Research Technician and PhD student
RILD Building Postgraduate Students' Roo
After completing my undergraduate degree at Liverpool University I moved to Portugal, where I stayed for just over a decade. During this time I worked in the family business, making bespoke furniture and restoring antiques.
When I returned to the UK, I joined the University of Exeter Medical School as a research technician working with both the ‘RNA-mediated mechanisms of disease’ and ‘Epidemiology and public health’ research groups.
Subsequently I was offered the opportunity to pursue a part-time PhD alongside my technician role, which I gladly accepted and am currently in my second year of study.
- 2000: 1st Class BSc (Hons) Applied Biology
My project focuses on the role of RNA regulation in ageing and longevity in mammals. I am investigating two aspects of this regulation; alternative RNA splicing and microRNA expression, in two mammalian model species (mouse and naked mole-rat) as well as in a human cohort.
Supervisors: Prof. Lorna W. Harries and Prof. David Melzer
Funding: Velux Stiftung Foundation, Wellcome Trust Seedcorn Fund.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mechanisms of ageing and development. 135, 50-56.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere. 120, 555-562.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW (2016a). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Molecular and cellular endocrinology. 428, 49-57.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW (2016b). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging cell. 15, 903-913.
Kamenska A, Simpson C, Vindry C, Broomhead H, Benard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic acids research. 44, 6318-6334.