University of Exeter Medical School

Dr Craig Beall

Dr Craig Beall

Senior Lecturer

 c.beall@exeter.ac.uk

 +44 (0)1392 408209

 RILD Building 4.06

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

The lab is open to accepting applications from self-funded postgraduate students, both Masters-by-research and PhD candidates. Email Craig for more information.

Follow on Twitter @Craig_Beall

Techniques
Glucose clamping
Electrophysiology
Western blotting
Fixed and live-cell imaging
Enzyme/kinase assays
Calcium imaging
 

Upcoming Talks
 

Invited academic talks (IAT)/media (ME), public engagement (PE) and industry engagement (IE)

• 16th Aug 2023: Hatherleigh Festival (PE)
• 6th Jul 2023: Hatherleigh Festival, West Devon (PE)
• 24th May 2023: Pint of Science Festival, Exeter (PE)
• 23rd Mar 2023: Mito Rx Therapeutics, (IE)
• 11th May 2021: Researcher Development University of Exeter ECR Career Development workshop (IAT)
• 14th Apr 2021: British Neuroscience Association Festival of Neuroscience, Symposia lecture (IAT)
• 11th Nov 2020: King’s College London, Department of Diabetes Webinar (IAT)
• 11th Mar 2020: Brain Awareness Week, Keynote lecture (PE)
• 6th June 2019: Rigel Pharmaceuticals invited guest lecture, San Francisco, USA (IE)
• 22nd May 2019: Diabetes UK Gifts in Wills event, Exeter Royal Albert Memorial Museum (PE)
• 12th Mar 2019: University of Exeter, Brain Awareness Week (PE)
• 21st Feb 2019: University of Bath, Invited guest speaker (IAT)
• 23rd Sept 2018: Vanderbilt University; Diabetes Research & Training Centre, Invited guest speaker (IAT)
• 4th Dec 2017: University of Aberdeen, Institute of Medical Sciences, Invited guest speaker (IAT)
• Nov 2017: JDRF Patrons Event, Marshall Wace building, London, Invited guest speaker (PE)
• Oct 2017: Sidmouth Science Festival, Invited guest speaker (PE)
• May 2017: Pint of Science Festival; Exeter (PE)
• Mar 2016: Diabetes UK annual professional conference; abstract selected for oral presentation (IAT)
• Oct 2016: Diabetes UK Exeter volunteer group, Invited guest speaker (PE)
• Oct 2016: JDRF Discovery Day; Eden Project, Invited guest speaker (PE)
• Sept 2016: Diabetes UK Torbay group, Invited guest speaker (PE)
• May 2016: Diabetes UK Gifts in Wills; Royal Albert Memorial Museum, Invited guest speaker (PE)
• Nov 2015: BBC Radio Devon; Hypoglycaemia awareness week radio interview (ME)
• July 2015: Diabetes UK Legacies: Plymouth Aquarium, Invited guest speaker (PE)
• Mar 2015: Diabetes UK South West Volunteering conference, Invited guest speaker (PE)
• May 2015: Pint of Science Exeter; Beautiful minds team leader and presenter (PE)
• Oct 2014: JDRF Patrons event; Armorers Hall, London, Invited guest speaker (PE)
• Apr 2012: University of Stirling; Invited guest speaker (IAT)

Honours and Awards

• 2019: University of Exeter Above and Beyond Award for Collaboration
• 2018: University of Exeter Above and Beyond Award for Challenge; Excellent student feedback in Problem-Based Learning activities
• 2017: University of Exeter Above and Beyond Award for Teaching; Problem-based learning facilitation
• 2016: University of Exeter Above and Beyond Award for Collaboration
• 2012: College of Medicine Staff Poster Prize (1st prize)
• 2011: College of Medicine Staff Poster Prize (1st prize)
• 2003: Awarded Carl Zeiss Prize for Best Laboratory-Based Honours Project and short-listed for the UK-wide Science, Engineering and Technology Student of the Year Award
• 2000: Awarded Schering Group award for Academic Excellence and Dedication to Course (Fife College)

Professional Memberships

• Physiological society (2003-)
• Diabetes UK (2011-)
• Society for Endocrinology (2011-)
• British Society for Neuroendocrinology (2011-)
• British Pharmacological Society (2014-2018)

Qualifications

  • PhD
  • BSc(Hons) First Class

Career

Dr Craig Beall completed his degree in Pharmacology (BSc Hons; University of Dundee) in 2003 before obtaining a Wellcome Trust Prize Studentship to undertake doctoral studies in the laboratory of Prof Mike Ashford, University of Dundee. Doctoral studies focused on mechanisms of glucose sensing in pancreatic beta cells and hypothalamic neurons, with a particular focus on AMP-activated protein kinase and ATP-sensitive K+ channels.

Following a year in at the University of Liverpool investigating the role of K+ channels in skeletal muscle insulin sensitivity, Dr Beall moved back to the University of Dundee to work with Professors Rory McCrimmon and Prof Ashford to focus on mechanisms of hypoglycaemia detection. Dr Beall was a recipient of a Juvenile Diabetes Research Foundation postdoctoral fellowship (2010-2013) to develop and establish an in vitro model for investigating the mechanisms of hypothalamic glucose sensing.

Links

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Research

Research interests

The Beall laboratory is interested in the integrated physiology of glucose homeostasis and Type 1 and Type 2 Diabetes. This includes regulation of alpha cell function, brain-alpha cell communication, neural regulation of hepatic glucose output and skeletal muscle insulin sensitivity/glucose disposal.

Working with Dr Kate Ellacott, we are also interested in astrocyte-neuron communication during energy excess, such as a high fat diet and whether astrocytes play in a role in regulating feeding behaviour.

In collaboration with Rigel Pharmaceuticals, we are examining whether brain permeable AMPK activators can influence hypoglycaemia glucose counterregulation in diabetes.

In collaboration with Prof Matt Whiteman, we are investigating the anti-hypoglycaemic actions of novel hydrogen sulfide donors in diabetes.

Current Lab Members (as DoS/line manager):
Dr Jiping Zhang (MRC funded PhD student)
Natasha MacDonald (Diabetes UK funded PhD student)
Eleanor Pearson (MRC funded PhD student)
Maisie Payne (undergraduate placement student, Society for Endocrinology summer student)

Second/Co-supervisor:
Asmaa Al-Khalidi (PhD student)
Wyn Firth (PhD student)

Alumni:
Dr Paul Weightman Potter (currently lecturer at University of Exeter)
Dr Ana Miguel Cruz (currently at Novo Nordisk, Medical Science Liaison)
Katie Partridge (PDRA, University of Exeter)
Tom Worthington (Placement student, University of Exeter)
Valentina Abba (Placement student; University of Surrey)
Cristina Lumbreras (E3 funded PhD student)
Nicole Morrissey (PhD student, currently a postdoc in Oxford)
Benjamin Hall (PhD student)
Hannah Smithers (Postdoc, Associate lecturer, University of Exeter)
Aishwarya Vaidya (PhD student)
Josephine Robb (PhD student, currently a postdoc in Canada)
Alice Pink (Final Year Research Project student, 2019-20)
Daria Shevtsova (Final Year Research Project student, 2019-20)
Brittannie Willis (BSN funding summer student 2019)
Kealan Jones (U/G final year research project, 2018-19)
Alice Crocker (U/G final year research project, 2018-19)
Lisa Logie (PhD student; University of Dundee; 2015-2018)
Dr Lydia Hanna (postdoctoral researcher)
Julia Vlachaki-Walker, P/T MPhil student/research technician (Diabetes UK)
Chloe Tredgett, professional training year student (2017-18)
​Ellie Davis, summer intern (2018)
Dr Yasaman Malekizadeh, postdoctoral research associate (2017-18)
Brad Hoskin, U/G final year research project student (2017-18)
Khalid Bukhashem, U/G final year research project student (2017-18)
William Casasola, U/G final year research project student (2017-18)
Brenda Vescance Caroprese; Physiological Society funded summer student (summer 2017)
Magdalena Kowalska; Alzheimer's Society funded summer studentAimes Somes (U/G laboratory-based project student; summer 2017)
Jade Shoulder, associate researcher
Dr Ashley Nicholls (research assistant. Currently a postdoc at the University of Cambridge)
Amrinder Malhi (British Society for Neuroendocrinology funded summer studentship; 2015; currently an intern at the International Diabetes Federation, London)
Dr Amy Cameron (visiting postdoctoral research fellow; Society for Endocrinology; 2015-16)
Jennie Gabriel (Society for Endocrinology funded summer student; 2014, currently studying for a PhD studying dementia at the University of Dundee).

Research projects

  • Brain penetration of metformin: friend or foe in diabetes? Diabetes UK PhD studentship: 2023-2026
  • AMPK and autoimmune type 1 diabetes: MRC funded PhD studentship: 2023-2027
  • Royal Society Research Grant: 2023-2024
  • The role of astroglial mitochondrial dysfunction in neurotransmitter recycling during hypoglycaemia in diabetes (European Foundation for the Study of Diabetes/Novo Nordisk Programme 2018-2020)
  • Does an orally active brain permeable AMPK activator amplify the counterregulatory response to hypoglycaemia in a model of type 1 diabetes; JDRF Innovative Grant (2017-2018)
  • The role of astroytes in the homeostatic control of food intake; MRC project grant (2016-2019)
  • Does acute and recurrent insulin-induced hypoglycaemia alter DNA methylation in human neural cells? Novo Nordisk Research Foundation UK; (2016-2017)
  • Defining the role of hypothalamic astroglia in the regulation of the homeostatic control of food intake; GW4 MRC doctoral training partnership (2016-2019)
  • Targeting the hypothalamic purinergic system for the regulation of whole body energy homeostasis; Diabetes UK (2013-2018)
  • Impact of diabetes glucose variability on neural signalling in human brain cells - relationship to dementia risk; Mary Kinross Charitable Trust PhD studentship; collaboration with Prof A Randall, Exeter (2015-2018)
  • Mechanisms of muscle anabolic resistance in diabetes and ageing; UEMS PhD studentship; collaboration with Dr B Wall, Exeter (2016-2019)

Grants/Funding

  • JDRF Innovative Grant (2020-2021)
  • Novonordisk UK Research Foundation (2020-2021; PI: Weightman Potter)
  • Diabetes UK PhD Studentship (2019-2022)
  • Diabetes UK Early Career Small Grant (2019)
  • European Foundation for the Study of Diabetes (2018-2020)
  • British Society for Neuroendocrinology Research Visit Grant (2017-18)
  • Physiological Society summer vacation scholarship to Brenda Vescance Caroprese (2017)
  • Alzheimer's Society biomedical vacation scholarship to Magdalena Kowalska (2017)
  • University of Exeter Summer vacation scholarship to Brad Hoskin ((2017)
  • Mary Kinross Charitable Trust PhD Studentship (2015-2018)
  • British Society for Neuroendocrinology Summer Studentship (Amrinder Malhi; summer 2015)
  • Diabetes UK RD Lawrence Fellowship (2013-2018)
  • Society for Endocrinology Early Career Grant (2014-2015)
  • Society for Endocrinology Summer Studentship (Jennie Gabriel; summer 2014)
  • Anonymous Trust (PI; Co-I: Professors Ashford & McCrimmon, University of Dundee, 2014-2015)
  • British Society for Neuroendocrinology (PI; 2013-2014)
  • Tenovus Scotland (PI; Co-I: Professors Ashford & Mccrimmon, 013-2014)
  • Anonymous Trust (2012-2013)
  • Juvenile Diabetes Research Foundation Postdoctoral Fellowship (2010-2013)

Research networks

Collaborations:
Prof Kate Ellacott (University of Exeter; neural mechanisms of energy sensing)
Dr Simon Shaw (Rigel Pharmaceuticals, Inc, CA, USA).
Prof Matt Whiteman (University of Exeter)
Dr James Pearson (Cardiff University)
Prof Susan Wong (Cardiff University)
 

Anyone interested in working in the Beall laboratory, either undergraduate, postgraduate or postdoctoral, please get in touch with Dr Beall.

Research grants

  • 2017 Medical Research Council
    Title: IMPC - Understanding the role of 18kDa Translocator protein (TSPO) in the regulation of energy homeostasis in mice
  • 2016 Medical Research Council
    Title: The role of hypothalamic astrocytes in the homeostatic regulation of feeding behaviour
  • 2016 Medical Research Council
    GW4 MRC Doctoral Training Partnership PhD Studentship Title: Defining the contribution of hypothalamic astroglia to the homeostatic regulation of food intake
  • 2016 Juvenile Diabetes Research Foundation
    Title: Does an orally active, brain permeable AMPK activator improve hypoglycemia counterregulation in type 1 diabetes?

Links


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Publications

Journal articles

Weightman Potter P, Vlachaki Walker J, Robb J, Chilton J, Williamson R, Randall A, Ellacott K, Beall C (In Press). Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes. Diabetologia
Firth W, Robb JL, Stewart D, Pye KR, Bamford R, Oguro‐Ando A, Beall C, Ellacott KLJ (2024). Regulation of astrocyte metabolism by mitochondrial translocator protein <scp>18 kDa</scp>. Journal of Neurochemistry Abstract.
Forteath C, Mordi I, Nisr R, Gutierrez-Lara EJ, Alqurashi N, Phair IR, Cameron AR, Beall C, Bahr I, Mohan M, et al (2023). Amino acid homeostasis is a target of metformin therapy. Mol Metab, 74 Abstract.  Author URL.
MacDonald AJ, Pye KR, Beall C, Ellacott KLJ (2023). Impact of chemogenetic activation of dorsal vagal complex astrocytes in mice on adaptive glucoregulatory responses. Journal of Neuroendocrinology, 35(8). Abstract.
Weightman Potter PG, Ellacott KLJ, Randall AD, Beall C (2022). Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes. Cells, 11(21), 3422-3422. Abstract.
Morrissey NA, Beall C, Ellacott KLJ (2021). Absence of the mitochondrial translocator protein 18 kDa in mice does not affect body weight or food intake responses to altered energy availability. Journal of Neuroendocrinology, 33(9). Abstract.
Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C (2021). Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. FRONTIERS IN ENDOCRINOLOGY, 12  Author URL.
Cruz AM, Partridge KM, Malekizadeh Y, Vlachaki Walker JM, Weightman Potter PG, Pye KR, Shaw SJ, Ellacott KLJ, Beall C (2021). Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats. Frontiers in Endocrinology, 12 Abstract.
MacDonald AJ, Yang YHC, Cruz AM, Beall C, Ellacott KLJ (2021). Brain-Body Control of Glucose Homeostasis—Insights from Model Organisms. Frontiers in Endocrinology, 12 Abstract.
Potter PGW, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster E, Beall C (2020). Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes. Abstract.
Hanna L, Kawalek TJ, Beall C, Ellacott KLJ (2020). Changes in neuronal activity across the mouse ventromedial nucleus of the hypothalamus in response to low glucose: Evaluation using an extracellular multi‐electrode array approach. Journal of Neuroendocrinology, 32(3). Abstract.
Cruz AM, Beall C (2020). Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Frontiers in Physiology, 11
Robb JL, Morrissey NA, Weightman Potter PG, Smithers HE, Beall C, Ellacott KLJ (2020). Immunometabolic Changes in Glia – a Potential Role in the Pathophysiology of Obesity and Diabetes. Neuroscience, 447, 167-181.
Robb JL, Hammad NA, Weightman Potter PG, Chilton JK, Beall C, Ellacott KLJ (2020). The metabolic response to inflammation in astrocytes is regulated by nuclear factor‐kappa B signaling. Glia, 68(11), 2246-2263. Abstract.
MacDonald AJ, Robb JL, Morrissey NA, Beall C, Ellacott KLJ (2019). Astrocytes in neuroendocrine systems: an overview. J Neuroendocrinol, 31(5). Abstract.  Author URL.
MacDonald AJ, Holmes FE, Beall C, Pickering AE, Ellacott KLJ (2019). Regulation of food intake by astrocytes in the brainstem dorsal vagal complex. Glia, 68(6), 1241-1254. Abstract.
Weightman Potter PG, Walker JMV, Robb JL, Chilton JK, Williamson R, Randall A, Ellacott KLJ, Beall C (2018). Human primary astrocytes increase basal fatty acid oxidation following recurrent low glucose to maintain intracellular nucleotide levels. Abstract.
Logie L, Lees Z, Allwood JW, McDougal G, Beall C, Rena G (2018). Regulation of hepatic glucose production and AMPK by AICAR but not metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1). Diabetes, Obesity and Metabolism, (In press)
Vlachaki Walker JM, Robb JL, Cruz AM, Malhi A, Weightman Potter PG, Ashford MLJ, McCrimmon RJ, Ellacott KLJ, Beall C (2017). AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes, Obesity and Metabolism, 19(7), 997-1005. Abstract.
Beall C, Hanna L, Ellacott KLJ (2017). CNS Targets of Adipokines. Compr Physiol, 7(4), 1359-1406. Abstract.  Author URL.
Dadak S, Beall C, Vlachaki Walker JM, Soutar MPM, McCrimmon RJ, Ashford MLJ (2017). Oleate induces K ATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge. Neuroscience, 346, 29-42.
Jeffery N, Richardson S, Beall C, Harries LW (2017). The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells. Experimental Cell Research, 361(2), 284-291.
Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AKF, et al (2016). Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res, 119(5), 652-665. Abstract.  Author URL.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, et al (2016). Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab, 23(5), 821-836. Abstract.  Author URL.
Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford MLJ (2016). Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology, 111, 212-222.
Beall C, Walker JMV, Ashford MLJ, McCrimmon RJ (2015). A critical role for AMP-activated protein kinase in regulation of gliotransmitter release from astrocytes. DIABETIC MEDICINE, 32, 62-62.  Author URL.
Cameron AR, Morrison V, McNeilly AD, Forteath C, Beall C, Stewart CA, Balfour DJK, Sutherland CD, Sakamoto K, Fagerholm SC, et al (2015). Anti-inflammatory effects of metformin. DIABETIC MEDICINE, 32, 54-55.  Author URL.
Hamilton DL, Beall C, Jeromson S, Chevtzoff C, Cuthbertson DJ, Ashford MLJ (2014). Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci, 64(1), 13-20. Abstract.  Author URL.
Beall C, Watterson KR, McCrimmon RJ, Ashford MLJ (2013). AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. J Bioenerg Biomembr, 45(3), 229-241. Abstract.  Author URL.
Beall C, Haythorne E, Fan X, Du Q, Jovanovic S, Sherwin RS, Ashford MLJ, McCrimmon RJ (2013). Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro. Diabetologia, 56(9), 2088-2092. Abstract.  Author URL.
Ashford M, Beall C, McCrimmon R (2012). Hypoglycaemia: exercise for the brain?. J Neuroendocrinol, 24(10), 1365-1366. Abstract.  Author URL.
Beall C, Hamilton DL, Gallagher J, Logie L, Wright K, Soutar MP, Dadak S, Ashford FB, Haythorne E, Du Q, et al (2012). Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia, 55(9), 2432-2444. Abstract.  Author URL.
Beall C, Ashford ML, McCrimmon RJ (2012). The physiology and pathophysiology of the neural control of the counterregulatory response. Am J Physiol Regul Integr Comp Physiol, 302(2), R215-R223. Abstract.  Author URL.
Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ (2010). Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J, 429(2), 323-333. Abstract.  Author URL.

Conferences

Zhang JZ, Ellacott KE, Beall CB (2022). AMP-activated protein kinase (AMPK) activation suppresses low glucose-induced macrophage migration inhibitory factor (MIF) release from central and peripheral immune cells.  Author URL.
Partridge KM, Morgan NG, Ellacott KLJ, Beall C (2022). Recurrent low glucose exposure (RLG) induces intrinsic metabolic adaptations in pancreatic alphaTC1.9 cells.  Author URL.
Partridge KM, Shaw SJ, Morgan NG, Ellacott KLJ, Beall C (2021). Novel AMP-activated protein kinase (AMPK) activator R481 promotes glucose and fat utilisation in pancreatic alpha cells.  Author URL.
Potter PW, Beall C (2021). Recurrent low glucose-induced mitochondrial adaptations are restored by concurrent glutamate treatment in hypothalamic but not cortical rat astrocytes.  Author URL.
Beall C, Cruz AM, Potter PGW, Walker JMV, Malekizadeh Y, Pye KR, Shaw SJ, Ellacott KLJ (2020). Amp-activated protein kinase (AMPK) activator R481 amplifies the glucagon response to hypoglycaemia without worsening hyperglycaemia in diabetic rats.  Author URL.
Cruz A, Potter PW, Pye K, Shaw S, Ellacott K, Beall C (2020). Brain permeable AMPK activator R481 acutely raises blood glucose by activating the autonomic nervous system without altering insulin sensitivity.  Author URL.
Potter PGW, Randall A, Beall C (2020). Cellular metabolism and Ca<SUP>2+</SUP> signalling are modified differentially in rat hypothalamic and cortical primary astrocytes by acute and recurrent low glucose.  Author URL.
Cruz AM, Beall C (2020). Exogenous ATP promotes glucose uptake and utilisation in skeletal muscle cells but does not alter glucose clearance in vivo.  Author URL.
Robb JL, Hammad NA, Beall C, Ellacott KL (2019). A role for translocator protein 18kDa (TSPO) in immunometabolic regulation in astrocytes.  Author URL.
Cruz AM, Malekizadeh Y, Walker JMV, Shaw S, Ellacott KLJ, Beall C (2019). AMP-activated protein kinase (AMPK) activator R481 improves the counterregulatory response to hypoglycaemia by amplifying glucagon release in healthy rats.  Author URL.
Cruz AML, Malekizadeh Y, Vlachaki Walker J, Ellacott K, Shaw S, Beall C (2019). Amplified Glucagon Response to Hypoglycemia following AMP-Activated Protein Kinase (AMPK) Activator R481 Treatment in Healthy Rats. American Diabetes Association. 7th - 11th Jun 2019. Abstract.
Hall BC, Beall C, Randall AD (2018). Alzheimer's disease drug Memantine inhibits Adenosine triphosphate (ATP)-sensitive potassium (KATP) channel activation in hypothalamic GT1-7 cells.  Author URL.
Logie L, Beall C, Rena G (2018). Effect of metformin but not AICAR on total adenosine triphosphate (ATP) levels in primary hepatocytes.  Author URL.
Potter PGW, Walker JMV, Robb JL, Chilton J, Williamson R, Randall A, Ellacott KLJ, Beall C (2018). Recurrent hypoglycaemia increases human primary astrocyte oxygen consumption, fatty acid dependency and pentose phosphate pathway activity.  Author URL.
Robb J, Hammad N, Beall C, Ellacott K (2018). The 18-kDa translocator protein (TSPO) regulates cellular metabolism in astrocytes.  Author URL.
Walker JMV, Potter PGW, Somes A, Beall C (2017). Altered adenosine triphosphate (ATP)-induced calcium responses in glucosensing GT1-7 neurons during hypoglycaemia and in astrocytes following recurrent hypoglycaemia.  Author URL.
Walker JMV, Potter PGW, Robb J, Ellacott KLJ, Beall C (2017). Exposure of Astrocytes to Recurrent Hypoglycemia in Vitro Alters Gliotransmission and Purinergic Signaling.  Author URL.
Potter PGW, Cruz JMV, Cruz AM, Williamson R, Randall A, Beall C (2017). Human astrocytes are altered following chronic glucose variation: differential regulation of cytokine release and increased basal metabolism.  Author URL.
Beall C, Dadak S, Walker JMV, Soutar MPM, McCrimmon RJ, Ashford MLJ (2017). Oleate induces ATP-sensitive channel (K<sub>ATP</sub>)-dependent hyperpolarisation of mouse hypothalamic glucose-excited neurons without altering cellular energy charge.  Author URL.
Logie L, Beall C, Rena G (2017). Repression of hepatic glucose production by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) is inhibited by 8-CPT-cAMP mediated blockade of equilibrative nucleotide transporter 1 (ENT1).  Author URL.
Walker JMV, Malhi A, Hardy H, Chilton J, Beall C (2016). A769662 regulates intracellular calcium and extracellular ATP independent of AMPK.  Author URL.
Piipari K, Beall C, Al-Qassab H, Smith MA, Carling D, Viollet B, Ashford MLJ, Withers DJ (2010). Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis.  Author URL.

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External Engagement and Impact

Administrative responsibilities

Departmental Theme Co-Lead: Diabetes, Obesity and Metabolism research theme


Committee/panel activities

2024-2028 Socierty for Endocrinology science committee member

2023-2027 Diabetes UK Annual Professional Conference Programme organising committee (basic science lead)

May 2018-2022: JDRF Scientific Advisory Committee

January 2017- present: Diabetes Research Steering Group (DRSG5; Diabetes UK): Long term self-management & glycaemic control

2017-2018 University of Exeter Medical School Senate Representative (elected)

Society for Endocrinology Endocrine Ambassador

2019-2023 Society for Endocrinology Neuroendocrinology network co-convenor and scientific committee member

2019-2020 Socety for Endocrinology Leadership and Development Awards selection committee


International recognition, such as international research collaborations, visiting research posts in overseas institutions, involvement at senior levels in international research associations, acting as referee for national and international research councils.

March 2017: JDRF Strategies to Prevent and Treat Hypoglycemia Unawareness Workshop; New York.
Sept 2018: Mouse Metabolic Phenotyping Course: Glucose clamping in the conscious mouse


Workshops organised

Diabetes Obesity and Metabolic Health mixer; University of Exeter; 4th October 2023
British Society for Neuroendocrinology annual conference; University of Exeter, 4-6th September 2023 (co-organiser; w/ Prof K Ellacott)
January 2017: Agilent Seahorse users workshop - University of Exeter

September 2017: Exeter Neuroscience Seminar Series: Causes and Consequences of Dementia

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Supervision / Group

Postgraduate researchers

  • Natasha MacDonald
  • Eleanor Pearson
  • Jiping Zhang

Alumni

  • Jennie Gabriel (University of Dundee; 2014)
  • Cristina Lumbreras
  • Aman Malhi
  • Ashley Nicholls
  • Josephine Robb

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Office Hours:

Undergraduate teaching virtual office hours: Fridays 9-11am.

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