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Dr David Llewellyn

Dr David Llewellyn

Senior Research Fellow

6018

+44 (0) 1392 726018

Dr David Llewellyn is a Senior Research Fellow in Clinical Epidemiology at the University of Exeter Medical School. Dr Llewellyn has a background in neuropsychology and is a Chartered Psychologist and an Associate Fellow of the British Psychological Society. His research focuses on the risk factors, overlapping pathologies and functional consequences of Alzheimer’s disease and dementia, particularly where vascular and metabolic pathways are implicated. He conducted the first population-based studies to identify the associations between vitamin D deficiency and cognitive impairment in the Health Survey for England and cognitive decline in the InCHIANTI study, both of which were widely reported in the international media. More recently he has begun to investigate how systems medicine can be applied to generate novel ideas and improve the way in which we conceptualize neurocognitive disorders in order to improve diagnosis, treatment and prevention. Dr. Llewellyn was the first UK-based researcher to receive a New Investigator Award from the Alzheimer’s Association and also receives support from the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care for the South West Peninsula (PenCLAHRC) and other funders.

Research

Research projects

1. Vitamin D and neurocognitive dysfunction

We are conducting an official Ancillary Study to the NHLBI-funded Cardiovascular Health Study (CHS) investigating vitamin D levels in relation to Alzheimer‘s disease, dementia and neuroimaging abnormalities (supported by the Alzheimer‘s Association, the NIHR Peninsula Collaboration for Leadership in Applied Health Research and Care [PenCLAHRC] and other funders). This follows on from our earlier work which established that low serum vitamin D levels increase the odds of cognitive impairment in older English and US adults, and increases the risk of cognitive decline in older Italian adults. Vitamin D supplementation offers an inexpensive and well tolerated way to increase vitamin D levels thus raising new possibilities for dementia prevention and treatment.

 

2. Metabolic dysfunction, lifestyle factors and dementia

It is now estimated that up to half of all cases of dementia could be prevented by targeting modifiable risk factors. This programme of work therefore investigates a range of potentially modifiable risk factors for dementia including parathyroid hormone levels, leptin, obesity, and alcohol consumption (supported by the NIHR PenCLAHRC, the Norman Family Charitable Trust and other funders). This includes a Health and Retirement Study (HRS) 2014 Experimental Module on alcohol consumption and drinking history.

 

3. Brief cognitive assessment and diagnostic pathways for dementia

Dr Llewellyn joined the Scientific Advisory Board of the English Longitudinal Study of Ageing (ELSA) in 2013 and is collaborating with the team to improve the cognitive assessments in future waves of data collection. Ongoing projects also include a diagnostic accuracy study of brief cognitive assessments suitable for use in primary care, and a test development project investigating whether existing measures can be improved by using contemporary psychometric approaches. We are also interested in whether the potential harms of dementia screening can be minimized by using an adaptive targeted approach whilst improving dementia diagnosis rates by enhancing clinical decision making.

 

4. Vascular aspects of cognitive impairment and dementia

 We are currently investigating the vascular aspects of neurocognitive dysfunction in a range of clinical and population-based studies including the HRS (supported by the Mary Kinross Charitable Trust and other funders). For example, we are currently conducting a systematic review and Monte Carlo simulation study incorporating quasi-experimental analyses to establish whether coronary artery bypass graft surgery (CABG) increases the long-term risk of cognitive decline or dementia. 

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Ukoumunne OC, 1. Farrand P, Woodford J, Llewellyn D, Anderson M, Venkatasubramanian S, Adlam A, Dickens C (2016). Behavioural activation written self-help to improve mood, wellbeing and quality of life in people with dementia supported by informal carers (PROMOTE): study protocol for a single-arm feasibility study. Pilot and Feasibility Studies Full text.
van Schoor NM, Comijs HC, Llewellyn DJ, Lips P (2016). Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning. Int Psychogeriatr, 28(5), 759-768. Abstract.  Author URL.  Full text.
Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, et al (2016). GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry, 21(2), 189-197. Abstract.  Author URL.
Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, et al (2016). Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med, 46(8), 1613-1623. Abstract.  Author URL.
Kuzma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PHM, Kestenbaum BR, Kuller LH, et al (2016). Vitamin D and Memory Decline: Two Population-Based Prospective Studies. J Alzheimers Dis, 50(4), 1099-1108. Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR, Kuller LH, Langa KM, et al (2016). Vitamin D and Risk of Neuroimaging Abnormalities. PLoS One, 11(5). Abstract.  Author URL.  Full text.
Annweiler C, Dursun E, Féron F, Gezen-Ak D, Kalueff AV, Littlejohns T, Llewellyn DJ, Millet P, Scott T, Tucker KL, et al (2015). 'Vitamin D and cognition in older adults': Updated international recommendations. Journal of Internal Medicine, 277(1), 45-57. Abstract.  Full text.
Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuzma E, Kos K, Llewellyn DJ (2015). Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS One, 10(5). Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.
Hubbard RE, Goodwin VA, Llewellyn DJ, Warmoth K, Lang IA (2014). Frailty, financial resources and subjective well-being in later life. Archives of Gerontology and Geriatrics, 58(3), 364-369.
Hubbard RE, Goodwin VA, Llewellyn DJ, Warmoth K, Lang IA (2014). Frailty, financial resources and subjective well-being in later life. Archives of Gerontology and Geriatrics, 58(3), 364-369. Abstract.  Full text.
Kuzma E, Llewellyn DJ, Langa KM, Wallace RB, Lang IA (2014). History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study. Am J Geriatr Psychiatry, 22(10), 1047-1054. Abstract.  Author URL.  Full text.
Woodford J, Farrand P, Watkins ER, Richards DA, Llewellyn DJ (2014). Supported cognitive-behavioural self-help versus treatment-as-usual for depressed informal carers of stroke survivors (CEDArS): study protocol for a feasibility randomized controlled trial. Trials, 157 Abstract.  Author URL.
Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract.  Author URL.  Full text.
Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Annweiler C, Llewellyn DJ, Beauchet O (2013). Low serum vitamin D concentrations in Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis, 33(3), 659-674. Abstract.  Author URL.
Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ (2013). Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology, 24(4), 479-489. Abstract.
Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard-Devantoy S, Duque G, Beauchet O (2013). Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis, 37(1), 147-171. Abstract.  Author URL.
Woodford J, Farrand P, Richards D, Llewellyn DJ (2013). Psychological treatments for common mental health problems experienced by informal carers of adults with chronic physical health conditions (Protocol). Syst Rev, 2 Abstract.  Author URL.  Full text.
Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, et al (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-A review of recent evidence. Autoimmunity Reviews, 12(10), 976-989. Abstract.
Brouwer-Brolsma EM, Bischoff-Ferrari HA, Bouillon R, Feskens EJM, Gallagher CJ, Hypponen E, Llewellyn DJ, Stoecklin E, Dierkes J, Kies AK, et al (2013). Vitamin D: Do we get enough?: a discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporosis International, 24(5), 1567-1577. Abstract.
Brouwer-Brolsma EM, Bischoff-Ferrari HA, Bouillon R, Feskens EJM, Gallagher CJ, Hypponen E, Llewellyn DJ, Stoecklin E, Dierkes J, Kies AK, et al (2013). Vitamin D: do we get enough? a discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int, 24(5), 1567-1577. Abstract.  Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Stephan BCM, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C (2012). The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Molecular Psychiatry, 17(11), 1056-1076. Abstract.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.
Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P (2012). Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology, 79(13), 1397-1405. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D (2011). Income and the midlife peak in common mental disorder prevalence. Psychol Med, 41(7), 1365-1372. Abstract.  Author URL.
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM (2011). Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study. J Am Geriatr Soc, 59(3), 473-481. Abstract.  Author URL.
Balion CM, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina PS (2011). Vitamin D and cognition: a meta-analysis. CLINICAL BIOCHEMISTRY, 44(13), 1166-1166. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 66 A(1), 59-65. Abstract.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol a Biol Sci Med Sci, 66(1), 59-65. Abstract.  Author URL.
Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-639. Abstract.  Author URL.
Zivin K, Llewellyn DJ, Lang IA, Vijan S, Kabeto MU, Miller EM, Langa KM (2010). Depression among older adults in the United States and England. Am J Geriatr Psychiatry, 18(11), 1036-1044. Abstract.  Author URL.
Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K (2010). Frailty, body mass index, and abdominal obesity in older people. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 65 A(4), 377-381. Abstract.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Sanchez X, Boschker MSJ, Llewellyn DJ (2010). Pre-performance psychological states and performance in an elite climbing competition. Scand J Med Sci Sports, 20(2), 356-363. Abstract.  Author URL.
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM (2010). Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc, 58(2), 330-337. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Friedland RP, Lang IA (2010). Serum Albumin Concentration and Cognitive Impairment. CURRENT ALZHEIMER RESEARCH, 7(1), 91-96. Author URL.
Llewellyn DJ, Langa KM, Friedland RP, Lang IA (2010). Serum albumin concentration and cognitive impairment. Curr Alzheimer Res, 7(1), 91-96. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM (2010). Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther, 2(3). Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.
Langa KM, Llewellyn DJ, Lang IA, Weir DR, Wallace RB, Kabeto MU, Huppert FA (2009). Cognitive health among older adults in the United States and in England. BMC Geriatr, 9 Abstract.  Author URL.  Full text.
Potter GG, Plassman BL, Burke JR, Kabeto MU, Langa KM, Llewellyn DJ, Rogers MAM, Steffens DC (2009). Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites. Alzheimers Dement, 5(6), 445-453. Abstract.  Author URL.
Llewellyn DJ, Lang LA, Langa KM, Naughton F, Matthews FE (2009). Exposure to secondhand smoke and cognitive impairment in non-smokers: National cross sectional study with cotinine measurement. BMJ (Online), 338(7695). Abstract.  Full text.
Llewellyn DJ, Matthews FE (2009). Increasing levels of semantic verbal fluency in elderly English adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 16(4), 433-445. Abstract.  Author URL.
Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K (2009). Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc, 57(10), 1776-1780. Abstract.  Author URL.
Rogers MAM, Plassman BL, Kabeto M, Fisher GG, McArdle JJ, Llewellyn DJ, Potter GG, Langa KM (2009). Parental education and late-life dementia in the United States. J Geriatr Psychiatry Neurol, 22(1), 71-80. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Lang IA (2009). Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol, 22(3), 188-195. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Huppert FA (2008). Cognitive function and psychological well-being: findings from a population-based cohort. Age Ageing, 37(6), 685-689. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008). Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol, 8 Abstract.  Author URL.  Full text.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D (2008). Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing. J Am Geriatr Soc, 56(2), 191-198. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D (2008). Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing, 37(4), 403-410. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Alexander K, Melzer D (2008). Obesity, physical function, and mortality in older adults. J Am Geriatr Soc, 56(8), 1474-1478. Abstract.  Author URL.
Llewellyn DJ, Sanchez X, Asghar A, Jones G (2008). Self-efficacy, risk taking and performance in rock climbing. Personality and Individual Differences, 45(1), 75-81. Abstract.
Jones G, Asghar A, Llewellyn DJ (2008). The epidemiology of rock-climbing injuries. Br J Sports Med, 42(9), 773-778. Abstract.  Author URL.
Llewellyn DJ (2008). The psychology of risk taking: toward the integration of psychometric and neuropsychological paradigms. Am J Psychol, 121(3), 363-376. Abstract.  Author URL.

Conferences

Hubbard RE, Lang IA, Goodwin V, Llewellyn DJ (2012). CHANGES IN MEDICATION PRESCRIBING FOR THE OLDEST OLD.  Author URL.
Hubbard RE, Lang IA, Goodwin V, Llewellyn DJ (2012). FRAILTY AND OBESITY IN LATER LIFE.  Author URL.
Goodwin VA, Hubbard RE, Llewellyn DJ, Lang IA (2012). HEALTH, WEALTH AND WELL-BEING IN OLDER PEOPLE.  Author URL.
Lang IA, Goodwin V, Hubbard R, Llewellyn DJ (2012). HEALTHY BEHAVIOURS IN MIDDLE AGE AND LONG-TERM CONSEQUENCES FOR MORTALITY, PHYSICAL AND COGNITIVE FUNCTION, AND MENTAL HEALTH.  Author URL.
Lang I, Hubbard R, Goodwin V, Llewellyn DJ (2011). DOES FRAILTY EXPLAIN "AGE-RELATED" DECLINES IN WELLBEING IN LATER LIFE?.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Xie J, Huppert FA (2009). Stroke risk profile and reduced cognitive function: Findings from the English Longitudinal Study of Ageing.  Author URL.
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Langa KM (2009). THE QUANTITY OF ACTIVE HELP AND SUPERVISION PROVIDED TO OLDER ADULTS WITH NEUROPSYCHIATRIC SYMPTOMS: THE AGING, DEMOGRAPHICS, AND MEMORY STUDY (ADAMS).  Author URL.
Llewellyn DJ, Langa KM, Lang I (2009). VITAMIN D DEFICIENCY AND COGNITIVE DYSFUNCTION IN OLDER ADULTS.  Author URL.
Llewellyn DJ, Sanchez X (2008). Individual differences and risk taking in rock climbing.  Abstract.
Llewellyn DJ, Lang I, Lang K, Huppert F (2008). Psychological well-being is associated with higher levels of cognitive function.  Author URL.
Lang IA, Llewellyn DJ, Melzer D (2008). The importance of income to the "midlife crisis": Findings from a cross-section of 88,000 adults.  Author URL.

Publications by year


2016

Ukoumunne OC, 1. Farrand P, Woodford J, Llewellyn D, Anderson M, Venkatasubramanian S, Adlam A, Dickens C (2016). Behavioural activation written self-help to improve mood, wellbeing and quality of life in people with dementia supported by informal carers (PROMOTE): study protocol for a single-arm feasibility study. Pilot and Feasibility Studies Full text.
van Schoor NM, Comijs HC, Llewellyn DJ, Lips P (2016). Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning. Int Psychogeriatr, 28(5), 759-768. Abstract.  Author URL.  Full text.
Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, et al (2016). GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry, 21(2), 189-197. Abstract.  Author URL.
Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, et al (2016). Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med, 46(8), 1613-1623. Abstract.  Author URL.
Kuzma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PHM, Kestenbaum BR, Kuller LH, et al (2016). Vitamin D and Memory Decline: Two Population-Based Prospective Studies. J Alzheimers Dis, 50(4), 1099-1108. Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR, Kuller LH, Langa KM, et al (2016). Vitamin D and Risk of Neuroimaging Abnormalities. PLoS One, 11(5). Abstract.  Author URL.  Full text.

2015

Annweiler C, Dursun E, Féron F, Gezen-Ak D, Kalueff AV, Littlejohns T, Llewellyn DJ, Millet P, Scott T, Tucker KL, et al (2015). 'Vitamin D and cognition in older adults': Updated international recommendations. Journal of Internal Medicine, 277(1), 45-57. Abstract.  Full text.
Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuzma E, Kos K, Llewellyn DJ (2015). Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS One, 10(5). Abstract.  Author URL.  Full text.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.  Full text.

2014

Hubbard RE, Goodwin VA, Llewellyn DJ, Warmoth K, Lang IA (2014). Frailty, financial resources and subjective well-being in later life. Archives of Gerontology and Geriatrics, 58(3), 364-369.
Hubbard RE, Goodwin VA, Llewellyn DJ, Warmoth K, Lang IA (2014). Frailty, financial resources and subjective well-being in later life. Archives of Gerontology and Geriatrics, 58(3), 364-369. Abstract.  Full text.
Kuzma E, Llewellyn DJ, Langa KM, Wallace RB, Lang IA (2014). History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study. Am J Geriatr Psychiatry, 22(10), 1047-1054. Abstract.  Author URL.  Full text.
Woodford J, Farrand P, Watkins ER, Richards DA, Llewellyn DJ (2014). Supported cognitive-behavioural self-help versus treatment-as-usual for depressed informal carers of stroke survivors (CEDArS): study protocol for a feasibility randomized controlled trial. Trials, 157 Abstract.  Author URL.
Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract.  Author URL.  Full text.

2013

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Annweiler C, Llewellyn DJ, Beauchet O (2013). Low serum vitamin D concentrations in Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis, 33(3), 659-674. Abstract.  Author URL.
Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ (2013). Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology, 24(4), 479-489. Abstract.
Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard-Devantoy S, Duque G, Beauchet O (2013). Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis, 37(1), 147-171. Abstract.  Author URL.
Woodford J, Farrand P, Richards D, Llewellyn DJ (2013). Psychological treatments for common mental health problems experienced by informal carers of adults with chronic physical health conditions (Protocol). Syst Rev, 2 Abstract.  Author URL.  Full text.
Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, et al (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-A review of recent evidence. Autoimmunity Reviews, 12(10), 976-989. Abstract.
Brouwer-Brolsma EM, Bischoff-Ferrari HA, Bouillon R, Feskens EJM, Gallagher CJ, Hypponen E, Llewellyn DJ, Stoecklin E, Dierkes J, Kies AK, et al (2013). Vitamin D: Do we get enough?: a discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporosis International, 24(5), 1567-1577. Abstract.
Brouwer-Brolsma EM, Bischoff-Ferrari HA, Bouillon R, Feskens EJM, Gallagher CJ, Hypponen E, Llewellyn DJ, Stoecklin E, Dierkes J, Kies AK, et al (2013). Vitamin D: do we get enough? a discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int, 24(5), 1567-1577. Abstract.  Author URL.

2012

Hubbard RE, Lang IA, Goodwin V, Llewellyn DJ (2012). CHANGES IN MEDICATION PRESCRIBING FOR THE OLDEST OLD.  Author URL.
Hubbard RE, Lang IA, Goodwin V, Llewellyn DJ (2012). FRAILTY AND OBESITY IN LATER LIFE.  Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.  Full text.
Goodwin VA, Hubbard RE, Llewellyn DJ, Lang IA (2012). HEALTH, WEALTH AND WELL-BEING IN OLDER PEOPLE.  Author URL.
Lang IA, Goodwin V, Hubbard R, Llewellyn DJ (2012). HEALTHY BEHAVIOURS IN MIDDLE AGE AND LONG-TERM CONSEQUENCES FOR MORTALITY, PHYSICAL AND COGNITIVE FUNCTION, AND MENTAL HEALTH.  Author URL.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.  Full text.
Stephan BCM, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C (2012). The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Molecular Psychiatry, 17(11), 1056-1076. Abstract.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.
Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P (2012). Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology, 79(13), 1397-1405. Abstract.  Author URL.

2011

Lang I, Hubbard R, Goodwin V, Llewellyn DJ (2011). DOES FRAILTY EXPLAIN "AGE-RELATED" DECLINES IN WELLBEING IN LATER LIFE?.  Author URL.
Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D (2011). Income and the midlife peak in common mental disorder prevalence. Psychol Med, 41(7), 1365-1372. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Lang IA, Melzer D (2011). Investigating factors of decline in cognitive function or dementia: Reply. Archives of Internal Medicine, 171(3).
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM (2011). Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study. J Am Geriatr Soc, 59(3), 473-481. Abstract.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Balion CM, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina PS (2011). Vitamin D and cognition: a meta-analysis. CLINICAL BIOCHEMISTRY, 44(13), 1166-1166. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 66 A(1), 59-65. Abstract.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol a Biol Sci Med Sci, 66(1), 59-65. Abstract.  Author URL.
Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-639. Abstract.  Author URL.

2010

Zivin K, Llewellyn DJ, Lang IA, Vijan S, Kabeto MU, Miller EM, Langa KM (2010). Depression among older adults in the United States and England. Am J Geriatr Psychiatry, 18(11), 1036-1044. Abstract.  Author URL.
Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K (2010). Frailty, body mass index, and abdominal obesity in older people. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 65 A(4), 377-381. Abstract.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Sanchez X, Boschker MSJ, Llewellyn DJ (2010). Pre-performance psychological states and performance in an elite climbing competition. Scand J Med Sci Sports, 20(2), 356-363. Abstract.  Author URL.
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM (2010). Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc, 58(2), 330-337. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Friedland RP, Lang IA (2010). Serum Albumin Concentration and Cognitive Impairment. CURRENT ALZHEIMER RESEARCH, 7(1), 91-96. Author URL.
Llewellyn DJ, Langa KM, Friedland RP, Lang IA (2010). Serum albumin concentration and cognitive impairment. Curr Alzheimer Res, 7(1), 91-96. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM (2010). Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther, 2(3). Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.

2009

Langa KM, Llewellyn DJ, Lang IA, Weir DR, Wallace RB, Kabeto MU, Huppert FA (2009). Cognitive health among older adults in the United States and in England. BMC Geriatr, 9 Abstract.  Author URL.  Full text.
Potter GG, Plassman BL, Burke JR, Kabeto MU, Langa KM, Llewellyn DJ, Rogers MAM, Steffens DC (2009). Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites. Alzheimers Dement, 5(6), 445-453. Abstract.  Author URL.
Llewellyn DJ, Lang LA, Langa KM, Naughton F, Matthews FE (2009). Exposure to secondhand smoke and cognitive impairment in non-smokers: National cross sectional study with cotinine measurement. BMJ (Online), 338(7695). Abstract.  Full text.
Llewellyn DJ, Matthews FE (2009). Increasing levels of semantic verbal fluency in elderly English adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 16(4), 433-445. Abstract.  Author URL.
Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K (2009). Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc, 57(10), 1776-1780. Abstract.  Author URL.
Rogers MAM, Plassman BL, Kabeto M, Fisher GG, McArdle JJ, Llewellyn DJ, Potter GG, Langa KM (2009). Parental education and late-life dementia in the United States. J Geriatr Psychiatry Neurol, 22(1), 71-80. Abstract.  Author URL.
Llewellyn DJ, Langa KM, Lang IA (2009). Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol, 22(3), 188-195. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Xie J, Huppert FA (2009). Stroke risk profile and reduced cognitive function: Findings from the English Longitudinal Study of Ageing.  Author URL.
Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Langa KM (2009). THE QUANTITY OF ACTIVE HELP AND SUPERVISION PROVIDED TO OLDER ADULTS WITH NEUROPSYCHIATRIC SYMPTOMS: THE AGING, DEMOGRAPHICS, AND MEMORY STUDY (ADAMS).  Author URL.
Llewellyn DJ, Langa KM, Lang I (2009). VITAMIN D DEFICIENCY AND COGNITIVE DYSFUNCTION IN OLDER ADULTS.  Author URL.

2008

Llewellyn DJ, Naughton F (2008). Antipsychotic-induced weight gain in patients with schizophrenia. JAMA, 299(16), 1898-1899. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Huppert FA (2008). Cognitive function and psychological well-being: findings from a population-based cohort. Age Ageing, 37(6), 685-689. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008). Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol, 8 Abstract.  Author URL.  Full text.
Llewellyn DJ, Sanchez X (2008). Individual differences and risk taking in rock climbing.  Abstract.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D (2008). Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing. J Am Geriatr Soc, 56(2), 191-198. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D (2008). Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing, 37(4), 403-410. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Alexander K, Melzer D (2008). Obesity, physical function, and mortality in older adults. J Am Geriatr Soc, 56(8), 1474-1478. Abstract.  Author URL.
Llewellyn DJ, Lang I, Lang K, Huppert F (2008). Psychological well-being is associated with higher levels of cognitive function.  Author URL.
Llewellyn DJ, Sanchez X, Asghar A, Jones G (2008). Self-efficacy, risk taking and performance in rock climbing. Personality and Individual Differences, 45(1), 75-81. Abstract.
Jones G, Asghar A, Llewellyn DJ (2008). The epidemiology of rock-climbing injuries. Br J Sports Med, 42(9), 773-778. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Melzer D (2008). The importance of income to the "midlife crisis": Findings from a cross-section of 88,000 adults.  Author URL.
Llewellyn DJ (2008). The psychology of risk taking: toward the integration of psychometric and neuropsychological paradigms. Am J Psychol, 121(3), 363-376. Abstract.  Author URL.

Awards

2012 Outward Mobility Academic Fellowship, University of Exeter

2012 Oral presentation selected for news media outreach at the Alzheimer's Association International Conference 2012 (AAIC)

2011
New Investigator Award, Alzheimer’s Association

2011 Winner of the Exeter Impact Awards Bright Future category, University of Exeter

2010 Oral presentation selected for news media outreach at the Alzheimer's Association

2010 International Conference on Alzheimer's Disease (ICAD)

2008 Elected Associate Fellow of the British Psychological Society (AFBPsS)

2008 Awarded Chartered psychologist (CPsychol) status, British Psychological Society

2007 Dr Willmar Schwabe Pharmaceuticals Second Prize for best free oral presentation, Fifth International Congress on Vascular Dementia

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