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Dr Anne Corbett

Dr Anne Corbett

Senior Lecturer in Dementia Research

4464

South Cloisters 2.40

Dr Anne Corbett is Senior Lecturer in Dementia Research and a member of the REACH research group. Anne conducted her post-graduate PhD research at Imperial College in the field of molecular biology, infection and disease, giving her a grounding in molecular science and genetics. She then spent several years outside of academia working in research communications and implementation in the research team at Alzheimer’s Society UK. She returned to academia in 2011, applying her combined experience in basic science, dementia and translational research to dementia and ageing research. She spent four years at King’s College London where she developed a wide portfolio of dementia research ranging from online studies into risk reduction, drug discovery, clinical trials and care home research. She has particular expertise in clinical trial delivery, online research, translational research and patient and public involvement.

Anne’s research at the University of Exeter focuses on two broad areas. The first is cognitive health in ageing, which is built around her large online research cohort of people over 50, the PROTECT study (www.protectstudy.org.uk). The second is care home research, focusing on training, psychosocial and pharmacological approaches to improving the quality of dementia care in these settings.

Anne has published widely in the dementia research field, including over 80 peer reviewed publications, several book chapters on dementia and two best practice guidelines, one of which has been translated into eight languages and is in use worldwide. She holds funding from the National Institute of Health Research, Wellcome Trust, Alzheimer’s Society and philanthropic donors. She holds visiting posts at King’s College London and Stavanger University in Norway.

Qualifications

  • PhD: Molecular microbiology and infection, Imperial College London (2008)
  • MRes: Infection and disease, Imperial College London (2005)
  • BSc: Biological Sciences, University of Bristol (2004)

Research

Research interests

Anne’s research at the University of Exeter focuses on two broad areas. Firstly, Anne leads the large-scale online Platform for Research Online to Investigate Genetics and Cognition in Ageing (PROTECT) study [hyperlink: www.protectstudy.org.uk). PROTECT is a longitudinal cohort of over 20,000 people over 50 that seeks to explore the various genetic, lifestyle, environmental and medical factors involved in cognitive health and dementia risk in older adults. PROTECT is also an online clinical trials platform which has already delivered a large trial of brain training games in 9700 people. Anne is developing this exciting portfolio of online ageing research with a series of nested studies including clinical trials and analysis of big data.

Anne’s research also focuses on care home settings and dementia care. She has a particular interest in developing approaches that respond to the unique challenges and pressures that exist in care homes, and her work includes clinical trials, qualitative studies and reviews focusing on key care areas such as pain management, use of technology, staff training and nighttime care.

Lead Investigator Grants

  • Platform for Research Online Investigating Genetics and Cognition in Ageing (PROTECT) study (Multiple funders)
  • Management of pain in people with dementia living in care homes (NIHR PDG) 2015 - 2017
  • Sleep disturbance in people with dementia living in care homes: Development of a nighttime care package (Alzheimer’s Society) 2014 – 2017
  • Can brain training lead to short term and sustained improvements in cognitive function? (Alzheimer’s Society) 2013 - 2017

Co-investigator Grants

  • A systematic programme to develop and evaluate the best candidate treatments for repositioning in Alzheimer’s Disease (SMART-AD) (Wellcome Trust) 2014 - 2017
  • Supporting Excellence in End of Life care in Dementia (SEED) (NIHR PGfAR) 2013 - 2018
  • Goal-oriented cognitive rehabilitation in early-stage Alzheimer's disease: multi-centre single-blind randomised controlled trial (GREAT) (NIHR HTA) 2012 - 2016
  • An optimized intervention to reduce and treat behavioural symptoms in people with dementia living in care homes (WHELD) (NIHR PGfAR) 2011 - 201

Research projects

PROTECT Portfolio Studies

  • PROTECT longitudinal study: Eight-year follow-up of cognition in older adults
  • PROTECT Genetics: Investigating the impact of genetic predictors of cognitive function in ageing
  • Can brain training lead to short-term and sustained improvements in cognitive function? Long-term engagement phase
  • Genetic predictors of treatment response to online brain training
  • Impact of short-term grammatical reasoning training on cognition in older adults
  • Self-directed exercise for adults over 50: A feasibility and proof-of-concept study
  • Associations of social cognition and overall cognitive function: Analysis of PROTECT baseline data
  • Identification of predictors of cognitive function in old age: Analysis of PROTECT longitudinal data
  • An examination of the relationship between Social Network Sites and Loneliness in Older Adults

Care Home Study Portfolio

  • Characterisation of the landscape of pain management in care homes: A qualitative study
  • Management of pain in people with dementia living in care homes: Intervention development and feasibility study
  • Mapping communication channels and barriers in care homes: A qualitative study
  • Sleep disturbance in people with dementia living in care homes: Development of a nighttime care package
  • Supporting Excellence in End of Life care in Dementia (SEED)
  • An optimized intervention to reduce and treat behavioural symptoms in people with dementia living in care homes (WHELD)
  • An eLearning Optimized Person Centred Intervention to Improve Staff Attitudes and Quality of Care for People with Dementia Living in Care Homes

Additional Studies:

  • A systematic programme to develop and evaluate the best candidate treatments for repositioning in Alzheimer’s Disease (SMART-AD)
  • Caregivers to people with different types of dementia (PhD Mentor, Stavanger University)
  • A randomised controlled feasibility trial evaluating the impact of an educational intervention regarding the treatment of hypertension for people with subcortical ischaemic vascular dementia (AFFECT EDUCATION) and their carers on treatment adherence and blood pressure  

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Rajkumar AP, Ballard C, Fossey J, Orrell M, Moniz-Cook E, Woods RT, Murray J, Whitaker R, Stafford J, Knapp M, et al (2017). Epidemiology of Pain in People with Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications. J Am Med Dir Assoc, 18(5), 453.e1-453.e6. Abstract.  Author URL.
Flo E, Bjorvatn B, Corbett A, Pallesen S, Husebo BS (2017). Joint Occurrence of Pain and Sleep Disturbances in People with Dementia. A Systematic Review. Curr Alzheimer Res, 14(5), 538-545. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry Abstract.  Author URL.  Full text.
Greenan C, Murphy L, Yu L-M, Kehoe PG, Coulthard E, Bath P, Stewart R, Jones R, Corbett A, Thomas A, et al (2016). A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine for the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials, 17(1). Abstract.  Author URL.  Full text.
Rajkumar AP, Ballard C, Fossey J, Corbett A, Woods B, Orrell M, Prakash R, Moniz-Cook E, Testad I (2016). Apathy and its Response to Antipsychotic Review and Nonpharmacological Interventions in People with Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial. Journal of the American Medical Directors Association, 17(8), 741-747. Abstract.
Svendsboe E, Terum T, Testad I, Aarsland D, Ulstein I, Corbett A, Rongve A (2016). Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry, 31(9), 1075-1083. Abstract.  Author URL.
Ballard C, Mobley W, Hardy J, Williams G, Corbett A (2016). Dementia in Down's syndrome. Lancet Neurol, 15(6), 622-636. Abstract.  Author URL.
Corbett A, Ballard C (2016). Dextromethorphan and quinidine are suitable for off-label short-term treatment of agitation in people with Alzheimer's disease following first-line non-drug approaches. Evid Based Med, 21(1). Author URL.
Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.  Full text.
Ballard C, Orrell M, YongZhong S, Moniz-Cook E, Stafford J, Whittaker R, Woods B, Corbett A, Garrod L, Khan Z, et al (2016). Impact of Antipsychotic Review and Nonpharmacological Intervention on Antipsychotic Use, Neuropsychiatric Symptoms, and Mortality in People with Dementia Living in Nursing Homes: a Factorial Cluster-Randomized Controlled Trial by the Well-Being and Health for People with Dementia (WHELD) Program. Am J Psychiatry, 173(3), 252-262. Abstract.  Author URL.
Ballard C, Orrell M, Sun Y, Moniz-Cook E, Stafford J, Whitaker R, Woods B, Corbett A, Banerjee S, Testad I, et al (2016). Impact of antipsychotic review and non-pharmacological intervention on health-related quality of life in people with dementia living in care homes: WHELD-a factorial cluster randomised controlled trial. Int J Geriatr Psychiatry Abstract.  Author URL.
Lichtner V, Dowding D, Allcock N, Keady J, Sampson EL, Briggs M, Corbett A, James K, Lasrado R, Swarbrick C, et al (2016). The assessment and management of pain in patients with dementia in hospital settings: a multi-case exploratory study from a decision making perspective. BMC Health Serv Res, 16(1). Abstract.  Author URL.
Corbett A, Nunez K-M, Smeaton E, Testad I, Thomas AJ, Closs SJ, Briggs M, Clifton L, Gjestsen MT, Lawrence V, et al (2016). The landscape of pain management in people with dementia living in care homes: a mixed methods study. Int J Geriatr Psychiatry, 31(12), 1354-1370. Abstract.  Author URL.
Khan A, Kalaria RN, Corbett A, Ballard C (2016). Update on Vascular Dementia. J Geriatr Psychiatry Neurol, 29(5), 281-301. Abstract.  Author URL.
Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.
Ferreira N, Owen A, Mohan A, Corbett A, Ballard C (2015). Associations between cognitively stimulating leisure activities, cognitive function and age-related cognitive decline. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 30(4), 422-430. Author URL.
Ballard C, Sharp S, Corbett A (2015). Dextromethorphan and Quinidine for Treating Agitation in Patients with Alzheimer Disease Dementia. JAMA, 314(12), 1233-1235. Author URL.
Corbett A, Williams G, Ballard C (2015). Drug repositioning in Alzheimer's disease. Front Biosci (Schol Ed), 7, 184-188. Abstract.  Author URL.
Ballard C, Isaacson S, Mills R, Williams H, Corbett A, Coate B, Pahwa R, Rascol O, Burn DJ (2015). Impact of Current Antipsychotic Medications on Comparative Mortality and Adverse Events in People with Parkinson Disease Psychosis. J Am Med Dir Assoc, 16(10), 898.e1-898.e7. Abstract.  Author URL.
Corbett A, Owen A, Hampshire A, Grahn J, Stenton R, Dajani S, Burns A, Howard R, Williams N, Williams G, et al (2015). The Effect of an Online Cognitive Training Package in Healthy Older Adults: an Online Randomized Controlled Trial. Journal of the American Medical Directors Association, 16(11), 990-997. Author URL.
Ballard C, Corbett A, Sharp S (2014). Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer’s disease. Expert Review of Neurotherapeutics, 11(3), 327-329.
Corbett A, Achterberg W, Husebo B, Lobbezoo F, de Vet H, Kunz M, Strand L, Constantinou M, Tudose C, Kappesser J, et al (2014). An international road map to improve pain assessment in people with impaired cognition: the development of the Pain Assessment in Impaired Cognition (PAIC) meta-tool. BMC Neurol, 14 Abstract.  Author URL.
Sultana J, Chang CK, Hayes RD, Broadbent M, Stewart R, Corbett A, Ballard C (2014). Associations between risk of mortality and atypical antipsychotic use in vascular dementia: a clinical cohort study. International Journal of Geriatric Psychiatry, 29(12), 1249-1254.
Drageset J, Corbett A, Selbaek G, Husebo BS (2014). Cancer-related pain and symptoms among nursing home residents: a systematic review. J Pain Symptom Manage, 48(4), 699-710.e1. Abstract.  Author URL.
Khan Z, Corbett A, Ballard C (2014). Cognitive stimulation therapy: training, maintenance and implementation in clinical trials. Pragmat Obs Res, 5, 15-19. Abstract.  Author URL.
Husebo BS, Corbett A (2014). Dementia: Pain management in dementia--the value of proxy measures. Nat Rev Neurol, 10(6), 313-314. Author URL.
Corbett A, Burns A, Ballard C (2014). Don't use antipsychotics routinely to treat agitation and aggression in people with dementia. BMJ, 349 Author URL.
Sandvik RK, Selbaek G, Seifert R, Aarsland D, Ballard C, Corbett A, Husebo BS (2014). Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. Eur J Pain, 18(10), 1490-1500. Abstract.  Author URL.
Broadstock M, Ballard C, Corbett A (2014). Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies. Expert Opin Pharmacother, 15(13), 1797-1810. Abstract.  Author URL.
Corbett A, Smith J, Ballard C (2014). New and emerging treatments for Alzheimer’s disease. Expert Review of Neurotherapeutics, 12(5), 535-543.
Broadstock M, Ballard C, Corbett A (2014). Novel pharmaceuticals in the treatment of psychosis in Parkinson's disease. Expert Rev Clin Pharmacol, 7(6), 779-786. Abstract.  Author URL.
Lichtner V, Dowding D, Esterhuizen P, Closs SJ, Long AF, Corbett A, Briggs M (2014). Pain assessment for people with dementia: a systematic review of systematic reviews of pain assessment tools. BMC Geriatr, 14 Abstract.  Author URL.
Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, Dhall R, Ballard C (2014). Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet, 383(9916), 533-540. Abstract.  Author URL.
Ballard C, Corbett A, Howard R (2014). Prescription of antipsychotics in people with dementia. Br J Psychiatry, 205(1), 4-5. Author URL.
Ballard C, Francis P, Corbett A (2014). Randomized controlled trial of mibampator for behavioral and psychological symptoms of dementia: comments on the trial and thoughts for future studies - ADDENDUM. Int Psychogeriatr Author URL.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.
Ballard C, Corbett A (2014). Screening for dementia: an opportunity for debate. Expert Review of Neurotherapeutics, 11(10), 1347-1349.
Fossey J, Masson S, Stafford J, Lawrence V, Corbett A, Ballard C (2014). The disconnect between evidence and practice: a systematic review of person-centred interventions and training manuals for care home staff working with people with dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 29(8), 797-807. Author URL.
Corbett A, Husebo BS, Achterberg WP, Aarsland D, Erdal A, Flo E (2014). The importance of pain management in older people with dementia. Br Med Bull, 111(1), 139-148. Abstract.  Author URL.
Testad I, Corbett A, Aarsland D, Lexow KO, Fossey J, Woods B, Ballard C (2014). The value of personalized psychosocial interventions to address behavioral and psychological symptoms in people with dementia living in care home settings: a systematic review. INTERNATIONAL PSYCHOGERIATRICS, 26(7), 1083-1098. Author URL.
Corbett A, Ballard C (2014). The value of vitamin E as a treatment for Alzheimer's disease remains unproven despite functional improvement, due to a lack of established effect on cognition or other outcomes from RCTs. Evidence Based Medicine, 19(4), 140-140.
Ballard C, Corbett A (2013). Agitation and aggression in people with Alzheimerʼs disease. Current Opinion in Psychiatry, 26(3), 252-259.
Corbett A, Husebo B, Malcangio M, Staniland A, Cohen-Mansfield J, Aarsland D, Ballard C (2013). Assessment and treatment of pain in people with dementia. Nature Reviews Neurology, 9(7), 358-358.
Corbett A, Nunez K, Thomas A (2013). Coping with dementia in care homes. Maturitas, 76(1), 3-4.
Corbett A, Williams G, Ballard C (2013). Drug Repositioning: an Opportunity to Develop Novel Treatments for Alzheimer’s Disease. Pharmaceuticals, 6(10), 1304-1321.
Clare L, Bayer A, Burns A, Corbett A, Jones R, Knapp M, Kopelman M, Kudlicka A, Leroi I, Oyebode J, et al (2013). Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials, 14 Abstract.  Author URL.
Corbett A, Ballard C (2013). Is a potential Alzheimer's therapy already in use for other conditions? can medications for hypertension, diabetes and acne help with the symptoms?. Expert Opinion on Investigational Drugs, 22(8), 941-943.
Ballard C, Aarsland D, Francis P, Corbett A (2013). Neuropsychiatric Symptoms in Patients with Dementias Associated with Cortical Lewy Bodies: Pathophysiology, Clinical Features, and Pharmacological Management. Drugs & Aging, 30(8), 603-611.
Achterberg W, Pieper MJC, van Dalen-Kok AH, de Waal MWM, Husebo BS, Lautenbacher S, Kunz M, Scherder EJA, Corbett A (2013). Pain management in patients with dementia. Clinical Interventions in Aging, 1471-1471.
Ballard C, Francis P, Corbett A (2013). Randomized controlled trial of mibampator for behavioral and psychological symptoms of dementia: comments on the trial and thoughts for future studies. International Psychogeriatrics, 25(05), 687-689.
Ballard C, Corbett A (2012). A small proportion of people with dementia and neuropsychiatric symptoms experience clinically significant worsening when antidepressants are discontinued. Evidence Based Medicine, 18(1), 27-28.
Corbett A, Ballard C (2012). Antipsychotics and Mortality in Dementia. American Journal of Psychiatry, 169(1), 7-9.
Corbett A, Husebo B, Malcangio M, Staniland A, Cohen-Mansfield J, Aarsland D, Ballard C (2012). Assessment and treatment of pain in people with dementia. Nature Reviews Neurology, 8(5), 264-274. Abstract.
Ballard C, Corbett A (2012). Dementia: New guidelines on disorders associated with dementia. Nature Reviews Neurology, 8(12), 663-664.
Corbett A, Pickett J, Burns A, Corcoran J, Dunnett SB, Edison P, Hagan JJ, Holmes C, Jones E, Katona C, et al (2012). Drug repositioning for Alzheimer's disease. Nature Reviews Drug Discovery, 11(11), 833-846.
Hanney M, Prasher V, Williams N, Jones EL, Aarsland D, Corbett A, Lawrence D, Yu L-M, Tyrer S, Francis PT, et al (2012). Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. LANCET, 379(9815), 528-536. Author URL.
Corbett A, Ballard C (2012). New and emerging treatments for Alzheimer's disease. Expert Opin Emerg Drugs, 17(2), 147-156. Abstract.  Author URL.
Ballard C, Jones E, Gauge N, Aarsland D, Nilsen OB, Saxby BK, Lowery D, Corbett A, Wesnes K, Katsaiti E, et al (2012). Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial. PLoS ONE, 7(6), e37410-e37410.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011). Alzheimer's disease. LANCET, 377(9770), 1019-1031. Author URL.
Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.
Ballard C, Corbett A, Jones EL (2011). Dementia: challenges and promising developments. The Lancet Neurology, 10(1), 7-9.
Ballard C, Corbett A, Pickett J (2011). Depression and dementia. Ment Health Today, 23-25. Author URL.
Talà A, Monaco C, Nagorska K, Exley RM, Corbett A, Zychlinsky A, Alifano P, Tang CM (2011). Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. Molecular Microbiology, 81(5), 1330-1342.
Corbett A, Ballard C (2011). Information provision services in dementia care. International Journal of Older People Nursing, 6(3), 217-226.
Ballard C, Khan Z, Clack H, Corbett A (2011). Nonpharmacological treatment of Alzheimer disease. Can J Psychiatry, 56(10), 589-595. Abstract.  Author URL.
Corbett A, Stevens J, Aarsland D, Day S, Moniz-Cook E, Woods R, Brooker D, Ballard C (2011). Systematic review of services providing information and/or advice to people with dementia and/or their caregivers. International Journal of Geriatric Psychiatry, 27(6), 628-636.
Ballard C, Smith J, Husebo B, Aarsland D, Corbett A (2011). The role of pain treatment in managing the behavioural and psychological symptoms of dementia (BPSD). Int J Palliat Nurs, 17(9), 420-424. Author URL.
Ballard C, Kahn Z, Corbett A (2011). Treatment of dementia with Lewy bodies and Parkinson's disease dementia. Drugs Aging, 28(10), 769-777. Abstract.  Author URL.
Ballard C, Corbett A (2010). Management of neuropsychiatric symptoms in people with dementia. CNS Drugs, 24(9), 729-739. Abstract.  Author URL.
Ballard C, Corbett A, Chitramohan R, Aarsland D (2009). Management of agitation and aggression associated with Alzheimerʼs disease: controversies and possible solutions. Current Opinion in Psychiatry, 22(6), 532-540.
Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, et al (2007). AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. The EMBO Journal, 26(5), 1363-1372.
Corbett A, Exley R, Bourdoulous S, Tang CM (2004). Interactions between Neisseria meningitidis and human cells that promote colonisation and disease. Expert Reviews in Molecular Medicine, 6(14).

Publications by year


2017

Rajkumar AP, Ballard C, Fossey J, Orrell M, Moniz-Cook E, Woods RT, Murray J, Whitaker R, Stafford J, Knapp M, et al (2017). Epidemiology of Pain in People with Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications. J Am Med Dir Assoc, 18(5), 453.e1-453.e6. Abstract.  Author URL.
Flo E, Bjorvatn B, Corbett A, Pallesen S, Husebo BS (2017). Joint Occurrence of Pain and Sleep Disturbances in People with Dementia. A Systematic Review. Curr Alzheimer Res, 14(5), 538-545. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry Abstract.  Author URL.  Full text.

2016

Greenan C, Murphy L, Yu L-M, Kehoe PG, Coulthard E, Bath P, Stewart R, Jones R, Corbett A, Thomas A, et al (2016). A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine for the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials, 17(1). Abstract.  Author URL.  Full text.
Rajkumar AP, Ballard C, Fossey J, Corbett A, Woods B, Orrell M, Prakash R, Moniz-Cook E, Testad I (2016). Apathy and its Response to Antipsychotic Review and Nonpharmacological Interventions in People with Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial. Journal of the American Medical Directors Association, 17(8), 741-747. Abstract.
Svendsboe E, Terum T, Testad I, Aarsland D, Ulstein I, Corbett A, Rongve A (2016). Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry, 31(9), 1075-1083. Abstract.  Author URL.
Ballard C, Mobley W, Hardy J, Williams G, Corbett A (2016). Dementia in Down's syndrome. Lancet Neurol, 15(6), 622-636. Abstract.  Author URL.
Corbett A, Ballard C (2016). Dextromethorphan and quinidine are suitable for off-label short-term treatment of agitation in people with Alzheimer's disease following first-line non-drug approaches. Evid Based Med, 21(1). Author URL.
Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.  Full text.
Ballard C, Orrell M, YongZhong S, Moniz-Cook E, Stafford J, Whittaker R, Woods B, Corbett A, Garrod L, Khan Z, et al (2016). Impact of Antipsychotic Review and Nonpharmacological Intervention on Antipsychotic Use, Neuropsychiatric Symptoms, and Mortality in People with Dementia Living in Nursing Homes: a Factorial Cluster-Randomized Controlled Trial by the Well-Being and Health for People with Dementia (WHELD) Program. Am J Psychiatry, 173(3), 252-262. Abstract.  Author URL.
Ballard C, Orrell M, Sun Y, Moniz-Cook E, Stafford J, Whitaker R, Woods B, Corbett A, Banerjee S, Testad I, et al (2016). Impact of antipsychotic review and non-pharmacological intervention on health-related quality of life in people with dementia living in care homes: WHELD-a factorial cluster randomised controlled trial. Int J Geriatr Psychiatry Abstract.  Author URL.
Lichtner V, Dowding D, Allcock N, Keady J, Sampson EL, Briggs M, Corbett A, James K, Lasrado R, Swarbrick C, et al (2016). The assessment and management of pain in patients with dementia in hospital settings: a multi-case exploratory study from a decision making perspective. BMC Health Serv Res, 16(1). Abstract.  Author URL.
Corbett A, Nunez K-M, Smeaton E, Testad I, Thomas AJ, Closs SJ, Briggs M, Clifton L, Gjestsen MT, Lawrence V, et al (2016). The landscape of pain management in people with dementia living in care homes: a mixed methods study. Int J Geriatr Psychiatry, 31(12), 1354-1370. Abstract.  Author URL.
Khan A, Kalaria RN, Corbett A, Ballard C (2016). Update on Vascular Dementia. J Geriatr Psychiatry Neurol, 29(5), 281-301. Abstract.  Author URL.

2015

Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.
Ferreira N, Owen A, Mohan A, Corbett A, Ballard C (2015). Associations between cognitively stimulating leisure activities, cognitive function and age-related cognitive decline. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 30(4), 422-430. Author URL.
Ballard C, Sharp S, Corbett A (2015). Dextromethorphan and Quinidine for Treating Agitation in Patients with Alzheimer Disease Dementia. JAMA, 314(12), 1233-1235. Author URL.
Corbett A, Williams G, Ballard C (2015). Drug repositioning in Alzheimer's disease. Front Biosci (Schol Ed), 7, 184-188. Abstract.  Author URL.
Ballard C, Isaacson S, Mills R, Williams H, Corbett A, Coate B, Pahwa R, Rascol O, Burn DJ (2015). Impact of Current Antipsychotic Medications on Comparative Mortality and Adverse Events in People with Parkinson Disease Psychosis. J Am Med Dir Assoc, 16(10), 898.e1-898.e7. Abstract.  Author URL.
Corbett A, Owen A, Hampshire A, Grahn J, Stenton R, Dajani S, Burns A, Howard R, Williams N, Williams G, et al (2015). The Effect of an Online Cognitive Training Package in Healthy Older Adults: an Online Randomized Controlled Trial. Journal of the American Medical Directors Association, 16(11), 990-997. Author URL.

2014

Ballard C, Corbett A, Sharp S (2014). Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer’s disease. Expert Review of Neurotherapeutics, 11(3), 327-329.
Corbett A, Achterberg W, Husebo B, Lobbezoo F, de Vet H, Kunz M, Strand L, Constantinou M, Tudose C, Kappesser J, et al (2014). An international road map to improve pain assessment in people with impaired cognition: the development of the Pain Assessment in Impaired Cognition (PAIC) meta-tool. BMC Neurol, 14 Abstract.  Author URL.
Sultana J, Chang CK, Hayes RD, Broadbent M, Stewart R, Corbett A, Ballard C (2014). Associations between risk of mortality and atypical antipsychotic use in vascular dementia: a clinical cohort study. International Journal of Geriatric Psychiatry, 29(12), 1249-1254.
Drageset J, Corbett A, Selbaek G, Husebo BS (2014). Cancer-related pain and symptoms among nursing home residents: a systematic review. J Pain Symptom Manage, 48(4), 699-710.e1. Abstract.  Author URL.
Khan Z, Corbett A, Ballard C (2014). Cognitive stimulation therapy: training, maintenance and implementation in clinical trials. Pragmat Obs Res, 5, 15-19. Abstract.  Author URL.
Husebo BS, Corbett A (2014). Dementia: Pain management in dementia--the value of proxy measures. Nat Rev Neurol, 10(6), 313-314. Author URL.
Corbett A, Burns A, Ballard C (2014). Don't use antipsychotics routinely to treat agitation and aggression in people with dementia. BMJ, 349 Author URL.
Sandvik RK, Selbaek G, Seifert R, Aarsland D, Ballard C, Corbett A, Husebo BS (2014). Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. Eur J Pain, 18(10), 1490-1500. Abstract.  Author URL.
Creese B, Ballard C, Corbett A (2014). Influence of the Tau Haplotype on Progression and Treatment Response of Neuropsychiatric Symptoms in People with Alzheimer's Disease.  Abstract.
Broadstock M, Ballard C, Corbett A (2014). Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies. Expert Opin Pharmacother, 15(13), 1797-1810. Abstract.  Author URL.
Corbett A, Smith J, Ballard C (2014). New and emerging treatments for Alzheimer’s disease. Expert Review of Neurotherapeutics, 12(5), 535-543.
Broadstock M, Ballard C, Corbett A (2014). Novel pharmaceuticals in the treatment of psychosis in Parkinson's disease. Expert Rev Clin Pharmacol, 7(6), 779-786. Abstract.  Author URL.
Lichtner V, Dowding D, Esterhuizen P, Closs SJ, Long AF, Corbett A, Briggs M (2014). Pain assessment for people with dementia: a systematic review of systematic reviews of pain assessment tools. BMC Geriatr, 14 Abstract.  Author URL.
Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, Dhall R, Ballard C (2014). Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet, 383(9916), 533-540. Abstract.  Author URL.
Ballard C, Corbett A, Howard R (2014). Prescription of antipsychotics in people with dementia. Br J Psychiatry, 205(1), 4-5. Author URL.
Ballard C, Francis P, Corbett A (2014). Randomized controlled trial of mibampator for behavioral and psychological symptoms of dementia: comments on the trial and thoughts for future studies - ADDENDUM. Int Psychogeriatr Author URL.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.
Ballard C, Corbett A (2014). Screening for dementia: an opportunity for debate. Expert Review of Neurotherapeutics, 11(10), 1347-1349.
Fossey J, Masson S, Stafford J, Lawrence V, Corbett A, Ballard C (2014). The disconnect between evidence and practice: a systematic review of person-centred interventions and training manuals for care home staff working with people with dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 29(8), 797-807. Author URL.
Corbett A, Husebo BS, Achterberg WP, Aarsland D, Erdal A, Flo E (2014). The importance of pain management in older people with dementia. Br Med Bull, 111(1), 139-148. Abstract.  Author URL.
Testad I, Corbett A, Aarsland D, Lexow KO, Fossey J, Woods B, Ballard C (2014). The value of personalized psychosocial interventions to address behavioral and psychological symptoms in people with dementia living in care home settings: a systematic review. INTERNATIONAL PSYCHOGERIATRICS, 26(7), 1083-1098. Author URL.
Corbett A, Ballard C (2014). The value of vitamin E as a treatment for Alzheimer's disease remains unproven despite functional improvement, due to a lack of established effect on cognition or other outcomes from RCTs. Evidence Based Medicine, 19(4), 140-140.

2013

Ballard C, Corbett A (2013). Agitation and aggression in people with Alzheimerʼs disease. Current Opinion in Psychiatry, 26(3), 252-259.
Corbett A, Husebo B, Malcangio M, Staniland A, Cohen-Mansfield J, Aarsland D, Ballard C (2013). Assessment and treatment of pain in people with dementia. Nature Reviews Neurology, 9(7), 358-358.
Corbett A, Nunez K, Thomas A (2013). Coping with dementia in care homes. Maturitas, 76(1), 3-4.
Corbett A, Williams G, Ballard C (2013). Drug Repositioning: an Opportunity to Develop Novel Treatments for Alzheimer’s Disease. Pharmaceuticals, 6(10), 1304-1321.
Clare L, Bayer A, Burns A, Corbett A, Jones R, Knapp M, Kopelman M, Kudlicka A, Leroi I, Oyebode J, et al (2013). Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials, 14 Abstract.  Author URL.
Corbett A, Ballard C (2013). Is a potential Alzheimer's therapy already in use for other conditions? can medications for hypertension, diabetes and acne help with the symptoms?. Expert Opinion on Investigational Drugs, 22(8), 941-943.
Ballard C, Aarsland D, Francis P, Corbett A (2013). Neuropsychiatric Symptoms in Patients with Dementias Associated with Cortical Lewy Bodies: Pathophysiology, Clinical Features, and Pharmacological Management. Drugs & Aging, 30(8), 603-611.
Achterberg W, Pieper MJC, van Dalen-Kok AH, de Waal MWM, Husebo BS, Lautenbacher S, Kunz M, Scherder EJA, Corbett A (2013). Pain management in patients with dementia. Clinical Interventions in Aging, 1471-1471.
Ballard C, Francis P, Corbett A (2013). Randomized controlled trial of mibampator for behavioral and psychological symptoms of dementia: comments on the trial and thoughts for future studies. International Psychogeriatrics, 25(05), 687-689.

2012

Ballard C, Corbett A (2012). A small proportion of people with dementia and neuropsychiatric symptoms experience clinically significant worsening when antidepressants are discontinued. Evidence Based Medicine, 18(1), 27-28.
Corbett A, Ballard C (2012). Antipsychotics and Mortality in Dementia. American Journal of Psychiatry, 169(1), 7-9.
Corbett A, Husebo B, Malcangio M, Staniland A, Cohen-Mansfield J, Aarsland D, Ballard C (2012). Assessment and treatment of pain in people with dementia. Nature Reviews Neurology, 8(5), 264-274. Abstract.
Ballard C, Corbett A (2012). Dementia: New guidelines on disorders associated with dementia. Nature Reviews Neurology, 8(12), 663-664.
Corbett A, Pickett J, Burns A, Corcoran J, Dunnett SB, Edison P, Hagan JJ, Holmes C, Jones E, Katona C, et al (2012). Drug repositioning for Alzheimer's disease. Nature Reviews Drug Discovery, 11(11), 833-846.
Hanney M, Prasher V, Williams N, Jones EL, Aarsland D, Corbett A, Lawrence D, Yu L-M, Tyrer S, Francis PT, et al (2012). Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. LANCET, 379(9815), 528-536. Author URL.
Corbett A, Ballard C (2012). New and emerging treatments for Alzheimer's disease. Expert Opin Emerg Drugs, 17(2), 147-156. Abstract.  Author URL.
Ballard C, Jones E, Gauge N, Aarsland D, Nilsen OB, Saxby BK, Lowery D, Corbett A, Wesnes K, Katsaiti E, et al (2012). Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial. PLoS ONE, 7(6), e37410-e37410.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.

2011

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011). Alzheimer's disease. LANCET, 377(9770), 1019-1031. Author URL.
Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.
Ballard C, Corbett A, Jones EL (2011). Dementia: challenges and promising developments. The Lancet Neurology, 10(1), 7-9.
Ballard C, Corbett A, Pickett J (2011). Depression and dementia. Ment Health Today, 23-25. Author URL.
Talà A, Monaco C, Nagorska K, Exley RM, Corbett A, Zychlinsky A, Alifano P, Tang CM (2011). Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. Molecular Microbiology, 81(5), 1330-1342.
Corbett A, Ballard C (2011). Information provision services in dementia care. International Journal of Older People Nursing, 6(3), 217-226.
Ballard C, Khan Z, Clack H, Corbett A (2011). Nonpharmacological treatment of Alzheimer disease. Can J Psychiatry, 56(10), 589-595. Abstract.  Author URL.
Corbett A, Stevens J, Aarsland D, Day S, Moniz-Cook E, Woods R, Brooker D, Ballard C (2011). Systematic review of services providing information and/or advice to people with dementia and/or their caregivers. International Journal of Geriatric Psychiatry, 27(6), 628-636.
Ballard C, Smith J, Husebo B, Aarsland D, Corbett A (2011). The role of pain treatment in managing the behavioural and psychological symptoms of dementia (BPSD). Int J Palliat Nurs, 17(9), 420-424. Author URL.
Ballard C, Kahn Z, Corbett A (2011). Treatment of dementia with Lewy bodies and Parkinson's disease dementia. Drugs Aging, 28(10), 769-777. Abstract.  Author URL.

2010

Ballard C, Corbett A (2010). Management of neuropsychiatric symptoms in people with dementia. CNS Drugs, 24(9), 729-739. Abstract.  Author URL.

2009

Ballard C, Corbett A, Chitramohan R, Aarsland D (2009). Management of agitation and aggression associated with Alzheimerʼs disease: controversies and possible solutions. Current Opinion in Psychiatry, 22(6), 532-540.

2007

Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, et al (2007). AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. The EMBO Journal, 26(5), 1363-1372.

2004

Corbett A, Exley R, Bourdoulous S, Tang CM (2004). Interactions between Neisseria meningitidis and human cells that promote colonisation and disease. Expert Reviews in Molecular Medicine, 6(14).

Media Coverage

Anne is fully media trained and has appeared on several media channels including television, radio and print. This has included BBC News, Sky News, ITV News, Channel 4 News, BBC Radio 4 Today Programme, Regional BBC Radio and a wide selection of print media. A selection is provided below:

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