COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

Profile

Loading content
 Jack Bowden

Jack Bowden

Professor of Biomedical Data Science

 8225

 RILD Building 04.05

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Jack Bowden is a statistician interested in developing statistical tools and methods to support cutting edge biomedical research. In 2019 he was appointed Professor of Biomedical Data Science within the University of Exeter Medical School.

Before moving to Exeter, he led a research programme within the MRC Integrative Epidemiology Unit at the University of Bristol, developing robust approaches for causal inference within observational studies using genetic data.  Prior to that, his work focused on developing methods to preserve the validity and improve the efficiency of clinical trials, within the MRC Biostatistics Unit at the University of Cambridge.

In Exeter, he will primarily support the world class research undertaken into Diabetes. He is keen to apply his expertise to help learn about fundamental causes of this varied condition and its effective treatment, using genetics, observational studies and clinical trials.  He maintains an honorary position at the University of Bristol and hopes to use his existing research connections to further strengthen the collaborative links between these two great institutions.

Qualifications

BSc Hons  Mathematics

MSc. Medical Statistics

PhD  Biostatistics

Research

Research interests

Mendelian randomization (MR)

MR uses individuals’ genetic variants as `Instrumental Variables’ (IVs) to turn observational data into a pseudo randomized controlled trial. The technique enables scientists to estimate the causal effect of intervening and modifying a health exposure (such as a person’s diet or body mass index) on downstream disease outcome (such as the risk of developing Type 2 Diabetes).  MR circumvents the problem of confounding that inhibits straightforward causal estimation using observational studies.   Jack has helped to develop a range of statistical methods for MR, as well as methods for sensitivity analysis that help to determine whether individual genetic variants satisfy the IV assumptions, in order for the approach to draw reliable causal conclusions.  

Clinical Trials Methodology

Jack has developed a range of statistical methods to preserve the validity, improve the efficiency and increase the patient benefit of randomized clinical trials. Specific areas of interest include:

  • Estimating treatment effects in multi-arm multi-stage trials;

  • Accounting for non-adherence and intercurrent events;

  • Performing sample size re-estimation;

  • Implementing response adaptive randomization;

  • Optimizing clinical trial design.

Research projects

Current Projects:

  • Adjusting for selection bias and missing data in clinical trials and epidemiology  - in collaboration with Kate Tilling, Matt Tudball and Dea Hazewinkel (Bristol);
  • Assessing the causal role of sleep disturbance on Type II diabetes traits – in collaboration with Martin Rutter (Manchester), Deborah Lawlor (Bristol) and Mike Weedon (Exeter);
  • Developing Instrumental variable methods to account for intercurrent events in academic and industry-led trials - in collaborations with Jonathan Bartlett (Uni of Bath) and Novartis;
  • Adjusting for pleiotropy, weak instrument bias and winner’s curse in Mendelian randomization - in collaboration with Ciarrah Barry (Bath), Chin Yang Shapland and Gibran Hemani,  (Bristol);
  • Utilizing gene-environment interactions in Mendelian randomization – in collaboration with Wesley Spiller and George Davey Smith (Bristol);
  • Multivariable Mendelian randomization – in collaboration with Eleanor Sanderson (Bristol)

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Lane JM, Jones S, Dashti HS, Wood AR, Aragam K, van Hees VT, Brumpton B, Winsvold B, Wang H, Bowden J, et al (In Press). Biological and clinical insights from genetics of insomnia symptoms.  Abstract.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jefferies A, Dashti HS, Hillsdon M, Ruth KS, et al (In Press). Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease.  Abstract.
Vansteelandt S, Bowden J, Babanezhad M, Goetghebeur E (In Press). On Instrumental Variables Estimation of Causal Odds Ratios. Statistical Science, 26(3), 403-422. Abstract.  Author URL.
Hartwig FP, Smith GD, Schmidt AF, Bowden J (In Press). The median and the mode as robust meta-analysis methods in the presence of small study effects.  Abstract.
Zhao Q, Wang J, Bowden J, Small DS (In Press). Two-sample instrumental variable analyses using heterogeneous samples.  Abstract.  Author URL.  Full text.
Sanderson E, Smith GD, Windmeijer F, Bowden J (2020). Corrigendum to: an examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol, 49(3). Author URL.
Hartwig FP, Davey Smith G, Schmidt AF, Sterne JAC, Higgins JPT, Bowden J (2020). The median and the mode as robust meta‐analysis estimators in the presence of small‐study effects and outliers. Research Synthesis Methods, 11(3), 397-412. Full text.
Langan D, Higgins JPT, Jackson D, Bowden J, Veroniki AA, Kontopantelis E, Viechtbauer W, Simmonds M (2019). A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses. Res Synth Methods, 10(1), 83-98. Abstract.  Author URL.
Sanderson E, Davey Smith G, Windmeijer F, Bowden J (2019). An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol, 48(3), 713-727. Abstract.  Author URL.
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.  Full text.
Spiller W, Slichter D, Bowden J, Davey Smith G (2019). Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions. Int J Epidemiol, 48(3), 702-712. Abstract.  Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.  Full text.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.  Full text.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Bowden J, Del Greco M F, Minelli C, Zhao Q, Lawlor DA, Sheehan NA, Thompson J, Davey Smith G (2019). Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol, 48(3), 728-742. Abstract.  Author URL.
Sanderson E, Davey Smith G, Bowden J, Munafò MR (2019). Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour. Nat Commun, 10(1). Abstract.  Author URL.
Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, et al (2019). Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PLoS One, 14(5). Abstract.  Author URL.
Bowden J, Holmes MV (2019). Meta-analysis and Mendelian randomization: a review. Res Synth Methods, 10(4), 486-496. Abstract.  Author URL.
Wright KM, Dono J, Brownbill AL, Pearson Nee Gibson O, Bowden J, Wycherley TP, Keech W, O'Dea K, Roder D, Avery JC, et al (2019). Sugar-sweetened beverage (SSB) consumption, correlates and interventions among Australian Aboriginal and Torres Strait Islander communities: a scoping review. BMJ Open, 9(2). Abstract.  Author URL.
Jenkins DA, Bowden J, Robinson HA, Sattar N, Loos RJF, Rutter MK, Sperrin M (2018). Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking. Diabetes Care, 41(9), 1878-1886. Abstract.  Author URL.
Gill D, Brewer CF, Del Greco M F, Sivakumaran P, Bowden J, Sheehan NA, Minelli C (2018). Age at menarche and adult body mass index: a Mendelian randomization study. Int J Obes (Lond), 42(9), 1574-1581. Abstract.  Author URL.
Minelli C, van der Plaat DA, Leynaert B, Granell R, Amaral AFS, Pereira M, Mahmoud O, Potts J, Sheehan NA, Bowden J, et al (2018). Age at puberty and risk of asthma: a Mendelian randomisation study. PLoS Med, 15(8). Abstract.  Author URL.
Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, Forgett V, et al (2018). Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. The BMJ, 362 Abstract.
Hemani G, Bowden J, Davey Smith G (2018). Evaluating the potential role of pleiotropy in Mendelian randomization studies. Hum Mol Genet, 27(R2), R195-R208. Abstract.  Author URL.
Bowden J, Spiller W, Del Greco M F, Sheehan N, Thompson J, Minelli C, Davey Smith G (2018). Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int J Epidemiol, 47(6). Author URL.
Bowden J, Spiller W, Del Greco M F, Sheehan N, Thompson J, Minelli C, Davey Smith G (2018). Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int J Epidemiol, 47(4), 1264-1278. Abstract.  Author URL.
Gage SH, Bowden J, Davey Smith G, Munafò MR (2018). Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study. Int J Epidemiol, 47(4), 1131-1140. Abstract.  Author URL.
Bowden J, Hemani G, Davey Smith G (2018). Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?. Am J Epidemiol, 187(12), 2681-2685. Abstract.  Author URL.
Hartwig FP, Borges MC, Bowden J (2018). Mendelian Randomization Concerns-Reply. JAMA Psychiatry, 75(4), 407-408. Author URL.
Villar SS, Bowden J, Wason J (2018). Response-adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?. Pharm Stat, 17(2), 182-197. Abstract.  Author URL.  Full text.
Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, et al (2018). The MR-Base platform supports systematic causal inference across the human phenome. Elife, 7 Abstract.  Author URL.
Schmitz S, Maguire Á, Morris J, Ruggeri K, Haller E, Kuhn I, Leahy J, Homer N, Khan A, Bowden J, et al (2018). The use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma. BMC Med Res Methodol, 18(1). Abstract.  Author URL.
Bowden J, Del Greco M F, Minelli C, Davey Smith G, Sheehan N, Thompson J (2017). A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Stat Med, 36(11), 1783-1802. Abstract.  Author URL.
Wason J, Stallard N, Bowden J, Jennison C (2017). A multi-stage drop-the-losers design for multi-arm clinical trials. Stat Methods Med Res, 26(1), 508-524. Abstract.  Author URL.
Galbraith S, Bowden J, Mander A (2017). Accelerated longitudinal designs: an overview of modelling, power, costs and handling missing data. Stat Methods Med Res, 26(1), 374-398. Abstract.  Author URL.
Gage SH, Jones HJ, Burgess S, Bowden J, Davey Smith G, Zammit S, Munafò MR (2017). Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychol Med, 47(5), 971-980. Abstract.  Author URL.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, et al (2017). Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: a Mendelian Randomization Study. JAMA Oncol, 3(5), 636-651. Abstract.  Author URL.
Bowden J, Burgess S, Smith GD (2017). Difficulties in Testing the Instrument Strength Independent of Direct Effect Assumption in Mendelian Randomization. JAMA Cardiol, 2(8), 929-930. Author URL.
Ware JJ, Tanner J-A, Taylor AE, Bin Z, Haycock P, Bowden J, Rogers PJ, Davey Smith G, Tyndale RF, Munafò MR, et al (2017). Does coffee consumption impact on heaviness of smoking?. Addiction, 112(10), 1842-1853. Abstract.  Author URL.
Tillmann T, Vaucher J, Okbay A, Pikhart H, Peasey A, Kubinova R, Pajak A, Tamosiunas A, Malyutina S, Hartwig FP, et al (2017). Education and coronary heart disease: mendelian randomisation study. BMJ, 358 Abstract.  Author URL.
Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, et al (2017). Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet, 49(2), 274-281. Abstract.  Author URL.
Hartwig FP, Borges MC, Horta BL, Bowden J, Davey Smith G (2017). Inflammatory Biomarkers and Risk of Schizophrenia: a 2-Sample Mendelian Randomization Study. JAMA Psychiatry, 74(12), 1226-1233. Abstract.  Author URL.
Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, et al (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 Abstract.
Thompson JR, Minelli C, Bowden J, Del Greco FM, Gill D, Jones EM, Shapland CY, Sheehan NA (2017). Mendelian randomization incorporating uncertainty about pleiotropy. Stat Med, 36(29), 4627-4645. Abstract.  Author URL.
Bowden J (2017). Misconceptions on the use of MR-Egger regression and the evaluation of the InSIDE assumption. Int J Epidemiol, 46(6), 2097-2099. Author URL.
Hartwig FP, Davey Smith G, Bowden J (2017). Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol, 46(6), 1985-1998. Abstract.  Author URL.
Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG (2017). Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants. Epidemiology, 28(1), 30-42. Abstract.  Author URL.
Bowden J, Trippa L (2017). Unbiased estimation for response adaptive clinical trials. Stat Methods Med Res, 26(5), 2376-2388. Abstract.  Author URL.
Lawlor D, Richmond R, Warrington N, McMahon G, Davey Smith G, Bowden J, Evans DM (2017). Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. Wellcome Open Res, 2 Abstract.  Author URL.
Robertson DS, Prevost AT, Bowden J (2016). Accounting for selection and correlation in the analysis of two-stage genome-wide association studies. Biostatistics, 17(4), 634-649. Abstract.  Author URL.
Parashar D, Bowden J, Starr C, Wernisch L, Mander A (2016). An optimal stratified Simon two-stage design. Pharm Stat, 15(4), 333-340. Abstract.  Author URL.
Bowden J, Del Greco M F, Minelli C, Davey Smith G, Sheehan NA, Thompson JR (2016). Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol, 45(6), 1961-1974. Abstract.  Author URL.
Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, Timpson NJ (2016). BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization. Diabetes, 65(10), 3002-3007. Abstract.  Author URL.
Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey Smith G (2016). Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr, 103(4), 965-978. Abstract.  Author URL.
Hartwig FP, Bowden J, Loret de Mola C, Tovo-Rodrigues L, Davey Smith G, Horta BL (2016). Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep, 6 Abstract.  Author URL.
Jackson D, Bowden J (2016). Confidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics: should we use unequal tails?. BMC Med Res Methodol, 16(1). Abstract.  Author URL.
Bowden J, Davey Smith G, Haycock PC, Burgess S (2016). Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol, 40(4), 304-314. Abstract.  Author URL.
Bowden J, Seaman S, Huang X, White IR (2016). Gaining power and precision by using model-based weights in the analysis of late stage cancer trials with substantial treatment switching. Stat Med, 35(9), 1423-1440. Abstract.  Author URL.
Veroniki AA, Jackson D, Viechtbauer W, Bender R, Bowden J, Knapp G, Kuss O, Higgins JPT, Langan D, Salanti G, et al (2016). Methods to estimate the between-study variance and its uncertainty in meta-analysis. Res Synth Methods, 7(1), 55-79. Abstract.  Author URL.
Bowden J, Burgess S, Davey Smith G (2016). Response to Hartwig and Davies. Int J Epidemiol, 45(5), 1679-1680. Author URL.
Robertson DS, Prevost AT, Bowden J (2016). Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules. Stat Med, 35(22), 3907-3922. Abstract.  Author URL.
Bowden J, Jackson C (2016). Weighing Evidence "Steampunk" Style via the Meta-Analyser. Am Stat, 70(4), 385-394. Abstract.  Author URL.
Jackson D, Bowden J, Baker R (2015). Approximate confidence intervals for moment-based estimators of the between-study variance in random effects meta-analysis. Res Synth Methods, 6(4), 372-382. Abstract.  Author URL.
Robertson DS, Prevost AT, Bowden J (2015). Correcting for bias in the selection and validation of informative diagnostic tests. Stat Med, 34(8), 1417-1437. Abstract.  Author URL.
Bowden J, Davey Smith G, Burgess S (2015). Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol, 44(2), 512-525. Abstract.  Author URL.
Villar SS, Bowden J, Wason J (2015). Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges. Stat Sci, 30(2), 199-215. Abstract.  Author URL.
Villar SS, Wason J, Bowden J (2015). Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule. Biometrics, 71(4), 969-978. Abstract.  Author URL.
Bowden J, Mander A (2014). A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials. Pharm Stat, 13(3), 163-172. Abstract.  Author URL.
Bowden J, Glimm E (2014). Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trials. Biom J, 56(2), 332-349. Abstract.  Author URL.
Bowden J, Brannath W, Glimm E (2014). Empirical Bayes estimation of the selected treatment mean for two-stage drop-the-loser trials: a meta-analytic approach. Stat Med, 33(3), 388-400. Abstract.  Author URL.
Jackson D, Baker R, Bowden J (2013). A sensitivity analysis framework for the treatment effect measure used in the meta-analysis of comparative binary data from randomised controlled trials. Stat Med, 32(6), 931-940. Abstract.  Author URL.
Choodari-Oskooei B, Parmar MKB, Royston P, Bowden J (2013). Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome. Trials, 14 Abstract.  Author URL.
Bowden J, Wason J (2012). Identifying combined design and analysis procedures in two-stage trials with a binary end point. Stat Med, 31(29), 3874-3884. Abstract.  Author URL.
Bowden J, Tierney JF, Simmonds M, Copas AJ, Higgins JP (2011). Individual patient data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effects model. Res Synth Methods, 2(3), 150-162. Abstract.  Author URL.
Bowden J, Vansteelandt S (2011). Mendelian randomization analysis of case-control data using structural mean models. Stat Med, 30(6), 678-694. Abstract.  Author URL.
Bowden J, Tierney JF, Copas AJ, Burdett S (2011). Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol, 11 Abstract.  Author URL.
Burgess S, Thompson SG, CRP CHD Genetics Collaboration, Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, et al (2010). Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Stat Med, 29(12), 1298-1311. Abstract.  Author URL.
Jackson D, Bowden J, Baker R (2010). How does the DerSimonian and Laird procedure for random effects meta-analysis compare with its more efficient but harder to compute counterparts?. JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 140(4), 961-970. Author URL.
Bowden J, Jackson D, Thompson SG (2010). Modelling multiple sources of dissemination bias in meta-analysis. Stat Med, 29(7-8), 945-955. Abstract.  Author URL.
Jackson D, Bowden J (2009). A re-evaluation of the 'quantile approximation method' for random effects meta-analysis. Stat Med, 28(2), 338-348. Abstract.  Author URL.
Bowden J, Dudbridge F (2009). Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Genet Epidemiol, 33(5), 406-418. Abstract.  Author URL.
Bowden J, Glimm E (2008). Unbiased estimation of selected treatment means in two-stage trials. BIOMETRICAL JOURNAL, 50(4), 515-527. Author URL.
Bowden J, Thompson JR, Burton PR (2007). A two-stage approach to the correction of ascertainment bias in complex genetic studies involving variance components. Ann Hum Genet, 71(Pt 2), 220-229. Abstract.  Author URL.
Bowden J, Thompson JR, Burton P (2006). Using pseudo-data to correct for publication bias in meta-analysis. STATISTICS IN MEDICINE, 25(22), 3798-3813. Author URL.
Bowden J, Whittaker J (2005). A latent variable scorecard for neonatal baby frailty. STATISTICAL MODELLING, 5(2), 159-172. Author URL.

Chapters

Burton PR, Bowden JM, Tobin MD (2008). Epidemiology and Genetic Epidemiology. In  (Ed) Handbook of Statistical Genetics: Third Edition, 1109-1140.  Abstract.

Conferences

Spiller W, Slichter D, Bowden J, Smith GD (2018). Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions.  Author URL.
Hemani G, Zheng J, Wade KH, Laurin C, Elsworth B, Burgess S, Bowden J, Langdon R, Tan V, Yarmolinsky J, et al (2018). MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations.  Author URL.
Villar SS, Wason J, Bowden J (2015). Patient drift and response-adaptive randomisation: impact and solutions.  Author URL.

Publications by year


In Press

Lane JM, Jones S, Dashti HS, Wood AR, Aragam K, van Hees VT, Brumpton B, Winsvold B, Wang H, Bowden J, et al (In Press). Biological and clinical insights from genetics of insomnia symptoms.  Abstract.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jefferies A, Dashti HS, Hillsdon M, Ruth KS, et al (In Press). Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease.  Abstract.
Vansteelandt S, Bowden J, Babanezhad M, Goetghebeur E (In Press). On Instrumental Variables Estimation of Causal Odds Ratios. Statistical Science, 26(3), 403-422. Abstract.  Author URL.
Hartwig FP, Smith GD, Schmidt AF, Bowden J (In Press). The median and the mode as robust meta-analysis methods in the presence of small study effects.  Abstract.
Zhao Q, Wang J, Bowden J, Small DS (In Press). Two-sample instrumental variable analyses using heterogeneous samples.  Abstract.  Author URL.  Full text.

2020

Sanderson E, Smith GD, Windmeijer F, Bowden J (2020). Corrigendum to: an examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol, 49(3). Author URL.
Hartwig FP, Davey Smith G, Schmidt AF, Sterne JAC, Higgins JPT, Bowden J (2020). The median and the mode as robust meta‐analysis estimators in the presence of small‐study effects and outliers. Research Synthesis Methods, 11(3), 397-412. Full text.

2019

Langan D, Higgins JPT, Jackson D, Bowden J, Veroniki AA, Kontopantelis E, Viechtbauer W, Simmonds M (2019). A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses. Res Synth Methods, 10(1), 83-98. Abstract.  Author URL.
Sanderson E, Davey Smith G, Windmeijer F, Bowden J (2019). An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol, 48(3), 713-727. Abstract.  Author URL.
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.  Full text.
Spiller W, Slichter D, Bowden J, Davey Smith G (2019). Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions. Int J Epidemiol, 48(3), 702-712. Abstract.  Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.  Full text.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.  Full text.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Bowden J, Del Greco M F, Minelli C, Zhao Q, Lawlor DA, Sheehan NA, Thompson J, Davey Smith G (2019). Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol, 48(3), 728-742. Abstract.  Author URL.
Sanderson E, Davey Smith G, Bowden J, Munafò MR (2019). Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour. Nat Commun, 10(1). Abstract.  Author URL.
Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, et al (2019). Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PLoS One, 14(5). Abstract.  Author URL.
Bowden J, Holmes MV (2019). Meta-analysis and Mendelian randomization: a review. Res Synth Methods, 10(4), 486-496. Abstract.  Author URL.
Wright KM, Dono J, Brownbill AL, Pearson Nee Gibson O, Bowden J, Wycherley TP, Keech W, O'Dea K, Roder D, Avery JC, et al (2019). Sugar-sweetened beverage (SSB) consumption, correlates and interventions among Australian Aboriginal and Torres Strait Islander communities: a scoping review. BMJ Open, 9(2). Abstract.  Author URL.

2018

Jenkins DA, Bowden J, Robinson HA, Sattar N, Loos RJF, Rutter MK, Sperrin M (2018). Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking. Diabetes Care, 41(9), 1878-1886. Abstract.  Author URL.
Gill D, Brewer CF, Del Greco M F, Sivakumaran P, Bowden J, Sheehan NA, Minelli C (2018). Age at menarche and adult body mass index: a Mendelian randomization study. Int J Obes (Lond), 42(9), 1574-1581. Abstract.  Author URL.
Minelli C, van der Plaat DA, Leynaert B, Granell R, Amaral AFS, Pereira M, Mahmoud O, Potts J, Sheehan NA, Bowden J, et al (2018). Age at puberty and risk of asthma: a Mendelian randomisation study. PLoS Med, 15(8). Abstract.  Author URL.
Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, Forgett V, et al (2018). Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. The BMJ, 362 Abstract.
Spiller W, Slichter D, Bowden J, Smith GD (2018). Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions.  Author URL.
Hemani G, Bowden J, Davey Smith G (2018). Evaluating the potential role of pleiotropy in Mendelian randomization studies. Hum Mol Genet, 27(R2), R195-R208. Abstract.  Author URL.
Bowden J, Spiller W, Del Greco M F, Sheehan N, Thompson J, Minelli C, Davey Smith G (2018). Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int J Epidemiol, 47(6). Author URL.
Bowden J, Spiller W, Del Greco M F, Sheehan N, Thompson J, Minelli C, Davey Smith G (2018). Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int J Epidemiol, 47(4), 1264-1278. Abstract.  Author URL.
Gage SH, Bowden J, Davey Smith G, Munafò MR (2018). Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study. Int J Epidemiol, 47(4), 1131-1140. Abstract.  Author URL.
Bowden J, Hemani G, Davey Smith G (2018). Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?. Am J Epidemiol, 187(12), 2681-2685. Abstract.  Author URL.
Hemani G, Zheng J, Wade KH, Laurin C, Elsworth B, Burgess S, Bowden J, Langdon R, Tan V, Yarmolinsky J, et al (2018). MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations.  Author URL.
Hartwig FP, Borges MC, Bowden J (2018). Mendelian Randomization Concerns-Reply. JAMA Psychiatry, 75(4), 407-408. Author URL.
Villar SS, Bowden J, Wason J (2018). Response-adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?. Pharm Stat, 17(2), 182-197. Abstract.  Author URL.  Full text.
Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, et al (2018). The MR-Base platform supports systematic causal inference across the human phenome. Elife, 7 Abstract.  Author URL.
Schmitz S, Maguire Á, Morris J, Ruggeri K, Haller E, Kuhn I, Leahy J, Homer N, Khan A, Bowden J, et al (2018). The use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma. BMC Med Res Methodol, 18(1). Abstract.  Author URL.

2017

Bowden J, Del Greco M F, Minelli C, Davey Smith G, Sheehan N, Thompson J (2017). A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Stat Med, 36(11), 1783-1802. Abstract.  Author URL.
Wason J, Stallard N, Bowden J, Jennison C (2017). A multi-stage drop-the-losers design for multi-arm clinical trials. Stat Methods Med Res, 26(1), 508-524. Abstract.  Author URL.
Galbraith S, Bowden J, Mander A (2017). Accelerated longitudinal designs: an overview of modelling, power, costs and handling missing data. Stat Methods Med Res, 26(1), 374-398. Abstract.  Author URL.
Gage SH, Jones HJ, Burgess S, Bowden J, Davey Smith G, Zammit S, Munafò MR (2017). Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychol Med, 47(5), 971-980. Abstract.  Author URL.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, et al (2017). Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: a Mendelian Randomization Study. JAMA Oncol, 3(5), 636-651. Abstract.  Author URL.
Bowden J, Burgess S, Smith GD (2017). Difficulties in Testing the Instrument Strength Independent of Direct Effect Assumption in Mendelian Randomization. JAMA Cardiol, 2(8), 929-930. Author URL.
Ware JJ, Tanner J-A, Taylor AE, Bin Z, Haycock P, Bowden J, Rogers PJ, Davey Smith G, Tyndale RF, Munafò MR, et al (2017). Does coffee consumption impact on heaviness of smoking?. Addiction, 112(10), 1842-1853. Abstract.  Author URL.
Tillmann T, Vaucher J, Okbay A, Pikhart H, Peasey A, Kubinova R, Pajak A, Tamosiunas A, Malyutina S, Hartwig FP, et al (2017). Education and coronary heart disease: mendelian randomisation study. BMJ, 358 Abstract.  Author URL.
Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, et al (2017). Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet, 49(2), 274-281. Abstract.  Author URL.
Hartwig FP, Borges MC, Horta BL, Bowden J, Davey Smith G (2017). Inflammatory Biomarkers and Risk of Schizophrenia: a 2-Sample Mendelian Randomization Study. JAMA Psychiatry, 74(12), 1226-1233. Abstract.  Author URL.
Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, et al (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 Abstract.
Thompson JR, Minelli C, Bowden J, Del Greco FM, Gill D, Jones EM, Shapland CY, Sheehan NA (2017). Mendelian randomization incorporating uncertainty about pleiotropy. Stat Med, 36(29), 4627-4645. Abstract.  Author URL.
Bowden J (2017). Misconceptions on the use of MR-Egger regression and the evaluation of the InSIDE assumption. Int J Epidemiol, 46(6), 2097-2099. Author URL.
Hartwig FP, Davey Smith G, Bowden J (2017). Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol, 46(6), 1985-1998. Abstract.  Author URL.
Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG (2017). Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants. Epidemiology, 28(1), 30-42. Abstract.  Author URL.
Bowden J, Trippa L (2017). Unbiased estimation for response adaptive clinical trials. Stat Methods Med Res, 26(5), 2376-2388. Abstract.  Author URL.
Lawlor D, Richmond R, Warrington N, McMahon G, Davey Smith G, Bowden J, Evans DM (2017). Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. Wellcome Open Res, 2 Abstract.  Author URL.

2016

Robertson DS, Prevost AT, Bowden J (2016). Accounting for selection and correlation in the analysis of two-stage genome-wide association studies. Biostatistics, 17(4), 634-649. Abstract.  Author URL.
Parashar D, Bowden J, Starr C, Wernisch L, Mander A (2016). An optimal stratified Simon two-stage design. Pharm Stat, 15(4), 333-340. Abstract.  Author URL.
Bowden J, Del Greco M F, Minelli C, Davey Smith G, Sheehan NA, Thompson JR (2016). Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol, 45(6), 1961-1974. Abstract.  Author URL.
Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, Timpson NJ (2016). BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization. Diabetes, 65(10), 3002-3007. Abstract.  Author URL.
Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey Smith G (2016). Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr, 103(4), 965-978. Abstract.  Author URL.
Hartwig FP, Bowden J, Loret de Mola C, Tovo-Rodrigues L, Davey Smith G, Horta BL (2016). Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep, 6 Abstract.  Author URL.
Jackson D, Bowden J (2016). Confidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics: should we use unequal tails?. BMC Med Res Methodol, 16(1). Abstract.  Author URL.
Bowden J, Davey Smith G, Haycock PC, Burgess S (2016). Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol, 40(4), 304-314. Abstract.  Author URL.
Bowden J, Seaman S, Huang X, White IR (2016). Gaining power and precision by using model-based weights in the analysis of late stage cancer trials with substantial treatment switching. Stat Med, 35(9), 1423-1440. Abstract.  Author URL.
Veroniki AA, Jackson D, Viechtbauer W, Bender R, Bowden J, Knapp G, Kuss O, Higgins JPT, Langan D, Salanti G, et al (2016). Methods to estimate the between-study variance and its uncertainty in meta-analysis. Res Synth Methods, 7(1), 55-79. Abstract.  Author URL.
Bowden J, Burgess S, Davey Smith G (2016). Response to Hartwig and Davies. Int J Epidemiol, 45(5), 1679-1680. Author URL.
Robertson DS, Prevost AT, Bowden J (2016). Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules. Stat Med, 35(22), 3907-3922. Abstract.  Author URL.
Bowden J, Jackson C (2016). Weighing Evidence "Steampunk" Style via the Meta-Analyser. Am Stat, 70(4), 385-394. Abstract.  Author URL.

2015

Jackson D, Bowden J, Baker R (2015). Approximate confidence intervals for moment-based estimators of the between-study variance in random effects meta-analysis. Res Synth Methods, 6(4), 372-382. Abstract.  Author URL.
Robertson DS, Prevost AT, Bowden J (2015). Correcting for bias in the selection and validation of informative diagnostic tests. Stat Med, 34(8), 1417-1437. Abstract.  Author URL.
Bowden J, Davey Smith G, Burgess S (2015). Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol, 44(2), 512-525. Abstract.  Author URL.
Villar SS, Bowden J, Wason J (2015). Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges. Stat Sci, 30(2), 199-215. Abstract.  Author URL.
Villar SS, Wason J, Bowden J (2015). Patient drift and response-adaptive randomisation: impact and solutions.  Author URL.
Villar SS, Wason J, Bowden J (2015). Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule. Biometrics, 71(4), 969-978. Abstract.  Author URL.

2014

Bowden J, Mander A (2014). A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials. Pharm Stat, 13(3), 163-172. Abstract.  Author URL.
Bowden J, Glimm E (2014). Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trials. Biom J, 56(2), 332-349. Abstract.  Author URL.
Bowden J, Brannath W, Glimm E (2014). Empirical Bayes estimation of the selected treatment mean for two-stage drop-the-loser trials: a meta-analytic approach. Stat Med, 33(3), 388-400. Abstract.  Author URL.

2013

Jackson D, Baker R, Bowden J (2013). A sensitivity analysis framework for the treatment effect measure used in the meta-analysis of comparative binary data from randomised controlled trials. Stat Med, 32(6), 931-940. Abstract.  Author URL.
Choodari-Oskooei B, Parmar MKB, Royston P, Bowden J (2013). Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome. Trials, 14 Abstract.  Author URL.

2012

Bowden J, Wason J (2012). Identifying combined design and analysis procedures in two-stage trials with a binary end point. Stat Med, 31(29), 3874-3884. Abstract.  Author URL.

2011

Bowden J, Tierney JF, Simmonds M, Copas AJ, Higgins JP (2011). Individual patient data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effects model. Res Synth Methods, 2(3), 150-162. Abstract.  Author URL.
Bowden J, Vansteelandt S (2011). Mendelian randomization analysis of case-control data using structural mean models. Stat Med, 30(6), 678-694. Abstract.  Author URL.
Bowden J, Tierney JF, Copas AJ, Burdett S (2011). Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol, 11 Abstract.  Author URL.

2010

Burgess S, Thompson SG, CRP CHD Genetics Collaboration, Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, et al (2010). Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Stat Med, 29(12), 1298-1311. Abstract.  Author URL.
Jackson D, Bowden J, Baker R (2010). How does the DerSimonian and Laird procedure for random effects meta-analysis compare with its more efficient but harder to compute counterparts?. JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 140(4), 961-970. Author URL.
Bowden J, Jackson D, Thompson SG (2010). Modelling multiple sources of dissemination bias in meta-analysis. Stat Med, 29(7-8), 945-955. Abstract.  Author URL.

2009

Jackson D, Bowden J (2009). A re-evaluation of the 'quantile approximation method' for random effects meta-analysis. Stat Med, 28(2), 338-348. Abstract.  Author URL.
Bowden J, Dudbridge F (2009). Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. Genet Epidemiol, 33(5), 406-418. Abstract.  Author URL.

2008

Burton PR, Bowden JM, Tobin MD (2008). Epidemiology and Genetic Epidemiology. In  (Ed) Handbook of Statistical Genetics: Third Edition, 1109-1140.  Abstract.
Bowden J, Glimm E (2008). Unbiased estimation of selected treatment means in two-stage trials. BIOMETRICAL JOURNAL, 50(4), 515-527. Author URL.

2007

Bowden J, Thompson JR, Burton PR (2007). A two-stage approach to the correction of ascertainment bias in complex genetic studies involving variance components. Ann Hum Genet, 71(Pt 2), 220-229. Abstract.  Author URL.

2006

Bowden J, Thompson JR, Burton P (2006). Using pseudo-data to correct for publication bias in meta-analysis. STATISTICS IN MEDICINE, 25(22), 3798-3813. Author URL.

2005

Bowden J, Whittaker J (2005). A latent variable scorecard for neonatal baby frailty. STATISTICAL MODELLING, 5(2), 159-172. Author URL.

Refresh publications

Teaching

Supervision / Group

Back | Edit Profile