COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Chris Scotton

Dr Chris Scotton

Senior Lecturer (E&R)

 2934

 +44 (0) 1392 722934

 Medical School Building G.11

 

Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

Overview

Qualifications

  • BA(hons), University of Cambridge
  • MA, University of Cambridge
  • PhD, Cancer Research UK

Research

Research interests

Dr Scotton gives an overview of his research in the video below, filmed at the Living Systems Institute Symposium in March 2016. 

Publications

Key publications | Publications by category | Publications by year

Key publications


Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

Publications by category


Journal articles

Gibbons MA, Scotton CJ (In Press). Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface. Am J Respir Crit Care Med, 196(10), 1238-1240. Author URL.  Full text.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, et al (In Press). Differential Expression of VEGF-Axxx Isoforms is Critical for Development of Pulmonary Fibrosis. Am J Respir Crit Care Med, 196(4), 479-493. Abstract.  Author URL.  Full text.
Turner L, Scotton C, Negus R, Balkwill F (In Press). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.
Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Ali M, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16. Full text.
Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, et al (2017). Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort. Thorax Abstract.  Author URL.  Full text.
Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.  Full text.
Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.
Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.
Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.
Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.
Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.  Full text.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.

Conferences

Wollerton RL, Scotton CJ, Gibbons MA (2017). THE CHANGING SHAPE OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.
Chong DLW, Rebeyrol C, Khawaja A, Forty EJ, Kanda N, Scotton CJ, Porter JC (2016). THE ROLE OF PLATELET-DERIVED TGF beta IN PULMONARY FIBROSIS.  Author URL.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2014). Hypomethylation of the Tnxb Gene Contributes to Increased Expression and Deposition of Tenascin-X in Idiopathic Pulmonary Fibrosis.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Garner IM, Evans IC, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Genome-wide analysis identifies multiple genes with altered methylation and expression in IPF and SSc lung fibroblasts.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Hypomethylation of the TNXB gene contributes to increased expression and deposition of tenascin X in idiopathic pulmonary fibrosis.  Author URL.
McNulty K, Sage EK, Alexander R, Scotton CJ, Janes SM (2012). EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA.  Author URL.
Smoktunowicz N, Alexander R, Franklin L, Williams AE, Jarai G, Scotton CJ, Mercer PF, Chambers RC (2012). THE EXTRINSIC COAGULATION PATHWAY IS LOCALLY UPREGULATED IN AN EXPERIMENTAL MODEL OF VIRAL EXACERBATION OF PULMONARY FIBROSIS.  Author URL.
McNulty K, Scotton CJ, Sage EK, Chambers RC, Janes SM (2011). MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG.  Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role of Natriuretic Peptides in Pulmonary Fibrosis: a Novel Therapeutic Target?.  Author URL.
Alexander RE, Krupiczojc MA, Whitburn J, Alexander S, Chambers RC, Scotton CJ (2010). Production of Functional Coagulation Factor X (FX) By Human Lung Epithelium is Upregulated By Oxidative Stress.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-alpha induces TSLP expression by human lung fibroblasts in an AP-1 / JNK dependent manner.  Author URL.
McNulty K, Aguilar S, Scotton CJ, Bonnet D, Janes SM (2009). MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR.  Author URL.
Maher TM, Bottoms SE, Mercer PF, Scotton CJ, Thorley A, Wells AU, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, et al (2007). Differential modulation of lung fibroblast and alveolar epithelial cell apoptosis by cyclo-oxygenase (COX)-2 and prostaglandin E(2) is an important mechanism in the pathogenesis of idiopathic pulmonary fibrosis.  Author URL.
Kallis YN, Scotton CJ, Goldin RD, Russo FP, Chambers RC, Thomas HC, Forbes SJ (2007). PAR-1 knockout bone marrow stem cells can confer an anti-fibrotic phenotype to the injured liver.  Author URL.
Mercer PF, Moffatt JD, Scotton CJ, Derian CK, Chambers RC (2007). Par1 signalling in lipopolysaccharide-induced acute lung injury.  Author URL.
Scotton CJ, Krupiczojc M, Johns RH, Lee YCG, Koenigshoff M, Eickelberg O, Kaminski N, Laurent GJ, Chambers RC (2006). The coagulation cascade in fibrotic lung disease progression: local expression of factor X is increased in the injured and fibrotic lung.  Author URL.
Krupiczojc MA, Scotton CJ, Laurent GJ, Chambers RC (2005). Activation of PAR1 by FXa induces fibroblast to myofibroblast differentiation.  Author URL.
Johns RH, Scotton CJ, Laurent GJ, Chambers RC (2005). PAR1 signaling in lung epithelial cells induces the expression of CCL2/MCP-1 and CTGF.  Author URL.

Publications by year


In Press

Gibbons MA, Scotton CJ (In Press). Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface. Am J Respir Crit Care Med, 196(10), 1238-1240. Author URL.  Full text.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, et al (In Press). Differential Expression of VEGF-Axxx Isoforms is Critical for Development of Pulmonary Fibrosis. Am J Respir Crit Care Med, 196(4), 479-493. Abstract.  Author URL.  Full text.
Turner L, Scotton C, Negus R, Balkwill F (In Press). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.

2018

Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Ali M, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16. Full text.

2017

Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, et al (2017). Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort. Thorax Abstract.  Author URL.  Full text.
Wollerton RL, Scotton CJ, Gibbons MA (2017). THE CHANGING SHAPE OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.

2016

Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.
Chong DLW, Rebeyrol C, Khawaja A, Forty EJ, Kanda N, Scotton CJ, Porter JC (2016). THE ROLE OF PLATELET-DERIVED TGF beta IN PULMONARY FIBROSIS.  Author URL.

2015

Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.

2014

Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2014). Hypomethylation of the Tnxb Gene Contributes to Increased Expression and Deposition of Tenascin-X in Idiopathic Pulmonary Fibrosis.  Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.

2013

Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Garner IM, Evans IC, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Genome-wide analysis identifies multiple genes with altered methylation and expression in IPF and SSc lung fibroblasts.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Hypomethylation of the TNXB gene contributes to increased expression and deposition of tenascin X in idiopathic pulmonary fibrosis.  Author URL.

2012

Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
McNulty K, Sage EK, Alexander R, Scotton CJ, Janes SM (2012). EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Smoktunowicz N, Alexander R, Franklin L, Williams AE, Jarai G, Scotton CJ, Mercer PF, Chambers RC (2012). THE EXTRINSIC COAGULATION PATHWAY IS LOCALLY UPREGULATED IN AN EXPERIMENTAL MODEL OF VIRAL EXACERBATION OF PULMONARY FIBROSIS.  Author URL.

2011

Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
McNulty K, Scotton CJ, Sage EK, Chambers RC, Janes SM (2011). MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG.  Author URL.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.  Full text.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role of Natriuretic Peptides in Pulmonary Fibrosis: a Novel Therapeutic Target?.  Author URL.

2010

Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Alexander RE, Krupiczojc MA, Whitburn J, Alexander S, Chambers RC, Scotton CJ (2010). Production of Functional Coagulation Factor X (FX) By Human Lung Epithelium is Upregulated By Oxidative Stress.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-alpha induces TSLP expression by human lung fibroblasts in an AP-1 / JNK dependent manner.  Author URL.

2009

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
McNulty K, Aguilar S, Scotton CJ, Bonnet D, Janes SM (2009). MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR.  Author URL.
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.

2008

Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.

2007

Maher TM, Bottoms SE, Mercer PF, Scotton CJ, Thorley A, Wells AU, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, et al (2007). Differential modulation of lung fibroblast and alveolar epithelial cell apoptosis by cyclo-oxygenase (COX)-2 and prostaglandin E(2) is an important mechanism in the pathogenesis of idiopathic pulmonary fibrosis.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Kallis YN, Scotton CJ, Goldin RD, Russo FP, Chambers RC, Thomas HC, Forbes SJ (2007). PAR-1 knockout bone marrow stem cells can confer an anti-fibrotic phenotype to the injured liver.  Author URL.
Mercer PF, Moffatt JD, Scotton CJ, Derian CK, Chambers RC (2007). Par1 signalling in lipopolysaccharide-induced acute lung injury.  Author URL.

2006

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.
Scotton CJ, Krupiczojc M, Johns RH, Lee YCG, Koenigshoff M, Eickelberg O, Kaminski N, Laurent GJ, Chambers RC (2006). The coagulation cascade in fibrotic lung disease progression: local expression of factor X is increased in the injured and fibrotic lung.  Author URL.

2005

Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Krupiczojc MA, Scotton CJ, Laurent GJ, Chambers RC (2005). Activation of PAR1 by FXa induces fibroblast to myofibroblast differentiation.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Johns RH, Scotton CJ, Laurent GJ, Chambers RC (2005). PAR1 signaling in lung epithelial cells induces the expression of CCL2/MCP-1 and CTGF.  Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.

2002

Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

2001

Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.  Full text.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.

2000

Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.

Christopher_Scotton Details from cache as at 2018-12-10 22:04:56

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Teaching

Modules

2018/19


Supervision / Group

Research Fellows

  • Bry McCord
  • Rebecca Wollerton

Postgraduate researchers

  • Tom Hames
  • Philip Mitchelmore

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