COLLEGE OF MEDICINE AND HEALTH
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Dr Jinwei Zhang

Dr Jinwei Zhang

Senior Lecturer in Medicine

 +44 (0)1392 72 3828

 Hatherly D9

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Overview

Dr Jinwei Zhang has a very wide-ranging expertise, which makes him uniquely positioned to develop research at the interface between fields. He gained a solid theory and practice of training in the field of natural bioactive compounds, biochemistry and molecular biology, enzymology, pharmacology, drug discovery, signaling transduction and electrophysiology during his academic degrees and postdoc trainings. He studies signalling pathways that associated with human diseases, for examples, the neurodegenerative diseases including the LRRK2 associated Parkinson's disease (PD),  the amyloid precursor protein (APP) and Tau associated Alzheimer's disease (AD), neuropsychiatric disorders including epilepsy (WNK-SPAK-KCC2), High Blood Pressure & Kidney Disease (CUL3/KLHL3-WNK-SPAK-NCC) etc.. All these studies concern with elucidating and targeting ion transporters, kinases, protein-protein interactions using genetic mouse models, mass spectrometry, small molecules, electrophysiology, and CRISPR/Cas9 gene editing technologies to aid discovery and validation of new potential drug targets.

Qualifications

  • BSc, 2003, Fujian Normal University (Fuzhou City), China
  • MSc, 2007, Xiamen University (Xiamen City), and the Third Institute of Oceanography (Xiamen City), State Oceanic Administration, China
  • PhD, 2011, Newcastle University, Newcastle upon Tyne, UK
  • Fellow of the Higher Education Academy, 2019

Career

Dr Jinwei Zhang obtained a BSc degree in Bioengineering from Fujian Normal University China in 2003. While there, he studied mutagenesis of Aspergillus niger for higher yield of multicomponent enzymes. He then obtained a MSc degree in Marine Microbial Biochemistry and Molecular Biology at The Third Institute of Oceanography (Xiamen), State Oceanic Administration China in 2007. While there, he studied marine ecology and cold-adapted enzymes from deep-sea bacteria. He then obtained a PhD degree in Biotechnology from Newcastle University UK in 2011. While there, he studied natural bioactive compounds and their applications in human health.

Since 2011, Jinwei pursued his interest in cellular signalling with a post-doctoral fellowship at the Medical Research Council (MRC)- Protein Phosphorylation and Ubiquitination Unit (PPU) in Dundee with Professor Dario Alessi (FRS), and with Professor Nathanael Gray at Harvard Medical School. While there, he studied LRRK2 associated Parkinson's disease, and contributed to the discovery of the most potent LRRK2 kinase inhibitors TAE684 and TTT3002, most selective LRRK2 inhibitor GSK2578215A, and the first brain penetrable LRRK2 inhibitors HG-10-102-01 and JH-II-127.

Since 2014, Jinwei's research focused on CUL3/KLHL3-WNKs-SPAK/OSR1-cation chloride cotransporters (CCCs) signalling in cellular chloride homeostasis and cell volume regulation in collaboration with Professor Kristopher Kahle at Yale University School of Medicine. In 2017, Jinwei joined the Faculty of the University of Exeter Medical School, where his KCC2/ NKCC1 investigations can gain greater impact by integration with the clinical resources and basic science research at The Institute of Biomedical and Clinical Sciences.

Recent research in Zhang Laboratory has greatly improved our understanding of the function of Chloride ion transporters, e.g. NCC, NKCC2, NKCC1, KCC2 and KCC3, and their upstream regulatory mechanism by the WNK-SPAK/OSR1 signalling pathway in mammalian cells and tissues under physiological and pathological conditions (Cell Metabolism 2017; Nature Medicine 2017; Nature Communications 2017; eLife 2018; Neuron 2019; Science Signalling 2019a, 2019b; Molecular Psychiatry 2021; and Genetics in Medicine 2022), and subsequently led to the development of a drug-like molecular ZT-1a (Nature Communications 2020; Stroke 2022; US Patent WO2020072386, European Patent EP3873439 (A1), Canadian Patent CA3115075 (A1), China Patent CN113365614 (A)), as a neuroprotective agent.  Brain swelling after a stroke or epilepsy is a common and devastating problem for individuals and their families. This current discovery could address the urgent need for treatment that could provide an effective alternative to invasive surgery.

Links

Research group links

Research

Research interests

Genetic and pharmacological modulation of the WNK-SPAK-KCC2/NKCC1 signalling pathway: implications for function and pathology in cortical networks

Homeostasis of the intracellular ionic milieu is essential for the proper functioning of all cells and a diverse group of cellular processes. The mechanisms responsible for the homeostasis of the intracellular Cl- concentration [Cl-]i, for example, significantly impacts the rate of fluid secretion or absorption across epithelia; how red blood cells counteract potentially damaging osmotic-induced cell swelling or shrinkage; and whether the GABA neurotransmitter excites or inhibits post-synaptic neurons.

The neuronal potassium-chloride co-transporter KCC2 is one of the molecules effectively controlling intracellular Cl- and adjusting the inhibitory strength of GABA. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous neurological disorders including epilepsy, autism, post-surgical complication, neuropathic pain and neuropsychiatric disorders.

KCC2 activity is decreased in most diseases associated with GABAergic disinhibition. A positive modulator (i.e., “activator”) of KCC2 might be effective in reversing the effects of KCC2 downregulation and lowering [Cl–]i to restore GABAergic inhibition. 

The activity of KCC2 is critically controlled by phosphorylation of two highly conserved residues (KCC2 Thr906/Thr1007), our recent work discovered that it is WNK-regulated SPAK/OSR1 kinases that directly phosphorylate KCC2 at Thr1007 and Thr906, thereby leading to its inhibition (Biochem. J. 2014, Sci. Signal. 2015, Sci. Rep. 2016, Nat. Comm. 2017, eLife 2018, Sci. Sig. 2019a, Sci. Sig. 2019b, Nat. Comm. 2020, Molecular Psychiatry 2021,  and Genetics in Medicine 2022). This has potential implications for the therapeutic modulation of neurological disorders by targeting of WNK-SPAK/OSR1 with kinase inhibitors, with a new strategy to enhance cellular chloride extrusion. 

Dr Zhang and his colleagues aim to study Cul3/KLHL3-WNK-SPAK signalling pathway and KCC2 mouse models involved in control of the KCC2 activity and downstream GABAergic neurotransmission during neuronal development under physiological conditions and in models of epilepsy and autism, and to develop small molecular compounds that suppress WNK-SPAK kinase signalling pathway and therefore to activate KCC2. Indeed, our recent developed drug-like molecular ZT-1a (Nature Communications 2020; Stroke 2022;  US Patent WO2020072386, European Patent EP3873439 (A1), Canadian Patent CA3115075 (A1), China Patent CN113365614 (A)),  which could potently block the WNK-SPAK/OSR1 signalling and activate KCC2 for neuroprotection.

 

Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications

The marine environment is a vast, largely unexploited resource for acquiring a multitude of microbial communities with a number of unknown taxonomic groups and novel biosynthetic capabilities. Marine habitats provide unique conditions for microbial growth and secondary metabolite expressions that are not found in terrestrial ecosystems. The co-evolution of many marine macroorganisms, especially invertebrates, with these microorganisms often leads to a very close association or symbiotic relationship between the host organism and specific microbial species driven by natural products. The ocean basin floor is covered in sediments of different types and origins. Marine sediments are considered to be an incredibly rich source of microbial taxonomic diversity, including culturable and ‘unculturable’ microbes. For culturable microbes, we could either grow mixed strains as biofilms for certain purposes, e.g. electricity generation (Zhang et al., Environ. Sci. Technol. 2012), or isolate novel strains identified as new species (Zhang et al., J. Microbiol. Biotechnol, 2007; Zhang et al., Int. J. Syst. Evol., 2015), for cold active enzymes, or for bioactive compounds (Zhang et al. Marine Biotechnology, 2008; Zhang et al., World J. Microbiol. Biotechnol. 2011), e.g. Omega-3 polyunsaturated fatty acids (EPA and DHA) (Zhang et al. PLOS ONE, 2017).

Whereas, 'unculturable' microbial diversity presents a vast gene pool for biotechnological exploitation. In this context the secondary metabolites produced by the microbial species and their biosynthetic pathways represent a resource in the discovery of novel molecules or enzymes for a wide number of applications especially in the medical and cosmetic field. Sustainable use of these resources is a methodological challenge: new culture techniques in addition to culture-independent methods, such as PCR amplification from microbial community DNA (metagenome) and functional or sequence-based screening of metagenomic DNA libraries are proving useful for the exploitation of 'unculturable' microbes and their novel gene clusters responsible for biosynthetic pathways for new bioactive compounds and enzymes ((Zhang et al, Prog. Biochem. Biophys., 2006; Zhang et al., Marine Biotechnology, 2008).

In recent years, efforts to characterize marine microbial metagenomics and their associated compounds and enzymes have expanded significantly, but given the vastness of the marine environment and the different types of microbial habitats found there, this research is still in its infancy.

Zhang Laboratory also explores the marine microbial community dynamics, genome sequencing and gene editing technology, marine microbial-derived molecules and their potential medical and cosmetic applications (Zhang et al. Frontiers in Microbiology, 2021). The aim is to promote our understanding of marine-derived biomolecules and their applications.  An example of study, Staurosporine produced by marine-derived actinomycete Streptomyces roseoflavus, could potently inhibit WNK-SPAK/OSR1 signalling mediated phosphorylation of KCC2 at Thr906/1007 and NKCC1 Thr203/207/212 (Zhang et al. PLOS ONE 2020).

Research networks


 

Links


Publications

Key publications | Publications by category | Publications by year

Key publications

Zhang J, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Pigott VM, Zhang J, Huang H, Hassan MN, Skrzypiec AE, et al (2020). Modulation of brain cation-Cl‾ cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications, 7, 78-78.
Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine, 23(8), 997-1003. Abstract.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.
Zhang J, Deng X, Kahle KT (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450). Abstract.
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.

Publications by category

Books

(2021). Neuroprotection: Rescue from Neuronal Death in the Brain., MDPI.

Journal articles

Pracucci E, Graham R, S Alberio L, Nardi G, Cozzolino O, Pillai V, Saieva L, Walsh D, Landi S, Zhang J, et al (In Press). Circadian rhythm in cortical chloride homeostasis underpins variation in network excitability. bioRxiv
Chen Z, Zhang J, Heilig R, Sorrell FJ, D’Angiolella V, Fischer R, Alessi DR, Bullock AN (In Press). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.  Abstract.
Delmotte Q, Medina I, Hamze M, Buhler E, Zhang J, Belgacem YH, Porcher C (In Press). Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex.  Abstract.
Robert S, Reeves B, Karimy JK, Marlier A, Kiziltug E, DeSpenza T, Singh A, Allington G, Phan D, Zhang J, et al (2022). 374 Multi-omic Analysis Identifies a SPAK Kinase-regulated Ensemble of Choroid Plexus Ion Transport Proteins Relevant for Post-infectious Hydrocephalus. Neurosurgery, 68(Supplement_1), 89-89.
Zhang J, Yao J, Rong M (2022). Editorial: Role of Ion Channels in Pain. Frontiers in Pharmacology, 13
Chen L, Yu J, Wan L, Wu Z, Wang G, Hu Z, Ren L, Zhou J, Qian B, Zhao X, et al (2022). Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus. IBRO Neuroscience Reports, 12, 355-365.
Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, et al (2022). NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II–Hypertensive Mice. Stroke, 53(5), 1720-1734. Abstract.
Zhong C, Zhao H, Xie X, Qi Z, Li Y, Jia L, Zhang J, Lu Y (2022). Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. Frontiers in Physiology, 13 Abstract.
Küry S, Zhang J, Besnard T, Caro-Llopis A, Zeng X, Robert SM, Josiah SS, Kiziltug E, Denommé-Pichon A-S, Cogné B, et al (2022). Rare pathogenic variants in WNK3 cause X-linked intellectual disability. Genetics in Medicine
Wang J, Liu R, Hasan MN, Fischer S, Chen Y, Como M, Fiesler VM, Bhuiyan MIH, Dong S, Li E, et al (2022). Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke. Journal of Neuroinflammation, 19(1). Abstract.
Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning CE, Sorrell FJ, D'Angiolella V, Fischer R, et al (2022). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. Biochemical Journal, 479(5), 661-675. Abstract.
Seymour T, Zhang J (2021). <i>Porphyromonas Gingivalis</i> in the Pathogenesis of Alzheimer’s Disease and its Therapeutic Target. Journal of Exploratory Research in Pharmacology, 7(1), 45-53.
Zhang J, Labes A, Zeng R (2021). Book: Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications. Lausanne: Frontiers Media SA, 1-162.
Zhang J, Zeng R, Labes A (2021). Editorial: Marine microbial-derived molecules and their potential medical and cosmetic applications. Frontiers in Microbiology, 12:706152
Jonniya NA, Zhang J, Kar P (2021). Molecular Mechanism of Inhibiting WNK Binding to OSR1 by Targeting the Allosteric Pocket of the OSR1-CCT Domain with Potential Antihypertensive Inhibitors: an <i>In Silico</i> Study. The Journal of Physical Chemistry B, 125(32), 9115-9129.
Bertoni A, Schaller F, Tyzio R, Gaillard S, Santini F, Xolin M, Diabira D, Vaidyanathan R, Matarazzo V, Medina I, et al (2021). Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism. Mol Psychiatry, 26(12), 7582-7595. Abstract.  Author URL.
Meor Azlan NF, Koeners MP, Zhang J (2021). Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension. Acta Pharmaceutica Sinica B, 11(5), 1117-1128.
Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-De-Tejada F, Murillo-De-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, et al (2021). Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression. American Journal of Physiology - Renal Physiology, 320(5), F734-F747. Abstract.
Salihu S, Meor Azlan NF, Josiah SS, Wu Z, Wang Y, Zhang J (2021). Role of the cation-chloride-cotransporters in the circadian system. Asian Journal of Pharmaceutical Sciences, 16(5), 589-597.
Josiah SS, Meor Azlan NF, Zhang J (2021). Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke. International Journal of Molecular Sciences, 22(3), 1232-1232. Abstract.
Belaïdouni Y, Diabira D, Zhang J, Graziano J-C, Bader F, Montheil A, Menuet C, Wayman GA, Gaiarsa J-L (2021). The Chloride Homeostasis of CA3 Hippocampal Neurons is Not Altered in Fully Symptomatic Mepc2-null Mice. Frontiers in Cellular Neuroscience, 15 Abstract.
Kahle KT, Reeves B, Karimy JK, Zhang J, Schiff SJ, Limbrick DD, Alper S, JM S (2020). A Shared, Targetable Inflammatory Mechanism Drives Hemorrhagic and Infectious Hydrocephalus. Neurosurgery, 67 (Supplement_1), nyaa447_264-nyaa447_264.
Zhang J, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Pigott VM, Zhang J, Huang H, Hassan MN, Skrzypiec AE, et al (2020). Modulation of brain cation-Cl‾ cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications, 7, 78-78.
Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT (2020). New drugs on the horizon for cerebral edema: what’s in the clinical development pipeline?. Expert Opinion on Investigational Drugs, 29(10), 1099-1105.
Meor Azlan NF, Zhang J (2020). Role of the Cation-chloride-cotransporters in Cardiovascular Disease. Cells, 9(10). Abstract.
Delmotte Q, Hamze M, Medina I, Buhler E, Zhang J, Belgacem YH, Porcher C (2020). Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex. J Cell Sci, 133(20). Abstract.  Author URL.
Zhang J, Cordshagen A, Medina I, Nothwang HG, Wisniewski JR, Winklhofer M, Hartmann A-M (2020). Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. PLOS ONE, 15(5), e0232967-e0232967.
Andrews K, Josiah S, Zhang J (2020). The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and its Comorbidities. International Journal of Molecular Sciences, 21, 9142-9142.
Brown A, Farah Meor Azlan N, Wu Z, Zhang J (2020). WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 42, 508-517.
Brown A, Meor Azlan NF, Wu Z, Zhang J (2020). WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Acta Pharmacologica Sinica, 42(4), 508-517.
Tillman L, Zhang J (2019). Crossing the Chloride Channel: the Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2. BioMed Research International, 2019
Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT, et al (2019). Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signaling, 12(603) aaw9315
Pisella LI, Gaiarsa J-L, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I (2019). Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signaling, 12(603). Abstract.
Zhang J (2019). LRRK2 Signalling Pathways in Parkinson’s Disease. Archives in Neurology & Neuroscience, 2(3).
Zhang J (2019). Meet Our Editorial Board Member. Current Signal Transduction Therapy, 14(1), 1-2.
Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, et al (2019). Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron, 101(3), 429-443.e4. Abstract.
Abe K (2019). Neuroprotective therapy both for acute ischemic stroke and ALS. Journal of Neurology & Neurophysiology, 10
Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z (2019). The WNK-SPAK/OSR1 kinases and the cation-chloride cotransporters as therapeutic targets for neurological diseases. Aging and Disease, 10
Bhuiyan MIH, Huang H, Zhang T, Molyneaux BJ, Poloyac SM, Zhang J, Deng X, Sun D, Sun D (2018). Abstract P198: WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice with Hypertension Co-Morbidity after Ischemic Stroke. Hypertension, 72(Suppl_1). Abstract.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, et al (2018). Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. ACS Chemical Biology Abstract.
Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa J-L, et al (2018). The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. eLife, 7, e36726-e36726.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Furey CG, Gerzanich V, Simard JM, Kahle KT (2017). 166 TLR-4-Regulated Cerebrospinal Fluid Hypersecretion in Post-Hemorrhagic Hydrocephalus. Neurosurgery, 64(CN_suppl_1), 242-242.
Zhang J, Burgess JG (2017). Enhanced eicosapentaenoic acid production by a new deep-sea marine bacterium Shewanella electrodiphila MAR441(T). PLOS ONE, 12(11). Author URL.
Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine, 23(8), 997-1003. Abstract.
Zhang J, Karimy JK, Delpire E, Kahle KT (2017). Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opinion on Therapeutic Targets, 21(8), 795-804. Abstract.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.
Andrukhova O, Zhang J, Alessi D, Erben R (2016). Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance. Bone Abstracts
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de los Heros P, Davies P, Varghese J, et al (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1).
Kahle KT, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, et al (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling, 9(421). Abstract.
Zhang J, Deng X, Kahle KT (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450). Abstract.
Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E (2016). MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. Frontiers in Microbiology, 7
Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Begum G, Duran D, Liang B, Sun D, et al (2016). Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling, 9(439). Abstract.
Kazlauskaite A, Martínez‐Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, et al (2015). Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal. <scp>PINK</scp>. 1‐dependent phosphorylation and activation. EMBO reports, 16(8), 939-954.
Schumacher F, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, et al (2015). Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), 1285-1306.
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.
Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS (2015). Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett, 6(5), 584-589. Abstract.  Author URL.
Zhang J, Burgess JG (2015). Shewanella electrodiphila sp. nov. a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. Int J Syst Evol Microbiol, 65(9), 2882-2889. Abstract.  Author URL.
Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, et al (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383). Abstract.
Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D, et al (2014). Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery, 61(Supplement 1), 214-214.
Heros P, Zhang J, Gourlay R, Campbell D, Deak M, Macartney T, Kahle K, Alessi D (2014). SPAK/OSR1 kinases directly phosphorylate the K+‐Cl‐ co‐transporters (1109.7). The FASEB Journal, 28(S1).
Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling(334). Abstract.
de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+ -Cl- co-transporters. Biochemical Journal, 458(3), 559-573. Abstract.
Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, et al (2013). Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis, 76, 49-58. Abstract.
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi. DR, Zhu X, Mieyal JJ, Roder H, et al (2013). Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics, 22(2), 328-344. Abstract.
Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, et al (2013). Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry, 70, 758-767. Abstract.
Choi HS, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS (2012). Brain penetrant LRRK2 inhibitor. ACS Medicinal Chemistry Letters, 3(8), 658-662. Abstract.
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS (2012). Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(5), 1864-1869. Abstract.
Zhang. J, Zhang E, Scott K, Burgess JG (2012). Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science and Technology, 46(5), 2984-2992. Abstract.
Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, et al (2012). GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent- N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(17), 5625-5629. Abstract.
Zhang J, Zeng R (2011). Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. World Journal of Microbiology and Biotechnology, 27(4), 841-850. Abstract.
Zhang J, Zeng R (2008). Molecular cloning and expression of a cold-adapted lipase gene from an antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology, 10(5), 612-621. Abstract.
Zhang J, Zeng R (2008). Purification and characterization of a cold-adapted α-amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic. Marine Biotechnology, 10(1), 75-82. Abstract.
Zhang J, Lin S, Zeng R (2007). Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychorotrophic bacterium, Psychobacter sp. 7195. Journal of Microbiology and Biotechnology, 17(4), 604-610. Abstract.
Zhang J, Zeng R (2007). Isolation of antarctic psychrotrophilic Pseudomonas sp. 7197 and cloning of ppa gene for inorganic pyrophosphatase (PPase). Gaojishu Tongxin/Chinese High Technology Letters, 17(10), 1067-1071. Abstract.
Zhang J, Zeng R (2007). Psychrotrophic amylolytic bacteria from deep sea sediment of Prydz Bay, Antarctic: Diversity and characterization of amylases. World Journal of Microbiology and Biotechnology, 23(11), 1551-1557. Abstract.
Zhang J, Zeng R (2006). Cloning, expression and characterization of the cold active lipase (Lip3) from metagenomic DNA of an antarctic deep sea sediment. Progress in Biochemistry and Biophysics, 33(12), 1207-1214. Abstract.
Zhang J, Lian M, Zeng R (2006). Screening, fermentation condition and enzyme characterization of multicomponent enzymes producing Pseudomonas sp. NJ197. Chinese Journal of Applied and Environmental Biology, 12(5), 683-687. Abstract.

Chapters

Josiah S, Meor Azlan NF, Zhang J (2021). Targeting the WNK-SPAK/OSR1 pathway and Cation-Chloride Cotransporters for the therapy of stroke. In  (Ed) Neuroprotection Rescue from Neuronal Death in the Brain, MDPI (Basel, Switzerland).: Mdpi AG, 27-48.  Abstract.

Conferences

Meor Azlan NF, Koeners MP, Zhang J (In Press). Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension.  Abstract.
Wang J, Fiesler VM, Begum G, Bhuiyan MIH, Dong S, Li E, Kahle KT, Zhang J, Deng X, Yin Y, et al (2021). SPAK/OSR1 Signaling as a Novel Target for Post-Stroke Oxidative Stress Brain Injury. International Stroke Conference 2021. 10th - 12th Feb 2021. Abstract.
Jun W, Fiesler VM, Begum G, Bhuiyan MIH, Shuying D, Li E, Kahle KT, Jinwei Z, Xianming D, Yan Y, et al (2021). SPAK/OSR1 Signaling as a Novel Target for Post-Stroke Oxidative Stress Brain Injury.  Author URL.
Zhang J (2020). Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy. the 6th International Conference on Epilepsy & Treatment. 21st - 22nd Sep 2020. Abstract.
Zhang J (2019). Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy. 23rd International Conference on Neurology & Neurophysiology. 18th - 19th Mar 2019. Abstract.
Zhang J, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Kahle KT, Sun D, Deng X (2018). Restoration of brain water homeostasis and neurological function via a novel kinase-cotransporter modulator. Cell Symposia, Aging and Metabolism. 23rd - 25th Sep 2018. Abstract.
Bhuiyan MIH, Huang H, Zhang T, Molyneaux BJ, Poloyac SM, Zhang J, Deng X, Sun D (2018). WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice with Hypertension Comorbidity after Ischemic Stroke. Joint Hypertension 2018 Scientific Sessions. 6th - 9th Sep 2018. Abstract.
Karimy J, Zhang J, Medzhitov R, Simard M, Kahle K (2017). Inflammation-dependent cerebrospinal fluid hypersecretion from the choroid plexus in post-hemorrhagic hydrocephalus. 42nd FEBS congress. 10th - 14th Sep 2017. Abstract.
Kahle K, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Dion PA, Duan J, Woolf CJ, Inquimbert P, et al (2016). Antagonism of Wnk/Hsn2 kinase ameliorates neuropathic pain by reducing maladaptive KCC2 inhibitory phosphorylation after nerve injury. 84th AANS Annual Scientific Meeting. 30th Apr - 4th May 2016. Abstract.
Kahle K, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Dion PA, Duan J, Woolf CJ, Inquimbert P, et al (2016). Antagonism of Wnk/Hsn2 kinase ameliorates neuropathic pain by reducing maladaptive KCC2 inhibitory phosphorylation after nerve injury.  Author URL.
Siew K, Zhang J, Schumacher F, Alessi DR, Kurtz T, O'Shaughnessy KM (2015). Pulse waveform analysis reveals vascular contributions to Gordon Syndrome and Gitelman Syndrome blood pressure homeostasis. Proceedings Abstracts of the Physiological Society. 1st - 1st Jul 2015. Abstract.
Keith S, Jinwei Z, Dario R. A, Kevin M. O (2014). Disruption of STE20/SPS1-related Proline/Alanine-rich Kinase (SPAK) binding lowers blood pressure and recapitulates Gitelman syndrome in mice. American Society of Nephrology Kidney Week 2014 Annual Meeting.  Abstract.
Kahle KT, Gen G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S (2014). Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. 2014 CNS ANNUAL MEETING. 1st - 1st Aug 2014. Abstract.
Heros PDL, Zhang J, Gourlay R, Campbell D, Deak M, Macartney T, Kahle K, Alessi D (2014). SPAK/OSR1 kinases directly phosphorylate the K+-Cl- co-transporters. Federation of American Societies for Experimental Biology. 1st - 1st Apr 2014. Abstract.

Publications by year

In Press

Pracucci E, Graham R, S Alberio L, Nardi G, Cozzolino O, Pillai V, Saieva L, Walsh D, Landi S, Zhang J, et al (In Press). Circadian rhythm in cortical chloride homeostasis underpins variation in network excitability. bioRxiv
Meor Azlan NF, Koeners MP, Zhang J (In Press). Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension.  Abstract.
Wang J, Liu R, Hasan MN, Fischer S, Como M, Fiesler VM, Begum G, Chen Y, Bhuiyan MIH, Dong S, et al (In Press). Role of SPAK-NKCC1 Signaling Cascade in the Choroid Plexus Blood-CSF Barrier Damage After Stroke.  Abstract.
Chen Z, Zhang J, Heilig R, Sorrell FJ, D’Angiolella V, Fischer R, Alessi DR, Bullock AN (In Press). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.  Abstract.
Delmotte Q, Medina I, Hamze M, Buhler E, Zhang J, Belgacem YH, Porcher C (In Press). Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex.  Abstract.

2022

Robert S, Reeves B, Karimy JK, Marlier A, Kiziltug E, DeSpenza T, Singh A, Allington G, Phan D, Zhang J, et al (2022). 374 Multi-omic Analysis Identifies a SPAK Kinase-regulated Ensemble of Choroid Plexus Ion Transport Proteins Relevant for Post-infectious Hydrocephalus. Neurosurgery, 68(Supplement_1), 89-89.
Zhang J (2022). Current Methods in Studying the Functions and Activities of the SLC12 Family of Cation-Chloride-Cotransporters. Journal of Visualized Experiments (JoVE) Abstract.
Zhang J, Yao J, Rong M (2022). Editorial: Role of Ion Channels in Pain. Frontiers in Pharmacology, 13
Chen L, Yu J, Wan L, Wu Z, Wang G, Hu Z, Ren L, Zhou J, Qian B, Zhao X, et al (2022). Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus. IBRO Neuroscience Reports, 12, 355-365.
Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, et al (2022). NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II–Hypertensive Mice. Stroke, 53(5), 1720-1734. Abstract.
Zhong C, Zhao H, Xie X, Qi Z, Li Y, Jia L, Zhang J, Lu Y (2022). Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. Frontiers in Physiology, 13 Abstract.
Küry S, Zhang J, Besnard T, Caro-Llopis A, Zeng X, Robert SM, Josiah SS, Kiziltug E, Denommé-Pichon A-S, Cogné B, et al (2022). Rare pathogenic variants in WNK3 cause X-linked intellectual disability. Genetics in Medicine
Wang J, Liu R, Hasan MN, Fischer S, Chen Y, Como M, Fiesler VM, Bhuiyan MIH, Dong S, Li E, et al (2022). Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke. Journal of Neuroinflammation, 19(1). Abstract.
Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning CE, Sorrell FJ, D'Angiolella V, Fischer R, et al (2022). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. Biochemical Journal, 479(5), 661-675. Abstract.

2021

Seymour T, Zhang J (2021). <i>Porphyromonas Gingivalis</i> in the Pathogenesis of Alzheimer’s Disease and its Therapeutic Target. Journal of Exploratory Research in Pharmacology, 7(1), 45-53.
Zhang J, Labes A, Zeng R (2021). Book: Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications. Lausanne: Frontiers Media SA, 1-162.
Zhang J, Zeng R, Labes A (2021). Editorial: Marine microbial-derived molecules and their potential medical and cosmetic applications. Frontiers in Microbiology, 12:706152
Jonniya NA, Zhang J, Kar P (2021). Molecular Mechanism of Inhibiting WNK Binding to OSR1 by Targeting the Allosteric Pocket of the OSR1-CCT Domain with Potential Antihypertensive Inhibitors: an <i>In Silico</i> Study. The Journal of Physical Chemistry B, 125(32), 9115-9129.
(2021). Neuroprotection: Rescue from Neuronal Death in the Brain., MDPI.
Bertoni A, Schaller F, Tyzio R, Gaillard S, Santini F, Xolin M, Diabira D, Vaidyanathan R, Matarazzo V, Medina I, et al (2021). Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism. Mol Psychiatry, 26(12), 7582-7595. Abstract.  Author URL.
Meor Azlan NF, Koeners MP, Zhang J (2021). Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension. Acta Pharmaceutica Sinica B, 11(5), 1117-1128.
Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-De-Tejada F, Murillo-De-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, et al (2021). Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression. American Journal of Physiology - Renal Physiology, 320(5), F734-F747. Abstract.
Salihu S, Meor Azlan NF, Josiah SS, Wu Z, Wang Y, Zhang J (2021). Role of the cation-chloride-cotransporters in the circadian system. Asian Journal of Pharmaceutical Sciences, 16(5), 589-597.
SUN D, Deng X, Zhang J, Hossain Bhuiyan MI, Molyneaux BJ (2021). SPAK kinase inhibitors as neuroprotective agents.  Abstract.
Sun D, Deng X, Zhang J, BHUIYAN MOHAMMAD I, MOLYNEAUX B (2021). SPAK kinase inhibitors as neuroprotective agents.  Abstract.
Wang J, Fiesler VM, Begum G, Bhuiyan MIH, Dong S, Li E, Kahle KT, Zhang J, Deng X, Yin Y, et al (2021). SPAK/OSR1 Signaling as a Novel Target for Post-Stroke Oxidative Stress Brain Injury. International Stroke Conference 2021. 10th - 12th Feb 2021. Abstract.
Jun W, Fiesler VM, Begum G, Bhuiyan MIH, Shuying D, Li E, Kahle KT, Jinwei Z, Xianming D, Yan Y, et al (2021). SPAK/OSR1 Signaling as a Novel Target for Post-Stroke Oxidative Stress Brain Injury.  Author URL.
Josiah SS, Meor Azlan NF, Zhang J (2021). Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke. International Journal of Molecular Sciences, 22(3), 1232-1232. Abstract.
Josiah S, Meor Azlan NF, Zhang J (2021). Targeting the WNK-SPAK/OSR1 pathway and Cation-Chloride Cotransporters for the therapy of stroke. In  (Ed) Neuroprotection Rescue from Neuronal Death in the Brain, MDPI (Basel, Switzerland).: Mdpi AG, 27-48.  Abstract.
Belaïdouni Y, Diabira D, Zhang J, Graziano J-C, Bader F, Montheil A, Menuet C, Wayman GA, Gaiarsa J-L (2021). The Chloride Homeostasis of CA3 Hippocampal Neurons is Not Altered in Fully Symptomatic Mepc2-null Mice. Frontiers in Cellular Neuroscience, 15 Abstract.

2020

Kahle KT, Reeves B, Karimy JK, Zhang J, Schiff SJ, Limbrick DD, Alper S, JM S (2020). A Shared, Targetable Inflammatory Mechanism Drives Hemorrhagic and Infectious Hydrocephalus. Neurosurgery, 67 (Supplement_1), nyaa447_264-nyaa447_264.
Zhang J (2020). Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy. the 6th International Conference on Epilepsy & Treatment. 21st - 22nd Sep 2020. Abstract.
Zhang J, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Pigott VM, Zhang J, Huang H, Hassan MN, Skrzypiec AE, et al (2020). Modulation of brain cation-Cl‾ cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications, 7, 78-78.
Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT (2020). New drugs on the horizon for cerebral edema: what’s in the clinical development pipeline?. Expert Opinion on Investigational Drugs, 29(10), 1099-1105.
Bertoni A, Schaller F, Tyzio R, Gaillard S, Santini F, Xolin M, Diabira D, Vaidyanathan R, Matarazzo V, Medina I, et al (2020). Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism.
Rong M, Zhang J, Yao J (2020). Role of Ion Channels in Pain. Frontiers in Pharmacology Abstract.
Meor Azlan NF, Zhang J (2020). Role of the Cation-chloride-cotransporters in Cardiovascular Disease.  Abstract.
Meor Azlan NF, Zhang J (2020). Role of the Cation-chloride-cotransporters in Cardiovascular Disease. Cells, 9(10). Abstract.
Delmotte Q, Hamze M, Medina I, Buhler E, Zhang J, Belgacem YH, Porcher C (2020). Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex. J Cell Sci, 133(20). Abstract.  Author URL.
Zhang J (2020). Special Collection on Targeting Ion Channels and Transporters as New Strategies of Treatments for Brain Disorders. ASN NEURO Abstract.
Zhang J (2020). Special Issue "Regulation and Control of Intracellular Signalling". Processes Abstract.
Zhang J, Cordshagen A, Medina I, Nothwang HG, Wisniewski JR, Winklhofer M, Hartmann A-M (2020). Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. PLOS ONE, 15(5), e0232967-e0232967.
Andrews K, Josiah S, Zhang J (2020). The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and its Comorbidities. International Journal of Molecular Sciences, 21, 9142-9142.
Brown A, Farah Meor Azlan N, Wu Z, Zhang J (2020). WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 42, 508-517.
Brown A, Meor Azlan NF, Wu Z, Zhang J (2020). WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Acta Pharmacologica Sinica, 42(4), 508-517.

2019

Zhang J (2019). Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy. 23rd International Conference on Neurology & Neurophysiology. 18th - 19th Mar 2019. Abstract.
Tillman L, Zhang J (2019). Crossing the Chloride Channel: the Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2. BioMed Research International, 2019
Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT, et al (2019). Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signaling, 12(603) aaw9315
Pisella LI, Gaiarsa J-L, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I (2019). Impaired KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathogenesis.
Pisella LI, Gaiarsa J-L, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I (2019). Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signaling, 12(603). Abstract.
Zhang J (2019). LRRK2 Signalling Pathways in Parkinson’s Disease. Archives in Neurology & Neuroscience, 2(3).
Zhang J (2019). Meet Our Editorial Board Member. Current Signal Transduction Therapy, 14(1), 1-2.
Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, et al (2019). Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron, 101(3), 429-443.e4. Abstract.
Abe K (2019). Neuroprotective therapy both for acute ischemic stroke and ALS. Journal of Neurology & Neurophysiology, 10
Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z (2019). The WNK-SPAK/OSR1 kinases and the cation-chloride cotransporters as therapeutic targets for neurological diseases. Aging and Disease, 10

2018

Bhuiyan MIH, Huang H, Zhang T, Molyneaux BJ, Poloyac SM, Zhang J, Deng X, Sun D, Sun D (2018). Abstract P198: WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice with Hypertension Co-Morbidity after Ischemic Stroke. Hypertension, 72(Suppl_1). Abstract.
Pinkas DM, Bufton JC, Bartual SG, Chen Z, Daubner GM, Schumacher F-R, Georghiou G, Zhang J, Sorrell FJ, Kurz T, et al (2018). Human with No Lysine Kinase 3 (WNK3). A Target Enabling Package, Version 4, 1-15.
Zhang J, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Kahle KT, Sun D, Deng X (2018). Restoration of brain water homeostasis and neurological function via a novel kinase-cotransporter modulator. Cell Symposia, Aging and Metabolism. 23rd - 25th Sep 2018. Abstract.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, et al (2018). Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. ACS Chemical Biology Abstract.
Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa J-L, et al (2018). The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. eLife, 7, e36726-e36726.
Bhuiyan MIH, Huang H, Zhang T, Molyneaux BJ, Poloyac SM, Zhang J, Deng X, Sun D (2018). WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice with Hypertension Comorbidity after Ischemic Stroke. Joint Hypertension 2018 Scientific Sessions. 6th - 9th Sep 2018. Abstract.

2017

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Furey CG, Gerzanich V, Simard JM, Kahle KT (2017). 166 TLR-4-Regulated Cerebrospinal Fluid Hypersecretion in Post-Hemorrhagic Hydrocephalus. Neurosurgery, 64(CN_suppl_1), 242-242.
Zhang J, Burgess JG (2017). Enhanced eicosapentaenoic acid production by a new deep-sea marine bacterium Shewanella electrodiphila MAR441(T). PLOS ONE, 12(11). Author URL.
Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, et al (2017). GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun, 8(1). Abstract.  Author URL.
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, et al (2017). Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine, 23(8), 997-1003. Abstract.
Karimy J, Zhang J, Medzhitov R, Simard M, Kahle K (2017). Inflammation-dependent cerebrospinal fluid hypersecretion from the choroid plexus in post-hemorrhagic hydrocephalus. 42nd FEBS congress. 10th - 14th Sep 2017. Abstract.
Zhang J, Karimy JK, Delpire E, Kahle KT (2017). Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opinion on Therapeutic Targets, 21(8), 795-804. Abstract.
Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (2017). WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism, 25(2), 285-299.

2016

Kahle K, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Dion PA, Duan J, Woolf CJ, Inquimbert P, et al (2016). Antagonism of Wnk/Hsn2 kinase ameliorates neuropathic pain by reducing maladaptive KCC2 inhibitory phosphorylation after nerve injury. 84th AANS Annual Scientific Meeting. 30th Apr - 4th May 2016. Abstract.
Kahle K, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Dion PA, Duan J, Woolf CJ, Inquimbert P, et al (2016). Antagonism of Wnk/Hsn2 kinase ameliorates neuropathic pain by reducing maladaptive KCC2 inhibitory phosphorylation after nerve injury.  Author URL.
Andrukhova O, Zhang J, Alessi D, Erben R (2016). Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance. Bone Abstracts
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de los Heros P, Davies P, Varghese J, et al (2016). Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 6(1).
Kahle KT, Schmouth J-F, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, et al (2016). Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling, 9(421). Abstract.
Zhang J, Deng X, Kahle KT (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling, 9(450). Abstract.
Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E (2016). MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. Frontiers in Microbiology, 7
Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Begum G, Duran D, Liang B, Sun D, et al (2016). Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling, 9(439). Abstract.

2015

Kazlauskaite A, Martínez‐Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, et al (2015). Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal. <scp>PINK</scp>. 1‐dependent phosphorylation and activation. EMBO reports, 16(8), 939-954.
Schumacher F, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, et al (2015). Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), 1285-1306.
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR (2015). Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet, 24(16), 4545-4558. Abstract.  Author URL.
Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS (2015). Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett, 6(5), 584-589. Abstract.  Author URL.
Siew K, Zhang J, Schumacher F, Alessi DR, Kurtz T, O'Shaughnessy KM (2015). Pulse waveform analysis reveals vascular contributions to Gordon Syndrome and Gitelman Syndrome blood pressure homeostasis. Proceedings Abstracts of the Physiological Society. 1st - 1st Jul 2015. Abstract.
Zhang J, Burgess JG (2015). Shewanella electrodiphila sp. nov. a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. Int J Syst Evol Microbiol, 65(9), 2882-2889. Abstract.  Author URL.
Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, et al (2015). WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling, 8(383). Abstract.

2014

Keith S, Jinwei Z, Dario R. A, Kevin M. O (2014). Disruption of STE20/SPS1-related Proline/Alanine-rich Kinase (SPAK) binding lowers blood pressure and recapitulates Gitelman syndrome in mice. American Society of Nephrology Kidney Week 2014 Annual Meeting.  Abstract.
Kahle KT, Gen G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S (2014). Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. 2014 CNS ANNUAL MEETING. 1st - 1st Aug 2014. Abstract.
Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D, et al (2014). Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery, 61(Supplement 1), 214-214.
Heros PDL, Zhang J, Gourlay R, Campbell D, Deak M, Macartney T, Kahle K, Alessi D (2014). SPAK/OSR1 kinases directly phosphorylate the K+-Cl- co-transporters. Federation of American Societies for Experimental Biology. 1st - 1st Apr 2014. Abstract.
Heros P, Zhang J, Gourlay R, Campbell D, Deak M, Macartney T, Kahle K, Alessi D (2014). SPAK/OSR1 kinases directly phosphorylate the K+‐Cl‐ co‐transporters (1109.7). The FASEB Journal, 28(S1).
Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT (2014). The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. Science Signaling(334). Abstract.
de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+ -Cl- co-transporters. Biochemical Journal, 458(3), 559-573. Abstract.

2013

Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, et al (2013). Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis, 76, 49-58. Abstract.
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi. DR, Zhu X, Mieyal JJ, Roder H, et al (2013). Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics, 22(2), 328-344. Abstract.
Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, et al (2013). Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry, 70, 758-767. Abstract.

2012

Choi HS, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS (2012). Brain penetrant LRRK2 inhibitor. ACS Medicinal Chemistry Letters, 3(8), 658-662. Abstract.
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS (2012). Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(5), 1864-1869. Abstract.
Zhang. J, Zhang E, Scott K, Burgess JG (2012). Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science and Technology, 46(5), 2984-2992. Abstract.
Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, et al (2012). GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent- N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic and Medicinal Chemistry Letters, 22(17), 5625-5629. Abstract.

2011

Zhang J, Zeng R (2011). Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. World Journal of Microbiology and Biotechnology, 27(4), 841-850. Abstract.

2008

Zhang J, Zeng R (2008). Molecular cloning and expression of a cold-adapted lipase gene from an antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology, 10(5), 612-621. Abstract.
Zhang J, Zeng R (2008). Purification and characterization of a cold-adapted α-amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic. Marine Biotechnology, 10(1), 75-82. Abstract.

2007

Zhang J, Lin S, Zeng R (2007). Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychorotrophic bacterium, Psychobacter sp. 7195. Journal of Microbiology and Biotechnology, 17(4), 604-610. Abstract.
Zhang J, Zeng R (2007). Isolation of antarctic psychrotrophilic Pseudomonas sp. 7197 and cloning of ppa gene for inorganic pyrophosphatase (PPase). Gaojishu Tongxin/Chinese High Technology Letters, 17(10), 1067-1071. Abstract.
Zhang J, Zeng R (2007). Psychrotrophic amylolytic bacteria from deep sea sediment of Prydz Bay, Antarctic: Diversity and characterization of amylases. World Journal of Microbiology and Biotechnology, 23(11), 1551-1557. Abstract.

2006

Zhang J, Zeng R (2006). Cloning, expression and characterization of the cold active lipase (Lip3) from metagenomic DNA of an antarctic deep sea sediment. Progress in Biochemistry and Biophysics, 33(12), 1207-1214. Abstract.
Zhang J, Lian M, Zeng R (2006). Screening, fermentation condition and enzyme characterization of multicomponent enzymes producing Pseudomonas sp. NJ197. Chinese Journal of Applied and Environmental Biology, 12(5), 683-687. Abstract.

Jinwei_Zhang Details from cache as at 2022-08-12 21:43:36

Refresh publications

External Engagement and Impact

Awards

  • Above & Beyond Award (Excellent), the University of Exeter (2022)
  • Outstanding Contribution Award for his contributions to the development of the journal 'Journal of Exploratory Research in Pharmacology (2021)
  • Above & Beyond Award (rigour), the University of Exeter (2019)
  • Bursary Award, Parkinson's UK (2012)
  • Outstanding Young Scientist Award, American Oil Chemists Society (2010)
  • Travel Grant Award, European Section of the American Oil Chemists Society (2010)
  • Second-class Award of Publication, Journal 'Progress in Modern Biomedicine’ (2010)
  • BBSRC-Croda Dorothy Hodgkin Scholar, Newcastle University UK (2008-2011) 
  • Third-class Award of Publication, State Oceanic Administration, China (2008)
  • Outstanding Young Scientist Award, Chinese Enzyme Engineering Society (2005)
  • Fujian Normal University Scholarship Award (2009-2003)

Editorial responsibilities

Invited or ad hoc Reviewers for more than 85 manuscripts, for the following Journals:

  1. Cell Metabolism (Cell press) (IF 31.373)
  2. Chem (Cell press) (IF 25.832)
  3. Biochemical Journal (Portland press) (IF 3.766)
  4. Open Biology (Journal of the Royal Society) (IF 7.129)
  5. Journal of Biological Chemistry (IF 5.486)
  6. Human Molecular Genetics (IF 5.3)
  7. Biochemistry (IF 4.857)
  8. Microbial Biotechnology (IF 6.575)
  9. Journal Of Cellular and Molecular Medicine (IF 5.295)
  10. Frontiers in Pharmacology (IF 5.988)
  11. Frontiers in Microbiology (IF 6.064)
  12. Frontiers in Physiology (IF 4.755)
  13. Frontiers in Neuroscience (IF 5.152)
  14. Frontiers In Molecular Neuroscience (IF 6.261)
  15. Frontiers in Cellular Neuroscience (IF 6.147)
  16. Frontiers in Cell and Developmental Biology (IF 6.081)
  17. Frontiers in Pediatrics (IF 3.569)
  18. Biomedicines (MDPI) (IF 4.757)
  19. Cells (MDPI) (IF 7.666)
  20. International Journal of Molecular Sciences (MDPI) (IF 6.208)
  21. Metabolites (MDPI) (IF 5.581)
  22. Molecules (MDPI) (IF 4.927)
  23. Membranes (MDPI) (IF 4.562)
  24. Toxics (MDPI) (IF 4.472)
  25. Marine Drugs (MDPI) (IF 6.085)
  26. Antioxidants (MDPI) (IF 7.675)
  27. Pharmaceuticals (MDPI) (IF 5.677)
  28. Current Issues in Molecular Biology (MDPI) (IF 2.976)
  29. Journal of Cellular Physiology (IF 6.513)
  30. Microbiological Research (IF 5.070)
  31. Journal of Cancer (IF 4.478)
  32. Asian Journal of Pharmaceutical Sciences (Elsevier) (IF 9.273)
  33. Experimental Cell Research (Elsevier) (IF 4.145)
  34. Enzyme and Microbial Technology (Elsevier) (IF 3.705)
  35. Journal of Biotechnology (Elsevier) (IF 3.595)
  36. Molecular Pharmacology (IF 4.054)
  37. Applied Microbiology and Biotechnology (Springer) (IF 5.560)
  38. Neural Regeneration Research (IF 6.058)
  39. Marine Biotechnology (Springer) (IF 3.727)
  40. Preparative Biochemistry and Biotechnology (IF 3.141)
  41. Canadian Journal of Microbiology (Springer) (IF 3.226)
  42. ACS Omega (IF 4.132)
  43. Expert Opinion on Orphan Drugs (IF 1.041)
  44. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management (Elsevier)
  45. Journal of Pediatric Neurology
  46. Data in Brief (Elsevier)

International recognition, such as international research collaborations, visiting research posts in overseas institutions, involvement at senior levels in international research associations, acting as referee for national and international research councils.

2019- Visiting Professor, Xiamen University, China

2019- Visiting Scientist, Qingdao University, China

2015- Visiting Scholar, Yale University School of Medicine, USA 


Invited lectures

Aix-Marseille Université, Marseille, France 2015

Xiamen University, China 2015

Nankai University, China 2016

Newcastle University, UK 2017

University of Exeter, UK 2017

Xiamen University, China 2018

Nanjing University, China 2019

Xi'an Jiaotong University, China 2019

Fudan Univerisity, China 2020

Shanghai institute of Organic Chemistry,CAS, 2021

 


Journal and book series Editorships and Editorial board membership

As senior member of the editorial board, setting journal’s scope and direction, organize review processes for submitted manuscripts, including identifying and inviting qualified reviewers, analyzing reviewers’ critiques, comments, and overall scores to make final fair justifications, setting criteria for acceptance, rejection, and revision.   

  1. Associate Editor, Frontiers in Pharmacology (IF=5.988)
  2. Associate Editor, Frontiers in Physiology (IF=4.755)
  3. Editor in Chief, Journal of Pharmacogenomics & Pharmacoproteomics
  4. Editor in Chief, Journal of Modern Biology and Drug Discovery
  5. Executive Editor: Journal of Applied Pharmacy
  6. Section Editor, Current Signal Transduction Therapy
  7. Topic Editor, Frontiers in Pharmacology (IF=5.988) (from 2022) on “Targeting Pumps, Channels and Transporters for the Treatments of Vascular, Cardiovascular and Kidney Diseases”
  8. Topic Editor, International Journal of Molecular Sciences (IF=6.208) (from 2022) on "The Roles of Ion Channels and Transporters in Intracellular Signaling"
  9. Topic Editor, Brain Sciences (IF=3.333 (from 2022) on "Selected Papers from the 6th European Congress on Neurology and Brain Disorders"
  10. Topic Editor,  Frontiers in Physiology (IF=4.755) (from 2021) on “Chloride Homeostasis in Animal Cell Physiology”
  11. Topic Editor, Frontiers in Microbiology (IF=6.064) (from 2021) on “Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications, Volume II”
  12. Topic Editor, Journal of Visualized Experiments (JoVE)  (IF=1.424) (from 2021 ) on “ Current Methods in Studying the Functions and Activities of the SLC12 Family of Cation-Chloride-Cotransporters”
  13. Topic Editor, Frontiers in Bioscience-Elite (from 2022) on “Antimicrobial Resistance”
  14. Topic Editor, ASN Neuro (IF=5.20) (from 2020) on “Targeting Ion Channels and Transporters as New Strategies of Treatments for Brain Disorders”
  15. Topic Editor, Processes (IF=3.352) (from 2020)  on “Regulation and Control of Intracellular Signalling”
  16. Topic Editor, Journal of Modern Biology and Drug Discovery (from 2022) on “COVID-19 Therapies and Vaccine Development”
  17. Topic Editor, Frontiers in Pharmacology (IF=5.988) (from 2021-2022) on “Role of Ion Channels in Pain”
  18. Topic Editor, Frontiers in Microbiology (IF=6.064) (2019-2021) on “Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications, Volume I”
  19. Topic Editor, BioMed Research International (IF=3.246)

Research funding

2018-    Invited as an ad hoc Academic Adviser by reviewing applications for Medical Research Council (MRC) grant

2018-   Invited as an ad hoc Academic Adviser by reviewing applications for UK Biotechnology and Biological Sciences Research Council (BBSRC) grant

2020-      Invited as an ad hoc Academic Adviser by reviewing applications for Austrian Science Fund (FWF), Austria’s central funding body for basic research

2021-      Invited as an ad hoc Academic Adviser by reviewing applications for Carnegie Trust for the Universities of Scotland

2021-      Invited as an ad hoc Academic Adviser by reviewing applications for the Commonwealth Scholarship Commission (CSC).

Teaching

I have enjoyed varied and extensive teaching responsibilities, which covered the following areas:

  • Biochemistry, Signalling Transduction, Drug Discovery
  • Biological techniques and scientific practice to undergraduate students
  • Assessment and marking of coursework and exams

 

I contribute to the following undergraduate modules 

Anatomy and Physiology (PAM1011)

Integrated Human Physiology (CSC1005)

Translational Medical Science (CSC4019)

Fundamental Skills for Medical Scientists (CSC1004)

Academic and Professional Support (CSC1905)

Chemistry of Life (CSC1009)

Anatomical Sciences (CSC2009)

Academic tutor for BMBS year 1, 2 and 3

Dissertation supervisor for  CSC4020, CSC3028 and CSC3029

Rational Drug Design (CSC4006, CSC3010)

Modules

2021/22


Supervision / Group

Postgraduate researchers

  • Sunday Josiah
  • Nur Farah Meor Azlan
  • Shihan Salihu
  • Tom Seymour

Alumni

  • Katie Andrews (Project student since 2019)
  • Mr A. Brown (Research student since 2019)
  • Miss C. Davis (Research student since 2018)
  • Dr F. Donneger (Visiting Scholar from INSERM-Sorbonne Université since 2019)
  • Mr A. Haley (A2I funded research student from 2017)
  • Mr J. Y. Lee (Research student from 2018)
  • Prof. Pei-Feng Li (Visiting Professor from College of Medicine, University of Qingdao, China since 2019)
  • Mr G. Stewart (A2I funded research student since 2017)
  • Mr L. Tillman (Research student since 2018)
  • Dr. Z. Wu (Senior Visiting Scholar from Newcastle University UK since 2017)

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