Professor Anna Murray
Professor of Human Genetics
A.Murray@exeter.ac.uk
Medical School Building
Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK
Overview
Anna is Professor of Human Genetics and Director of Research and Impact for the Department of Clinical and Biomedical Sciences. She is part of the 'Reproductive Genomics' research group (https://sites.exeter.ac.uk/reprogenomics/). Her main research expertise is in the field of reproductive ageing and she has published on single gene mutations which cause premature ovarian insufficiency and also genome-wide studies to detect novel loci involved in menopause timing and other reproductive traits.
Qualifications
BSc, PhD
Career
Anna has a degree in biology from Southampton University, where she also completed her PhD, investigating the molecular biology of coeliac disease and T cell lymphoma of the gut. She spent 5 years as a postdoc in Professor Pat Jacobs' lab in Salisbury investigating the population genetics and molecular basis of fragile X syndrome. In 1998 Anna received a Career Development Fellowship from the Wellcome Trust to work on the association between the fragile X mutation and premature ovarian failure. Anna moved to Exeter in 2005 following a short career break to have her daughter. Following the Wellcome fellowship, Anna became a lecturer at Exeter in 2008 and was promoted to Professor in 2022. She is also currently the Director of Research and Impact for the Clinical and Biomedical Sciences Department.
Links
Research group links
Publications
Journal articles
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.
Ruth KS, Murray A (In Press). Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. Human Molecular Genetics Abstract.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2024). Penetrance of Pathogenic Genetic Variants Associated with Premature Ovarian Insufficiency. Obstetrical & Gynecological Survey, 79(1), 33-34.
Murray A, Perry J (2023). Genes linked to premature ovarian insufficiency show no pathogenicity in the general population. NATURE MEDICINE, 29(7), 1617-1618. Author URL.
Ruth KS, Beaumont RN, Locke JM, Tyrrell J, Crandall CJ, Hawkes G, Frayling TM, Prague JK, Patel KA, Wood AR, et al (2023). Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records. BMC Med Genomics, 16(1). Abstract. Author URL.
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2023). Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med, 29(7), 1692-1699. Abstract. Author URL.
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS, Wood AR, Beaumont RN, et al (2022). Detection and characterization of male sex chromosome abnormalities in the UK Biobank study. Genet Med, 24(9), 1909-1919. Abstract. Author URL.
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.
Trevino CE, Rounds JC, Charen K, Shubeck L, Hipp HS, Spencer JB, Johnston HR, Cutler DJ, Zwick ME, Epstein MP, et al (2021). Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation. Fertil Steril, 116(3), 843-854. Abstract. Author URL.
RUTH KS, DAY F, TYRRELL J, MURRAY A, ONG K, FRAYLING T, PERRY J (2020). 1907-P: Using Human Genetics to Test the Disease Consequences of Varying Testosterone Levels in Men and Women. Diabetes, 69(Supplement_1).
Clark R, Gregory S, Ring S, Jacobs P, Ennis S, Murray A, Ellis G, Golding J, Northstone K, Pembrey M, et al (2020). The FRAXA and FRAXE allele repeat size of boys from the Avon Longitudinal Study of Parents and Children (ALSPAC). Wellcome Open Research, 4, 116-116. Abstract.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract. Author URL.
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.
Eriksson AL, Perry JRB, Coviello AD, Delgado GE, Ferrucci L, Hoffman AR, Huhtaniemi IT, Ikram MA, Karlsson MK, Kleber ME, et al (2019). Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men (vol 103, pg 991, 2018). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 104(7), 2580-2580. Author URL.
Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y, et al (2019). Genetic predisposition to mosaic Y chromosome loss in blood. Nature, 575(7784), 652-657. Abstract. Author URL.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract. Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Clark R, Gregory S, Ring S, Jacobs P, Ennis S, Murray A, Ellis G, Golding J, Northstone K, Pembrey M, et al (2019). The FRAXA and FRAXE allele repeat size of boys from the Avon Longitudinal Study of Parents and Children (ALSPAC). Wellcome Open Research, 4, 116-116. Abstract.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract. Author URL.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, Forgett V, et al (2018). Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. The BMJ, 362 Abstract.
Eriksson AL, Perry JRB, Coviello AD, Delgado GE, Ferrucci L, Hoffman AR, Huhtaniemi IT, Ikram MA, Karlsson MK, Kleber ME, et al (2018). Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men. J Clin Endocrinol Metab, 103(3), 991-1004. Abstract. Author URL.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract. Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract. Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract. Author URL.
Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, et al (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet, 49(6), 834-841. Abstract. Author URL.
Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, et al (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 Abstract.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract. Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract. Author URL.
Murray A, Macpherson JN (2016). Development of genetic testing for Fragile X syndrome and associated disorders, and estimates of the prevalence of FMR1 expansion mutations. Genes, 7(12)
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract. Author URL.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract. Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract. Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics
Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. Eur J Hum Genet, 24(2), 284-290. Abstract. Author URL.
Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract. Author URL.
Ruth KS, Bennett CE, Schoemaker MJ, Weedon MN, Swerdlow AJ, Murray A (2016). Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause. Hum Reprod, 31(10), 2396-2403. Abstract. Author URL.
Ruth KS, Murray A (2016). Lessons from Genome-Wide Association Studies in Reproductive Medicine: Menopause. Semin Reprod Med, 34(4), 215-223. Abstract. Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.
Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, et al (2016). Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med, 46(8), 1613-1623. Abstract. Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract. Author URL.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair. Obstetrical and Gynecological Survey, 70(12), 758-762.
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet, 47(11), 1294-1303. Abstract. Author URL.
Perry JRB, Murray A, Day FR, Ong KK (2015). Molecular insights into the aetiology of female reproductive ageing. Nat Rev Endocrinol, 11(12), 725-734. Abstract. Author URL.
Day FR, Elks CE, Murray A, Ong KK, Perry JRB (2015). Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Sci Rep, 5 Abstract. Author URL.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Rare coding variants and X-linked loci associated with age at menarche. Nat Commun, 6 Abstract. Author URL.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract. Author URL.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract. Author URL.
Murray A, Nicol A, Murray I, Robson J (2014). Concussion: no longer a laughing matter in sport. Journal of the Royal Naval Medical Service, 100(1), 62-64.
Perry JRB, Hsu Y-H, Chasman DI, Johnson AD, Elks C, Albrecht E, Andrulis IL, Beesley J, Berenson GS, Bergmann S, et al (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Hum Mol Genet, 23(9), 2490-2497. Abstract. Author URL.
Murray A, Wood A (2014). Improving health through physical activity, and its importance for the Royal Navy. Journal of the Royal Naval Medical Service, 100(1), 70-72.
Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, et al (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514(7520), 92-97. Abstract. Author URL.
Murray A, Schoemaker MJ, Bennett CE, Ennis S, Macpherson JN, Jones M, Morris DH, Orr N, Ashworth A, Jacobs PA, et al (2014). Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency. Genet Med, 16(1), 19-24. Abstract. Author URL.
Weedon MN, Cebola I, Patch A-M, Flanagan SE, De Franco E, Caswell R, Rodríguez-Seguí SA, Shaw-Smith C, Cho CH-H, Allen HL, et al (2014). Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 46(1), 61-64. Abstract. Author URL.
Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract. Author URL.
Perry JRB, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, et al (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet, 22(7), 1465-1472. Abstract. Author URL.
Fernández-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, Smith AV, Gudnason V, Harris TB, Launer L, et al (2013). Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178(3), 451-460. Abstract.
aer M, Jonathan L, Anna M, Lorna WH (2013). Expression profiling of putative type 2 diabetes susceptibility genes in human islets and in rat beta cell lines. Journal of Diabetes Mellitus, 03(01), 27-32.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract. Author URL.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract. Author URL.
Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract. Author URL.
Murray A, Bennett CE, Perry JRB, Weedon MN, Jacobs PA, Morris DH, Orr N, Schoemaker MJ, Jones M, Ashworth A, et al (2011). Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet, 20(1), 186-192. Abstract. Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Koster A, Petersen A-K, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). Genetic Determinants of Serum Testosterone Concentrations in Men. PLOS GENETICS, 7(10). Author URL.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract. Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract. Author URL.
Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF). Human Reproduction, 25(8), 2139-2150. Abstract.
Bennett CE, Conway GS, Macpherson JN, Jacobs PA, Murray A (2010). Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure. Hum Reprod, 25(5), 1335-1338. Abstract. Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract. Author URL.
Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Reply: Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure. Human Reproduction, 25(12), 3160-3161.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract. Author URL.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract. Author URL.
Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, et al (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet, 41(6), 648-650. Abstract. Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract. Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract. Author URL.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract. Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract. Author URL.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.
Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes and Immunity, 8(7), 552-559.
Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mechanisms of Ageing and Development, 128(5-6), 370-377.
Frayling T, Murray A, Rafiq S, Melzer D (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biols Sci Med Sci, 62(1), 73-78.
Murray A, Brightwell G, Ennis S, Morton N (2007). Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMRI haplotypes. Human Mutation, 28, 1216-1224.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract. Author URL.
TFrayling, Clark VJ, Qian Y, Weedon MN (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. The American Journal of Human Genetics, 79(6), 991-1001.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Ennis S, Murray A, Youings S, Brightwell G, Herrick D, Ring S, Pembrey M, Morton NE, Jacobs PA (2006). An investigation of FRAXA intermediate allele phenotype in a longitudinal sample. Ann Hum Genet, 70(Pt 2), 170-180. Abstract. Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract. Author URL.
Murray A, Ennis S, Ward D (2006). Non-linear association between CGG repeat number and age of menopause in FMRI premutation carriers. European Journal of Human Genetics, 14(2), 253-255.
Murray A, Brightwell G, Ennis S, Youings S (2005). The ALSPAC study team. An investigation of FRAXA intermediate allele phenotype in longitudinal sample. Annals of Human Genetics, 69(1), 1-11.
Pinheiro P, Scarlett G, Rodger A, Rodger PM, Murray A, Brown T, Newbury SF, McClellan JA (2002). Structures of CUG repeats in RNA. Potential implications for human genetic diseases. J Biol Chem, 277(38), 35183-35190. Abstract. Author URL.
Ennis S, Collins A, Tapper W, Murray A, MacPherson JN, Morton NE (2001). Allelic association discriminates draft orders. Ann Hum Genet, 65(Pt 5), 503-504. Author URL.
Murray A, Ennis S, Morton N (2001). Haplotypic determinants of instability in FRAX region: concatenated mutation or founder defect?. Human Mutation, 18(1), 61-69.
Ennis S, Collins A, Murray A, Brightwell G, Morton NE (2001). LD, FRAX and sequence-based maps. AMERICAN JOURNAL OF HUMAN GENETICS, 69(4), 466-466. Author URL.
Ennis S, Collins A, Murray A, Macpherson JN, Morton NE (2000). Allelic association in the FRAX region. Ann Hum Genet, 64(Pt 6), 513-518. Abstract. Author URL.
Youings SA, Murray A, Dennis N, Ennis S, Lewis C, McKechnie N, Pound M, Sharrock A, Jacobs P (2000). FRAXA and FRAXE: the results of a five year survey. J Med Genet, 37(6), 415-421. Abstract. Author URL.
Murray A, Ennis S, Morton N (2000). No evidence for parent of origin influencing premature ovarian failure in fragile X premutation carriers. Am J Hum Genet, 67(1), 253-254. Author URL.
Murray A (2000). Premature ovarian failure and the FMR1 gene. Semin Reprod Med, 18(1), 59-66. Abstract. Author URL.
Murray A, Ennis S, MacSwiney F, Webb J, Morton NE (2000). Reproductive and menstrual history of females with fragile X expansions. Eur J Hum Genet, 8(4), 247-252. Abstract. Author URL.
Murray A, Ennis S, Youings SA, Sharrock AJ, Lewis C, Pound MC, Macpherson JN, Dennis NR, Morton NE, Jacobs PA, et al (2000). Stability and haplotype analysis of the FRAXE region. Eur J Hum Genet, 8(8), 583-589. Abstract. Author URL.
Holden JJ, Percy M, Allingham-Hawkins D, Brown WT, Chiurazzi P, Fisch G, Gane L, Gunter C, Hagerman R, Jenkins EC, et al (1999). Eighth International workshop on the fragile X syndrome and X-linked mental retardation, August 16-22, 1997. Am J Med Genet, 83(4), 221-236. Author URL.
Macpherson J, Murray A, Webb J, Jacobs P, De Vries BBA, Halley DJJ, Oostra BA, Niermeijer MF (1999). Fragile X syndrome: of POF and premutations (multiple letter) [1]. Journal of Medical Genetics, 36(2), 171-172.
Macpherson J, Murray A, Webb J, Jacobs P (1999). Fragile X syndrome: of POF and premutations. J Med Genet, 36(2), 171-172. Author URL.
Murray A, Webb J, Dennis N, Conway G, Morton N (1999). Microdeletions in FMR2 may be a significant cause of premature ovarian failure. J Med Genet, 36(10), 767-770. Abstract. Author URL.
Macpherson J, Youings SA, Murray A, Sharrock AJ, Lewis C, Dennis NR, McKechnie N, Morton NE, Jacobs PA (1999). Results of a 5-year screening survey of FRAXA and FRAXE: incidence, distributions and stability of alleles. JOURNAL OF MEDICAL GENETICS, 36, S75-S75. Author URL.
Murray A, Webb J, MacSwiney F, Shipley EL, Morton NE, Conway GS (1999). Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women. Hum Reprod, 14(5), 1217-1218. Abstract. Author URL.
Davison RM, Quilter CR, Webb J, Murray A, Fisher AM, Valentine A, Serhal P, Conway GS (1998). A familial case of X chromosome deletion ascertained by cytogenetic screening of women with premature ovarian failure. Hum Reprod, 13(11), 3039-3041. Abstract. Author URL.
Teague JW, Morton NE, Dennis NR, Curtis G, McKechnie N, Macpherson JN, Murray A, Pound MC, Sharrock AJ, Youings SA, et al (1998). FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability. Proc Natl Acad Sci U S A, 95(2), 719-724. Abstract. Author URL.
Conway GS, Payne NN, Webb J, Murray A, Jacobs PA (1998). Fragile X premutation screening in women with premature ovarian failure. Hum Reprod, 13(5), 1184-1187. Abstract. Author URL.
Gunter C, Paradee W, Crawford DC, Meadows KA, Newman J, Kunst CB, Nelson DL, Schwartz C, Murray A, Macpherson JN, et al (1998). Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1. Hum Mol Genet, 7(12), 1935-1946. Abstract. Author URL.
Murray A, Webb J, Grimley S, Conway G, Jacobs P (1998). Studies of FRAXA and FRAXE in women with premature ovarian failure. J Med Genet, 35(8), 637-640. Abstract. Author URL.
Sharrock A, Bunyan DJ, Pound MC, Murray A, Eccles D, Jacobs P (1997). FRAXA instability in a family with HNPCC. JOURNAL OF MEDICAL GENETICS, 34, SP55-SP55. Author URL.
Pound MC, Murray A, Jacobs PA (1997). Haplotype analysis at FRAXE. JOURNAL OF MEDICAL GENETICS, 34, 704-704. Author URL.
Webb J, Murray A, Conway G, Jacobs P (1997). Premature ovarian failure and fragile X. JOURNAL OF MEDICAL GENETICS, 34, SP69-SP69. Author URL.
Murray A, Macpherson JN, Pound MC, Sharrock A, Youings SA, Dennis NR, McKechnie N, Linehan P, Morton NE, Jacobs PA, et al (1997). The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission. Hum Mol Genet, 6(2), 173-184. Abstract. Author URL.
Macpherson JN, Murray A, Jacobs PA (1996). FRAXE microdeletions in two interesting families. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 13-13. Author URL.
Eichler EE, Macpherson JN, Murray A, Jacobs PA, Chakravarti A, Nelson DL (1996). Haplotype and interspersion analysis of the FMR1 CGG repeat identifies two different mutational pathways for the origin of the fragile X syndrome. Hum Mol Genet, 5(3), 319-330. Abstract. Author URL.
Macpherson JN, Murray A, Youings SA, Latsky LM, Pound MC, Morton NE, Jacobs PA (1996). Haplotype associations in FRA(X), 'intermediate' and control chromosomes identified in screening surveys: Founder effect or genomic instability?. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 12-12. Author URL.
Jacobs PA, Youings SA, Murray A, McKechnie N, Dennis NR (1996). Molecular screening for FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 3-3. Author URL.
Murray A, Youings S, Dennis N, Latsky L, Linehan P, McKechnie N, Macpherson J, Pound M, Jacobs P (1996). Population screening at the FRAXA and FRAXE loci: molecular analyses of boys with learning difficulties and their mothers. Hum Mol Genet, 5(6), 727-735. Abstract. Author URL.
Murray A, Conway GS, Jacobs PA (1996). Premature ovarian failure and fragile X. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 16-16. Author URL.
Murray A, Dennis NR, Latsky LM, Macpherson JN, McKechnie N, Pound MC, Youings SA, Jacobs PA (1996). Trinucleotide repeat stability in FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 15-15. Author URL.
Conway GS, Hettiarachchi S, Murray A, Jacobs PA (1995). Fragile X premutations in familial premature ovarian failure. Lancet, 346(8970), 309-310. Author URL.
Chapters
Murray A, Ruth KS (2023). Integrative Omics for Women’s Health. In (Ed) A Life Course Approach to Women's Health, Oxford University Press (OUP), 221-c13p108.
External Engagement and Impact
Awards
Wellcome Trust Research Career Development Fellowship (November 1999 – June 2005)
