Journal articles
Curnow A, Anayo L, Magnussen A, Perry A, Wood M (In Press). AN EXPERIMENTAL INVESTIGATION OF a NOVEL IRON CHELATING PROTOPORPHYRIN IX PRODRUG FOR THE ENHANCEMENT OF PHOTODYNAMIC THERAPY. Lasers in Surgery and Medicine
Curnow A, Horton SJ (In Press). An evaluation of root phytochemicals derived from Althea officinalis (Marshmallow) and Astragalus membranaceus as potential natural components of UV-protecting dermatological formulations.
Oxidative Medicine and Cellular Longevity Abstract.
Reburn C, Gawthorpe G, Perry A, Wood M, Curnow A (2023). Novel Iron-Chelating Prodrug Significantly Enhanced Fluorescence-Mediated Detection of Glioma Cells Experimentally in Vitro.
Pharmaceutics,
15(12), 2668-2668.
Abstract.
Curnow A, Magnussen A, Reburn C, Perry A, Wood M (2021). Experimental investigation of a combinational iron chelating. protoporphyrin IX prodrug for fluorescence detection and photodynamic therapy. Lasers in Medical Science
Curnow A, Perry A, Wood M (2019). Improving in vitro photodynamic therapy through the development of a novel iron chelating aminolaevulinic acid prodrug.
Photodiagnosis Photodyn Ther,
25, 157-165.
Abstract.
Author URL.
Jeynes JCG, Wordingham F, Moran LJ, Curnow A, Harries TJ (2019). Monte Carlo Simulations of Heat Deposition During Photothermal Skin Cancer Therapy Using Nanoparticles.
Biomolecules,
9(8).
Abstract.
Author URL.
Tyrrell J, Paterson C, Curnow A (2019). Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy.
Cancers (Basel),
11(1).
Abstract.
Author URL.
Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A, Winyard PG (2018). Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.
Free Radic Biol Med,
126, 322-333.
Abstract.
Author URL.
Yeo NL, White MP, Ronan N, Whinney DJ, Curnow A, Tyrrell J (2018). Stress and Unusual Events Exacerbate Symptoms in Menière's Disease: a Longitudinal Study.
Otol Neurotol,
39(1), 73-81.
Abstract.
Author URL.
Curnow A, Buxton C, Tyrrell J (2017). Mechanistic insights gained through regression analysis of PpIX accumulation and photobleaching during dermatological MAL-PDT. Photodiagnosis and Photodynamic Therapy, 17
Dogra Y, Ferguson DCJ, Dodd NJF, Smerdon GR, Curnow A, Winyard PG (2016). The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species.
Redox Biol,
9, 90-99.
Abstract.
Author URL.
Curnow A, MacRobert AJ, Bown SG (2015). Enhancing Protoporphyrin IX-induced Photodynamic Therapy with a Topical Iron Chelating Agent in a Normal Skin Model.
Journal of Heavy Metal Toxicity and Diseases,
1(1), 1-9.
Abstract.
Curnow A, Pye A (2015). The importance of iron chelation and iron availability during PpIX-induced photodynamic therapy.
Photonics and Lasers in Medicine,
4(1), 39-58.
Abstract.
Blake E, Allen J, Thorn C, Shore A, Curnow A (2013). Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
Lasers in Medical Science,
28(3), 997-1005.
Abstract.
Robertson A, Allen J, Laney R, Curnow A (2013). The cellular and molecular carcinogenic effects of radon exposure: a review.
Int J Mol Sci,
14(7), 14024-14063.
Abstract.
Author URL.
Blake E, Allen J, Curnow A (2013). The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditions.
Photodiagnosis and Photodynamic Therapy,
10(4), 575-582.
Abstract.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.
FREE RADICAL BIOLOGY AND MEDICINE,
53, S127-S127.
Author URL.
Wheeler BW, Allen J, Depledge MH, Curnow A (2012). Radon and skin cancer in southwest England: an ecologic study.
Epidemiology,
23(1), 44-52.
Abstract.
Blake E, Campbell S, Allen J, Mathew J, Helliwell P, Curnow A (2012). The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.
J Photochem Photobiol B,
117, 97-103.
Abstract.
Author URL.
Blake E, Allen J, Curnow A (2011). An in vitro comparison of the effects of the iron-chelating agents, CP94 and dexrazoxane, on protoporphyrin IX accumulation for photodynamic therapy and/or fluorescence guided resection.
Photochem Photobiol,
87(6), 1419-1426.
Abstract.
Author URL.
Morris J, Laing-Morton T, Marno P, Curnow A (2011). An investigation into the awareness and understanding of the ultraviolet index forecasts in the South West of England.
Photochem. Photobiol. Sci. Abstract.
Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Br J Dermatol,
164(6), 1362-1368.
Abstract.
Author URL.
Allen J, Tyrrell J, Morton C, Campbell S, Curnow A (2011). Comparison of protoporphyrin IX accumulation and photobleaching during methyl-aminolevulinate photodynamic therapy of skin tumours located at acral and non-acral sites. Photodiagnosis and Photodynamic Therapy, 8(2).
Blake E, Allen J, Curnow A (2011). Maximising protoporphyrin IX (PpIX) accumulation with the hydroxypyridinone iron chelator CP94. Photodiagnosis and Photodynamic Therapy, 8(2), 212-213.
Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification.
Photodiagnosis Photodyn Ther,
8(1), 30-38.
Abstract.
Author URL.
Curnow A, Tyrrell J, Campbell S (2011). Non-invasive monitoring of dermatological PDT. Photodiagnosis and Photodynamic Therapy, 8(2), 144-145.
Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology
Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy.
J Photochem Photobiol B,
103(1), 1-7.
Abstract.
Author URL.
Curnow A, Campbell SM (2010). Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification.
Br J Dermatol,
162(1), 224-225.
Author URL.
Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring.
Photodiagnosis Photodyn Ther,
7(3), 183-188.
Abstract.
Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy.
Photodiagnosis Photodyn Ther,
7(4), 232-238.
Abstract.
Author URL.
Blake E, Curnow A (2010). The hydroxypyridinone iron chelator CP94 can enhance PpIX-induced PDT of cultured human glioma cells.
Photochem Photobiol,
86(5), 1154-1160.
Abstract.
Author URL.
Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome.
Lasers Surg Med,
42(7), 613-619.
Abstract.
Author URL.
Malhomme de la Roche H, Seagrove S, Mehta A, Divekar P, Campbell S, Curnow A (2010). Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: an investigation of human green tea ingestion.
J Photochem Photobiol B,
101(2), 169-173.
Abstract.
Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT.
Photodiagnosis Photodyn Ther,
7(2), 86-97.
Abstract.
Author URL.
Curnow A (2009). 12th World Congress of the International Photodynamic Association (IPA), 11-15th June 2009, Seattle, USA.
Photodiagnosis Photodyn Ther,
6(2), 150-151.
Author URL.
Curnow A, Dogra Y, Winyard PG, Campbell S (2009). Using iron chelating agents to enhance dermatological PDT.
Campbell SM, Morton CA, Alyahya R, Horton S, Pye A, Curnow A (2008). Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma.
Br J Dermatol,
159(2), 387-393.
Abstract.
Author URL.
Donnelly RF, Curnow A, Demir YK, Singh RRT, McCarron PA, Woolfson AD (2008). Co-delivery of 5-aminolevulinic acid and the novel hydroxypyridinone iron chelator CP-94 from bioadhesive patches for enhanced topical photodynamic therapy.
JOURNAL OF PHARMACY AND PHARMACOLOGY,
60, A21-A22.
Author URL.
Pye A, Campbell S, Curnow A (2008). Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.
J Cancer Res Clin Oncol,
134(8), 841-849.
Abstract.
Author URL.
Campbell SM, Curnow A (2008). Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using meta-tetrahydroxychlorin (Foscan).
J Eur Acad Dermatol Venereol,
22(4), 502-503.
Author URL.
Campbell SM, Pye A, Horton S, Matthew J, Helliwell P, Curnow A (2007). A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular basal cell carcinoma of the skin.
J Environ Pathol Toxicol Oncol,
26(4), 295-303.
Abstract.
Author URL.
ACurnow, Pye A (2007). Direct comparison of delta-aminolevulinic acid and methyl-aminolevulinate-derived protoporphyrin IX accumulations potentiated by desferrioxamine or the novel hydroxypyridinone iron chelator CP94 in cultured human cells. Photochemistry and Photobiology, 83(3), 766-773.
Curnow A, MacRobert AJ, Bown SG (2006). Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid.
Lasers Surg Med,
38(4), 325-331.
Abstract.
Author URL.
Bradfield W, Pye A, Clifford T, Salter L, Gould D, Campbell S, Curnow A (2006). Hg(II) exposure exacerbates UV-induced DNA damage in MRC5 fibroblasts: a comet assay study.
J Environ Sci Health a Tox Hazard Subst Environ Eng,
41(2), 143-148.
Abstract.
Author URL.
Morley N, Rapp A, Dittmar H, Salter L, Gould D, Greulich KO, Curnow A (2006). UVA-induced apoptosis studied by the new apo/necro-Comet-assay which distinguishes viable, apoptotic and necrotic cells.
Mutagenesis,
21(2), 105-114.
Abstract.
Author URL.
Morley N, Clifford T, Salter L, Campbell S, Gould D, Curnow A (2005). The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage.
Photodermatol Photoimmunol Photomed,
21(1), 15-22.
Abstract.
Author URL.
Campbell SM, Gould DJ, Salter L, Clifford T, Curnow A (2004). Photodynamic therapy using meta-tetrahydroxyphenylchlorin (Foscan) for the treatment of vulval intraepithelial neoplasia.
Br J Dermatol,
151(5), 1076-1080.
Abstract.
Author URL.
Salter L, Clifford T, Morley N, Gould D, Campbell S, Curnow A (2004). The use of comet assay data with a simple reaction mechanism to evaluate the relative effectiveness of free radical scavenging by quercetin, epigallocatechin gallate and N-acetylcysteine in UV-irradiated MRC5 lung fibroblasts.
J Photochem Photobiol B,
75(1-2), 57-61.
Abstract.
Author URL.
Morley N, Curnow A, Salter L, Campbell S, Gould D (2003). N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts.
J Photochem Photobiol B,
72(1-3), 55-60.
Abstract.
Author URL.
Kömerik N, Curnow A, MacRobert AJ, Hopper C, Speight PM, Wilson M (2002). Fluorescence biodistribution and photosensitising activity of toluidine blue o on rat buccal mucosa.
Lasers Med Sci,
17(2), 86-92.
Abstract.
Author URL.
Tsutsui H, MacRobert AJ, Curnow A, Rogowska A, Buonaccorsi G, Kato H, Bown SG (2002). Optimisation of illumination for photodynamic therapy with mTHPC on normal colon and a transplantable tumour in rats.
Lasers Med Sci,
17(2), 101-109.
Abstract.
Author URL.
Curnow A, Salter L, Morley N, Campbell S, Gould D (2002). Paracetamol can exacerbate irradiation-induced DNA damage.
Br J Clin Pharmacol,
53(3), 338-340.
Author URL.
Curnow A, Bown SG (2002). The role of reperfusion injury in photodynamic therapy with 5-aminolaevulinic acid--a study on normal rat colon.
Br J Cancer,
86(6), 989-992.
Abstract.
Author URL.
ACurnow, Bown S (2002). The role of reperfusion injury in photodynamic therapy with aminolaevulinic acid - a study on normal rat colon. British Journal of Cancer, 86(6), 989-992.
Curnow A, Salter L, Morley N, Gould D (2001). A preliminary investigation of the effects of arsenate on irradiation-induced DNA damage in cultured human lung fibroblasts.
J Toxicol Environ Health A,
63(8), 605-616.
Abstract.
Author URL.
Curnow A, Parsons B, Salter L, Morley N, Gould D (2001). An investigation of the genotoxic effects of airborne particulate matter using single-cell gel electrophoresis.
Indoor and Built Environment,
10(3-4), 258-260.
Abstract.
Connell RJ, Curnow A, Cutner A, Brown S (2000). Endometrial ablation in the rabbit uterus by photodynamic therapy (PDT) using 5-aminolaevulinic acid with the iron chelator CP94.
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY,
107(6), 828-828.
Author URL.
Curnow A, Haller JC, Bown SG (2000). Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes.
J Photochem Photobiol B,
58(2-3), 149-155.
Abstract.
Author URL.
Curnow A, McIlroy BW, Postle-Hacon MJ, MacRobert AJ, Bown SG (1999). Light Dose Fractionation to Enhance Photodynamic Therapy Using 5-Aminolevulinic Acid in the Normal Rat Colon. Photochemistry and Photobiology, 69(1).
Curnow A, McIlroy BW, Postle-Hacon MJ, MacRobert AJ, Bown SG (1999). Light dose fractionation to enhance photodynamic therapy using 5-aminolevulinic acid in the normal rat colon.
Photochem Photobiol,
69(1), 71-76.
Abstract.
Author URL.
Curnow A, McIlroy B, Postle-Hacon M, Porter J, MacRobert A, Bown S (1998). Enhancement of 5-aminolaevulinic acid induced photodynamic therapy using iron chelating agents. British Journal of Cancer, 78, 1278-1282.
Curnow A, McIlroy BW, Postle-Hacon MJ, Porter JB, MacRobert AJ, Bown SG (1998). Enhancement of 5-aminolaevulinic acid-induced photodynamic therapy in normal rat colon using hydroxypyridinone iron-chelating agents.
Br J Cancer,
78(10), 1278-1282.
Abstract.
Author URL.
McIlroy BW, Curnow A, Buonaccorsi G, Scott MA, Bown SG, MacRobert AJ (1998). Spatial measurement of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy.
J Photochem Photobiol B,
43(1), 47-55.
Abstract.
Author URL.
Kömerik N, Speight P, Curnow A, Postle-Hacon M, Wilson M, Hopper C (1998). The effect of photodynamic therapy on rat buccal mucosa.
JOURNAL OF DENTAL RESEARCH,
77, 754-754.
Author URL.
Twelves CJ, Dobbs NA, Curnow A, Coleman RE, Stewart AL, Tyrrell CJ, Canney P, Rubens RD (1994). A phase II, multicentre, UK study of vinorelbine in advanced breast cancer.
Br J Cancer,
70(5), 990-993.
Abstract.
Author URL.
Chapters
Curnow A, Tyrrell J (2015). The mechanism of action of topical dermatological photodynamic therapy. In (Ed)
Photodynamic Therapy: Fundamentals, Applications and Health Outcomes, 59-102.
Abstract.
Pye A, Dogra Y, Tyrrell J, Winyard P, Curnow A (2009). Photodynamic therapy with aminolaevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard P (Eds.) Redox signaling and regulation in biology and medicine, Weinheim: Wiley-VCH, 381-404.
Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.
Curnow A (2006). Potential Future Indications. In Pottier R, Krammer B, Stepp H, Baumgartner R (Eds.) Photodynamic therapy with ALA: a clinical handbook, Cambridge: Royal Society of Chemistry, 249-259.
Conferences
Reburn C, Anayo L, Magnussen A, Perry A, Wood M, Curnow A (2019). Experimental findings utilising a new iron chelating ALA prodrug to enhance protoporphyrin IX-induced photodynamic therapy.
Abstract.
Tyrrell J, Paterson C, Curnow A (2019). Insights gained from regression analysis of PpIX fluorescence imaging undertaken during routine dermatological photodynamic therapy.
Abstract.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.
Wilkinson C, Saunders M, Curnow A (2010). Measures of ultraviolet radiation in the South West.
Author URL.
Curnow A, Pye A, Campbell S (2009). Enhancing protoporphyrin IX-induced PDT. Photodynamic Therapy - Back to the Future.
Abstract.
Tyrrell J, Campbell S, Curnow A (2009). The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. Photodynamic Therapy - Back to the Future.
Abstract.
McGovern G, Tyrrell J, Campbell S, Curnow A (2008). Audit on the use of photodynamic therapy (PDT) for various malignant and pre-malignant skin conditions. British Association of Dermatology.
Tyrrell J, Shore A, Curnow A (2008). Monitoring clinical dermatological photodynamic therapy: validation of a noninvasive fluorescence imaging system.
Author URL.
Curnow A, Peng Q (2007). 11th World Congress of the International Photodynamic Association (IPA) – meeting report.
Campbell S, Horton S, Curnow A (2007). A pilot study to determine the effect of pressure injection on the penetration of topical methyl aminolaevulinic acid (MAL) into nodular basal cell carcinoma (nBCC) of the skin.
Author URL.
Curnow A, Pye A (2007). Biochemical manipulation via iron chelation to enhance porphyrin production from porphyrin precursors.
Abstract.
Author URL.
Pye A, Curnow A (2007). DNA damage in photodynamic therapy through the production of reactive oxygen species parallels that of ionizing radiation and UVA.
Author URL.
Dogra Y, Curnow A, Winyard P (2007). Mechanisms of cell death induced by dermatological protoporphyrin IX-induced photodynamic therapy.
Author URL.
Pye A, Hallaq H, Horton S, Curnow A (2006). An <i>in vitro</i> investigation of 5-aminolaevulinic acid and methyl aminotaevulinate photodynamic therapy enhancement by iron removal using CP94.
Author URL.
Pye AJ, Wakeman TD, Horton SJ, Campbell SM, Salter L, Curnow A (2006). An <i>in vitro</i> investigation of the genotoxic role of iron during aminolaevulinic acid photodynamic therapy.
Author URL.
Adie K, Moody A, Pye A, Curnow A (2006). Does chronic therapeutic paracetamol use predispose to oxidative stress?.
Pye AJ, Campbell SM, Horton SJ, Salter L, Curnow A (2005). An <i>in vitro</i> investigation of the enhancement of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of nodular basal cell carcinoma using the hydroxypyridinone iron chelator CP94.
Author URL.
Curnow A, Campbell S, Leman J, Morton C, Salter L (2005). Enhancement of dermatological ALA-PDT with an iron chelating agent (CP94).
Campbell S, Gould D, Salter L, Curnow A (2005). Penile intraepidermal neoplasia treated with MAL-PDT.
Author URL.
Morley N, Clifford T, Salter L, Campbell S, Gould D, Pye A, Curnow A (2004). The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage.
Author URL.
Morton CA, Campbell S, Gould D, Curnow A (2004). Topical photodynamic therapy with the iron chelator, CP94, for nodular basal cell carcinoma.
Author URL.
Campbell S, Leman J, Curnow A, Morton C, Salter L, Gould D (2003). Enhancing dermatological 5-aminolaevulinic acid-photodynamic therapy with a novel iron chelator.
Author URL.
Gould D, Curnow A, Morley N, Salter L (2003). Synergy between pollutants and ultraviolet radiation: a comet assay investigation.
Author URL.
Morley RN, Dittmar H, Curnow A, Salter L, Gould D, Greulich KO (2003). Two waves of apoptosis occur after UV-A exposure as detected with repeated scanning comet-assay.
Author URL.
Stentiford FWM, Morley N, Curnow A (2002). Automatic identification of regions of interest with application to the quantification of DNA damage in cells.
Author URL.
Curnow A, Parsons B, Salter L, Morley N, Gould D (2001). An investigation of the genotoxic effects of airborne particulate matter using single-cell gel electrophoresis.
Abstract.
Curnow A, Gould D, Salter L (2000). A new method for the cultivation of human naevus melanocytes.
Curnow A, Postle-Hacon MJ, MacRobert AJ, Brown SG (1998). Enhancement of 5-aminolaevulinic acid induced photodynamic therapy using light dose fractionation and iron chelating agents.
Author URL.