COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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 Benjamin Lee

Benjamin Lee

Research Technician and PhD student

 01392 406760

 RILD Building Postgraduate Students' Roo

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

After completing my undergraduate degree at Liverpool University I moved to Portugal, where I stayed for just over a decade. During this time I worked in the family business, making bespoke furniture and restoring antiques.

When I returned to the UK, I joined the University of Exeter Medical School as a research technician working with both the ‘RNA-mediated mechanisms of disease’ and ‘Epidemiology and public health’ research groups.

Subsequently I was offered the opportunity to pursue a part-time PhD alongside my technician role, which I gladly accepted and am currently in my second year of study.

Qualifications

  • 2000: 1st Class BSc (Hons) Applied Biology

Research

Research interests

My project focuses on the role of RNA regulation in ageing and longevity in mammals.  I am investigating two aspects of this regulation; alternative RNA splicing and microRNA expression, in two mammalian model species (mouse and naked mole-rat) as well as in a human cohort.

Supervisors: Prof. Lorna W. Harries and Prof. David Melzer

Funding: Velux Stiftung Foundation, Wellcome Trust Seedcorn Fund.

Publications

Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mechanisms of ageing and development. 135, 50-56.

Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere. 120, 555-562.

Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM,  Harries LW (2016a). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Molecular and cellular endocrinology. 428, 49-57.

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D,  Harries LW (2016b). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging cell. 15, 903-913.

Kamenska A, Simpson C, Vindry C, Broomhead H, Benard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic acids research. 44, 6318-6334.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Abstract.  Author URL.  Full text.
Lee BP, Smith M, Buffenstein R, Harries LW (2020). Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation. Geroscience, 42(2), 633-651. Abstract.  Author URL.  Full text.
Kilroe SP, Fulford J, Holwerda AM, Jackman SR, Lee BP, Gijsen AP, van Loon LJC, Wall BT (2020). Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. American Journal of Physiology-Endocrinology and Metabolism, 318(2), E117-E130. Abstract.  Full text.
Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Abstract.  Author URL.  Full text.
Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128 Abstract.  Author URL.  Full text.
Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Abstract.  Full text.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.  Full text.
Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742. Full text.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.  Full text.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.

Chapters

Galloway TS, Lee BP, Burić I, Steele AM, Kocur AL, Pandeth AG, Harries LW (2019). Plastics Additives and Human Health: a Case Study of Bisphenol a (BPA). In  (Ed) , 131-155.  Abstract.  Full text.

Publications by year


2020

Lee B (2020). Changes in RNA regulatory processes during mammalian ageing.  Abstract.
Lee B (2020). Changes in RNA regulatory processes during mammalian ageing_TPC.  Abstract.  Full text.
Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Abstract.  Author URL.  Full text.
Lee BP, Smith M, Buffenstein R, Harries LW (2020). Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation. Geroscience, 42(2), 633-651. Abstract.  Author URL.  Full text.
Kilroe SP, Fulford J, Holwerda AM, Jackman SR, Lee BP, Gijsen AP, van Loon LJC, Wall BT (2020). Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. American Journal of Physiology-Endocrinology and Metabolism, 318(2), E117-E130. Abstract.  Full text.

2019

Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Abstract.  Author URL.  Full text.
Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128 Abstract.  Author URL.  Full text.
Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Abstract.  Full text.
Galloway TS, Lee BP, Burić I, Steele AM, Kocur AL, Pandeth AG, Harries LW (2019). Plastics Additives and Human Health: a Case Study of Bisphenol a (BPA). In  (Ed) , 131-155.  Abstract.  Full text.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.  Full text.

2018

Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742. Full text.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.  Full text.

2017

Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.  Full text.

2016

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.  Full text.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.  Full text.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.  Full text.

2015

Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.  Full text.

2014

Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.

Ben_Lee Details from cache as at 2020-07-09 08:23:32

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