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Dr Isabel Castanho

Dr Isabel Castanho

Postdoctoral Researcher

 +44 (0) 1392 40 6772

 RILD Building Level 4

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Isabel is a Postdoctoral Researcher in the Complex Disease Epigenetics Group where she is investigating the relevance of (epi)genomic changes in neurogenerative conditions such as Alzheimer's disease. She did her PhD under the supervision of Prof Jonathan Mill and Prof Katie Lunnon, which focused on evaluating functional genomics of rodent models relevant for Alzheimer’s Disease. As a postdoctoral researcher she is continuing the work from her PhD.

Qualifications

BSc, MSc, PhD

Career

Isabel Castanho originally graduated in Biomedical Laboratory Sciences at the Polytechnic Institute of Porto, spending part of her final year at the Metropolia University of Applied Sciences in Helsinki.

Isabel took a second degree in Applied Biology at the University of Minho. She also completed a Master’s degree in Health Sciences at the same university, having developed her thesis in the Neuroscience Research Domain of the Life and Health Sciences Research Institute under supervision of Dr Tiago Gil Oliveira. During her Master's degree she investigated the role of lipid signalling pathways in hippocampus functioning.

In 2016 Isabel enrolled in the University of Exeter as a PhD student of the Exeter Doctoral Training Centre (DTC) from the Alzheimer's Society, led by Prof Andrew Randall. As a PhD student, and now as a Postdoc, Isabel has been investigating the relevance of (epi)genomic changes in neurogenerative conditions such as Alzheimer's disease, with a particular interest in changes ocurring with progression of disease.

For more information check her Linkedin profile here.

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Marinha LS, Castanho I, Silva RR, Bravo FV, Miranda AM, Xu Y, Point du Jour K, Wenk M, Chan RB, Di Paolo G, et al (In Press). Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.

Publications by year


In Press

Marinha LS, Castanho I, Silva RR, Bravo FV, Miranda AM, Xu Y, Point du Jour K, Wenk M, Chan RB, Di Paolo G, et al (In Press). Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.

2020

Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.

2019

Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.

Isabel_Castanho Details from cache as at 2020-10-19 19:26:43

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Teaching

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