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Dr Jinwei Zhang

Dr Jinwei Zhang

Lecturer (Education and Research)

+44 (0)1392 72 3828

Hatherly D4

Dr Jinwei Zhang has a very wide-ranging expertise, which makes him uniquely positioned to develop research at the interface between fields. He gained a solid theory and practice of training in the field of microbial biotechnology, biochemistry and molecular biology, enzymology, pharmacology, drug discovery, signaling transduction during his academic degrees and postdoc trainings. He studies signalling pathways that associated with human diseases, for examples, Parkinson's Disease (LRRK2), neuropsychiatric disorders (WNK-SPAK-KCC2) and hypertension (CUL3/KLHL3-WNK-SPAK-NCC) and concern with elucidating and targeting ion transporters, kinases, protein-protein interactions using genetic mouse models, small molecules and CRISPR/Cas9 knock-in and knock-out technologies to aid discovery and validation of new potential drug targets

Qualifications

  • BSc, 2003, Fujian Normal University (Fuzhou City), China
  • MSc, 2007, The Third Institute of Oceanography (Xiamen City), State Oceanic Administration, China
  • PhD, 2011, Newcastle University, Newcastle upon Tyne, UK

Career

Dr Jinwei Zhang obtained a BSc degree in Microbial Biotechnology from Fujian Normal University China in 2003. While there, he studied mutation of Aspergillus niger for higher yield of multicomponent enzymes. He then obtained a MSc degree in Marine Microbial Biochemistry and Molecular Biology at The Third Institute of Oceanography (Xiamen), State Oceanic Administration China in 2007. While there, he studied marine ecology and cold-adapted enzymes from deep-sea becteria. He then obtained a PhD degree in Biotechnology from Newcastle University UK in 2011. While there, he studied natural bioactive compounds and electricity generation by marine microorganisms. Since 2011, he pursued his interest in cellular signaling with a post-doctoral fellowship at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit in Dundee with Professor Dario Alessi (FRS). While there, he studied LRRK2 associated Parkinson's disease in collaboration with Professor Nathanael Gray at Harvard, and contributed to the discovery of the most potent LRRK2 kinase inhibitors TAE684 and TTT3002, most selective LRRK2 inhibitor GSK2578215A, and the first brain penetrable LRRK2 inhibitors HG-10-102-01 and JH-II-127. Since 2013, his research focuses broadly on CUL3/KLHL3-WNKs-SPAK/OSR1-CCCs signaling in ion homeostasis and human diseases (neuropsychiatric disorders and hypertension) in collaboration with Professor Kristopher T. Kahle at Yale. He joined The University of Exeter Medical School in 2017 where his KCC2 investigations can gain greater impact by integration with the clinical resources and basic science research at The Institute of Biomedical and Clinical Sciences.

Links

Research

Research interests

Homeostasis of the intracellular ionic milieu is essential for the proper functioning of all cells and a diverse group of cellular processes. The mechanisms responsible for the homeostasis of the intracellular Cl- concentration [Cl-]i, for example, significantly impacts the rate of fluid secretion or absorption across epithelia; how red blood cells counteract potentially damaging osmotic-induced cell swelling or shrinkage; and whether the GABA neurotransmitter excites or inhibits post-synaptic neurons.

The neuronal potassium-chloride co-transporter KCC2 is one of the molecules effectively controlling intracellular Cl- and adjusting the inhibitory strength of GABA. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous neurological disorders including epilepsy, autism, post-surgical complication, neuropathic pain and neuropsychiatric disorders.

KCC2 activity is decreased in most diseases associated with GABAergic disinhibition. A positive modulator (i.e., “activator”) of KCC2 might be effective in reversing the effects of KCC2 downregulation and lowering [Cl–]i to restore GABAergic inhibition. 

Previous work in Lifton Lab at Yale revealed that activity of KCC2 is critically controlled by phosphorylation of two highly conserved residues (KCC2 Thr906/Thr1007) (Cell, 2009). Dr Zhang's recent work in Alessi Lab at Dundee and Kahle Lab at Yale discovered that it is WNK-regulated SPAK/OSR1 kinases that directly phosphorylate KCC2 at Thr1007 and Thr906, thereby leading to its inhibition (Biochem. J. 2014, Sci. Signal. 2015, Sci. Rep. 2016). This has potential implications for the therapeutic modulation of neurological disorders by targeting of WNK-SPAK/OSR1 with kinase inhibitors, with a new strategy to enhance cellular chloride extrusion.

Dr Zhang and his colleagues aim to study Cul3/KLHL3-WNK-SPAK signalling pathway and KCC2 mouse models involved in control of the KCC2 activity and downstream GABAergic neurotransmission during neuronal development under physiological conditions and in models of epilepsy and autism, and to develop small molecular compounds that suppress WNK-SPAK kinase signalling pathway and therefore to activate KCC2.

Key publications | Publications by category | Publications by year

Key publications


Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med, 23(8), 997-1003. Abstract.  Author URL.  Full text.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de los Heros P, Davies P, Varghese J, et al (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1).
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.
De Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+ -Cl- co-transporters. Biochemical Journal, 458(3), 559-573. Abstract.

Publications by category


Journal articles

Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med, 23(8), 997-1003. Abstract.  Author URL.  Full text.
Zhang J, Karimy JK, Delpire E, Kahle KT (2017). Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opin Ther Targets, 21(8), 795-804. Abstract.  Author URL.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.
Andrukhova O, Zhang J, Alessi D, Erben R (2016). Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance. Bone Abstracts
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de los Heros P, Davies P, Varghese J, et al (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1).
Kahle KT, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganiere J, Rochefort D, Hince P, et al (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling, 9(421), ra32-ra32.
Zhang J, Deng X, Kahle KT (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450), pe3-pe3.
Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E (2016). MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. Frontiers in Microbiology, 7
Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Begum G, Duran D, Liang B, Sun D, et al (2016). Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling, 9(439), ra77-ra77.
Kazlauskaite A, Martinez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, et al (2015). Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO reports, 16(8), 939-954.
Schumacher F-R, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, et al (2015). Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), 1285-1306.
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.
Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS (2015). Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett, 6(5), 584-589. Abstract.  Author URL.
Zhang J, Burgess JG (2015). Shewanella electrodiphila sp. nov. a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. Int J Syst Evol Microbiol, 65(9), 2882-2889. Abstract.  Author URL.
Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, et al (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383), ra65-ra65.
Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling(334). Abstract.
De Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+ -Cl- co-transporters. Biochemical Journal, 458(3), 559-573. Abstract.
Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, et al (2013). Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis, 76, 49-58. Abstract.
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, et al (2013). Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics, 22(2), 328-344. Abstract.
Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS (2012). Brain penetrant LRRK2 inhibitor. ACS Medicinal Chemistry Letters, 3(8), 658-662. Abstract.
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS (2012). Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(5), 1864-1869. Abstract.
Zhang J, Zhang E, Scott K, Burgess JG (2012). Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science and Technology, 46(5), 2984-2992. Abstract.
Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, et al (2012). GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent- N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(17), 5625-5629. Abstract.
Zhang J, Zeng R (2011). Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. World Journal of Microbiology and Biotechnology, 27(4), 841-850. Abstract.
Zhang JW, Zeng RY (2008). Molecular cloning and expression of a cold-adapted lipase gene from an antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology, 10(5), 612-621. Abstract.
Zhang JW, Zeng RY (2008). Purification and characterization of a cold-adapted α-amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic. Marine Biotechnology, 10(1), 75-82. Abstract.
Zhang J, Lin S, Zeng R (2007). Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychorotrophic bacterium, Psychobacter sp. 7195. Journal of Microbiology and Biotechnology, 17(4), 604-610. Abstract.
Zhang J, Zeng R (2007). Isolation of antarctic psychrotrophilic Pseudomonas sp. 7197 and cloning of ppa gene for inorganic pyrophosphatase (PPase). Gaojishu Tongxin/Chinese High Technology Letters, 17(10), 1067-1071. Abstract.
Zhang JW, Zeng RY (2007). Psychrotrophic amylolytic bacteria from deep sea sediment of Prydz Bay, Antarctic: Diversity and characterization of amylases. World Journal of Microbiology and Biotechnology, 23(11), 1551-1557. Abstract.
Zhang JW, Zeng RY (2006). Cloning, expression and characterization of the cold active lipase (Lip3) from metagenomic DNA of an antarctic deep sea sediment. Progress in Biochemistry and Biophysics, 33(12), 1207-1214. Abstract.
Zhang J, Lian M, Zeng R (2006). Screening, fermentation condition and enzyme characterization of multicomponent enzymes producing Pseudomonas sp. NJ197. Chinese Journal of Applied and Environmental Biology, 12(5), 683-687. Abstract.
Lian M, Zhang J, Zeng R (2005). Classification and analyses of fermentation conditions and enzyme characteristics of an Antarctic strain producing cold-active chitinase. Gaojishu Tongxin/Chinese High Technology Letters, 15(9), 58-61. Abstract.

Publications by year


2017

Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med, 23(8), 997-1003. Abstract.  Author URL.  Full text.
Zhang J, Karimy JK, Delpire E, Kahle KT (2017). Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opin Ther Targets, 21(8), 795-804. Abstract.  Author URL.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.

2016

Andrukhova O, Zhang J, Alessi D, Erben R (2016). Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance. Bone Abstracts
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de los Heros P, Davies P, Varghese J, et al (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1).
Kahle KT, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganiere J, Rochefort D, Hince P, et al (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling, 9(421), ra32-ra32.
Zhang J, Deng X, Kahle KT (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450), pe3-pe3.
Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E (2016). MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. Frontiers in Microbiology, 7
Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Begum G, Duran D, Liang B, Sun D, et al (2016). Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling, 9(439), ra77-ra77.

2015

Kazlauskaite A, Martinez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, et al (2015). Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO reports, 16(8), 939-954.
Schumacher F-R, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, et al (2015). Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), 1285-1306.
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.
Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS (2015). Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett, 6(5), 584-589. Abstract.  Author URL.
Zhang J, Burgess JG (2015). Shewanella electrodiphila sp. nov. a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. Int J Syst Evol Microbiol, 65(9), 2882-2889. Abstract.  Author URL.
Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, et al (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383), ra65-ra65.

2014

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling(334). Abstract.
De Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+ -Cl- co-transporters. Biochemical Journal, 458(3), 559-573. Abstract.

2013

Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, et al (2013). Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis, 76, 49-58. Abstract.
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, et al (2013). Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics, 22(2), 328-344. Abstract.

2012

Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS (2012). Brain penetrant LRRK2 inhibitor. ACS Medicinal Chemistry Letters, 3(8), 658-662. Abstract.
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS (2012). Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(5), 1864-1869. Abstract.
Zhang J, Zhang E, Scott K, Burgess JG (2012). Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science and Technology, 46(5), 2984-2992. Abstract.
Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, et al (2012). GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent- N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(17), 5625-5629. Abstract.

2011

Zhang J, Zeng R (2011). Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. World Journal of Microbiology and Biotechnology, 27(4), 841-850. Abstract.

2008

Zhang JW, Zeng RY (2008). Molecular cloning and expression of a cold-adapted lipase gene from an antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology, 10(5), 612-621. Abstract.
Zhang JW, Zeng RY (2008). Purification and characterization of a cold-adapted α-amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic. Marine Biotechnology, 10(1), 75-82. Abstract.

2007

Zhang J, Lin S, Zeng R (2007). Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychorotrophic bacterium, Psychobacter sp. 7195. Journal of Microbiology and Biotechnology, 17(4), 604-610. Abstract.
Zhang J, Zeng R (2007). Isolation of antarctic psychrotrophilic Pseudomonas sp. 7197 and cloning of ppa gene for inorganic pyrophosphatase (PPase). Gaojishu Tongxin/Chinese High Technology Letters, 17(10), 1067-1071. Abstract.
Zhang JW, Zeng RY (2007). Psychrotrophic amylolytic bacteria from deep sea sediment of Prydz Bay, Antarctic: Diversity and characterization of amylases. World Journal of Microbiology and Biotechnology, 23(11), 1551-1557. Abstract.

2006

Zhang JW, Zeng RY (2006). Cloning, expression and characterization of the cold active lipase (Lip3) from metagenomic DNA of an antarctic deep sea sediment. Progress in Biochemistry and Biophysics, 33(12), 1207-1214. Abstract.
Zhang J, Lian M, Zeng R (2006). Screening, fermentation condition and enzyme characterization of multicomponent enzymes producing Pseudomonas sp. NJ197. Chinese Journal of Applied and Environmental Biology, 12(5), 683-687. Abstract.

2005

Lian M, Zhang J, Zeng R (2005). Classification and analyses of fermentation conditions and enzyme characteristics of an Antarctic strain producing cold-active chitinase. Gaojishu Tongxin/Chinese High Technology Letters, 15(9), 58-61. Abstract.

Awards

  • Bursary Award, Parkinson's UK (2012)
  • Outstanding Young Scientist Award, American Oil Chemists Society (2010)
  • Travel Grant Award, European Section of the American Oil Chemists Society (2010)
  • Second-class Award of Publication, Journal 'Progress in Modern Biomedicine’ (2010)
  • BBSRC-Dorothy Hodgkin Postgraduate Award (DHPA), Newcastle University UK (2008-2011)
  • Third-class Award of Publication, State Oceanic Administration, China (2008)
  • Outstanding Young Scientist Award, Chinese Enzyme Engineering Society (2005)
  • Fujian Normal University Scholarship Award (2009-2003)

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