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Dr Eilis Hannon

Research Fellow

8162

RILD Building 

Eilis graduated with a degree in Mathematics in 2010 and went on to complete a PhD in the department of Neuropsychiatric Genetics and Genomics at Cardiff University. As a student of both the Medical School and the School of Computer Science, she developed a knowledge of genetics, with a particular focus on psychiatric disorders, and bioinformatics skills when investigating spatial and temporal expression patterns of genes associated with schizophrenia. After completion, she joined the Complex Disease Epigenetics group in Exeter at the end of 2013 as a Bioinformatician. Her research focuses on integrating epigenetic, transcriptomic and genetic data to aid the understanding of the molecular aetiology of psychiatric illnesses.

Qualifications

BSc Mathematics Cardiff University

PhD Bioinformatics Cardiff Univeristy

Career

Research Fellow (from Dec 2014); Research Associate Fellow,

Complex Disease Epigenetics Group, University of Exeter

Nov 2013-present

 

 

Bioinformatics post with primary focus on integrating epigenetic data with genomic and transcriptomic data and establishing analysis pipelines for the research group. Responsibilities include designing, implementing and supporting bioinformatic and statistical analyses of multidimensional datasets across a broad range of projects and phenotypes including identifying methylation QTLs, and epigenome-wide association studies; presenting and reporting findings.

Summer Student, Biomedical Systems Analysis Research Group, MRC, Human Genetics Unit, Edinburgh

June 2009- Sept 2009

 

10 week research project entitled ‘Visualization of Genome Wide Association Studies Data in Networks’. Used R and Biolayout software programs to investigate presenting correlations between traits in GWAS data as networks. Produced a written report and performed an oral presentation of conclusions.

Research

Research grants

  • 2016 Software Sustainability Institute
    Software Sustainability Institute Fellowship
  • 2016 Alzheimers Society
    PhD Studentship
  • 2015 Alzheimers Society
    The contribution of epigenetic phenomena to Alzheimer's disease: an integrated genetic-epigenetic analysis.

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract.  Author URL.
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.
Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantoj√§rvi K, Karagiannidis I, et al (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 96-121.

Publications by year


2017

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract.  Author URL.
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.

2016

Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract.  Author URL.  Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.

2014

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.

2013

Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantoj√§rvi K, Karagiannidis I, et al (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 96-121.

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