Postgraduate Research Student
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Charli graduated with a First-Class Batchelor’s degree in Biochemistry from the University of Cardiff, before studying for an MSc in Genomic Medicine at the University of Exeter, Medical School.
She has joined Professor Tim Frayling’s team as a PhD student at the University of Exeter Medical School on a research project to determine the role of common genetic variants for predicting the modulation of cardiovascular outcome.
Charli has a keen interest in genomics and chronic diseases with a particular focus on diabetes and cardiovascular diseases.
Using human genetics to inform the drug discovery pipeline
This research focuses on identifying genetic variants that influence circulating factors, like erythropoietin (EPO) and pro-adrenomedullin (Pro-ADM), which are altered in chronic kidney disease (CKD) and adverse cardiac outcomes. These variants will then be used as instruments to carry out Mendelian Randomisation to test the causal relationship between higher levels of circulating EPO, pro-ADM and haemoglobin and adverse cardiac outcomes. Data will be obtained from the UK Biobank alongside the InCHIANTI, PREVEND and HealthABC studies.
Supervisor: Prof Tim Frayling
Funding: Medical Research Council