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University of Exeter Medical School

Dr Janice Ranson

Dr Janice Ranson

Senior Research Fellow

 J.Ranson@exeter.ac.uk

 College House 

 

College House, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK


Overview

Janice is a Senior Research Fellow and Deputy Director of the Deep Dementia Phenotyping (DEMON) Network, a global initiative supporting the application of data science and artificial intelligence to dementia research with over 1,600 innovators across 6 continents. Janice oversees strategic partnership development and manages the research activity of 7 multidisciplinary Working Groups, which focus on delivery of collaborative publications, funding applications and knowledge exchange.

A Fellow of the Royal Society for Public Health (FRSPH), Janice's scientific expertise includes development and validation of clinical prediction models, incorporating a wide range of clinical, biomarker and genetic features from large population-based cohorts and clinical datasets. Her work has included development of prognostic models for use in specialist settings such as the National Prion Disease Unit, screening tools for clinical trial recruitment, and prediction models for primary care, including a clinical decision support system for dementia identification in non-specialist settings.

Leadership Roles

  • Theme Lead for Reproducibility, Institute for Data Science and Artificial Intelligence (IDSAI)
  • Deputy Director, Deep Dementia Phenotyping (DEMON) Network
  • Vice Chair, AI for Precision Dementia Medicine, Alzheimer's Association
  • Local Network Lead, UK Reproducibility Network
  • Co-Lead, Precision Dementia Medicine, Alan Turing Institute 

International collaborations include invited membership of the NIH/NIA-funded Integrative Analysis of Longitudinal Studies of Aging (IALSA) initiative, and the European Task Force for Brain Health Services. Most recently, she co-founded a new Alan Turing Institute Interest Group in Precision Dementia Medicine, and a new Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Professional Interest Area in AI for Precision Dementia Medicine.

Prospective Students

I enjoy supporting early career researchers. I welcome enquiries from research students interested in brain health, prevention and diagnosis of dementia or related conditions, as well as those interested in working across disciplines. 

Follow me

Twitter: @Janice_Ranson

LinkedIn: linkedin.com/in/dr-janice-ranson

Qualifications

  • PhD Medical Studies, University of Exeter
  • MSc Psychological Research Methods (Distinction, Programme Prize and Dean's Commendation), University of Exeter
  • BSc Psychology (First Class), Royal Holloway, University of London

Links

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Publications

Journal articles

Frisoni GB, Altomare D, Ribaldi F, Villain N, Brayne C, Mukadam N, Abramowicz M, Abramowicz F, Berthier M, Bieler-Aeschlimann M, et al (In Press). Dementia prevention in memory clinics: recommendations from the European task force for brain health services. The Lancet Regional Health - Europe
Ranson J, Llewellyn D, Lourida I (In Press). Harnessing the potential of machine learning and artificial intelligence for dementia research. Brain Informatics Abstract.
Hendriks S, Ranson JM, Peetoom K, Lourida I, Tai XY, de Vugt M, Llewellyn DJ, Köhler S (2024). Risk Factors for Young-Onset Dementia in the UK Biobank. JAMA Neurol, 81(2), 134-142. Abstract.  Author URL.
Winchester LM, Harshfield EL, Shi L, Badhwar A, Khleifat AA, Clarke N, Dehsarvi A, Lengyel I, Lourida I, Madan CR, et al (2023). Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia. Alzheimers Dement, 19(12), 5860-5871. Abstract.  Author URL.
Doherty T, Yao Z, Khleifat AAL, Tantiangco H, Tamburin S, Albertyn C, Thakur L, Llewellyn DJ, Oxtoby NP, Lourida I, et al (2023). Artificial intelligence for dementia drug discovery and trials optimization. Alzheimers Dement, 19(12), 5922-5933. Abstract.  Author URL.
Bettencourt C, Skene N, Bandres-Ciga S, Anderson E, Winchester LM, Foote IF, Schwartzentruber J, Botia JA, Nalls M, Singleton A, et al (2023). Artificial intelligence for dementia genetics and omics. Alzheimer's and Dementia, 19(12), 5905-5921. Abstract.
Newby D, Orgeta V, Marshall CR, Lourida I, Albertyn CP, Tamburin S, Raymont V, Veldsman M, Koychev I, Bauermeister S, et al (2023). Artificial intelligence for dementia prevention. Alzheimer's and Dementia, 19(12), 5952-5969. Abstract.
Lyall DM, Kormilitzin A, Lancaster C, Sousa J, Petermann-Rocha F, Buckley C, Harshfield EL, Iveson MH, Madan CR, McArdle R, et al (2023). Artificial intelligence for dementia-Applied models and digital health. Alzheimers Dement, 19(12), 5872-5884. Abstract.  Author URL.
Borchert RJ, Azevedo T, Badhwar A, Bernal J, Betts M, Bruffaerts R, Burkhart MC, Dewachter I, Gellersen HM, Low A, et al (2023). Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: a systematic review. Alzheimers Dement, 19(12), 5885-5904. Abstract.  Author URL.
Marzi SJ, Schilder BM, Nott A, Frigerio CS, Willaime-Morawek S, Bucholc M, Hanger DP, James C, Lewis PA, Lourida I, et al (2023). Artificial intelligence for neurodegenerative experimental models. Alzheimers Dement, 19(12), 5970-5987. Abstract.  Author URL.
Du R, Zhou Y, you C, Liu K, King DA, Liang Z-S, Ranson JM, Llewellyn DJ, Huang J, Zhang Z, et al (2023). Attention-deficit/hyperactivity disorder and ischemic stroke: a Mendelian randomization study. Int J Stroke, 18(3), 346-353. Abstract.  Author URL.
Shannon OM, Ranson JM, Gregory S, Macpherson H, Milte C, Lentjes M, Mulligan A, McEvoy C, Griffiths A, Matu J, et al (2023). Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study. BMC Med, 21(1). Abstract.  Author URL.
Hendriks S, Ranson JM, Peetoom K, Tai XY, Lourida I, de Vugt M, Llewellyn DJ, Köhler S (2023). Risk factors of young‐onset dementia: a UK Biobank study. Alzheimer's & Dementia, 19(S23).
Klee M, Leist AK, Veldsman M, Ranson JM, Llewellyn DJ (2023). Socioeconomic Deprivation, Genetic Risk, and Incident Dementia. American Journal of Preventive Medicine, 64(5), 621-630.
Winchester LM, Newby D, Bauermeister S, Ranson JM, Chien S, Hu P, Llewellyn DJ, Lee J, Nevado‐Holgado AJ (2023). The role of anemia and haemoglobin concentration on cognitive function in the Longitudinal Ageing Study of India‐Diagnostic Assessment of Dementia (LASI‐DAD). Alzheimer's & Dementia, 19(S8).
Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, Ranson J, Llewellyn DJ (2022). Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet Healthy Longev, 3(6), e428-e436. Abstract.  Author URL.
Nihat A, Ranson JM, Harris D, McNiven K, Mok T, Rudge P, Collinge J, Llewellyn DJ, Mead S (2022). Development of prognostic models for survival and care status in sporadic Creutzfeldt-Jakob disease. Brain Commun, 4(4). Abstract.  Author URL.
Ward DD, Ranson JM, Wallace LMK, Llewellyn DJ, Rockwood K (2022). Frailty, lifestyle, genetics and dementia risk. J Neurol Neurosurg Psychiatry, 93(4), 343-350. Abstract.  Author URL.
Huang J, Liang Z-S, Pallotti S, Ranson JM, Llewellyn DJ, Zheng Z-J, King DA, Zhou Q, Zheng H, Napolioni V, et al (2022). PAGEANT: personal access to genome and analysis of natural traits. Nucleic Acids Res, 50(7). Abstract.  Author URL.
Jenkins ND, Hoogendijk EO, Armstrong JJ, Lewis NA, Ranson JM, Rijnhart JJM, Ahmed T, Ghachem A, Mullin DS, Ntanasi E, et al (2022). Trajectories of Frailty with Aging: Coordinated Analysis of Five Longitudinal Studies. Innovation in Aging, 6(2).
Altomare D, Molinuevo JL, Ritchie C, Ribaldi F, Carrera E, Dubois B, Jessen F, McWhirter L, Scheltens P, van der Flier WM, et al (2021). Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services—part 1 of 6. Alzheimer's Research and Therapy, 13(1). Abstract.
Zhang N, Ranson JM, Zheng Z-J, Hannon E, Zhou Z, Kong X, Llewellyn DJ, King DA, Huang J (2021). Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Sci Rep, 11(1). Abstract.  Author URL.
Ranson JM, Rittman T, Hayat S, Brayne C, Jessen F, Blennow K, van Duijn C, Barkhof F, Tang E, Mummery CJ, et al (2021). Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6. Alzheimers Res Ther, 13(1). Abstract.  Author URL.
Solomon A, Stephen R, Altomare D, Carrera E, Frisoni GB, Kulmala J, Molinuevo JL, Nilsson P, Ngandu T, Ribaldi F, et al (2021). Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6. Alzheimer's Research and Therapy, 13(1). Abstract.
James C, Ranson JM, Everson R, Llewellyn DJ (2021). Performance of Machine Learning Algorithms for Predicting Progression to Dementia in Memory Clinic Patients. JAMA Netw Open, 4(12). Abstract.  Author URL.
Ranson JM, Kuźma E, Hamilton W, Muniz-Terrera G, Langa KM, Llewellyn DJ (2019). Predictors of dementia misclassification when using brief cognitive assessments. Neurol Clin Pract, 9(2), 109-117. Abstract.  Author URL.
Ranson JM, Kuźma E, Hamilton W, Lang I, Llewellyn DJ (2018). Case-finding in clinical practice: an appropriate strategy for dementia identification?. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 4, 288-296. Abstract.
Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PHM, Kestenbaum BR, Kuller LH, et al (2016). Vitamin D and Memory Decline: Two Population-Based Prospective Studies. J Alzheimers Dis, 50(4), 1099-1108. Abstract.  Author URL.

Chapters

Ranson JM, Bucholc M, Lyall D, Newby D, Winchester L, Oxtoby N, Veldsman M, Rittman T, Marzi S, Skene N, et al (2022). The Emerging Role of AI in Dementia Research and Healthcare. In  (Ed) Artificial Intelligence in Healthcare, Springer Nature, 95-106.

Conferences

Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, Ranson JM, Llewellyn DJ (2022). Cardiometabolic multimorbidity, genetic risk and dementia.
Klee M, Leist AK, Veldsman M, Ranson JM, Llewellyn DJ (2022). Socioeconomic Deprivation, Genetics and Risk of Dementia.
Ranson JM, Khleifat AA, Lyall DM, Newby D, Winchester LM, Proitsi P, Veldsman M, Rittman T, Marzi S, Yao Z, et al (2022). The Deep Dementia Phenotyping (DEMON) Network: a global platform for innovation using data science and artificial intelligence.
Ranson JM, Khleifat AA, Lyall DM, Newby D, Winchester LM, Proitsi P, Veldsman M, Rittman T, Marzi S, Yao Z, et al (2022). The Deep Dementia Phenotyping (DEMON) Network: a global platform for innovation using data science and artificial intelligence.  Abstract.  Author URL.
Ranson J, Lourida I, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Genetic risk, education and incidence of dementia. Alzheimer’s Association International Conference. 27th - 31st Jul 2020.
Ranson JM, Lourida I, Hannon E, Littlejohns TJ, Ballard C, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2020). Genetic risk, education and incidence of dementia.
Ranson J, Lourida ILIANNA, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Stroke, genetic risk and incidence of dementia. Alzheimer's Association International Conference. 27th - 31st Jul 2020.
Ranson JM, James C, Routledge C, Everson R, Bauermeister SD, Llewellyn DJ (2020). The DEMON Network: the first UK network for deep dementia phenotyping.
Ranson JM, Kuzma E, Hamilton W, Llewellyn DJ (2019). P2‐307: DECODE DEMENTIA: INITIAL DEVELOPMENT AND EXTERNAL VALIDATION OF CLINICAL PREDICTION MODELS FOR DEMENTIA IDENTIFICATION.
Ranson JM, Kuzma E, Hamilton W, Llewellyn DJ (2017). [P1–498]: MISCLASSIFICATION OF DEMENTIA BY BRIEF COGNITIVE ASSESSMENTS IN THE AGING, DEMOGRAPHICS AND MEMORY STUDY.
Lourida I, Kuzma E, Ranson JM, Hunt H, Talens‐Bou J, Rogers M, Thompson‐Coon J, Llewellyn DJ (2017). [P2–094]: DEVELOPMENT OF a DEMENTIA META‐EVIDENCE DATABASE (EMANATE).
Ranson JM, Kuzma E, Langa KM, Llewellyn DJ (2015). P3‐192: Primary care‐relevant predictors of dementia status in the aging, demographics and memory study.

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Supervision / Group

Research Fellows

  • Cecilia Golborne Project Manager
  • Zoe Humble Project Manager

Postgraduate researchers

  • Jamie Howe
  • Jiajia Huang

Research Technicians

  • Janice Alcott Administrator

Alumni

  • Saravana Sekar MSc student
  • Harry Woollen MSc student

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