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Dr Hannah Welters

Dr Hannah Welters

Lecturer

6361

01392 726361

Medical School Building G01

I am lecturer (Education and Scholarship) and teach in a wide range of aspects of the Medical Science and Medicine courses.

My background is in islet biology research. My main interest is the cellular and molecular aspects of beta-cell biology, with a focus on the regulation of beta-cell growth, survival and insulin secretion. My previous research career focused on the beta-cell dysfunction that occurs with diabetes and obesity.

I’ve trained as a mentor through the UEMS Mentoring Scheme, and would be available to provide PhD, peer and other mentoring opportunities. 

Qualifications

  • 2003 - PhD in Endocrine pharmacology (Exeter University)
  • 2000 - BSc in Cellular and Molecular Biology (Bristol University)

Research

Research interests

Dr Welters’ current research continues to be focussed on the pancreatic β-cell, looking specifically at how the β-cell is influenced by obesity and diabetes. The rise in diabetes incidence has been causally linked to increasing levels of obesity. However most (~80%) obese individuals do not have type 2 diabetes due to an expansion of the β-cell mass and a corresponding increase in insulin secretion levels. Type 2 diabetes only occurs when the β-cells fail to compensate for the increased insulin resistance. The β-cell function has been shown to start declining before diabetes onset with a correlating decrease in β-cell mass that continues to decline with diabetes duration. Obese patients with diabetes have a reduced β-cell mass compared to obese people without diabetes and this has been suggested to be due to increases in levels of β-cell apoptosis. The cause of the expansion of the β-cell mass with obesity and then the subsequent decline with diabetes on-set are as yet unclear.

Her current research sets out to investigate this problem. One of the signalling pathways they are investigating is the Wnt signalling pathway. Recently the Wnt signalling pathway has been identified as being important for stimulating β-cell growth and involved in regulating insulin secretion. Variants in an important component of this pathway, the transcription factor TCF7L2, have been strongly linked to the onset of type 2 diabetes, due to defects in β-cell function. Adipocytes secrete Wnts, which have been shown to inhibit adipocyte differentiation but could also potentially influence β-cells. In addition they are investigating the effect another adipose secreted molecule, SPARC, looking at its effect on β-cell function and potential cross talk with the Wnt signalling pathway.

They also are investigating mechanisms to promote β-cell growth with a view to identifying targets for the treatment of diabetes. One of their current projects is investigating the potential for neurotrophic factors such as the glial-cell-line derived neurotrophic factor (GDNF) family to stimulate growth in beta-cells.

Key publications | Publications by category | Publications by year

Key publications


Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN (2012). Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Endocrinology, 153(10), 4593-4599. Abstract.  Author URL.
Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Dhayal S, Welters HJ, Morgan NG (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11.  Abstract.  Author URL.
Welters HJ, oknianska A, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase, PTP-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. Journal of Endocrinolgy(197), 543-552.

Publications by category


Journal articles

Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.
Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.
Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN (2012). Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Endocrinology, 153(10), 4593-4599. Abstract.  Author URL.
Kawamori D, Welters HJ, Kulkarni RN (2010). Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol, 654, 421-445. Abstract.  Author URL.
Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Dhayal S, Welters HJ, Morgan N (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. British Journal of Pharmacoloy, 153, 1718-1727.
Welters HJ, oknianska A, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase, PTP-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. Journal of Endocrinolgy(197), 543-552.
Welters HJ, Kulkarni RN (2008). Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab, 19(10), 349-355. Abstract.  Author URL.
Newsholme P, Keane D, Welters HJ, Morgan NG (2007). Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond), 112(1), 27-42. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.
Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM (2006). A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes, 55(11), 3075-3082. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
NMorgan, Diakogiannaki E, Mordue J, Welters H (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic b-cells exposed to pamitate. APOPTOSIS, 11(7), 1231-1238.
Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA, Morgan NG (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate. Apoptosis, 11(7), 1231-1238. Abstract.  Author URL.
Welters HJ, Smith SA, Tadayyon M, Scarpello JHB, Morgan NG (2004). Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. J Mol Endocrinol, 32(1), 227-235. Abstract.  Author URL.
Welters HJ, McBain SC, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol, 142(7), 1162-1170. Abstract.  Author URL.
Welters HJ, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett, 560(1-3), 103-108. Abstract.  Author URL.
Tadayyon M, Welters HJ, Haynes AC, Cluderay JE, Hervieu G (2000). Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines. Biochem Biophys Res Commun, 275(2), 709-712. Abstract.  Author URL.

Conferences

Oknianska AR, Welters HJ, Morgan NG (2009). The protein tyrosine phosphatase, PTP-BL, interacts with the Wnt signalling pathway to regulate cell proliferation in INS-1 cells.  Author URL.
Dhayal S, Welters HJ, Morgan NG (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11.  Abstract.  Author URL.
Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008). The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.  Abstract.  Author URL.
Oknianska AR, Welters HJ, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase, PTP-BL, regulates pancreatic beta cell proliferation by interacting with components of the Writ signalling pathway.  Author URL.
Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.  Abstract.  Author URL.
Dhayal S, Diakogiannaki E, Welters HJ, Morgan NG (2007). Structural requirements for the cytoprotective effects of monounsaturated fatty acids in pancreatic beta cells.  Author URL.
Diakogiannaki E, Welters HJ, Morgan NG (2007). The mono-unsaturated fatty acid, palmitoleate, attenuates the expression of the ER stress-associated proteins, ATF4 and CHOP-10, in pancreatic beta cells exposed to palmitate or tunicamycin.  Author URL.
Welters HJ, Senkel S, Erdmann S, Thomas H, Morgan NG (2004). Functional effects of regulated expression of wild type and mutant hepatocyte nuclear factor-l beta (HNF1-beta) in pancreatic beta-cells.  Author URL.

Publications by year


2016

Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.

2013

Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract.  Author URL.  Full text.

2012

Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN (2012). Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Endocrinology, 153(10), 4593-4599. Abstract.  Author URL.

2010

Kawamori D, Welters HJ, Kulkarni RN (2010). Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol, 654, 421-445. Abstract.  Author URL.

2009

Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Oknianska AR, Welters HJ, Morgan NG (2009). The protein tyrosine phosphatase, PTP-BL, interacts with the Wnt signalling pathway to regulate cell proliferation in INS-1 cells.  Author URL.

2008

Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Dhayal S, Welters HJ, Morgan N (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. British Journal of Pharmacoloy, 153, 1718-1727.
Dhayal S, Welters HJ, Morgan NG (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11.  Abstract.  Author URL.
Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008). The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.  Abstract.  Author URL.
Welters HJ, oknianska A, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase, PTP-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. Journal of Endocrinolgy(197), 543-552.
Oknianska AR, Welters HJ, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase, PTP-BL, regulates pancreatic beta cell proliferation by interacting with components of the Writ signalling pathway.  Author URL.
Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG (2008). The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.  Abstract.  Author URL.
Welters HJ, Kulkarni RN (2008). Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab, 19(10), 349-355. Abstract.  Author URL.

2007

Newsholme P, Keane D, Welters HJ, Morgan NG (2007). Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond), 112(1), 27-42. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.
Dhayal S, Diakogiannaki E, Welters HJ, Morgan NG (2007). Structural requirements for the cytoprotective effects of monounsaturated fatty acids in pancreatic beta cells.  Author URL.
Diakogiannaki E, Welters HJ, Morgan NG (2007). The mono-unsaturated fatty acid, palmitoleate, attenuates the expression of the ER stress-associated proteins, ATF4 and CHOP-10, in pancreatic beta cells exposed to palmitate or tunicamycin.  Author URL.

2006

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM (2006). A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes, 55(11), 3075-3082. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
NMorgan, Diakogiannaki E, Mordue J, Welters H (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic b-cells exposed to pamitate. APOPTOSIS, 11(7), 1231-1238.
Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA, Morgan NG (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate. Apoptosis, 11(7), 1231-1238. Abstract.  Author URL.

2004

Welters HJ, Smith SA, Tadayyon M, Scarpello JHB, Morgan NG (2004). Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. J Mol Endocrinol, 32(1), 227-235. Abstract.  Author URL.
Welters HJ, McBain SC, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol, 142(7), 1162-1170. Abstract.  Author URL.
Welters HJ, Senkel S, Erdmann S, Thomas H, Morgan NG (2004). Functional effects of regulated expression of wild type and mutant hepatocyte nuclear factor-l beta (HNF1-beta) in pancreatic beta-cells.  Author URL.
Welters HJ, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett, 560(1-3), 103-108. Abstract.  Author URL.

2000

Tadayyon M, Welters HJ, Haynes AC, Cluderay JE, Hervieu G (2000). Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines. Biochem Biophys Res Commun, 275(2), 709-712. Abstract.  Author URL.

Co-module lead for Integrating Clinical Science 4 (ICS4) – final year Medical Science module.

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