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Professor David Melzer

Professor David Melzer

Professor of Epidemiology and Public Health

+44 (0) 1392 406751

RILD Building L3/22

Dr David Melzer is Professor of Epidemiology and Public Health at the Medical School, University of Exeter, UK. His research interests are in the causes and consequences of chronic disease in later life. His group’s research programme includes analysis of genomic and conventional biomarkers, plus studies of medical treatment in later life.

He trained in medicine in South Africa (graduating 1981), studied public health at the London School of Hygiene and completed his PhD at the University of Cambridge. He received a Harkness Fellowship in 1998, spent at the Guralnik laboratory at the US National Institute on Aging. He worked as an NHS consultant in Public Health Medicine in the early 1990s before becoming a full time academic. He was formerly Director of the Epidemiology for Policy Group, in the Department of Public Health and Primary Care, University of Cambridge.

Prof. Melzer has received research support from the US National Institutes of Health, the Wellcome Trust, British Heart Foundation, the Medical Research Council, Age UK, NIHR and other funders.

Broad research specialisms

The Melzer group has undertaken work on environmental and genomic factors associated with chronic disease, as well as studies of health care quality in later life. 

Environmental factor work has included a series of studies of adult human exposure to Bisphenol A (BPA), an estrogenic chemical added to certain polycarbonate plastics. BPA can leach out of polycarbonate containers and contaminate food.  With Professor Galloway (Biosciences, University of Exeter) the group undertook the first cross-sectional epidemiological study of the effects of BPA on adult health. The group then reported a successful replication of an association between BPA and heart disease, a longitudinal study confirming this association and a study of BPA in people undergoing coronary artery bypass surgery. This work has been widely cited academically and in policy documents and may have spurred global policy efforts to restrict human BPA exposures, especially through reducing BPA food contamination.

Professor Melzer’s group has also explored large genomics array datasets, contributing to many genome-wide association studies of disease-associated and phenotypic traits. Recent work (in collaboration with Dr Lorna Harries, Molecular Genetics UEMS) has extended such approaches to gene expression and methylation array data. This work is part of a long term collaboration with the Ferrucci research group at the US National Institute on Aging (at NIH). 

Dr Melzer is a member of the executive of the NIHR National Institute for Public Health Research, England.

Dr Melzer’s group has also led studies of medical quality of care for older people in England, in collaboration with Age UK.

Notable outputs have included:

  1. The first studies linking environmental endocrine disrupting chemical BPA to adult disease in the general population (JAMA, 2008) with first longitudinal study (Circulation, 2012), and several related studies
  2. Contributions to identifying common genetic variants, including the first genome wide analysis of 42 clinical markers in blood, identifying 8 larger effect variants. (Melzer et al, Plos Genetics 2008)
  3. First evidence in a human population of splice ratio changes with advancing age (Harries et al, Aging cell, 2011)
  4. First evidence in older humans that CEBP-Beta expression is associated with muscle strength – concordant with a mouse model of macrophage mediated muscle repair (Aging Cell, 2011)
  5. First report of CCR2 expression in humans associated with cognitive impairment – concordant with mouse model of beta-amyloid phagocytosis in Alzheimer’s mouse model  (Rejuvenation Research, 2012)
  6. The first longitudinal analysis of low vitamin D levels, showing association with later cognitive impairment in older people (Archives of Internal Medicine, 2010)
  7. A report on the quality of health prevention and treatment for older people in the UK - Health Care Quality for an Active Later Life (PDF)

 

Qualifications

  • 1981 MB BCh Medicine and Surgery, University of Witwatersrand, South Africa
  • 1987 MSc Community Medicine, London School of Hygiene and Tropical Medicine
  • 1998 Fellow of the Faculty of Public Health Medicine
  • 2006 PhD Public Health, Cambridge University

Research

Research interests

Notable research outputs have included

  • First evidence (to the best of my knowledge) in a human population of splice ratio changes with advancing age (Aging cell, 2011)
  • First evidence in older humans that CEBP-Beta expression is associated with muscle strength – concordant with a mouse model of macrophage mediated muscle repair (Aging Cell, 2012)
  • First report of CCR2 expression in humans associated with cognitive impairment – concordant with mouse model of beta-amyloid phagocytosis in Alzheimer’s mouse model (Rejuvenation Research, 2012)
  • The first longitudinal analysis of low vitamin D levels, showing association with later cognitive impairment in older people (Archives of Internal Medicine, 2010)
  • First evidence of p16 (CDKN2a, 9p21) loci SNP associated with frailty – nearby loci later implicated in diabetes and cardiovascular disease (Mechanisms of Ageing & Development, 2007)
  • The first studies linking environmental endocrine disrupting chemical BPA to adult disease in the general population (JAMA, 2008) with first longitudinal study (Circulation, 2012).

Notable policy contributions:

  • Age UK sponsored report on health care quality Health Care Quality for an Active Later Life
  • Regulation of genetic tests and pharmacogenetics (attracting a US Food and Drug administration Director’s award 2006).

Professor Melzer gives an overview of his work in the following video, which was filmed at the Livings Systems Institute Symposium 2016.

Research projects

  • Genomic biomarkers in human ageing
  • Health care quality in later life (for Age UK and NIHR)
  • NIHR School for Public Health Research
  • Effects of endocrine disrupting chemicals in adults

Grants/Funding

Current grants

  • Genomic markers of biological age in human leukocytes. Wellcome Trust / University of Exeter. David Melzer (PI), Lorna Harries and Jonathan Mill. February 2013 to February 2014.
  • Genomic biomarkers of ageing: dynamic predicting outcomes (InCHIANTI). Vellux Stiftung. David Melzer (PI), Lorna Harries, Luigi Ferrucci, Stefania Bandinelli and Jack Guralnik.
  • Influence of dietary nitrate supplementation on blood pressure, walking economy, functional physical capacity and cognitive function in healthy older adults. Dunhill Medical Trust. Andrew Jones (PI), Anni Vanhatalo, Paul Winyard, David Melzer and Jonathan Fulford.
  • Fair comparisons of interventions: Extending the Prior Event Rate Ratio method (EPERR study). Methodology project grant. (UK) Medical Research Council. William Henley (PI), Chris Hyde, Iain Lang, Dave Wright and David Melzer (initiated by DM). October 2010 to September 2013.
  • Health care quality in later life: trends for the UK 2011 to 2014. Programme grant. Age UK. David Melzer (PI). 2011 to 2014.
  • National School of Public Health Research: Programme / infrastructure funding. UK National Institute for Health Research. David Melzer (PI), Charles Abraham, Ken Stein and Lora Fleming. 2012 to 2017.
  • The role of Bisphenol A in the development of chronic disease. Project grant. APP1022923. National Health and Medical Research Council, Australia. Dianna Magliano (PI) and colleagues, Baker IDI Heart and Diabetes Institute, Australia. David Melzer and Tamara Galloway.

Key publications | Publications by category | Publications by year

Key publications


Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.  Full text.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). Association of urinary bisphenol a concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303-1310. Abstract.  Author URL.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.

Publications by category


Journal articles

correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (In Press). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier) Full text.
Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D (2017). Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: a Quasi-Experimental Study. J Gerontol a Biol Sci Med Sci, 72(2), 243-250. Abstract.  Author URL.  Full text.
Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Magi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract.  Author URL.  Full text.
Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Hum Mol Genet, 25(21), 4611-4623. Author URL.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, et al (2016). DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol, 17(1). Abstract.  Author URL.
Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai P-C, Roetker NS, Just AC, Demerath EW, Guan W, et al (2016). DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY), 8(9), 1844-1865. Abstract.  Author URL.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, et al (2016). Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet, 9(5), 436-447. Abstract.  Author URL.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract.  Author URL.
Tanaka T, Dutta A, Pilling LC, Xue L, Lunetta KL, Murabito JM, Bandinelli S, Wallace R, Melzer D, Ferrucci L, et al (2016). Genome-wide Association Study of Parental Life Span. J Gerontol a Biol Sci Med Sci Abstract.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (2016). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A, et al (2016). Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. Journal of the American Geriatrics Society Abstract.
Chen BH, Hivert M-F, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, et al (2016). Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes, 65(12), 3794-3804. Abstract.  Author URL.
Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB (2015). A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLOS ONE, 10(2), e0118463-e0118463.
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, et al (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet, 11(3). Abstract.  Author URL.  Full text.
Ble A, Masoli JAH, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH, et al (2015). Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr, 15 Abstract.  Author URL.  Full text.
Bowman K, Ble A, Delgado J, Melzer D (2015). CHRONIC KIDNEY DISEASE AS a RISK FACTOR FOR CARDIOVASCULAR EVENTS OR MORTALITY. GERONTOLOGIST, 55, 25-25. Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract.  Author URL.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. Journal of Physiological Sciences, 65(1), 145-150. Abstract.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract.  Author URL.  Full text.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract.  Author URL.  Full text.
Moore AZ, Ding J, Tuke MA, Wood A, Melzer D, Bandinelli S, Frayling T, Ferrucci L (2015). DISTRIBUTION OF MITOCHONDRIAL DNA HETEROPLASMY IN PARTICIPANTS OF THE INCHIANTI STUDY. GERONTOLOGIST, 55, 67-67. Author URL.
Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, et al (2015). DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet, 8(2), 334-342. Abstract.  Author URL.  Full text.
Steel N, Hardcastle AC, Bachmann MO, Richards SH, Mounce LTA, Clark A, Lang I, Melzer D, Campbell JL (2015). Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. BMJ Open, 4(10). Abstract.  Full text.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract.  Author URL.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract.  Author URL.  Full text.
Melzer D, Tavakoly B, Winder RE, Masoli JAH, Henley WE, Ble A, Richards SH (2015). Much more medicine for the oldest old: trends in UK electronic clinical records. Age Ageing, 44(1), 46-53. Abstract.  Author URL.  Full text.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract.  Author URL.  Full text.
Mounce LTA, Steel N, Hardcastle AC, Henley WE, Bachmann MO, Campbell JL, Melzer D, Richards SH (2015). Patient characteristics predicting failure to receive indicated care for type 2 diabetes. Diabetes Research and Clinical Practice, 107(2), 247-258. Abstract.  Full text.
Lafortune L, Xu K, Wood A, Melzer D, Brayne C, Mant J (2015). RISK FACTOR ASSOCIATIONS WITH CARDIOVASCULAR OUTCOMES IN LATER LIFE. GERONTOLOGIST, 55, 25-25. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.
Melzer D, Bowman K, Delgado J, Ble A (2015). THE RISK FACTOR PARADOX: BIG DATA ESTIMATES FROM 1.9 MILLION OLDER PATIENTS. GERONTOLOGIST, 55, 800-801. Author URL.
Hardcastle AC, Mounce LTA, Richards SH, Bachmann MO, Clark A, Henley WE, Campbell JL, Melzer D, Steel N (2015). The dynamics of quality: a national panel study of evidence-based standards. Health Services and Delivery Research, 3(11), 1-128. Full text.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract.  Author URL.  Full text.
Ble A, Delgado J, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING CARDIOVASCULAR DISEASE AND ALL-CAUSE MORTALITY IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Delgado J, Ble A, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING THE INCIDENCE\ ONSET OF DEMENTIA IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.
Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D (2014). Aging children of long-lived parents experience slower cognitive decline. Alzheimer's and Dementia, 10(5), S315-S322. Abstract.
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.  Full text.
Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Abstract.  Author URL.
Melzer D, Joehanes R, Pilling L, Levy D, Munson P, Ferrucci L (2014). INFLAMMATION IN AGING: RESULTS FROM TRANSCRIPTOME-WIDE ANALYSIS IN TWO HUMAN COHORTS. GERONTOLOGIST, 54, 32-32. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Steel N, Hardcastle AC, Clark A, Mounce LTA, Bachmann MO, Richards SH, Henley WE, Campbell JL, Melzer D (2014). Self-reported quality of care for older adults from 2004 to 2011: a cohort study. Age Ageing, 43(5), 716-720. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Keller MF, Reiner AP, Okada Y, van Rooij FJA, Johnson AD, Chen M-H, Smith AV, Morris AP, Tanaka T, Ferrucci L, et al (2014). Trans-ethnic meta-analysis of white blood cell phenotypes. Human Molecular Genetics, 23(25), 6944-6960.
Lin H, Joehanes R, Pilling LC, Dupuis J, Lunetta KL, Ying S-X, Benjamin EJ, Hernandez D, Singleton A, Melzer D, et al (2014). Whole blood gene expression and interleukin-6 levels. Genomics, 104(6 Pt B), 490-495. Abstract.  Author URL.  Full text.
Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Abstract.  Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Abstract.  Author URL.
Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, et al (2013). Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics, 22(10), 2119-2127. Abstract.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.  Full text.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract.  Author URL.  Full text.
Dutta A, Henley W, Robine J-M, Langa KM, Wallace RB, Melzer D (2013). Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol a Biol Sci Med Sci, 68(11), 1409-1418. Abstract.  Author URL.
Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2013). Microarray-based whole transcriptome expression profiling as a tool to understand human ageing. , 209-220. Abstract.
Antoniou EE, Dutta A, Langa KM, Melzer D, Llewellyn D (2013). Personality profile of the children of long-lived parents. J Gerontol B Psychol Sci Soc Sci, 68(5), 730-738. Abstract.  Author URL.
Dutta A, Wallace RB, Melzer D (2013). Response letter to Shil and colleagues. J Am Geriatr Soc, 61(12). Author URL.
Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45(10), 1238-1243. Abstract.
Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.  Full text.
Dutta A, Henley W, Pilling LC, Wallace RB, Melzer D (2013). Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Geriatr Soc, 61(3), 319-326. Abstract.  Author URL.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mechanisms of Ageing and Development, 133(8), 556-562. Abstract.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Abstract.  Author URL.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract.  Author URL.  Full text.
Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Correction: Urinary Bisphenol a Concentration and Angiography-Defined Coronary Artery Stenosis. PLoS One, 7(11). Abstract.  Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD, Foster MC, Greenawalt DM, et al (2012). Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women. PLoS Genetics, 8(5), e1002695-e1002695.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, et al (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET, 379(9822), 1205-1213. Author URL.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Melzer D, Dutta A, Henley W, Langa K, Wallace RB, Robine J (2012). MIDDLE-AGED OFFSPRING OF LONG LIVED PARENTS IN HRS. GERONTOLOGIST, 52, 414-414. Author URL.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268. Abstract.  Full text.
Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.
Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw K-T, Wareham NJ, et al (2012). Urinary bisphenol a concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 125(12), 1482-1490. Full text.
Melzer D, Gates P, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. PLoS One, 7(8). Abstract.  Author URL.  Full text.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Ann Intern Med, 155(6), 392-394. Author URL.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Annals of internal medicine, 155(6), 392-394.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Pilling L, Bandinelli S, Guralnik JM, Singleton A, Hernandez D, Ferrucci L (2011). CONFIRMATION OF MOUSE MODEL OF SARCOPENIA BY GENOME WIDE EXPRESSION STUDY IN HUMANS. GERONTOLOGIST, 51, 506-507. Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2011). Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing. Age Ageing, 40(1), 54-61. Abstract.  Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, et al (2011). Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4). Abstract.
Melzer D (2011). Environmental Medicine. JOURNAL OF PUBLIC HEALTH, 33(3), 469-469. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, et al (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLoS Genetics, 7(3), e1001324-e1001324.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, et al (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1138.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D (2011). Income and the midlife peak in common mental disorder prevalence. Psychol Med, 41(7), 1365-1372. Abstract.  Author URL.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7(6). Abstract.
Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D (2011). Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc, 59(6), 963-971. Abstract.  Author URL.
Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, et al (2011). Report from the second cytomegalovirus and immunosenescence workshop. Immunity and Ageing, 8 Abstract.
Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE (2011). Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS ONE, 6(2). Abstract.
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, et al (2011). The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell, 147(1), 81-94.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and Risk of Cognitive Decline in Elderly Persons EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY, 66(6), 354-355. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 66 A(1), 59-65. Abstract.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol a Biol Sci Med Sci, 66(1), 59-65. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and risk of cognitive decline in elderly persons. Obstetrical and Gynecological Survey, 66(6), 354-355.
Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010). Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect, 118(5), 686-692. Abstract.  Author URL.  Full text.
Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010). Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 5(1). Abstract.  Author URL.  Full text.
Rice NE, Lang IA, Henley W, Melzer D (2010). Baby boomers nearing retirement: the healthiest generation?. Rejuvenation Res, 13(1), 105-114. Abstract.  Author URL.
Melzer D, Galloway T (2010). Burden of proof. NEW SCIENTIST, 208(2783), 26-27. Author URL.
Melzer D (2010). COMMON HUMAN GENETIC VARIATION IN PATHWAYS TO SUCCESSFUL AGEING. GERONTOLOGIST, 50, 436-436. Author URL.
Melzer D, Lang I (2010). Chronological and Functional Ageing. , 65-69.
Galloway T, Cipelli R, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Money C, McCormack P, Melzer D (2010). Daily bisphenol a excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study. Environ Health Perspect, 118(11), 1603-1608. Abstract.  Author URL.  Full text.
Dutta A, Guralnik J, Wallace R, Melzer D (2010). EARLY LIFE PREDICTORS OF EXCEPTIONAL SURVIVAL IN THE IOWA EPESE-STUDY. GERONTOLOGIST, 50, 19-19. Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)). Nature Genetics, 42(5).
Wallace RB, Dutta A, Guralnik J, Melzer D (2010). IOWA 2: BLOOD BIOCHEMISTRY AND THE PREDICTION OF SURVIVAL IN THE IOWA-EPESE. GERONTOLOGIST, 50, 20-20. Author URL.
Dalton HR, Bendall RP, Pritchard C, Henley W, Melzer D (2010). National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect, 138(2), 174-182. Abstract.  Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet, 42(2), 105-116. Abstract.  Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Williams B, Lang I, Llewellyn D, Melzer D, Rice N (2010). Vitamin D and lower reproductive tract infections in women: National Health and Nutrition Examination Survey (NHANES) 2001-2004. HIV MEDICINE, 11, 76-76. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.
Brent Richards J, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics, 5(12). Abstract.
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS genetics, 5(12). Abstract.
Lang I, Scarlett A, Guralnik J, Depledge M, Melzer D, Galloway T (2009). Age-Related Impairments of Mobility Associated with Cobalt and Other Heavy Metals: Data from NHANES 1999-2004. Journal of Toxicology and Environmental Health-Part a-Current Issues, 72(6), 402-409. Abstract.
Lang IA, Scarlett A, Guralnik JM, Depledge MH, Melzer D, Galloway TS (2009). Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004. J Toxicol Environ Health A, 72(6), 402-409. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). Association of Bisphenol a with Diabetes and Other Abnormalities Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 301(7), 721-722. Author URL.
Perry JRB, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D, DIAGRAM Consortium, Saxena R, Scott LJ, et al (2009). Circulating beta-carotene levels and type 2 diabetes-cause or effect?. Diabetologia, 52(10), 2117-2121. Abstract.  Author URL.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.  Full text.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2009). Erratum: Epidemiology of balance and dizziness in a national population: Findings from the English Longitudinal Study of Ageing (Age and Ageing 2008) vol. 37 (3) (300-305)). Age and Ageing, 38(1).
Cluett C, Melzer D (2009). Human genetic variations: Beacons on the pathways to successful ageing. Mech Ageing Dev, 130(9), 553-563. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). In reply. JAMA - Journal of the American Medical Association, 301(7), 721-722.
Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, et al (2009). Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol a Biol Sci Med Sci, 64(11), 1177-1182. Abstract.  Author URL.
Lang IA, Melzer D (2009). Moderate alcohol consumption in later life: Time for a trial?. Journal of the American Geriatrics Society, 57(6), 1110-1112.
Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K (2009). Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc, 57(10), 1776-1780. Abstract.  Author URL.
Parahyba MI, Stevens K, Henley W, Lang IA, Melzer D (2009). Reductions in disability prevalence among the highest income groups of older Brazilians. Am J Public Health, 99(1), 81-86. Abstract.  Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract.  Author URL.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract.  Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract.  Author URL.  Full text.
Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). Association of urinary bisphenol a concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303-1310. Abstract.  Author URL.
Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, et al (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57(5), 1419-1426. Abstract.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing (vol 37, pg 300, 2008). AGE AND AGEING, 37(5), 610-610. Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing. Age Ageing, 37(3), 300-305. Abstract.  Author URL.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008). Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol, 8 Abstract.  Author URL.  Full text.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.
Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ, DIAGRAM Consortium, Palmer CNA, Morris AD, McCarthy MI, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. Abstract.  Author URL.
Melzer D, Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern RL (2008). Genetic tests for common diseases: new insights, old concerns. BMJ, 336(7644), 590-593. Author URL.
Lang IA, Melzer D (2008). LOW-DOSE HEAVY METAL EXPOSURE AND AGING IN HUMANS. GERONTOLOGIST, 48, 758-758. Author URL.
Lang IA, Melzer D (2008). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence - Reply. AGE AND AGEING, 37(1), 121-121. Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D (2008). Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing. J Am Geriatr Soc, 56(2), 191-198. Abstract.  Author URL.
Lang IA, Gibbs SJ, Steel N, Melzer D (2008). Neighbourhood deprivation and dental service use: a cross-sectional analysis of older people in England. J Public Health (Oxf), 30(4), 472-478. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D (2008). Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing, 37(4), 403-410. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Alexander K, Melzer D (2008). Obesity, physical function, and mortality in older adults. J Am Geriatr Soc, 56(8), 1474-1478. Abstract.  Author URL.
Yuan X, Waterworth D, Perry JRB, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, et al (2008). Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet, 83(4), 520-528. Abstract.  Author URL.
Steel N, Clark A, Lang IA, Wallace RB, Melzer D (2008). Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004. J Gerontol a Biol Sci Med Sci, 63(6), 629-634. Abstract.  Author URL.
Lang IA, Melzer D (2008). Reply [6]. Age and Ageing, 37(1).
Steel N, Bachmann M, Maisey S, Shekelle P, Breeze E, Marmot M, Melzer D (2008). Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England. BMJ, 337 Abstract.  Author URL.  Full text.
Hogarth S, Javitt G, Melzer D (2008). The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet, 9, 161-182. Abstract.  Author URL.
Lang IA, Llewellyn D, Melzer D (2008). VITAMIN D DEFICIENCY IN OLDER PEOPLE: PREVALENCE AND RELATION TO NEIGHBOURHOOD DEPRIVATION. GERONTOLOGIST, 48, 758-758. Author URL.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, et al (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun, 8(7), 552-559. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi A-M, Ferrucci L, Guralnik JM, et al (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biol Sci Med Sci, 62(1), 73-78. Abstract.  Author URL.
Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern R, Melzer D (2007). Closing the gaps--enhancing the regulation of genetic tests using responsive regulation. Food Drug Law J, 62(4), 831-848. Author URL.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract.  Author URL.
Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS (2007). Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol, 36(2), 358-365. Abstract.  Author URL.
Melzer D, Hurst AJ, Frayling T (2007). Genetic variation and human aging: progress and prospects. J Gerontol a Biol Sci Med Sci, 62(3), 301-307. Abstract.  Author URL.
Lang I, Wallace RB, Huppert FA, Melzer D (2007). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence. Age Ageing, 36(3), 256-261. Abstract.  Author URL.
Lang IA, Guralnik JM, Melzer D (2007). Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight. J Am Geriatr Soc, 55(11), 1836-1841. Abstract.  Author URL.
Lang IA, Rice NE, Wallace RB, Guralnik JM, Melzer D (2007). Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing. Age Ageing, 36(6), 638-643. Abstract.  Author URL.
Lang I, Gardener E, Huppert FA, Melzer D (2007). Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England. Public Health, 121(7), 518-524. Abstract.  Author URL.
Lang I, Guralnik J, Wallace RB, Melzer D (2007). What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts. J Am Geriatr Soc, 55(1), 49-57. Abstract.  Author URL.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001. Abstract.  Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract.  Author URL.  Full text.
Villamil E, Huppert FA, Melzer D (2006). Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey. Psychol Med, 36(7), 999-1009. Abstract.  Author URL.
Gill SC, Butterworth P, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Mental health and the timing of men's retirement. Soc Psychiatry Psychiatr Epidemiol, 41(7), 515-522. Abstract.  Author URL.
Gardener EA, Huppert FA, Guralnik JM, Melzer D (2006). Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey. J Gen Intern Med, 21(10), 1091-1096. Abstract.  Author URL.
Steel N, Melzer D, Gardener E, McWilliams B (2006). Need for and receipt of hip and knee replacement--a national population survey. Rheumatology (Oxford), 45(11), 1437-1441. Abstract.  Author URL.
Butterworth P, Gill SC, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Retirement and mental health: analysis of the Australian national survey of mental health and well-being. Soc Sci Med, 62(5), 1179-1191. Abstract.  Author URL.
Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet, 7 Abstract.  Author URL.  Full text.
Angleman SB, Harris TB, Melzer D (2006). The role of waist circumference in predicting disability in periretirement age adults. Int J Obes (Lond), 30(2), 364-373. Abstract.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). Disability among elderly women in Brazil. Revista de Saude Publica, 39(3), 383-391. Abstract.
Melzer D, Guralnik J, Wallace R (2005). Epidemiologic studies on disability prevention - Perspectives from the English longitudinal study of ageing (ELSA) and the US health and retirement study. GERONTOLOGIST, 45, 153-154. Author URL.
Melzer D, Guralnik J, Pharoah P (2005). Genetic variation and human aging: Large-scale associations study in the EPIC Cohort. GERONTOLOGIST, 45, 249-249. Author URL.
Melzer D, Gardener E, Guralnik JM (2005). Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing. Age Ageing, 34(6), 594-602. Abstract.  Author URL.
Melzer D, Raven A, Ling T, Detmer D, Zimmern R (2005). Pharmacogenetics: policy needs for personal prescribing. J Health Serv Res Policy, 10(1), 40-44. Abstract.  Author URL.
Brugha T, Singleton N, Meltzer H, Bebbington P, Farrell M, Jenkins R, Coid J, Fryers T, Melzer D, Lewis G, et al (2005). Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity. Am J Psychiatry, 162(4), 774-780. Abstract.  Author URL.
Melzer D, Dik MG, van Kamp GJ, Jonker C, Deeg DJ (2005). The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people. J Gerontol a Biol Sci Med Sci, 60(10), 1319-1323. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R, Brugha T (2005). The distribution of the common mental disorders: social inequalities in Europe. Clin Pract Epidemiol Ment Health, 1 Abstract.  Author URL.  Full text.
Buxton JW, Singleton N, Melzer D (2005). The mental health of early retirees-- national interview survey in Britain. Soc Psychiatry Psychiatr Epidemiol, 40(2), 99-105. Abstract.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). [Disability among elderly women in Brazil]. Rev Saude Publica, 39(3), 383-390. Abstract.  Author URL.
Melzer D, Tom BDM, Brugha T, Fryers T, Gatward R, Grounds A, Johnson T, Meltzer H (2004). Access to medium secure psychiatric care in England and Wales. 1: a national survey of admission assessments. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 7-31. Author URL.
Melzer D, Buxton J, Villamil E (2004). Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey. Soc Psychiatry Psychiatr Epidemiol, 39(1), 33-38. Abstract.  Author URL.
Steel N, Melzer D, Shekelle PG, Wenger NS, Forsyth D, McWilliams BC (2004). Developing quality indicators for older adults: transfer from the USA to the UK is feasible. Qual Saf Health Care, 13(4), 260-264. Abstract.  Author URL.
Angleman S, Harris T, Melzer D (2004). Obesity more than doubles mobility disability in peri-retirement age British men and women. GERONTOLOGIST, 44, 352-353. Author URL.
Melzer D, Parahyba MI (2004). Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey. Age Ageing, 33(3), 253-259. Abstract.  Author URL.
Brugha TS, Bebbington PE, Singleton N, Melzer D, Jenkins R, Lewis G, Farrell M, Bhugra D, Lee A, Meltzer H, et al (2004). Trends in service use and treatment for mental disorders in adults throughout Great Britain. Br J Psychiatry, 185, 378-384. Abstract.  Author URL.
Melzer D, Lan T-Y, Tom BDM, Deeg DJH, Guralnik JM (2004). Variation in thresholds for reporting mobility disability between national population subgroups and studies. J Gerontol a Biol Sci Med Sci, 59(12), 1295-1303. Abstract.  Author URL.
Ramana R, Paykel ES, Melzer D, Mehta MA, Surtees PG (2003). Aftercare of depressed inpatients--service delivery and unmet needs. Soc Psychiatry Psychiatr Epidemiol, 38(3), 109-115. Abstract.  Author URL.
Melzer D, Detmer D, Zimmern R (2003). Pharmacogenetics and public policy: expert views in Europe and North America. Pharmacogenomics, 4(6), 689-691. Abstract.  Author URL.
Melzer D, Guralnik JM, Brock D (2003). Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life. Aging Clin Exp Res, 15(1), 60-66. Abstract.  Author URL.
Melzer D, Zimmern RL, Detmer DE, Ling T (2003). Regulatory options for pharmacogenetics. Pharmacogenomics, 4(5), 527-530. Author URL.
Lan T-Y, Deeg DJH, Guralnik JM, Melzer D (2003). Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam. J Gerontol a Biol Sci Med Sci, 58(8), 721-727. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R (2003). Social inequalities and the common mental disorders: a systematic review of the evidence. Soc Psychiatry Psychiatr Epidemiol, 38(5), 229-237. Abstract.  Author URL.
Melzer D, Fryers T, Jenkins R, Brugha T, McWilliams B (2003). Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain. Soc Psychiatry Psychiatr Epidemiol, 38(5), 238-243. Abstract.  Author URL.
Melzer D, Lan T-Y, Guralnik JM (2003). The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study. Age Ageing, 32(6), 619-625. Abstract.  Author URL.
Melzer D, Tom BDM, Brugha TS, Fryers T, Meltzer H (2002). Common mental disorder symptom counts in populations: are there distinct case groups above epidemiological cut-offs?. Psychol Med, 32(7), 1195-1201. Abstract.  Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation - Genetics could drive a new wave of medicalisation if genetic tests are accepted without appropriate clinical evaluation. BRITISH MEDICAL JOURNAL, 324(7342), 863-864. Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation. BMJ, 324(7342), 863-864. Author URL.
Melzer D (2002). Mental health outcome measures, 2nd edition. JOURNAL OF PUBLIC HEALTH MEDICINE, 24(1), 71-72. Author URL.
Lan T-Y, Melzer D, Tom BDM, Guralnik JM (2002). Performance tests and disability: developing an objective index of mobility-related limitation in older populations. J Gerontol a Biol Sci Med Sci, 57(5), M294-M301. Abstract.  Author URL.
Melzer D, Izmirlian G, Leveille SG, Guralnik JM (2001). Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery. J Gerontol B Psychol Sci Soc Sci, 56(5), S294-S301. Abstract.  Author URL.
Bedford S, Melzer D, Guralnik J (2001). Problem behavior in the last year of life: prevalence, risks, and care receipt in older Americans. J Am Geriatr Soc, 49(5), 590-595. Abstract.  Author URL.
Birks JS, Melzer D, Beppu H (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane database of systematic reviews (Online)(4). Abstract.
Birks J S, Melzer D (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane Database Syst Rev(2). Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (2000). Socioeconomic status and the expectation of disability in old age: estimates for England. J Epidemiol Community Health, 54(4), 286-292. Abstract.  Author URL.
Melzer D, Watters L, Paykel E, Singh K, Gormley N (1999). Factors explaining the use of psychiatric services by general practices. Br J Gen Pract, 49(448), 887-891. Abstract.  Author URL.
Melzer D (1999). Health economics of dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 14(5), 405-406. Author URL.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: Adequacy and relation to outcome. British Journal of Psychiatry, 174(FEB.), 128-134. Abstract.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: adequacy and relation to outcome. Br J Psychiatry, 174, 128-134. Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (1999). Profile of disability in elderly people: estimates from a longitudinal population study. BMJ, 318(7191), 1108-1111. Abstract.  Author URL.
Melzer D (1998). Health policy and the scientific literature: What kinds of evidence should we expect to find?. Evidence-based Healthcare, 2(1), 2-3.
Melzer D (1998). New drug treatment for Alzheimer's disease: lessons for healthcare policy. BMJ, 316(7133), 762-764. Author URL.
Melzer D (1998). Patent protection for medical technologies: why some and not others?. Lancet, 351(9101), 518-519. Author URL.
Melzer D (1998). Personal paper - New drug treatment for Alzheimer's disease: lessons for healthcare policy. BRITISH MEDICAL JOURNAL, 316(7133), 762-764. Author URL.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners. BMJ, 317(7165), 1025-1026.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners: a persistent problem that needs a concerted and long term response. BMJ, 317(7165), 1025-1026. Author URL.
Melzer D (1998). Some of the barriers to evidence-based decision-making can be overcome without additional resources. Evidence-based Healthcare, 2(1).
Melzer D, Ely M, Brayne C (1997). Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales. BMJ, 315(7106). Author URL.
Hanson RM, Melzer DJ (1997). Estrogen replacement therapy: new options, continuing concerns. JAMA, 277(19). Author URL.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. International Journal of Geriatric Psychiatry, 12(9), 883-887.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. Int J Geriatr Psychiatry, 12(9), 883-887. Abstract.  Author URL.
Melzer D, Bedford S, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). Carers and the monitoring of psychogeriatric community teams. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1057-1061. Author URL.
Bedford S, Melzer D, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). What becomes of people with dementia referred to community psychogeriatric teams?. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1051-1056. Author URL.
Pharoah PD, Melzer D (1995). Variation in prescribing of hypnotics, anxiolytics and antidepressants between 61 general practices. Br J Gen Pract, 45(400), 595-599. Abstract.  Author URL.
Conway AS, Melzer D, Hale AS (1994). The outcome of targeting community mental health services: evidence from the West Lambeth schizophrenia cohort. BMJ, 308(6929), 627-630. Abstract.  Author URL.
Melzer D (1993). Diversion from custody. BMJ, 306(6870). Author URL.
Hogman G, Melzer D (1992). Mental health. Talk--don't inject. Nurs Times, 88(49), 61-62. Author URL.
Melzer D, Hale AS, Malik SJ, Hogman GA, Wood S (1991). Community care for patients with schizophrenia one year after hospital discharge. BMJ, 303(6809), 1023-1026. Abstract.  Author URL.
Melzer D (1990). An evaluation of a respite care unit for elderly people with dementia: framework and some results. Health Trends, 22(2), 64-67. Abstract.  Author URL.
Melzer D (1989). Paying for health services: a public health view. Public Health, 103(5), 363-367. Abstract.  Author URL.
Swerdlow AJ, Melzer D (1988). The value of England and Wales congenital malformation notification scheme data for epidemiology: male genital tract malformations. J Epidemiol Community Health, 42(1), 8-13. Abstract.  Author URL.

Chapters

Ble A, Melzer D (2015). Multiple health problems and medication. In  (Ed) Improving later life: vulnerability and resiliance in older people.
Hogarth S, Barton D, Melzer D (2010). The European IVD directive and genetic testing. In  (Ed) Quality Issues in Clinical Genetic Services, 49-62.  Abstract.

Conferences

Delgado J, Melzer D (2016). AGING WITHOUT THE SIMPLE 7-EVIDENCE FROM PRIMARY CARE ELECTRONIC MEDICAL RECORDS.  Author URL.
Melzer D, Atkins J, Pilling L (2016). AGING WITHOUT THE SIMPLE 7: EVIDENCE FROM 131,000 VOLUNTEERS IN UK BIOBANK.  Author URL.
Bowman K, Melzer D (2016). OBESITY IN THE SIMPLE 7: WOULD WAIST CIRCUMFERENCE BE a BETTER MEASURE.  Author URL.
Melzer D, Delgado J, Masoli J, Kuchel GA (2016). Outcomes of treated hypertension in 79,376 patients aged 80 years and older: Linked records based cohort analysis.  Author URL.
Atkins J, Pilling L, Melzer D (2016). PARENTAL LONGEVITY AND LIFESTYLE FACTORS IN AGING.  Author URL.
Masoli J, Winder R, Tavakoly B, Henley W, Ble A, Richards S, Melzer D (2014). OVERDIAGNOSING AND MISSING THE POINT?.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III.  Author URL.
Fingleton J, Webster S, Rice N, Melzer D, Patel B (2009). RELATIONSHIP BETWEEN SERUM IGE LEVELS, SMOKING AND SMOKING CESSATION IN AN AGEING POPULATION IN THE UK (THE ELSA COHORT).  Author URL.
Perry JRB, Melzer D, Maggio M, Hernandez D, Singleton A, Ferrucci L, Palmer C, Bennett A, Ruokonen A, Panicker V, et al (2008). A Mendelian randomisation study provides initial evidence that sex hormone binding globulin (SHBG) levels alter type 2 diabetes risk.  Author URL.
Melzer D, Lang IA, Scarlett A, Galloway TS (2008). Bisphenol A, Age, Ethnicity and Health Outcomes.  Author URL.
Frayling TM, Rafiq S, Melzer D, Maggio M, Paulisso G, Hernandez D, Singleton A, Zeggini E, Morris A, Palmer CN, et al (2008). Evidence that common genetic variation altering sex hormone binding globulin levels influences type 2 diabetes risk.  Author URL.
Rafiq S, Melzer D, Weedon MN, Zeggini E, Lindgren CM, Lango H, Hattersley AT, McCarthy MI, Frayling TM, Diabetes WTCCCUKT2, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases do not alter the risk of type 2 diabetes.  Author URL.
Melzer D (2008). Genetic polymorphisms and human aging: association studies deliver.  Abstract.  Author URL.
Hall A, Hogarth S, Jader L, Melzer D, Burton H, Moorthie S (2008). Genetic susceptibility testing: a report of the Society for Genomics Policy and Population Health (SGPPH) Spring Conference 2008.  Author URL.
Lang IA, Llewellyn DJ, Melzer D (2008). The importance of income to the "midlife crisis": Findings from a cross-section of 88,000 adults.  Author URL.
Webster SE, Rice NE, Melzer D, Patel BD (2007). Cross sectional relation between total ige levels, cigarette smoking and FEV1 in an ageing population (the ELSA cohort).  Author URL.
Ward N, Rice NE, Melzer D, Patel BD (2007). Elevated C reactive protein levels are associated with an accelerated decline in lung function in an ageing population.  Author URL.
Brune JC, Tormin A, Melzer D, Borg A, Scheding S (2007). Propagation of human mesenchymal stem cells under defined serum-free culture conditions.  Author URL.
Brune JC, Melzer D, Neumann U, Jacobsen S, Scheding S (2006). Identification and characterisation of human mesenchymal stem cell subpopulations.  Author URL.
Melzer D, Tormin A, Neumann U, Ebell W, Seeger K, Brummendorf T, Gaedicke G, Scheding S (2006). Normal human mesenchymal stem cells are severely affected by imatinib in vitro.  Author URL.
Angleman S, Harris T, Melzer D (2005). C-reactive protein, obesity, and risk of peri-retirement age disability.  Author URL.
Leveille SG, Penninx BW, Melzer D, Izmirlian G, Guralnik JM (2000). Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, recovery, and mortality.  Abstract.  Author URL.

Publications by year


In Press

correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (In Press). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier) Full text.

2017

Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D (2017). Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: a Quasi-Experimental Study. J Gerontol a Biol Sci Med Sci, 72(2), 243-250. Abstract.  Author URL.  Full text.

2016

Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Magi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract.  Author URL.  Full text.
Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Hum Mol Genet, 25(21), 4611-4623. Author URL.
Delgado J, Melzer D (2016). AGING WITHOUT THE SIMPLE 7-EVIDENCE FROM PRIMARY CARE ELECTRONIC MEDICAL RECORDS.  Author URL.
Melzer D, Atkins J, Pilling L (2016). AGING WITHOUT THE SIMPLE 7: EVIDENCE FROM 131,000 VOLUNTEERS IN UK BIOBANK.  Author URL.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, et al (2016). DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol, 17(1). Abstract.  Author URL.
Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai P-C, Roetker NS, Just AC, Demerath EW, Guan W, et al (2016). DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY), 8(9), 1844-1865. Abstract.  Author URL.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, et al (2016). Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet, 9(5), 436-447. Abstract.  Author URL.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract.  Author URL.  Full text.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract.  Author URL.
Tanaka T, Dutta A, Pilling LC, Xue L, Lunetta KL, Murabito JM, Bandinelli S, Wallace R, Melzer D, Ferrucci L, et al (2016). Genome-wide Association Study of Parental Life Span. J Gerontol a Biol Sci Med Sci Abstract.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Bowman K, Melzer D (2016). OBESITY IN THE SIMPLE 7: WOULD WAIST CIRCUMFERENCE BE a BETTER MEASURE.  Author URL.
Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (2016). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A, et al (2016). Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. Journal of the American Geriatrics Society Abstract.
Melzer D, Delgado J, Masoli J, Kuchel GA (2016). Outcomes of treated hypertension in 79,376 patients aged 80 years and older: Linked records based cohort analysis.  Author URL.
Atkins J, Pilling L, Melzer D (2016). PARENTAL LONGEVITY AND LIFESTYLE FACTORS IN AGING.  Author URL.
Chen BH, Hivert M-F, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, et al (2016). Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes, 65(12), 3794-3804. Abstract.  Author URL.

2015

Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB (2015). A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLOS ONE, 10(2), e0118463-e0118463.
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, et al (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet, 11(3). Abstract.  Author URL.  Full text.
Ble A, Masoli JAH, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH, et al (2015). Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr, 15 Abstract.  Author URL.  Full text.
Bowman K, Ble A, Delgado J, Melzer D (2015). CHRONIC KIDNEY DISEASE AS a RISK FACTOR FOR CARDIOVASCULAR EVENTS OR MORTALITY. GERONTOLOGIST, 55, 25-25. Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract.  Author URL.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. Journal of Physiological Sciences, 65(1), 145-150. Abstract.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract.  Author URL.  Full text.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract.  Author URL.  Full text.
Moore AZ, Ding J, Tuke MA, Wood A, Melzer D, Bandinelli S, Frayling T, Ferrucci L (2015). DISTRIBUTION OF MITOCHONDRIAL DNA HETEROPLASMY IN PARTICIPANTS OF THE INCHIANTI STUDY. GERONTOLOGIST, 55, 67-67. Author URL.
Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, et al (2015). DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet, 8(2), 334-342. Abstract.  Author URL.  Full text.
Steel N, Hardcastle AC, Bachmann MO, Richards SH, Mounce LTA, Clark A, Lang I, Melzer D, Campbell JL (2015). Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. BMJ Open, 4(10). Abstract.  Full text.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract.  Author URL.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract.  Author URL.  Full text.
Melzer D, Tavakoly B, Winder RE, Masoli JAH, Henley WE, Ble A, Richards SH (2015). Much more medicine for the oldest old: trends in UK electronic clinical records. Age Ageing, 44(1), 46-53. Abstract.  Author URL.  Full text.
Ble A, Melzer D (2015). Multiple health problems and medication. In  (Ed) Improving later life: vulnerability and resiliance in older people.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract.  Author URL.  Full text.
Mounce LTA, Steel N, Hardcastle AC, Henley WE, Bachmann MO, Campbell JL, Melzer D, Richards SH (2015). Patient characteristics predicting failure to receive indicated care for type 2 diabetes. Diabetes Research and Clinical Practice, 107(2), 247-258. Abstract.  Full text.
Lafortune L, Xu K, Wood A, Melzer D, Brayne C, Mant J (2015). RISK FACTOR ASSOCIATIONS WITH CARDIOVASCULAR OUTCOMES IN LATER LIFE. GERONTOLOGIST, 55, 25-25. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.
Melzer D, Bowman K, Delgado J, Ble A (2015). THE RISK FACTOR PARADOX: BIG DATA ESTIMATES FROM 1.9 MILLION OLDER PATIENTS. GERONTOLOGIST, 55, 800-801. Author URL.
Hardcastle AC, Mounce LTA, Richards SH, Bachmann MO, Clark A, Henley WE, Campbell JL, Melzer D, Steel N (2015). The dynamics of quality: a national panel study of evidence-based standards. Health Services and Delivery Research, 3(11), 1-128. Full text.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract.  Author URL.  Full text.
Ble A, Delgado J, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING CARDIOVASCULAR DISEASE AND ALL-CAUSE MORTALITY IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Delgado J, Ble A, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING THE INCIDENCE\ ONSET OF DEMENTIA IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.

2014

Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D (2014). Aging children of long-lived parents experience slower cognitive decline. Alzheimer's and Dementia, 10(5), S315-S322. Abstract.
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.  Full text.
Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Abstract.  Author URL.
Melzer D, Joehanes R, Pilling L, Levy D, Munson P, Ferrucci L (2014). INFLAMMATION IN AGING: RESULTS FROM TRANSCRIPTOME-WIDE ANALYSIS IN TWO HUMAN COHORTS. GERONTOLOGIST, 54, 32-32. Author URL.
Masoli J, Winder R, Tavakoly B, Henley W, Ble A, Richards S, Melzer D (2014). OVERDIAGNOSING AND MISSING THE POINT?.  Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Steel N, Hardcastle AC, Clark A, Mounce LTA, Bachmann MO, Richards SH, Henley WE, Campbell JL, Melzer D (2014). Self-reported quality of care for older adults from 2004 to 2011: a cohort study. Age Ageing, 43(5), 716-720. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Keller MF, Reiner AP, Okada Y, van Rooij FJA, Johnson AD, Chen M-H, Smith AV, Morris AP, Tanaka T, Ferrucci L, et al (2014). Trans-ethnic meta-analysis of white blood cell phenotypes. Human Molecular Genetics, 23(25), 6944-6960.
Lin H, Joehanes R, Pilling LC, Dupuis J, Lunetta KL, Ying S-X, Benjamin EJ, Hernandez D, Singleton A, Melzer D, et al (2014). Whole blood gene expression and interleukin-6 levels. Genomics, 104(6 Pt B), 490-495. Abstract.  Author URL.  Full text.

2013

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Abstract.  Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Abstract.  Author URL.
Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, et al (2013). Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics, 22(10), 2119-2127. Abstract.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.  Full text.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract.  Author URL.  Full text.
Dutta A, Henley W, Robine J-M, Langa KM, Wallace RB, Melzer D (2013). Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol a Biol Sci Med Sci, 68(11), 1409-1418. Abstract.  Author URL.
Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2013). Microarray-based whole transcriptome expression profiling as a tool to understand human ageing. , 209-220. Abstract.
Antoniou EE, Dutta A, Langa KM, Melzer D, Llewellyn D (2013). Personality profile of the children of long-lived parents. J Gerontol B Psychol Sci Soc Sci, 68(5), 730-738. Abstract.  Author URL.
Dutta A, Wallace RB, Melzer D (2013). Response letter to Shil and colleagues. J Am Geriatr Soc, 61(12). Author URL.
Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45(10), 1238-1243. Abstract.
Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.  Full text.
Dutta A, Henley W, Pilling LC, Wallace RB, Melzer D (2013). Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Geriatr Soc, 61(3), 319-326. Abstract.  Author URL.

2012

Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mechanisms of Ageing and Development, 133(8), 556-562. Abstract.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Abstract.  Author URL.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract.  Author URL.  Full text.
Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Correction: Urinary Bisphenol a Concentration and Angiography-Defined Coronary Artery Stenosis. PLoS One, 7(11). Abstract.  Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD, Foster MC, Greenawalt DM, et al (2012). Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women. PLoS Genetics, 8(5), e1002695-e1002695.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, et al (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET, 379(9822), 1205-1213. Author URL.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Melzer D, Dutta A, Henley W, Langa K, Wallace RB, Robine J (2012). MIDDLE-AGED OFFSPRING OF LONG LIVED PARENTS IN HRS. GERONTOLOGIST, 52, 414-414. Author URL.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268. Abstract.  Full text.
Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.
Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw K-T, Wareham NJ, et al (2012). Urinary bisphenol a concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 125(12), 1482-1490. Full text.
Melzer D, Gates P, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. PLoS One, 7(8). Abstract.  Author URL.  Full text.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.

2011

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Ann Intern Med, 155(6), 392-394. Author URL.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Annals of internal medicine, 155(6), 392-394.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract.  Author URL.  Full text.
Melzer D, Harries L, Pilling L, Bandinelli S, Guralnik JM, Singleton A, Hernandez D, Ferrucci L (2011). CONFIRMATION OF MOUSE MODEL OF SARCOPENIA BY GENOME WIDE EXPRESSION STUDY IN HUMANS. GERONTOLOGIST, 51, 506-507. Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2011). Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing. Age Ageing, 40(1), 54-61. Abstract.  Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, et al (2011). Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4). Abstract.
Melzer D (2011). Environmental Medicine. JOURNAL OF PUBLIC HEALTH, 33(3), 469-469. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, et al (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLoS Genetics, 7(3), e1001324-e1001324.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, et al (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1138.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D (2011). Income and the midlife peak in common mental disorder prevalence. Psychol Med, 41(7), 1365-1372. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Lang IA, Melzer D (2011). Investigating factors of decline in cognitive function or dementia: Reply. Archives of Internal Medicine, 171(3).
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7(6). Abstract.
Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D (2011). Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc, 59(6), 963-971. Abstract.  Author URL.
Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, et al (2011). Report from the second cytomegalovirus and immunosenescence workshop. Immunity and Ageing, 8 Abstract.
Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE (2011). Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS ONE, 6(2). Abstract.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, et al (2011). The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell, 147(1), 81-94.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and Risk of Cognitive Decline in Elderly Persons EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY, 66(6), 354-355. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 66 A(1), 59-65. Abstract.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol a Biol Sci Med Sci, 66(1), 59-65. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and risk of cognitive decline in elderly persons. Obstetrical and Gynecological Survey, 66(6), 354-355.

2010

Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010). Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect, 118(5), 686-692. Abstract.  Author URL.  Full text.
Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010). Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 5(1). Abstract.  Author URL.  Full text.
Rice NE, Lang IA, Henley W, Melzer D (2010). Baby boomers nearing retirement: the healthiest generation?. Rejuvenation Res, 13(1), 105-114. Abstract.  Author URL.
Melzer D, Galloway T (2010). Burden of proof. NEW SCIENTIST, 208(2783), 26-27. Author URL.
Melzer D (2010). COMMON HUMAN GENETIC VARIATION IN PATHWAYS TO SUCCESSFUL AGEING. GERONTOLOGIST, 50, 436-436. Author URL.
Melzer D, Lang I (2010). Chronological and Functional Ageing. , 65-69.
Galloway T, Cipelli R, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Money C, McCormack P, Melzer D (2010). Daily bisphenol a excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study. Environ Health Perspect, 118(11), 1603-1608. Abstract.  Author URL.  Full text.
Dutta A, Guralnik J, Wallace R, Melzer D (2010). EARLY LIFE PREDICTORS OF EXCEPTIONAL SURVIVAL IN THE IOWA EPESE-STUDY. GERONTOLOGIST, 50, 19-19. Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)). Nature Genetics, 42(5).
Wallace RB, Dutta A, Guralnik J, Melzer D (2010). IOWA 2: BLOOD BIOCHEMISTRY AND THE PREDICTION OF SURVIVAL IN THE IOWA-EPESE. GERONTOLOGIST, 50, 20-20. Author URL.
Dalton HR, Bendall RP, Pritchard C, Henley W, Melzer D (2010). National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect, 138(2), 174-182. Abstract.  Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet, 42(2), 105-116. Abstract.  Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Hogarth S, Barton D, Melzer D (2010). The European IVD directive and genetic testing. In  (Ed) Quality Issues in Clinical Genetic Services, 49-62.  Abstract.
Williams B, Lang I, Llewellyn D, Melzer D, Rice N (2010). Vitamin D and lower reproductive tract infections in women: National Health and Nutrition Examination Survey (NHANES) 2001-2004. HIV MEDICINE, 11, 76-76. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.

2009

Brent Richards J, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics, 5(12). Abstract.
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS genetics, 5(12). Abstract.
Lang I, Scarlett A, Guralnik J, Depledge M, Melzer D, Galloway T (2009). Age-Related Impairments of Mobility Associated with Cobalt and Other Heavy Metals: Data from NHANES 1999-2004. Journal of Toxicology and Environmental Health-Part a-Current Issues, 72(6), 402-409. Abstract.
Lang IA, Scarlett A, Guralnik JM, Depledge MH, Melzer D, Galloway TS (2009). Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004. J Toxicol Environ Health A, 72(6), 402-409. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). Association of Bisphenol a with Diabetes and Other Abnormalities Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 301(7), 721-722. Author URL.
Perry JRB, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D, DIAGRAM Consortium, Saxena R, Scott LJ, et al (2009). Circulating beta-carotene levels and type 2 diabetes-cause or effect?. Diabetologia, 52(10), 2117-2121. Abstract.  Author URL.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.  Full text.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract.  Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2009). Erratum: Epidemiology of balance and dizziness in a national population: Findings from the English Longitudinal Study of Ageing (Age and Ageing 2008) vol. 37 (3) (300-305)). Age and Ageing, 38(1).
Cluett C, Melzer D (2009). Human genetic variations: Beacons on the pathways to successful ageing. Mech Ageing Dev, 130(9), 553-563. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). In reply. JAMA - Journal of the American Medical Association, 301(7), 721-722.
Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, et al (2009). Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol a Biol Sci Med Sci, 64(11), 1177-1182. Abstract.  Author URL.
Lang IA, Melzer D (2009). Moderate alcohol consumption in later life: Time for a trial?. Journal of the American Geriatrics Society, 57(6), 1110-1112.
Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K (2009). Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc, 57(10), 1776-1780. Abstract.  Author URL.
Fingleton J, Webster S, Rice N, Melzer D, Patel B (2009). RELATIONSHIP BETWEEN SERUM IGE LEVELS, SMOKING AND SMOKING CESSATION IN AN AGEING POPULATION IN THE UK (THE ELSA COHORT).  Author URL.
Parahyba MI, Stevens K, Henley W, Lang IA, Melzer D (2009). Reductions in disability prevalence among the highest income groups of older Brazilians. Am J Public Health, 99(1), 81-86. Abstract.  Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract.  Author URL.

2008

Perry JRB, Melzer D, Maggio M, Hernandez D, Singleton A, Ferrucci L, Palmer C, Bennett A, Ruokonen A, Panicker V, et al (2008). A Mendelian randomisation study provides initial evidence that sex hormone binding globulin (SHBG) levels alter type 2 diabetes risk.  Author URL.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract.  Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract.  Author URL.  Full text.
Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). Association of urinary bisphenol a concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303-1310. Abstract.  Author URL.
Melzer D, Lang IA, Scarlett A, Galloway TS (2008). Bisphenol A, Age, Ethnicity and Health Outcomes.  Author URL.
Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, et al (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57(5), 1419-1426. Abstract.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing (vol 37, pg 300, 2008). AGE AND AGEING, 37(5), 610-610. Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing. Age Ageing, 37(3), 300-305. Abstract.  Author URL.
Frayling TM, Rafiq S, Melzer D, Maggio M, Paulisso G, Hernandez D, Singleton A, Zeggini E, Morris A, Palmer CN, et al (2008). Evidence that common genetic variation altering sex hormone binding globulin levels influences type 2 diabetes risk.  Author URL.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008). Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol, 8 Abstract.  Author URL.  Full text.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.
Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ, DIAGRAM Consortium, Palmer CNA, Morris AD, McCarthy MI, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. Abstract.  Author URL.
Rafiq S, Melzer D, Weedon MN, Zeggini E, Lindgren CM, Lango H, Hattersley AT, McCarthy MI, Frayling TM, Diabetes WTCCCUKT2, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases do not alter the risk of type 2 diabetes.  Author URL.
Melzer D (2008). Genetic polymorphisms and human aging: association studies deliver.  Abstract.  Author URL.
Hall A, Hogarth S, Jader L, Melzer D, Burton H, Moorthie S (2008). Genetic susceptibility testing: a report of the Society for Genomics Policy and Population Health (SGPPH) Spring Conference 2008.  Author URL.
Melzer D, Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern RL (2008). Genetic tests for common diseases: new insights, old concerns. BMJ, 336(7644), 590-593. Author URL.
Lang IA, Melzer D (2008). LOW-DOSE HEAVY METAL EXPOSURE AND AGING IN HUMANS. GERONTOLOGIST, 48, 758-758. Author URL.
Lang IA, Melzer D (2008). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence - Reply. AGE AND AGEING, 37(1), 121-121. Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D (2008). Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing. J Am Geriatr Soc, 56(2), 191-198. Abstract.  Author URL.
Lang IA, Gibbs SJ, Steel N, Melzer D (2008). Neighbourhood deprivation and dental service use: a cross-sectional analysis of older people in England. J Public Health (Oxf), 30(4), 472-478. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D (2008). Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing, 37(4), 403-410. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Alexander K, Melzer D (2008). Obesity, physical function, and mortality in older adults. J Am Geriatr Soc, 56(8), 1474-1478. Abstract.  Author URL.
Yuan X, Waterworth D, Perry JRB, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, et al (2008). Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet, 83(4), 520-528. Abstract.  Author URL.
Steel N, Clark A, Lang IA, Wallace RB, Melzer D (2008). Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004. J Gerontol a Biol Sci Med Sci, 63(6), 629-634. Abstract.  Author URL.
Lang IA, Melzer D (2008). Reply [6]. Age and Ageing, 37(1).
Steel N, Bachmann M, Maisey S, Shekelle P, Breeze E, Marmot M, Melzer D (2008). Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England. BMJ, 337 Abstract.  Author URL.  Full text.
Hogarth S, Javitt G, Melzer D (2008). The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet, 9, 161-182. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Melzer D (2008). The importance of income to the "midlife crisis": Findings from a cross-section of 88,000 adults.  Author URL.
Lang IA, Llewellyn D, Melzer D (2008). VITAMIN D DEFICIENCY IN OLDER PEOPLE: PREVALENCE AND RELATION TO NEIGHBOURHOOD DEPRIVATION. GERONTOLOGIST, 48, 758-758. Author URL.

2007

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, et al (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun, 8(7), 552-559. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi A-M, Ferrucci L, Guralnik JM, et al (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biol Sci Med Sci, 62(1), 73-78. Abstract.  Author URL.
Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern R, Melzer D (2007). Closing the gaps--enhancing the regulation of genetic tests using responsive regulation. Food Drug Law J, 62(4), 831-848. Author URL.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract.  Author URL.
Webster SE, Rice NE, Melzer D, Patel BD (2007). Cross sectional relation between total ige levels, cigarette smoking and FEV1 in an ageing population (the ELSA cohort).  Author URL.
Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS (2007). Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol, 36(2), 358-365. Abstract.  Author URL.
Ward N, Rice NE, Melzer D, Patel BD (2007). Elevated C reactive protein levels are associated with an accelerated decline in lung function in an ageing population.  Author URL.
Melzer D, Hurst AJ, Frayling T (2007). Genetic variation and human aging: progress and prospects. J Gerontol a Biol Sci Med Sci, 62(3), 301-307. Abstract.  Author URL.
Lang I, Wallace RB, Huppert FA, Melzer D (2007). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence. Age Ageing, 36(3), 256-261. Abstract.  Author URL.
Lang IA, Guralnik JM, Melzer D (2007). Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight. J Am Geriatr Soc, 55(11), 1836-1841. Abstract.  Author URL.
Brune JC, Tormin A, Melzer D, Borg A, Scheding S (2007). Propagation of human mesenchymal stem cells under defined serum-free culture conditions.  Author URL.
Lang IA, Rice NE, Wallace RB, Guralnik JM, Melzer D (2007). Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing. Age Ageing, 36(6), 638-643. Abstract.  Author URL.
Lang I, Gardener E, Huppert FA, Melzer D (2007). Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England. Public Health, 121(7), 518-524. Abstract.  Author URL.
Lang I, Guralnik J, Wallace RB, Melzer D (2007). What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts. J Am Geriatr Soc, 55(1), 49-57. Abstract.  Author URL.

2006

Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001. Abstract.  Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract.  Author URL.  Full text.
Brune JC, Melzer D, Neumann U, Jacobsen S, Scheding S (2006). Identification and characterisation of human mesenchymal stem cell subpopulations.  Author URL.
Villamil E, Huppert FA, Melzer D (2006). Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey. Psychol Med, 36(7), 999-1009. Abstract.  Author URL.
Gill SC, Butterworth P, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Mental health and the timing of men's retirement. Soc Psychiatry Psychiatr Epidemiol, 41(7), 515-522. Abstract.  Author URL.
Gardener EA, Huppert FA, Guralnik JM, Melzer D (2006). Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey. J Gen Intern Med, 21(10), 1091-1096. Abstract.  Author URL.
Steel N, Melzer D, Gardener E, McWilliams B (2006). Need for and receipt of hip and knee replacement--a national population survey. Rheumatology (Oxford), 45(11), 1437-1441. Abstract.  Author URL.
Melzer D, Tormin A, Neumann U, Ebell W, Seeger K, Brummendorf T, Gaedicke G, Scheding S (2006). Normal human mesenchymal stem cells are severely affected by imatinib in vitro.  Author URL.
Butterworth P, Gill SC, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Retirement and mental health: analysis of the Australian national survey of mental health and well-being. Soc Sci Med, 62(5), 1179-1191. Abstract.  Author URL.
Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet, 7 Abstract.  Author URL.  Full text.
Angleman SB, Harris TB, Melzer D (2006). The role of waist circumference in predicting disability in periretirement age adults. Int J Obes (Lond), 30(2), 364-373. Abstract.  Author URL.

2005

Angleman S, Harris T, Melzer D (2005). C-reactive protein, obesity, and risk of peri-retirement age disability.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). Disability among elderly women in Brazil. Revista de Saude Publica, 39(3), 383-391. Abstract.
Melzer D, Guralnik J, Wallace R (2005). Epidemiologic studies on disability prevention - Perspectives from the English longitudinal study of ageing (ELSA) and the US health and retirement study. GERONTOLOGIST, 45, 153-154. Author URL.
Melzer D, Guralnik J, Pharoah P (2005). Genetic variation and human aging: Large-scale associations study in the EPIC Cohort. GERONTOLOGIST, 45, 249-249. Author URL.
Melzer D, Gardener E, Guralnik JM (2005). Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing. Age Ageing, 34(6), 594-602. Abstract.  Author URL.
Melzer D, Raven A, Ling T, Detmer D, Zimmern R (2005). Pharmacogenetics: policy needs for personal prescribing. J Health Serv Res Policy, 10(1), 40-44. Abstract.  Author URL.
Brugha T, Singleton N, Meltzer H, Bebbington P, Farrell M, Jenkins R, Coid J, Fryers T, Melzer D, Lewis G, et al (2005). Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity. Am J Psychiatry, 162(4), 774-780. Abstract.  Author URL.
Melzer D, Dik MG, van Kamp GJ, Jonker C, Deeg DJ (2005). The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people. J Gerontol a Biol Sci Med Sci, 60(10), 1319-1323. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R, Brugha T (2005). The distribution of the common mental disorders: social inequalities in Europe. Clin Pract Epidemiol Ment Health, 1 Abstract.  Author URL.  Full text.
Buxton JW, Singleton N, Melzer D (2005). The mental health of early retirees-- national interview survey in Britain. Soc Psychiatry Psychiatr Epidemiol, 40(2), 99-105. Abstract.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). [Disability among elderly women in Brazil]. Rev Saude Publica, 39(3), 383-390. Abstract.  Author URL.

2004

Melzer D, Tom BDM, Brugha T, Fryers T, Gatward R, Grounds A, Johnson T, Meltzer H (2004). Access to medium secure psychiatric care in England and Wales. 1: a national survey of admission assessments. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 7-31. Author URL.
Melzer D, Buxton J, Villamil E (2004). Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey. Soc Psychiatry Psychiatr Epidemiol, 39(1), 33-38. Abstract.  Author URL.
Steel N, Melzer D, Shekelle PG, Wenger NS, Forsyth D, McWilliams BC (2004). Developing quality indicators for older adults: transfer from the USA to the UK is feasible. Qual Saf Health Care, 13(4), 260-264. Abstract.  Author URL.
Angleman S, Harris T, Melzer D (2004). Obesity more than doubles mobility disability in peri-retirement age British men and women. GERONTOLOGIST, 44, 352-353. Author URL.
Melzer D, Parahyba MI (2004). Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey. Age Ageing, 33(3), 253-259. Abstract.  Author URL.
Brugha TS, Bebbington PE, Singleton N, Melzer D, Jenkins R, Lewis G, Farrell M, Bhugra D, Lee A, Meltzer H, et al (2004). Trends in service use and treatment for mental disorders in adults throughout Great Britain. Br J Psychiatry, 185, 378-384. Abstract.  Author URL.
Melzer D, Lan T-Y, Tom BDM, Deeg DJH, Guralnik JM (2004). Variation in thresholds for reporting mobility disability between national population subgroups and studies. J Gerontol a Biol Sci Med Sci, 59(12), 1295-1303. Abstract.  Author URL.

2003

Ramana R, Paykel ES, Melzer D, Mehta MA, Surtees PG (2003). Aftercare of depressed inpatients--service delivery and unmet needs. Soc Psychiatry Psychiatr Epidemiol, 38(3), 109-115. Abstract.  Author URL.
Melzer D, Detmer D, Zimmern R (2003). Pharmacogenetics and public policy: expert views in Europe and North America. Pharmacogenomics, 4(6), 689-691. Abstract.  Author URL.
Melzer D, Guralnik JM, Brock D (2003). Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life. Aging Clin Exp Res, 15(1), 60-66. Abstract.  Author URL.
Melzer D, Zimmern RL, Detmer DE, Ling T (2003). Regulatory options for pharmacogenetics. Pharmacogenomics, 4(5), 527-530. Author URL.
Lan T-Y, Deeg DJH, Guralnik JM, Melzer D (2003). Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam. J Gerontol a Biol Sci Med Sci, 58(8), 721-727. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R (2003). Social inequalities and the common mental disorders: a systematic review of the evidence. Soc Psychiatry Psychiatr Epidemiol, 38(5), 229-237. Abstract.  Author URL.
Melzer D, Fryers T, Jenkins R, Brugha T, McWilliams B (2003). Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain. Soc Psychiatry Psychiatr Epidemiol, 38(5), 238-243. Abstract.  Author URL.
Melzer D, Lan T-Y, Guralnik JM (2003). The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study. Age Ageing, 32(6), 619-625. Abstract.  Author URL.

2002

Melzer D, Tom BDM, Brugha TS, Fryers T, Meltzer H (2002). Common mental disorder symptom counts in populations: are there distinct case groups above epidemiological cut-offs?. Psychol Med, 32(7), 1195-1201. Abstract.  Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation - Genetics could drive a new wave of medicalisation if genetic tests are accepted without appropriate clinical evaluation. BRITISH MEDICAL JOURNAL, 324(7342), 863-864. Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation. BMJ, 324(7342), 863-864. Author URL.
Melzer D (2002). Mental health outcome measures, 2nd edition. JOURNAL OF PUBLIC HEALTH MEDICINE, 24(1), 71-72. Author URL.
Lan T-Y, Melzer D, Tom BDM, Guralnik JM (2002). Performance tests and disability: developing an objective index of mobility-related limitation in older populations. J Gerontol a Biol Sci Med Sci, 57(5), M294-M301. Abstract.  Author URL.

2001

Melzer D, Izmirlian G, Leveille SG, Guralnik JM (2001). Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery. J Gerontol B Psychol Sci Soc Sci, 56(5), S294-S301. Abstract.  Author URL.
Bedford S, Melzer D, Guralnik J (2001). Problem behavior in the last year of life: prevalence, risks, and care receipt in older Americans. J Am Geriatr Soc, 49(5), 590-595. Abstract.  Author URL.

2000

Birks JS, Melzer D, Beppu H (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane database of systematic reviews (Online)(4). Abstract.
Birks J S, Melzer D (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane Database Syst Rev(2). Abstract.  Author URL.
Leveille SG, Penninx BW, Melzer D, Izmirlian G, Guralnik JM (2000). Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, recovery, and mortality.  Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (2000). Socioeconomic status and the expectation of disability in old age: estimates for England. J Epidemiol Community Health, 54(4), 286-292. Abstract.  Author URL.

1999

Melzer D, Watters L, Paykel E, Singh K, Gormley N (1999). Factors explaining the use of psychiatric services by general practices. Br J Gen Pract, 49(448), 887-891. Abstract.  Author URL.
Melzer D (1999). Health economics of dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 14(5), 405-406. Author URL.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: Adequacy and relation to outcome. British Journal of Psychiatry, 174(FEB.), 128-134. Abstract.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: adequacy and relation to outcome. Br J Psychiatry, 174, 128-134. Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (1999). Profile of disability in elderly people: estimates from a longitudinal population study. BMJ, 318(7191), 1108-1111. Abstract.  Author URL.

1998

Melzer D (1998). Health policy and the scientific literature: What kinds of evidence should we expect to find?. Evidence-based Healthcare, 2(1), 2-3.
Melzer D (1998). New drug treatment for Alzheimer's disease: lessons for healthcare policy. BMJ, 316(7133), 762-764. Author URL.
Melzer D (1998). Patent protection for medical technologies: why some and not others?. Lancet, 351(9101), 518-519. Author URL.
Melzer D (1998). Personal paper - New drug treatment for Alzheimer's disease: lessons for healthcare policy. BRITISH MEDICAL JOURNAL, 316(7133), 762-764. Author URL.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners. BMJ, 317(7165), 1025-1026.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners: a persistent problem that needs a concerted and long term response. BMJ, 317(7165), 1025-1026. Author URL.
Melzer D (1998). Some of the barriers to evidence-based decision-making can be overcome without additional resources. Evidence-based Healthcare, 2(1).

1997

Melzer D, Ely M, Brayne C (1997). Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales. BMJ, 315(7106). Author URL.
Hanson RM, Melzer DJ (1997). Estrogen replacement therapy: new options, continuing concerns. JAMA, 277(19). Author URL.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. International Journal of Geriatric Psychiatry, 12(9), 883-887.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. Int J Geriatr Psychiatry, 12(9), 883-887. Abstract.  Author URL.

1996

Melzer D, Bedford S, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). Carers and the monitoring of psychogeriatric community teams. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1057-1061. Author URL.
Bedford S, Melzer D, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). What becomes of people with dementia referred to community psychogeriatric teams?. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1051-1056. Author URL.

1995

Pharoah PD, Melzer D (1995). Variation in prescribing of hypnotics, anxiolytics and antidepressants between 61 general practices. Br J Gen Pract, 45(400), 595-599. Abstract.  Author URL.

1994

Conway AS, Melzer D, Hale AS (1994). The outcome of targeting community mental health services: evidence from the West Lambeth schizophrenia cohort. BMJ, 308(6929), 627-630. Abstract.  Author URL.

1993

Melzer D (1993). Diversion from custody. BMJ, 306(6870). Author URL.

1992

Hogman G, Melzer D (1992). Mental health. Talk--don't inject. Nurs Times, 88(49), 61-62. Author URL.

1991

Melzer D, Hale AS, Malik SJ, Hogman GA, Wood S (1991). Community care for patients with schizophrenia one year after hospital discharge. BMJ, 303(6809), 1023-1026. Abstract.  Author URL.

1990

Melzer D (1990). An evaluation of a respite care unit for elderly people with dementia: framework and some results. Health Trends, 22(2), 64-67. Abstract.  Author URL.

1989

Melzer D (1989). Paying for health services: a public health view. Public Health, 103(5), 363-367. Abstract.  Author URL.

1988

Swerdlow AJ, Melzer D (1988). The value of England and Wales congenital malformation notification scheme data for epidemiology: male genital tract malformations. J Epidemiol Community Health, 42(1), 8-13. Abstract.  Author URL.

Awards

Harkness Fellowship, 1998/9, Commonwealth Fund of New York: Guest Researcher, US National Institute on Aging, August 1998 to July 1999

UK National Public Health Career Scientist Award, 2001

Director’s Collaboration Award from the US Food and Drug Administration (for work on clinical evaluation of genetic testing), July 2006


Committee/panel activities

Member of Executive, NIHR National School of Public Health Research, England 2012 (planned to 2017)


Editorial responsibilities

Associate Editor, (US) Journals of Gerontology: Medical Sciences (November 2004 - )

Invited Committee member for 2013 theme issue on aging: Epidemiological reviews


Invited lectures

British Geriatric Society meeting, Harrogate, November 2012: Facing the Facts – joint session with Age UK / Dr David Oliver, National Clinical Director for Older People

European Union Geriatric Medicine Society conference, Brussels, September 2012: Invited talk on gene expression and ageing

LIFE Study Symposium, Washington DC, March 2012: Invited talk on gene expression and ageing

American Geriatrics Society, Seattle, May 2012: Invited talk on gene expression and ageing


Media Coverage

Extensive coverage for studies of Bisphenol A and adult health

Coverage for several group outputs, including on vitamin D and cognitive decline

Undergraduate Teaching

  • UEMS academic tutor for years 3 and 4 academic tutees
  • Research in Action Special Study Unit teaching for UEMS medical students

Postgraduate Teaching

  • PhD supervisor

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