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Anna Steele

Senior Research Nurse

+44 (0) 1392 408173

NIHR Exeter Clinical Research Facility 2.15

Anna has been a member of Prof Andrew Hattersley’s research team since 2002. She trained as a nurse in Exeter and has worked in both cardiology and diabetes (Ward Sister). Anna gained a PhD in 2013 – her work focused on a monogenic form of hyperglycaemia. This hyperglycaemia is caused by a mutation in the glucokinase gene.

Anna’s is a Senior Nurse and her current work continues to focus on those with glucokinase but she also has a great interest in all monogenic forms of diabetes. She also helps to set-up and co-ordinate studies into type 2 diabetes and its prevention, treatment and drug responses.

Broad research specialisms

  • Glucokinase
  • Monogenic diabetes
  • Type 2 diabetes

Qualifications

  • RGN in adult health
  • PhD in Medical Sciences
  • MSc in Health
  • BSc in Health and Social Care

Awards

  • Awards: Marjorie Simpson New Researcher Award from the Royal College of Nursing, 2009

Research

Research interests

Anna’s research interests include:

  • Hyperglycaemia caused by mutations in the glucokinase gene
  • Monogenic diabetes/MODY
  • Type 2 diabetes

Research projects

  • ProMaster
  • RetroMaster
  • DARE (Diabetes Alliance for Research in England)
  • EXTEND (Exeter 10,000)
  • InterStroke (Conventional and Emerging Risk Factors for Stroke)

Grants and funding

  • Diabetes UK project grant, £152,178
  • NIHR RDA funding for PhD, £228,636, 2007
  • Novonordisk UK Diabetes Fund £805, 2006
  • RCN Trevor Clay Scholarship £2000, 2004
  • Novornordisk UK Diabetes Fund £500, 2004
  • The Florence Nightingale Foundation/ The Band Trust £340, 2004
  • RCN/Johnson & Johnson/Ethicon Nurse Education Trust Fund £500, 2003

Publications

  • Steele AM, Wensley KJ, Ellard S, Murphy R, Shepherd M, Colclough K, Hattersley AT, Shields BM. Use of HbA1c in the identification of patients with hyperglycaemia caused by a GCK mutation: observational case control studies. PLOS ONE, 8:6, 2013
  • Steele AM, Wensley KJ, Brewer E, Shields BM, Hattersley AT, McDonald TJ. Preanalytical sample handling of venous blood: how to ensure your glucose measurement is accurate and reliable. Practical Diabetes, 30:3, 2013
  • Beer NL, Osbak KK, van de Bunt M, Tribble ND, Steele AM, Wensley KJ, Edghill EL, Colcough K, Barrett A, Valentínová L, Rundle JK, Raimondo A, Grimsby J, Ellard E, Gloyn AL. Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterisation of compound heterozygous and double mutations inherited in cis. Diabetes Care, 2012
  • Winney B, Boumertit A, DayT, Davison D, Echeta C, Evseeva I, Hutnik K, LeslieS, Nicodemus K, Royrvik EC, n Tonks S, Yang X, Cheshire J, Longley P, Mateos P, Groom A, Relton C, Bishop T, Black K, Northwood E, Parkinson L, Frayling TM, Steele AM, Sampson JR, King T, Dixon R, Middleton D, Jenning B, Bowden R, Donnelly P and Bodmer W. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. European Journal of Human Genetics, 2012, 20: 203-210
  • Steele AM, Tribble ND, Caswell R, Wensley KJ, Hattersley AT, Gloyn AL, Ellard S. The rare GCK missense substitution T342P is not a pathogenic mutation. Diabetologia, May 2011, 54:2202–2205
  • Steele AM, Shields BM, Shepherd M, Ellard S, Hattersley AT, Pearson ER. Increased all-cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene. Diabetic Medicine. 2010 (27), 157 -161
  • CJ Greaves, A Middlebrooke, L O'Loughlin, S Holland, J Piper, A Steele, T Gale, F Hammerton, M Daly. Motivational interviewing for modifying diabetes risk: A Randomised controlled trial. The British Journal of General Practice. Aug 2008, 535-541
  • W Harries L, Locke JM, Shields B, Hanley NA, Piper Hanley K, Steele A, Njølstad PR, Ellard S, Hattersley AT. The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes. 2008 Mar 20
  • De Silva NM, Steele A, Shields B, Knight B, Parnell K, Weedon MN, Hattersley AT, Frayling TM.The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.Diabet Med. 2007 Oct;24(10):1067-72. Epub 2007 Aug 24
  • Anna M Steele, Ewan R Pearson, Sylvia F. Boj, Timothy Barrett, Karen Stals, Julian P Shield, Sian Ellard, Jorge Ferrer, Andrew T Hattersley 2007. Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF-4A gene. PLoS Medicine, 7 (4), e118, 1-10
  • Freathy RM, Lonnen KF, AM Steele, Minton JAL, Frayling TM, AT Hattersley and KM Macleod 2006. The Impact of Angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycaemia in Type 2 diabetes. The Review of Diabetic Studies. 3:76-81
  • Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HAJ, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d’Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT and Matschinsky FM 2005. Insights into the structure and Regulation of Glucokinase from a Novel Mutation (V62M), which causes Maturity-onset Diabetes of the young. The Journal of Biological Chemistry, 280: 14, 14105-14113
  • Steele AM, Shields BM, Knight B, Pearson ER 2005. Waist circumference: a predictive tool for insulin resistance. Journal of Diabetes Nursing. 9 (10) 389-393
  • Steele AM 2003. Implementing a research project on the development of diabetes. Nursing Times 99: 19, 34-36

Awards

Marjorie Simpson New Researcher Award from the Royal College of Nursing, 2009

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