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Dr, PhD Francesco Tamagnini

Junior Research Fellow

2757

+44 (0) 1392 722757

Hatherly 

My work within Prof Randall's group is aimed to characterise the functional electrophysiological profile of neuronal cells from different models of Alzheimer's disease. In the last years, we have been focusing on characterising the intrinsic excitability properties of hippocampal pyramidal and gabaergic neurons in Aß-overexpressing and altered tau-protein cleavage transgenic mouse models. My experiments mainly consist in performing whole-cell patch clamp recordings on acute brain slices obtained by such models and their age-matched wild-type controls.

Recently we have started a new project, aimed to characterize the maturation functional profile of 3D-cultured human iPS-derived neuronal stem cells. We check intrinsic excitability and synaptic transmission at different time-points of maturation. 

Research in neuroscience is what I do. It is my journey.

During my spare time I like to exercise and read. My favourite readings are novels, poetry and phylosophical studies, with particular focus on 19th century German authors (particularly the triad Kant-Schopenhauer-Nietzsche) and I like to speculate about their relevance to recent neuroscientific studies.

Qualifications

1) University of Bologna

PhD in Neurophysiology, Neuronal correlates of memory and learning, PhD

2008 – 2011

2) Università di Bologna

Pharmaceutical Biotechnologies (MSc equivalent, 110/110 cum laude) Pharmaceutical biotechnologies, MSc

2000 – 2006

Career

1) Post-doctoral research assistant

University of Exeter, Prof A. Randall lab

April 2012 – Present (2 years 9 months) Exeter, United Kingdom

2) Science presenter

Explorer Dome

February 2012 – August 2012 (7 months) Bristol, United Kingdom

3) Post-doctoral research assistant

Funded from August 2011 by Wellcome Trust 'Value in People' Award (VIP): The University of Bristol Biomedical Science Academic Support Scheme

University of Bristol, Prof Zafar Bashir lab 

May 2011 - December 2011 Bristol, United Kingdom

4) Drug developer R&D in nutraceutical, pharmaceutical and cosmetics industry

Difass S.p.A.

November 2006 – December 2007 (1 year 2 months), Borgo Maggiore, Republic of San Marino

Research

Research interests

My reasearch goals have been and currently are  aimed to clarify, describe and characterize the neuronal correlates of complex cognitive functions, such as memory and learning. I try to understand, at a cellular level, and how mind works and, if a disease (such as Alzheimer's disease) is going on, how this beautiful machinery starts malfunctioning.

My research is focused on the characterization of neuronal activity alterations on animal models of Alzheimer's disease, bearing genetic mutations which resemble some of the pathological hallmarks of the pathology. Particularly, I am currently caractherizing intrinsic excitability alterations in the interneuronal network in the CA1 subfield of the hippocampal formation in two different models of Abeta overexpressing transgenic mice.

In addition, I am currently involved in different collaboration projects, aimed to characterize the functional intrinsic and synaptic properties of stem cell-derived neuronal progenitors grown on synthetic 3D and 2D extracellular matrices

Research projects

 1) Intrinsic properties of hippocampal neurons in murine models of AD-related amyloidopathy

2) Intrinsic properties of stem cells growing on responsive biocompatible biogels

 

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, et al (2015). Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomater Sci Eng, 1(6), 431-439. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous Amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Nistor PA, May PW, Tamagnini F, Randall AD, Caldwell MA (2015). Long-term culture of pluripotent stem-cell-derived human neurons on diamond--A substrate for neurodegeneration research and therapy. Biomaterials, 61, 139-149. Abstract.  Author URL.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Burattini C, Battistini G, Tamagnini F, Aicardi G (2014). Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid. J Neurophysiol, 111(5), 1046-1055. Abstract.  Author URL.
Balietti M, Giorgetti B, Casoli T, Solazzi M, Tamagnini F, Burattini C, Aicardi G, Fattoretti P (2013). Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease. J Alzheimers Dis, 34(4), 887-896. Abstract.  Author URL.
Tamagnini F, Barker G, Warburton EC, Burattini C, Aicardi G, Bashir ZI (2013). Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory. J Physiol, 591(16), 3963-3979. Abstract.  Author URL.
Tamagnini F, Burattini C, Casoli T, Balietti M, Fattoretti P, Aicardi G (2012). Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease. Rejuvenation Res, 15(2), 231-234. Abstract.  Author URL.
Balietti M, Tamagnini F, Fattoretti P, Burattini C, Casoli T, Platano D, Lattanzio F, Aicardi G (2012). Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease. Rejuvenation Res, 15(2), 235-238. Abstract.  Author URL.
Scott HL, Tamagnini F, Narduzzo KE, Howarth JL, Lee Y-B, Wong L-F, Brown MW, Warburton EC, Bashir ZI, Uney JB, et al (2012). MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex. Eur J Neurosci, 36(7), 2941-2948. Abstract.  Author URL.

Publications by year


2015

Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, et al (2015). Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomater Sci Eng, 1(6), 431-439. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous Amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Nistor PA, May PW, Tamagnini F, Randall AD, Caldwell MA (2015). Long-term culture of pluripotent stem-cell-derived human neurons on diamond--A substrate for neurodegeneration research and therapy. Biomaterials, 61, 139-149. Abstract.  Author URL.

2014

Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Burattini C, Battistini G, Tamagnini F, Aicardi G (2014). Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid. J Neurophysiol, 111(5), 1046-1055. Abstract.  Author URL.

2013

Balietti M, Giorgetti B, Casoli T, Solazzi M, Tamagnini F, Burattini C, Aicardi G, Fattoretti P (2013). Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease. J Alzheimers Dis, 34(4), 887-896. Abstract.  Author URL.
Tamagnini F, Barker G, Warburton EC, Burattini C, Aicardi G, Bashir ZI (2013). Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory. J Physiol, 591(16), 3963-3979. Abstract.  Author URL.

2012

Tamagnini F, Burattini C, Casoli T, Balietti M, Fattoretti P, Aicardi G (2012). Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease. Rejuvenation Res, 15(2), 231-234. Abstract.  Author URL.
Balietti M, Tamagnini F, Fattoretti P, Burattini C, Casoli T, Platano D, Lattanzio F, Aicardi G (2012). Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease. Rejuvenation Res, 15(2), 235-238. Abstract.  Author URL.
Scott HL, Tamagnini F, Narduzzo KE, Howarth JL, Lee Y-B, Wong L-F, Brown MW, Warburton EC, Bashir ZI, Uney JB, et al (2012). MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex. Eur J Neurosci, 36(7), 2941-2948. Abstract.  Author URL.

Sep 2014 - now

Structured small group learning facilitator for 1st year Integrated clinical sciences (ICS1) students 

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