James Premdoss
Postdoctoral Research Associate
J.P.Chelliah@exeter.ac.uk
Publications
Journal articles
Purushotham SS, Reddy NMN, D’Souza MN, Choudhury NR, Ganguly A, Gopalakrishna N, Muddashetty R, Clement JP (2022). A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder. Experimental Brain Research
Chakraborty S, Parayil R, Mishra S, Nongthomba U, Clement JP (2022). Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder. International Journal of Molecular Sciences, 23(18), 10807-10807. Abstract.
Verma V, Mandora A, Botre A, Clement JP (2021). Correction to: Identification of an individual with a SYNGAP1 pathogenic mutation in India. Molecular Biology Reports, 48(9), 6663-6663.
Verma V, Kumar MJV, Sharma K, Rajaram S, Muddashetty R, Manjithaya R, Behnisch T, Clement JP (2021). Pharmacological intervention in young adolescents rescues synaptic physiology and behavioural deficits in Syngap1+/− mice. Experimental Brain Research, 240(1), 289-309.
Kumar MJV, Shah D, Giridharan M, Yadav N, Manjithaya R, Clement JP (2021). Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model. Scientific Reports, 11(1). Abstract.
Verma V, Mandora A, Botre A, Clement JP (2020). Identification of an individual with a SYNGAP1 pathogenic mutation in India. Molecular Biology Reports, 47(11), 9225-9234.
Pati S, Salvi SS, Kallianpur M, Vaidya B, Banerjee A, Maiti S, Clement JP, Vaidya VA (2019). Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner. eneuro, 6(6), ENEURO.0124-19.2019. Abstract.
Paul A, Nawalpuri B, Shah D, Sateesh S, Muddashetty RS, Clement JP (2019). Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity. Frontiers in Molecular Neuroscience, 12
Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, Rai S, Paul A, Yarreiphang H, Pillai MS, et al (2019). Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine, 50, 260-273. Abstract. Author URL.
Verma V, Paul A, Amrapali Vishwanath A, Vaidya B, Clement JP (2019). Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour. Open Biology, 9(6). Abstract.
Singh AK, Halder-Sinha S, Clement JP, Kundu TK (2018). Epigenetic modulation by small molecule compounds for neurodegenerative disorders. Pharmacological Research, 132, 135-148.
Suresh SN, Chavalmane AK, Pillai M, Ammanathan V, Vidyadhara DJ, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, et al (2018). Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα is Neuroprotective. Frontiers in Molecular Neuroscience, 11
Suresh SN, Verma V, Sateesh S, Clement JP, Manjithaya R (2018). Neurodegenerative diseases: model organisms, pathology and autophagy. Journal of Genetics, 97(3), 679-701.
Suresh SN, Chavalmane AK, DJ V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R (2017). A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy, 13(7), 1221-1234.
Petrovic MM, Viana da Silva S, Clement JP, Vyklicky L, Mulle C, González-González IM, Henley JM (2017). Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation. Nature Neuroscience, 20(4), 529-539.
Jeyabalan N, Clement JP (2016). SYNGAP1: Mind the Gap. Frontiers in Cellular Neuroscience, 10
Clement JP, Ozkan ED, Aceti M, Miller CA, Rumbaugh G (2013). SYNGAP1 Links the Maturation Rate of Excitatory Synapses to the Duration of Critical-Period Synaptic Plasticity. Journal of Neuroscience, 33(25), 10447-10452.
Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, et al (2012). Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses. Cell, 151(4), 709-723.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract. Author URL.
Rajan R, Clement JP, Bhalla US (2006). Rats Smell in Stereo. Science, 311(5761), 666-670. Abstract.
Conferences
Chelliah JP, Brown J, Randall A (2008). Transient activation of mGluR1 produces an NMDA receptor-dependent long-lasting depression of CA1 pyramidal cell excitability. Author URL.
