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Dr Chris Scotton

Dr Chris Scotton

Senior Lecturer (E&R)

2934

Medical School Building G.11

Qualifications

  • BA(hons), University of Cambridge
  • MA, University of Cambridge
  • PhD, Cancer Research UK

Research

Research interests

Dr Scotton gives an overview of his research in the video below, filmed at the Living Systems Institute Symposium in March 2016. 

Key publications | Publications by category | Publications by year

Key publications


Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

Publications by category


Journal articles

Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.
Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.
Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.
Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.
Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.
Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.
Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.
Turner L, Scotton C, Negus R, Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.

Conferences

Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.

Publications by year


2016

Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.

2015

Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.

2014

Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.

2013

Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.

2012

Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.

2011

Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.

2010

Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.

2009

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.

2008

Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.

2007

Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.

2006

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.

2005

Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.

2002

Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

2001

Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.

2000

Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.

1999

Turner L, Scotton C, Negus R, Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.

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