary cell model. J Math Neurosci, 1(12). Abstract.  Author URL.  Full text.

2010

Bertram R, Helena CV, Gonzalez-Iglesias AE, Tabak J, Freeman ME (2010). A tale of two rhythms: the emerging roles of oxytocin in rhythmic prolactin release. J Neuroendocrinol, 22(7), 778-784. Abstract.  Author URL.
Tomaiuolo M, Bertram R, Gonzalez-Iglesias AE, Tabak J (2010). Investigating heterogeneity of intracellular calcium dynamics in anterior pituitary lactotrophs using a combined modelling/experimental approach. J Neuroendocrinol, 22(12), 1279-1289. Abstract.  Author URL.
Stojilkovic SS, Tabak J, Bertram R (2010). Ion Channels and Signaling in the Pituitary Gland. ENDOCRINE REVIEWS, 31(6), 845-915. Author URL.
Tabak J, Mascagni M, Bertram R (2010). Mechanism for the universal pattern of activity in developing neuronal networks. J Neurophysiol, 103(4), 2208-2221. Abstract.  Author URL.
Vo T, Bertram R, Tabak J, Wechselberger M (2010). Mixed mode oscillations as a mechanism for pseudo-plateau bursting. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 28(3), 443-458. Author URL.
Tsaneva-Atanasova K, Osinga HM, Tabak J, Pedersen MG (2010). Modeling mechanisms of cell secretion. Acta Biotheor, 58(4), 315-327. Abstract.  Author URL.
Tabak J, Shermann A, Leng G (2010). The Modern Box and Arrow Diagram. JOURNAL OF NEUROENDOCRINOLOGY, 22(12), 1215-1216. Author URL.
Tabak J, Gonzalez-Iglesias AE, Toporikova N, Bertram R, Freeman ME (2010). Variations in the response of pituitary lactotrophs to oxytocin during the rat estrous cycle. Endocrinology, 151(4), 1806-1813. Abstract.  Author URL.

2009

Tomaiuolo M, Tabak J, Bertram R (2009). Correlation analysis a tool for comparing relaxation-type models to experimental data. Methods Enzymol, 467, 1-22. Abstract.  Author URL.

2008

Toporikova N, Tabak J, Freeman ME, Bertram R (2008). A-type K(+) current can act as a trigger for bursting in the absence of a slow variable. Neural Comput, 20(2), 436-451. Abstract.  Author URL.
Vladimirski BB, Tabak J, O'Donovan MJ, Rinzel J (2008). Episodic activity in a heterogeneous excitatory network, from spiking neurons to mean field. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 25(1), 39-63. Author URL.

2007

Tabak J, Toporikova N, Freeman ME, Bertram R (2007). Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents. J Comput Neurosci, 22(2), 211-222. Abstract.  Author URL.

2006

Tabak J, O'Donovan MJ, Rinzel J (2006). Differential control of active and silent phases in relaxation models of neuronal rhythms. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 21(3), 307-328. Author URL.
Bertram R, Tabak J, Toporikova N, Freeman ME (2006). Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Sci STKE, 2006(321). Abstract.  Author URL.

2005

Marchetti C, Tabak J, Chub N, O'Donovan MJ, Rinzel J (2005). Modeling spontaneous activity in the developing spinal cord using activity-dependent variations of intracellular chloride. JOURNAL OF NEUROSCIENCE, 25(14), 3601-3612. Author URL.

2003

Tabak J, Latham PE (2003). Analysis of spontaneous bursting activity in random neural networks. NEUROREPORT, 14(11), 1445-1449. Author URL.

2001

Tabak J, Rinzel J, O'Donovan MJ (2001). The role of activity-dependent network depression in the expression and self-regulation of spontaneous activity in the developing spinal cord. JOURNAL OF NEUROSCIENCE, 21(22), 8966-8978. Author URL.

2000

Tabak J, Senn W, O'Donovan MJ, Rinzel J (2000). Modeling of spontaneous activity in developing spinal cord using activity-dependent depression in an excitatory network. JOURNAL OF NEUROSCIENCE, 20(8), 3041-3056. Author URL.
Tabak J, Murphey CR, Moore LE (2000). Parameter estimation methods for single neuron models. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 9(3), 215-236. Author URL.

1999

Tabak J, Senn W, O'Donovan MJ, Rinzel J (1999). Comparison of two models for pattern generation based on synaptic depression.  Author URL.
Tabak J, Senn W, O'Donovan MJ, Rinzel J (1999). Comparison of two models for pattern generation based on synaptic depression. NEUROCOMPUTING, 26-7, 551-556. Author URL.
Moore LE, Chub N, Tabak J, O'Donovan M (1999). NMDA-induced dendritic oscillations during a soma voltage clamp of chick spinal neurons. JOURNAL OF NEUROSCIENCE, 19(19), 8271-8280. Author URL.
Fedirchuk B, Wenner P, Whelan PJ, Ho S, Tabak J, O'Donovan MJ (1999). Spontaneous network activity transiently depresses synaptic transmission in the embryonic chick spinal cord. JOURNAL OF NEUROSCIENCE, 19(6), 2102-2112. Author URL.

1998

O'Donovan MJ, Wenner P, Chub N, Tabak J, Rinzel J (1998). Mechanisms of spontaneous activity in the developing spinal cord and their relevance to locomotion.  Author URL.
Tabak J, Moore LE (1998). Simulation and parameter estimation study of a simple neuronal model of rhythm generation: role of NMDA and non-NMDA receptors. J Comput Neurosci, 5(2), 209-235. Abstract.  Author URL.
Tabak J, O'Donovan MJ (1998). Statistical analysis and intersegmental delays reveal possible roles of network depression in the generation of spontaneous activity in the chick embryo spinal cord.  Author URL.

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