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Dr David Strain

Dr David Strain

Senior Clinical Lecturer (E&R) (HEFCE-NHS CSLA)

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Dr Strain graduated from Liverpool University and initially embarked on a career in cardiology. In 2000, he moved to London and started work in the International Centre for Cardiovascular Health, where he completed an MD on “The ethnic difference in the effects of insulin resistance on the vasculature”, during which he described a marker of microcirculatory autoregulatory dysfunction. This measure, now known as “the Strain index”, statistically accounts for the associations between left ventricular hypertrophy, urinary albumin excretion and, in Europeans at least, coronary atherosclerotic load.

After completion of his clinical training, he moved to the University of Exeter Medical School (formally Peninsula Medical School), where he has attained a National Institute of Healthcare Research Clinical Senior Lecturer Award Fellowship to continue his research. He currently works in a research team exploring the aetiopathogenic mechanisms of a diverse range of vascular disease, from stroke to diabetic cardiomyopathy. He was the UK Chief investigator for the Diabetes in the Elderly trial that explored the feasibility of setting individualized treatment targets for older people with diabetes. This reported recently in the Lancet and is the basis for one of his current projects which plans to look at the longer term benefit from individualizing treatment for older patients.

He is also chairing the steering committee that includes Sir Michael Hirst, current president of the International Diabetes Federation, working on the “Time 2 Do More” project. This aims to address the phenomenon of “clinical inertia” by encouraging patients and physicians to communicate more effectively and respond appropriately to changes in patient circumstances.

Research

Key publications | Publications by category | Publications by year

Key publications


Strain WD, Chaturvedi N, Hughes A, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens, 28(5), 952-958. Abstract.  Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2010). Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent. BMC Cardiovasc Disord, 10 Abstract.  Author URL.  Full text.
Mahal S, Strain WD, Martinez-Perez ME, Thom SAM, Chaturvedi N, Hughes AD (2009). Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes. Clin Sci (Lond), 117(6), 229-236. Abstract.  Author URL.
Gates PE, Strain WD, Shore AC (2009). Human endothelial function and microvascular ageing. Exp Physiol, 94(3), 311-316. Abstract.  Author URL.

Publications by category


Journal articles

correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (In Press). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier) Full text.
Strain WD, Cos X, Prünte C (2017). Considerations for management of patients with diabetic macular edema: Optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration. Diabetes Res Clin Pract, 126, 1-9. Abstract.  Author URL.  Full text.
strain WD, Abhijit A, Paldanius PM (2017). Individualizing treatment targets for elderly patients with type 2 diabetes: factors influencing clinical decision making in the 24-week, randomized INTERVAL study. Aging Full text.
Strain WD, Smith C (2016). Cardiovascular Outcome Studies in Diabetes: How Do We Make Sense of These New Data?. Diabetes Ther, 7(2), 175-185. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Low c-peptide is associated with high glycaemic variability and hypoglycaemia in insulin-treated patients with Type 2 diabetes. DIABETIC MEDICINE, 33, 18-18. Author URL.
Elyas S, Shore AC, Kingwell H, Keenan S, Boxall L, Stewart J, James MA, Strain WD (2016). Microalbuminuria could improve risk stratification in patients with TIA and minor stroke. Ann Clin Transl Neurol, 3(9), 678-683. Abstract.  Author URL.  Full text.
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A, et al (2016). Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. Journal of the American Geriatrics Society Abstract.
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, et al (2016). Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. New England Journal of Medicine, 374(14), 1321-1331.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.  Full text.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The Effects of Lumbar Sympathectomy on Bone and Soft Tissue Haemodynamics of the Leg recorded using Near Infrared Spectroscopy: a Case Report. Journal of Biomedical Engineering and Informatics, 3, 28-32.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). [PP.11.05] RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Journal of Hypertension, 34, e178-e178.
Jones LC, Strain WD, Sword J, Ostrowski C (2015). 53. THE CORRELATION BETWEEN PATIENTS, PATIENT'S RELATIVES AND HEALTHCARE PROFESSIONALS INTERPRETATION OF QUALITY OF LIFE - a PROSPECTIVE STUDY. Age and Ageing, 44(suppl 1), i16-i16.
Meertens RM, Strain WD, Knapp KM (2015). A Review of the Mechanisms, Diagnosis and Preventative Treatment of Osteoporotic Fragility Fractures in Patients with Type 2 Diabetes Mellitus. Journal of Endocrinology and Metabolism, Volume 5(Number 1-2), 157-162. Abstract.  Full text.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Elyas S, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral hemodynamics in patients with large vessel disease stroke and lacunar stroke. INTERNATIONAL JOURNAL OF STROKE, 10, 368-368. Author URL.
(2015). Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The Lancet, 385(9968), 617-628.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson D, Shore AC, Strain WD, Gates PE (2015). PP.20.26. Journal of Hypertension, 33, e314-e314.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu D, Gooding K, Strain D, Shore A, Gates P (2015). Type 2 diabetes exacerbates carotid artery echogenicity and central artery stiffness in middle-aged and older individuals. Artery Research, 12, 11-12.
Strain WD, Blüher M, Paldánius P (2014). Clinical inertia in individualising care for diabetes: is there time to do more in type 2 diabetes?. Diabetes Ther, 5(2), 347-354. Abstract.  Author URL.
McCluskey L, Jagger O, Strain WD (2014). Hypoglycemia associated with impaired mobility and diminished confidence in an elderly person with type 2 diabetes. Diabetic Hypoglycemia, 7(1), 11-14. Abstract.
Clark C, Casanova F, Gooding K, Pamphilon N, Aizawa K, Mawson D, Adingupu D, Ball C, Worthington F, Elyas S, et al (2014). Inter-arm blood pressure difference and differences in arterial stiffness. JOURNAL OF HUMAN HYPERTENSION, 28(10), 626-627. Author URL.
Jones LC, Sword J, Strain WD, Ostrowski C (2014). P083: the correlation between patients, patient's relatives and healthcare professionals interpretation of quality of life – a prospective study. European Geriatric Medicine, 5, S108-S108.
Aizawa K, Elyas S, Adingpu D, Shore A, Strain D, Gates P (2014). Reactivity to low-flow in the brachial artery: a potential determinant for flow-mediated dilatory response. Artery Research, 8(4), 138-138.
Strain WD, Cos X, Hirst M, Vencio S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM (2014). Time to do more: addressing clinical inertia in the management of type 2 diabetes mellitus. Diabetes Res Clin Pract, 105(3), 302-312. Abstract.  Author URL.
Gooding KM, Shore AC, Mawson D, Ball CI, Pitt A, Aizawa K, Strain WD (2013). A pilot study investigating whether dipeptidyl peptidase-IV inhibition alters vascular function in obese men. DIABETIC MEDICINE, 30, E8-E9. Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2013). Attenuated systemic microvascular function in men with coronary artery disease is associated with angina but not explained by atherosclerosis. Microcirculation, 20(7), 670-677. Abstract.  Author URL.
Gosling O, Morgan-Hughes G, Iyengar S, Strain W, Loader R, Shore A, Roobottom C (2013). Computed tomography to diagnose coronary artery disease: a reduction in radiation dose increases applicability. Clin Radiol, 68(4), 340-345. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2013). Echogenicity of the common carotid artery intima-media complex in stroke. Artery Research, 7(3-4), 123-123.
Hope SV, Strain WD (2013). Hypoglycemia in the elderly. Diabetic Hypoglycemia, 6(1), 3-10. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger MJ, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. The Lancet, 382(9890), 409-416. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. Lancet, 382(9890), 409-416. Abstract.  Author URL.
Strain WD, Elyas S, Gooding K, Eastwood H, Keenan S, Stewart J, James MA, Shore AC (2013). Microalbuminuria could improve risk prediction of stroke in patients with TIA and minor stroke: the Prognostic Markers of TIA Evolution (ProMOTE) pilot study. CEREBROVASCULAR DISEASES, 35, 103-103. Author URL.
Adingupu DD, Elyas S, Casanova F, Gates PE, Shore AC, Strain WD (2013). Microvascular autoregulatory response to ischaemia and pulse pressure. JOURNAL OF HUMAN HYPERTENSION, 27(10), 652-653. Author URL.
Adingupu DD, Thorn C, Casanova F, Elyas S, Gates PE, Strain WD, Shore AC (2013). Microvascular autoregulatory response to ischaemia in the skin and association with mean blood oxygen saturation. JOURNAL OF HUMAN HYPERTENSION, 27(10), 640-641. Author URL.
Elyas S, Adingupu D, Thorn C, Gates PE, Shore AC, Strain WD (2013). Skin microvascular function is impaired in patients with small vessel disease stroke but not in patients with large vessel disease stroke when compared to healthy controls. CEREBROVASCULAR DISEASES, 35, 521-521. Author URL.
Adingupu DD, Elyas S, Thorn CE, Gates PE, Shore AC, Strain WD (2013). The prevalence of abnormal microvascular response (peaks) in stroke or transient ischaemic attack (TIA) patients compared with Controls and association with impaired sympathetic activity. CEREBROVASCULAR DISEASES, 35, 547-547. Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). Brachial Artery Low Flow-Mediated Constriction in Individuals with Increased Cardiovascular Risk. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, 585-585. Author URL.
Foster J, Baillie PA, Strain WD (2012). Hypoglycemia precipitating prolonged QT interval and myocardial ischemia in a patient with coronary heart disease and renal failure. Diabetic Hypoglycemia, 4(3), 9-11. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). Influence of estimated wall shear rate indices on carotid artery intima-media thickness and intima-media complex echogenicity. Artery Research, 6(4), 188-188.
Strain WD, Adingupu DD, Shore AC (2012). Microcirculation on a large scale: techniques, tactics and relevance of studying the microcirculation in larger population samples. Microcirculation, 19(1), 37-46. Abstract.  Author URL.
Elyas S, Majekolagbe D, D'Abate F, Aizawa K, Gates PE, Shore AC, Strain WD (2012). PREVALENCE OF SKIN MICROVASCULAR AUTOREGULATORY DYSFUNCTION IN PATIENTS WHO SUFFER STROKE OR TIA COMPARED TO THE GENERAL POPULATION. AGE AND AGEING, 41, 81-81. Author URL.
Thompson D, Thornes J, Woods J, Khan A, Kreppel S, Palmer D, Phillips S, Shamsuddin N, Solman J, Strain WD, et al (2012). SODIUM DYSREGULATION AND ITS ASSOCIATION WITH MORTALITY. AGE AND AGEING, 41, 37-37. Author URL.
Shamsuddin N, Solman J, Khan A, Kreppel S, Palmer D, Phillips S, Thompson D, Thornes J, Woods J, Strain WD, et al (2012). THE RELATIONSHIP BETWEEN HYPONATRAEMIA AND LENGTH OF STAY IN ELDERLY CARE PATIENTS. AGE AND AGEING, 41, 42-42. Author URL.
Aizawa K, Gates PE, Strain WD, Gosling OE, Mazzaro L, Zhang F, Barker AJ, Fulford J, Shore AC, Bellenger NG, et al (2011). Arterial Wall Shear Stress Measurement in Vivo Using Echo Particle Image Velocimetry (Echo PIV). MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5), 743-744. Author URL.
Zhang F, Lanning C, Mazzaro L, Barker AJ, Gates PE, Strain WD, Fulford J, Gosling OE, Shore AC, Bellenger NG, et al (2011). In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging. Ultrasound Med Biol, 37(3), 450-464. Abstract.  Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. JOURNAL OF HUMAN HYPERTENSION, 25(10), 651-651. Author URL.
Aizawa K, Elyas S, D'Abate F, Majekolagbe D, Shore AC, Strain WD, Gates PE (2011). The relationship between brachial artery flow-mediated dilation and shear rate in individuals with increased cardiovascular risk. Artery Research, 5(4), 184-184.
Strain WD, Elyas S, Gates PE, Shore AC (2010). Age-related change in endothelial and microvessel function and therapeutic consequences. Reviews in Clinical Gerontology, 20(3), 161-170. Abstract.
Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Strain WD, Chaturvedi N, Hughes A, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens, 28(5), 952-958. Abstract.  Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2010). Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent. BMC Cardiovasc Disord, 10 Abstract.  Author URL.  Full text.
Mahal S, Strain WD, Martinez-Perez ME, Thom SAM, Chaturvedi N, Hughes AD (2009). Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes. Clin Sci (Lond), 117(6), 229-236. Abstract.  Author URL.
Gates PE, Strain WD, Shore AC (2009). Human endothelial function and microvascular ageing. Exp Physiol, 94(3), 311-316. Abstract.  Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). Noninvasive wall shear stress measurements in human carotid artery using echo particle image velocimetry: Initial clinical studies. Proceedings - IEEE Ultrasonics Symposium Abstract.
Todd DM, Strain WD (2007). Ethnic differences in infants and maternal outcomes in gestational diabetes. DIABETIC MEDICINE, 24, 19-19. Author URL.
Strain WD, Chaturvedi N, Dockery F, Shiff R, Shore AC, Bulpitt CJ, Rajkumar C (2006). Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factors. Am J Hypertens, 19(9), 889-896. Abstract.  Author URL.
AShore, Bulpitt C, Chaturvedi N, Strain W (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction. Diabetes, 54(6), 1816-1822.
Strain WD, Chaturvedi N, Bulpitt CJ, Rajkumar C, Shore AC (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction?. Diabetes, 54(6), 1816-1822. Abstract.  Author URL.
Strain WD, Chaturvedi N, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2005). Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans. Diabetologia, 48(11), 2269-2277. Abstract.  Author URL.
Strain WD, Chaturvedi N, Shore A, Cruickshank JK, Heagerty AM (2005). Ethnic differences in microvascular structure and function [3] (multiple letters). Journal of Hypertension, 23(7), 1434-1436.
Strain WD, Chaturvedi N, Shore A (2005). Ethnic differences in microvascular structure and function. J Hypertens, 23(7), 1434-1435. Author URL.
Strain WD, Chaturvedi N, Leggetter S, Nihoyannopoulos P, Rajkumar C, Bulpitt CJ, Shore AC (2005). Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage. J Hypertens, 23(1), 133-140. Abstract.  Author URL.
Strain D, Bulpitt C, Chaturvedi N, Leggetter S (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage. Journal of Hypertension, 22(9), 1731-1737.
Strain WD (2004). The use of recombinant human B-type natriuretic peptide (nesiritide) in the management of acute decompensated heart failure. Int J Clin Pract, 58(11), 1081-1087. Abstract.  Author URL.
Strain WD, Lye M (2002). Chronic pain, bereavement and overdose in a depressed elderly woman. Age Ageing, 31(3), 218-219. Author URL.
Strain WD, Chaturvedi N (2002). The renin-angiotensin-aldosterone system and the eye in diabetes. J Renin Angiotensin Aldosterone Syst, 3(4), 243-246. Abstract.  Author URL.
Gill G, Swift AC, Jones A, Strain D, Weston PJ (2001). Severe adrenal suppression by steroid nasal drops. J R Soc Med, 94, 350-351.

Conferences

Meertens R, Knapp K, Strain D, Casanova F (2016). NEAR INFRARED SPECTROSCOPY: a POTENTIAL TOOL FOR ASSESSING HAEMODYNAMIC MARKERS OF THE MICROVASCULAR BLOOD SUPPLY WITHIN BONE TISSUE.  Author URL.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. National Osteoporosis Society 2016. 7th - 9th Nov 2016.
Elyas SP, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral haemodynamics are different in patients with and without cerebral white matter hyperintensities.  Author URL.
Strain WD, Paldanius PM (2015). Clinical inertia affects younger and older adults with type 2 diabetes mellitus equally, with or without CKD.  Author URL.
Hope SV, McDonald TJ, Hill AV, Strain WD, Hattersley AT (2015). Low c-peptide is associated in insulin-treated patients with hypoglycaemia unawareness as well as hypoglycaemia frequency.  Author URL.
Elyas S, Shore AC, James MA, Peters A, Eastwood H, Keenan S, Stewart J, Strain WD (2014). Microalbuminuria could predict critical carotid artery stenosis in patients presenting with TIA and minor strokes.  Author URL.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera AJ, Strain WD, Hattersley AT (2014). Non-specific symptoms associated with hypoglycaemia in the elderly are common in patients treated with metformin only, as well as those treated with insulin or sulphonylureas.  Author URL.
Palmer D, Strain WD, Webb B (2014). TURNING OF THE TIDE: DOES TIDEMARK ADVANCEMENT PERPETUATE OSTEOARTHRITIS.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson DM, Shore AC, Strain WD, Gates PE (2013). Carotid artery intima-media echogenicity and aortic stiffness in healthy middle-aged and older humans.  Author URL.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldanius P (2013). INdividualised Treatment targets for EldeRly patients using Vildagliptin Add-on or Lone therapy (INTERVAL) study.  Author URL.
Elyas S, Shore AC, Eastwood H, Keenan S, Stewart J, Strain WD (2013). Microalbuminuria could improve risk prediction of stroke in patients with transient ischaemic attacks and minor strokes.  Author URL.
Majekolagbe D, Strain WD, Gates PE, Elyas S, Thorn C, Shore A (2011). Post occlusive microvascular autoregulatory dysfunction is not associated with endothelium dependent or independent vasodilatation.  Author URL.
Gosling OE, Iyengar S, Loader R, Morgan-Hughes G, Strain WD, Roobottom C (2011). RADIATION DOSES TRENDS FROM CARDIAC CT USING a CARDIAC SPECIFIC CONVERSION FACTOR: SYSTEM UNDERSTANDING & AN OPTIMISATION STRATEGY SIGNIFICANTLY REDUCES THE DOSE TO THE PATIENTS IN a CLINICAL SERVICE.  Author URL.
Zhang F, Gates PE, Barker AJ, Strain WD, Gosling OE, Mazzaro L, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2010). A Novel Ultrasound-Based Vascular Profiling Technique (Echo Particle Image Velocimetry): Clinical Validation in 28 Human Subjects and Associations with Age.  Author URL.
Zhang F, Gates PE, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). A Novel Ultrasound-based Wall Shear Stress Biomarker (Echo Particle Image Velocimetry) to Generate Hemodynamic Vascular Profiles in Carotid Arteries: Clinical Studies on 16 Healthy Subjects.  Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III.  Author URL.
Gates PE, Zhang F, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). ECHO PARTICLE IMAGE VELOCIMETRY (ECHO PIV): a NOVEL ULTRASOUND-BASED METHOD FOR THE IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN HUMAN CAROTID ARTERIES.  Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). In vivo validation of echo particle image velocimetry (Echo PIV) in human carotid arteries using phase-contrast MRI.
Strain WD, Chaturvedi NC, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Hughes AD, Shore AC (2009). MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH CONCENTRIC REMODELLING AND LEFT ATRIAL SIZE INDEPENDENT OF BLOOD PRESSURE AND CARDIOVASCULAR RISK FACTORS.  Author URL.
Strain WD, Gilbert KL, Macleod KM, Fulford J, Shore AC, Stokes KA (2009). The effects of suppression of endogenous insulin on hepatic and quadriceps glycogen stores after 60 min of submaximal exercise in healthy adult males.  Author URL.
Strain WD, Harman K, Leitch S, Forsythe E (2008). Albumin : creatinine ratio at presentation predicts mortality and functional outcomes after stroke.  Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt C, Shore AC (2006). Microvascular functional abnormalities are associated left ventricular hypertrophy.  Author URL.
Chaturvedi N, Rajkumar C, Strain WD, Nihoyannopoulos P, Shore AC, Bulpitt CJ (2004). Ethnic differences in central and augmentation index; Do they account for differing susceptibility to left ventricular hypertrophy.  Author URL.
Chaturvedi N, Bulpitt CJ, Leggetter S, Schiff R, Nihoyannopoulos P, Strain WD, Shore AC, Rajkumar C (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage.  Abstract.  Author URL.
Debney MT, Hughes AD, Thom SAM, Strain WD, Chaturvedi N (2004). Explanations for the elevated stroke risk in south Asians.  Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). Pulse wave velocity is worse, but systemic arterial compliance is better in African Caribbeans compared to Europeans; the breaking of "natural confounders".  Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). The effects of diabetes on arterial stiffness in a bi-ethnic populations.  Author URL.
Strain WD, Chaturvedi NC, Rajkumar C, Nihoyannopoulos P, Bulpitt CJ, Shore AC (2003). Ethnic differences in microvasculature in diabetes: a possible explanation for the greater vulnerability of people of Black African descent to vascular target organ damage.  Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Shore AC (2003). Ethnic differences in microvasculature: a possible explanation for the greater vulnerability of people of Black African descent to hypertensive target organ damage.  Author URL.

Publications by year


In Press

correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (In Press). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier) Full text.

2017

Strain WD, Cos X, Prünte C (2017). Considerations for management of patients with diabetic macular edema: Optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration. Diabetes Res Clin Pract, 126, 1-9. Abstract.  Author URL.  Full text.
strain WD, Abhijit A, Paldanius PM (2017). Individualizing treatment targets for elderly patients with type 2 diabetes: factors influencing clinical decision making in the 24-week, randomized INTERVAL study. Aging Full text.

2016

Strain WD, Smith C (2016). Cardiovascular Outcome Studies in Diabetes: How Do We Make Sense of These New Data?. Diabetes Ther, 7(2), 175-185. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Low c-peptide is associated with high glycaemic variability and hypoglycaemia in insulin-treated patients with Type 2 diabetes. DIABETIC MEDICINE, 33, 18-18. Author URL.
Elyas S, Shore AC, Kingwell H, Keenan S, Boxall L, Stewart J, James MA, Strain WD (2016). Microalbuminuria could improve risk stratification in patients with TIA and minor stroke. Ann Clin Transl Neurol, 3(9), 678-683. Abstract.  Author URL.  Full text.
Meertens R, Knapp K, Strain D, Casanova F (2016). NEAR INFRARED SPECTROSCOPY: a POTENTIAL TOOL FOR ASSESSING HAEMODYNAMIC MARKERS OF THE MICROVASCULAR BLOOD SUPPLY WITHIN BONE TISSUE.  Author URL.
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A, et al (2016). Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. Journal of the American Geriatrics Society Abstract.
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, et al (2016). Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. New England Journal of Medicine, 374(14), 1321-1331.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.  Full text.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The Effects of Lumbar Sympathectomy on Bone and Soft Tissue Haemodynamics of the Leg recorded using Near Infrared Spectroscopy: a Case Report. Journal of Biomedical Engineering and Informatics, 3, 28-32.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. National Osteoporosis Society 2016. 7th - 9th Nov 2016.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). [PP.11.05] RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Journal of Hypertension, 34, e178-e178.

2015

Jones LC, Strain WD, Sword J, Ostrowski C (2015). 53. THE CORRELATION BETWEEN PATIENTS, PATIENT'S RELATIVES AND HEALTHCARE PROFESSIONALS INTERPRETATION OF QUALITY OF LIFE - a PROSPECTIVE STUDY. Age and Ageing, 44(suppl 1), i16-i16.
Meertens RM, Strain WD, Knapp KM (2015). A Review of the Mechanisms, Diagnosis and Preventative Treatment of Osteoporotic Fragility Fractures in Patients with Type 2 Diabetes Mellitus. Journal of Endocrinology and Metabolism, Volume 5(Number 1-2), 157-162. Abstract.  Full text.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Elyas SP, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral haemodynamics are different in patients with and without cerebral white matter hyperintensities.  Author URL.
Elyas S, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral hemodynamics in patients with large vessel disease stroke and lacunar stroke. INTERNATIONAL JOURNAL OF STROKE, 10, 368-368. Author URL.
Strain WD, Paldanius PM (2015). Clinical inertia affects younger and older adults with type 2 diabetes mellitus equally, with or without CKD.  Author URL.
(2015). Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The Lancet, 385(9968), 617-628.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Hope SV, McDonald TJ, Hill AV, Strain WD, Hattersley AT (2015). Low c-peptide is associated in insulin-treated patients with hypoglycaemia unawareness as well as hypoglycaemia frequency.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson D, Shore AC, Strain WD, Gates PE (2015). PP.20.26. Journal of Hypertension, 33, e314-e314.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu D, Gooding K, Strain D, Shore A, Gates P (2015). Type 2 diabetes exacerbates carotid artery echogenicity and central artery stiffness in middle-aged and older individuals. Artery Research, 12, 11-12.

2014

Strain WD, Blüher M, Paldánius P (2014). Clinical inertia in individualising care for diabetes: is there time to do more in type 2 diabetes?. Diabetes Ther, 5(2), 347-354. Abstract.  Author URL.
McCluskey L, Jagger O, Strain WD (2014). Hypoglycemia associated with impaired mobility and diminished confidence in an elderly person with type 2 diabetes. Diabetic Hypoglycemia, 7(1), 11-14. Abstract.
Clark C, Casanova F, Gooding K, Pamphilon N, Aizawa K, Mawson D, Adingupu D, Ball C, Worthington F, Elyas S, et al (2014). Inter-arm blood pressure difference and differences in arterial stiffness. JOURNAL OF HUMAN HYPERTENSION, 28(10), 626-627. Author URL.
Elyas S, Shore AC, James MA, Peters A, Eastwood H, Keenan S, Stewart J, Strain WD (2014). Microalbuminuria could predict critical carotid artery stenosis in patients presenting with TIA and minor strokes.  Author URL.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera AJ, Strain WD, Hattersley AT (2014). Non-specific symptoms associated with hypoglycaemia in the elderly are common in patients treated with metformin only, as well as those treated with insulin or sulphonylureas.  Author URL.
Jones LC, Sword J, Strain WD, Ostrowski C (2014). P083: the correlation between patients, patient's relatives and healthcare professionals interpretation of quality of life – a prospective study. European Geriatric Medicine, 5, S108-S108.
Aizawa K, Elyas S, Adingpu D, Shore A, Strain D, Gates P (2014). Reactivity to low-flow in the brachial artery: a potential determinant for flow-mediated dilatory response. Artery Research, 8(4), 138-138.
Palmer D, Strain WD, Webb B (2014). TURNING OF THE TIDE: DOES TIDEMARK ADVANCEMENT PERPETUATE OSTEOARTHRITIS.  Author URL.
Strain WD, Cos X, Hirst M, Vencio S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM (2014). Time to do more: addressing clinical inertia in the management of type 2 diabetes mellitus. Diabetes Res Clin Pract, 105(3), 302-312. Abstract.  Author URL.

2013

Gooding KM, Shore AC, Mawson D, Ball CI, Pitt A, Aizawa K, Strain WD (2013). A pilot study investigating whether dipeptidyl peptidase-IV inhibition alters vascular function in obese men. DIABETIC MEDICINE, 30, E8-E9. Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2013). Attenuated systemic microvascular function in men with coronary artery disease is associated with angina but not explained by atherosclerosis. Microcirculation, 20(7), 670-677. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson DM, Shore AC, Strain WD, Gates PE (2013). Carotid artery intima-media echogenicity and aortic stiffness in healthy middle-aged and older humans.  Author URL.
Gosling O, Morgan-Hughes G, Iyengar S, Strain W, Loader R, Shore A, Roobottom C (2013). Computed tomography to diagnose coronary artery disease: a reduction in radiation dose increases applicability. Clin Radiol, 68(4), 340-345. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2013). Echogenicity of the common carotid artery intima-media complex in stroke. Artery Research, 7(3-4), 123-123.
Hope SV, Strain WD (2013). Hypoglycemia in the elderly. Diabetic Hypoglycemia, 6(1), 3-10. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldanius P (2013). INdividualised Treatment targets for EldeRly patients using Vildagliptin Add-on or Lone therapy (INTERVAL) study.  Author URL.
Strain WD, Lukashevich V, Kothny W, Hoellinger MJ, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. The Lancet, 382(9890), 409-416. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. Lancet, 382(9890), 409-416. Abstract.  Author URL.
Strain WD, Elyas S, Gooding K, Eastwood H, Keenan S, Stewart J, James MA, Shore AC (2013). Microalbuminuria could improve risk prediction of stroke in patients with TIA and minor stroke: the Prognostic Markers of TIA Evolution (ProMOTE) pilot study. CEREBROVASCULAR DISEASES, 35, 103-103. Author URL.
Elyas S, Shore AC, Eastwood H, Keenan S, Stewart J, Strain WD (2013). Microalbuminuria could improve risk prediction of stroke in patients with transient ischaemic attacks and minor strokes.  Author URL.
Adingupu DD, Elyas S, Casanova F, Gates PE, Shore AC, Strain WD (2013). Microvascular autoregulatory response to ischaemia and pulse pressure. JOURNAL OF HUMAN HYPERTENSION, 27(10), 652-653. Author URL.
Adingupu DD, Thorn C, Casanova F, Elyas S, Gates PE, Strain WD, Shore AC (2013). Microvascular autoregulatory response to ischaemia in the skin and association with mean blood oxygen saturation. JOURNAL OF HUMAN HYPERTENSION, 27(10), 640-641. Author URL.
Elyas S, Adingupu D, Thorn C, Gates PE, Shore AC, Strain WD (2013). Skin microvascular function is impaired in patients with small vessel disease stroke but not in patients with large vessel disease stroke when compared to healthy controls. CEREBROVASCULAR DISEASES, 35, 521-521. Author URL.
Adingupu DD, Elyas S, Thorn CE, Gates PE, Shore AC, Strain WD (2013). The prevalence of abnormal microvascular response (peaks) in stroke or transient ischaemic attack (TIA) patients compared with Controls and association with impaired sympathetic activity. CEREBROVASCULAR DISEASES, 35, 547-547. Author URL.

2012

Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). Brachial Artery Low Flow-Mediated Constriction in Individuals with Increased Cardiovascular Risk. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, 585-585. Author URL.
Foster J, Baillie PA, Strain WD (2012). Hypoglycemia precipitating prolonged QT interval and myocardial ischemia in a patient with coronary heart disease and renal failure. Diabetic Hypoglycemia, 4(3), 9-11. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). Influence of estimated wall shear rate indices on carotid artery intima-media thickness and intima-media complex echogenicity. Artery Research, 6(4), 188-188.
Strain WD, Adingupu DD, Shore AC (2012). Microcirculation on a large scale: techniques, tactics and relevance of studying the microcirculation in larger population samples. Microcirculation, 19(1), 37-46. Abstract.  Author URL.
Elyas S, Majekolagbe D, D'Abate F, Aizawa K, Gates PE, Shore AC, Strain WD (2012). PREVALENCE OF SKIN MICROVASCULAR AUTOREGULATORY DYSFUNCTION IN PATIENTS WHO SUFFER STROKE OR TIA COMPARED TO THE GENERAL POPULATION. AGE AND AGEING, 41, 81-81. Author URL.
Thompson D, Thornes J, Woods J, Khan A, Kreppel S, Palmer D, Phillips S, Shamsuddin N, Solman J, Strain WD, et al (2012). SODIUM DYSREGULATION AND ITS ASSOCIATION WITH MORTALITY. AGE AND AGEING, 41, 37-37. Author URL.
Shamsuddin N, Solman J, Khan A, Kreppel S, Palmer D, Phillips S, Thompson D, Thornes J, Woods J, Strain WD, et al (2012). THE RELATIONSHIP BETWEEN HYPONATRAEMIA AND LENGTH OF STAY IN ELDERLY CARE PATIENTS. AGE AND AGEING, 41, 42-42. Author URL.

2011

Aizawa K, Gates PE, Strain WD, Gosling OE, Mazzaro L, Zhang F, Barker AJ, Fulford J, Shore AC, Bellenger NG, et al (2011). Arterial Wall Shear Stress Measurement in Vivo Using Echo Particle Image Velocimetry (Echo PIV). MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5), 743-744. Author URL.
Zhang F, Lanning C, Mazzaro L, Barker AJ, Gates PE, Strain WD, Fulford J, Gosling OE, Shore AC, Bellenger NG, et al (2011). In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging. Ultrasound Med Biol, 37(3), 450-464. Abstract.  Author URL.
Majekolagbe D, Strain WD, Gates PE, Elyas S, Thorn C, Shore A (2011). Post occlusive microvascular autoregulatory dysfunction is not associated with endothelium dependent or independent vasodilatation.  Author URL.
Gosling OE, Iyengar S, Loader R, Morgan-Hughes G, Strain WD, Roobottom C (2011). RADIATION DOSES TRENDS FROM CARDIAC CT USING a CARDIAC SPECIFIC CONVERSION FACTOR: SYSTEM UNDERSTANDING & AN OPTIMISATION STRATEGY SIGNIFICANTLY REDUCES THE DOSE TO THE PATIENTS IN a CLINICAL SERVICE.  Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. JOURNAL OF HUMAN HYPERTENSION, 25(10), 651-651. Author URL.
Aizawa K, Elyas S, D'Abate F, Majekolagbe D, Shore AC, Strain WD, Gates PE (2011). The relationship between brachial artery flow-mediated dilation and shear rate in individuals with increased cardiovascular risk. Artery Research, 5(4), 184-184.

2010

Zhang F, Gates PE, Barker AJ, Strain WD, Gosling OE, Mazzaro L, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2010). A Novel Ultrasound-Based Vascular Profiling Technique (Echo Particle Image Velocimetry): Clinical Validation in 28 Human Subjects and Associations with Age.  Author URL.
Strain WD, Elyas S, Gates PE, Shore AC (2010). Age-related change in endothelial and microvessel function and therapeutic consequences. Reviews in Clinical Gerontology, 20(3), 161-170. Abstract.
Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Strain WD, Chaturvedi N, Hughes A, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens, 28(5), 952-958. Abstract.  Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2010). Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent. BMC Cardiovasc Disord, 10 Abstract.  Author URL.  Full text.

2009

Zhang F, Gates PE, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). A Novel Ultrasound-based Wall Shear Stress Biomarker (Echo Particle Image Velocimetry) to Generate Hemodynamic Vascular Profiles in Carotid Arteries: Clinical Studies on 16 Healthy Subjects.  Author URL.
Mahal S, Strain WD, Martinez-Perez ME, Thom SAM, Chaturvedi N, Hughes AD (2009). Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes. Clin Sci (Lond), 117(6), 229-236. Abstract.  Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III.  Author URL.
Gates PE, Zhang F, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). ECHO PARTICLE IMAGE VELOCIMETRY (ECHO PIV): a NOVEL ULTRASOUND-BASED METHOD FOR THE IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN HUMAN CAROTID ARTERIES.  Author URL.
Gates PE, Strain WD, Shore AC (2009). Human endothelial function and microvascular ageing. Exp Physiol, 94(3), 311-316. Abstract.  Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). In vivo validation of echo particle image velocimetry (Echo PIV) in human carotid arteries using phase-contrast MRI.
Strain WD, Chaturvedi NC, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Hughes AD, Shore AC (2009). MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH CONCENTRIC REMODELLING AND LEFT ATRIAL SIZE INDEPENDENT OF BLOOD PRESSURE AND CARDIOVASCULAR RISK FACTORS.  Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). Noninvasive wall shear stress measurements in human carotid artery using echo particle image velocimetry: Initial clinical studies. Proceedings - IEEE Ultrasonics Symposium Abstract.
Strain WD, Gilbert KL, Macleod KM, Fulford J, Shore AC, Stokes KA (2009). The effects of suppression of endogenous insulin on hepatic and quadriceps glycogen stores after 60 min of submaximal exercise in healthy adult males.  Author URL.

2008

Strain WD, Harman K, Leitch S, Forsythe E (2008). Albumin : creatinine ratio at presentation predicts mortality and functional outcomes after stroke.  Author URL.

2007

Todd DM, Strain WD (2007). Ethnic differences in infants and maternal outcomes in gestational diabetes. DIABETIC MEDICINE, 24, 19-19. Author URL.

2006

Strain WD, Chaturvedi N, Dockery F, Shiff R, Shore AC, Bulpitt CJ, Rajkumar C (2006). Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factors. Am J Hypertens, 19(9), 889-896. Abstract.  Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt C, Shore AC (2006). Microvascular functional abnormalities are associated left ventricular hypertrophy.  Author URL.

2005

AShore, Bulpitt C, Chaturvedi N, Strain W (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction. Diabetes, 54(6), 1816-1822.
Strain WD, Chaturvedi N, Bulpitt CJ, Rajkumar C, Shore AC (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction?. Diabetes, 54(6), 1816-1822. Abstract.  Author URL.
Strain WD, Chaturvedi N, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2005). Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans. Diabetologia, 48(11), 2269-2277. Abstract.  Author URL.
Strain WD, Chaturvedi N, Shore A, Cruickshank JK, Heagerty AM (2005). Ethnic differences in microvascular structure and function [3] (multiple letters). Journal of Hypertension, 23(7), 1434-1436.
Strain WD, Chaturvedi N, Shore A (2005). Ethnic differences in microvascular structure and function. J Hypertens, 23(7), 1434-1435. Author URL.
Strain WD, Chaturvedi N, Leggetter S, Nihoyannopoulos P, Rajkumar C, Bulpitt CJ, Shore AC (2005). Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage. J Hypertens, 23(1), 133-140. Abstract.  Author URL.

2004

Chaturvedi N, Rajkumar C, Strain WD, Nihoyannopoulos P, Shore AC, Bulpitt CJ (2004). Ethnic differences in central and augmentation index; Do they account for differing susceptibility to left ventricular hypertrophy.  Author URL.
Strain D, Bulpitt C, Chaturvedi N, Leggetter S (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage. Journal of Hypertension, 22(9), 1731-1737.
Chaturvedi N, Bulpitt CJ, Leggetter S, Schiff R, Nihoyannopoulos P, Strain WD, Shore AC, Rajkumar C (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage.  Abstract.  Author URL.
Debney MT, Hughes AD, Thom SAM, Strain WD, Chaturvedi N (2004). Explanations for the elevated stroke risk in south Asians.  Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). Pulse wave velocity is worse, but systemic arterial compliance is better in African Caribbeans compared to Europeans; the breaking of "natural confounders".  Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). The effects of diabetes on arterial stiffness in a bi-ethnic populations.  Author URL.
Strain WD (2004). The use of recombinant human B-type natriuretic peptide (nesiritide) in the management of acute decompensated heart failure. Int J Clin Pract, 58(11), 1081-1087. Abstract.  Author URL.

2003

Strain WD, Chaturvedi NC, Rajkumar C, Nihoyannopoulos P, Bulpitt CJ, Shore AC (2003). Ethnic differences in microvasculature in diabetes: a possible explanation for the greater vulnerability of people of Black African descent to vascular target organ damage.  Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Shore AC (2003). Ethnic differences in microvasculature: a possible explanation for the greater vulnerability of people of Black African descent to hypertensive target organ damage.  Author URL.

2002

Strain WD, Lye M (2002). Chronic pain, bereavement and overdose in a depressed elderly woman. Age Ageing, 31(3), 218-219. Author URL.
Strain WD, Chaturvedi N (2002). The renin-angiotensin-aldosterone system and the eye in diabetes. J Renin Angiotensin Aldosterone Syst, 3(4), 243-246. Abstract.  Author URL.

2001

Gill G, Swift AC, Jones A, Strain D, Weston PJ (2001). Severe adrenal suppression by steroid nasal drops. J R Soc Med, 94, 350-351.

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