Dr Aaron Jeffries
Senior Research Fellow and Head of Exeter Sequencing Facility
A.R.Jeffries@exeter.ac.uk
4275
01392 724275
Geoffrey Pope 313B
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Overview
Senior Research Fellow and Head of Exeter Sequencing Facility
Aaron Jeffries is a Senior Research Fellow working in the Faculty of Health and Life Science and is the head of Exeter Sequencing Facility. Aaron obtained an Honours degree in Genetics from Cardiff University and completed his PhD in King’s College London in 2004. Aaron’s PhD involved mapping and sequencing of t (6;11) translocation associated with schizophrenia like psychosis in a three generation pedigree, leading to the identification of a potential candidate gene explaining the psychosis and the winning publication for the Lilly Molecular Psychiatry award 2003. He also undertook the largest genotype/phenotype study of ring chromosome 22 to date.
Aaron joined a developmental neurobiology group at King’s College London in 2005 where he shifted focus from his initial work around signalling pathways to studying allele specific heterogeneity observed in clonal cells, known as Random Monoallelic Expression. Working with clonal stem cells, and later epigenetic reprogramming techniques, he has furthered this work using stem cells as model systems. Aaron joined the Complex Disease Epigenetics group in January 2014 to further his research in single cell heterogeneity and its relation to disease. Through this he has performed single cell research using a variety of platforms and further psychiatric genetic/transcriptomic and epigenetic research.
In April 2017, Aaron joined the Exeter Sequencing Facility and continues to develop long read sequencing technology for applications in neurodegenerative disease and epigenetics and in July 2019 became Head of Exeter Sequencing Facility.
Among a variety of sequencing projects Aaron was involved in sequencing relating to the SARS-CoV-2 epidemic, first as a contributor to COG-UK and later through development and use of rapid SARS-CoV-2 genome sequencing from wastewater samples to track the dynamic nature of variants/lineages at a population level.
The Exeter Sequencing Facility now provides collaboration to a wide range of projects in various faculties and research areas including biosciences, epigenetics/neurodegeneration, aquaculture, geography and many others.
Qualifications
Honours Degree in Genetics, Cardiff University
PhD King's College London 2004
Links
Publications
Journal articles
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions
Bamford RA, Leung SK, Jeffries AR, Franklin A, Commin G, Davies J, Dempster E, Hannon E, Mill J (2023). 59. ULTRA-DEEP LONG READ TRANSCRIPTOME SEQUENCING REVEALS DRAMATIC ISOFORM DIVERSITY ACROSS HUMAN CORTEX DEVELOPMENT: RELEVANCE FOR GENETIC STUDIES OF PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 75
Child HT, Airey G, Maloney DM, Parker A, Wild J, McGinley S, Evens N, Porter J, Templeton K, Paterson S, et al (2023). Comparison of metagenomic and targeted methods for sequencing human pathogenic viruses from wastewater. mBio, 14(6). Abstract. Author URL.
Cotton S, McHugh MP, Dewar R, Haas JG, Templeton K, Consortium TCGU, Robson SC, Connor TR, Loman NJ, Golubchik T, et al (2023). Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection, 135, 28-36.
Leung SK, Castanho I, Jeffries A, Moore K, Dempster E, Brown JT, Bamford R, Hannon E, Mill J (2023). Isoform characterisation & splicing signatures of AD‐risk genes using long‐read sequencing. Alzheimer's & Dementia, 19(S12).
Smith AR, Soanes D, Moore K, Jeffries A, Lunnon K (2023). New mitochondrial DNA methylation profiling method confirms epigenetic marker in the brain. Alzheimer's & Dementia, 19(S12).
Child HT, O'Neill PA, Moore K, Rowe W, Denise H, Bass D, Wade MJ, Loose M, Paterson S, van Aerle R, et al (2023). Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing. PLoS One, 18(4). Abstract. Author URL.
Toffoli M, Chohan H, Mullin S, Jesuthasan A, Yalkic S, Koletsi S, Menozzi E, Rahall S, Limbachiya N, Loefflad N, et al (2023). Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: the RAPSODI study. Neurobiol Dis, 188 Abstract. Author URL.
Gates S, Andreani J, Dewar R, Smith DB, Templeton K, Child HT, Breuer J, Golubchik T, Bassano I, Wade MJ, et al (2023). Postpandemic rebound of adeno-associated virus type 2 (AAV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom. J Med Virol, 95(7). Abstract. Author URL.
Brunner FS, Payne A, Cairns E, Airey G, Gregory R, Pickwell ND, Wilson M, Carlile M, Holmes N, Hill V, et al (2023). Utility of wastewater genomic surveillance compared to clinical surveillance to track the spread of the SARS-CoV-2 Omicron variant across England. Water Res, 247 Abstract. Author URL.
Mill J, Hannon E, Dempster E, Franklin A, Burrage J, Davies J, Chioza B, Commin G, Jeffries AR, Bamford RA, et al (2023). W76. CELL-SPECIFIC METHYLOMIC VARIATION IN NEURODEVELOPMENT AND SCHIZOPHRENIA. European Neuropsychopharmacology, 75, s144-s145.
Hannon E, Jeffries AR, Policicchio S, Viana J, Leung SK, Dempster E, Mill J (2022). 42. LEVERAGING a BESPOKE CORTICAL TRANSCRIPTOME TO ASSESS THE ROLE OF ALTERNATIVE SPLICING IN SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e67-e68.
Bamford R, Jeffries AR, Walker E, Leung SK, Commin G, Davies JP, Dempster E, Hannon E, Mill J (2022). 67. LONG READ TRANSCRIPTOME SEQUENCING REVEALS ISOFORM DIVERSITY ACROSS HUMAN NEURODEVELOPMENT. European Neuropsychopharmacology, 63, e81-e82.
Hannon E, Davies J, Chioza B, Policicchio S, Burrage J, Commin G, Jeffries AR, Schalkwyk L, Dempster E, Mill J, et al (2022). 89. IDENTIFYING CELL-TYPE-SPECIFIC EPIGENETIC VARIATION IN THE CORTEX ASSOCIATED WITH SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e93-e94.
Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH, Saunders C, Summers C, et al (2022). Author Correction: SARS-CoV-2 evolution during treatment of chronic infection. Nature, 608(7922), e23-e23.
Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH, Saunders C, Summers C, et al (2022). Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature, 608(7922), e24-e24.
Brunner FS, Brown MR, Bassano I, Denise H, Khalifa MS, Wade MJ, van Aerle R, Kevill JL, Jones DL, Farkas K, et al (2022). City-wide wastewater genomic surveillance through the successive emergence of SARS-CoV-2 Alpha and Delta variants. Water Research, 226
Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Hum Mol Genet, 31(18), 3181-3190. Abstract. Author URL.
Washer SJ, Flynn R, Oguro‐Ando A, Hannon E, Burrage J, Jeffries A, Mill J, Dempster EL (2022). Functional characterization of the schizophrenia associated gene <scp><i>AS3MT</i></scp> identifies a role in neuronal development. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189(5), 151-162. Abstract.
Aggarwal D, Page AJ, Schaefer U, Savva GM, Myers R, Volz E, Ellaby N, Platt S, Groves N, Gallagher E, et al (2022). Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13(1).
Aggarwal D, Warne B, Jahun AS, Hamilton WL, Fieldman T, du Plessis L, Hill V, Blane B, Watkins E, Wright E, et al (2022). Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13(1). Abstract.
Lybaek H, Robson M, de Leeuw N, Hehir-Kwa JY, Jeffries A, Haukanes BI, Berland S, de Bruijn D, Mundlos S, Spielmann M, et al (2022). LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions. AUTISM RESEARCH, 15(3), 421-433. Author URL.
Robson SC, Connor TR, Loman NJ, Golubchik T, Martinez Nunez RT, Bonsall D, Rambaut A, Snell LB, Ludden C, Corden S, et al (2022). Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England. Nature, 606(7915), e18-e18.
Ashford F, Best A, Dunn SJ, Ahmed Z, Siddiqui H, Melville J, Wilkinson S, Mirza J, Cumley N, Stockton J, et al (2022). SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel to Find Variants in Real Time. Journal of Clinical Microbiology, 60(4), e02408-e02421.
Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C (2021). Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. FRONTIERS IN ENDOCRINOLOGY, 12 Author URL.
Imm J, Pishva E, Ali M, Kerrigan TL, Jeffries A, Burrage J, Glaab E, Cope EL, Jones KM, Allen ND, et al (2021). Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation. Frontiers in Cell and Developmental Biology, 9 Abstract.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi. Microbiology Resource Announcements, 10(39), e00715-e00721.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Erratum for Betts et al. “Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi”. Microbiology Resource Announcements, 10(42), e00985-e00921.
Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.
Vöhringer HS, Sanderson T, Sinnott M, De Maio N, Nguyen T, Goater R, Schwach F, Harrison I, Hellewell J, Ariani CV, et al (2021). Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), 506-511. Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract. Author URL.
Goode O, Smith A, Zarkan A, Cama J, Invergo BM, Belgami D, Caño-Muñiz S, Metz J, O’Neill P, Jeffries A, et al (2021). Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment. mBio, 12(4). Abstract.
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, et al (2021). SARS-CoV-2 evolution during treatment of chronic infection. Nature, 592(7853), 277-282. Abstract.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, et al (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. Author URL.
Masoli JAH, Jeffries A, Temperton B, Auckland C, Michelsen M, Warwick-Dugdale J, Manley R, Farbos A, Ellard S, Knight B, et al (2021). Viral genetic sequencing identifies staff transmission of COVID-19 is important in a community hospital outbreak. Abstract.
Aanensen DM, Abudahab K, Adams A, Afifi S, Alam MT, Alderton A, Alikhan N-F, Allan J, Almsaud M, Alrezaihi A, et al (2020). An integrated national scale SARS-CoV-2 genomic surveillance network. LANCET MICROBE, 1(3), E99-E100. Author URL.
Potter PGW, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster E, Beall C (2020). Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes. Abstract.
Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (2020). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex. Abstract.
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).
Mizuno K, Jeffries AR, Abel T, Giese KP (2020). Long-lasting transcription in hippocampal area CA1 after contextual fear conditioning. Neurobiol Learn Mem, 172 Abstract. Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.
Borsini A, Stangl D, Jeffries AR, Pariante CM, Thuret S (2020). The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis. Transl Psychiatry, 10(1). Abstract. Author URL.
Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, et al (2020). Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual is Associated with Conserved Epigenetic Erosion. Cell Stem Cell, 27(2), 326-335.e4. Abstract. Author URL.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract. Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Dempster E, Temple IK, Mackay DJG, Rezwan FI, et al (2019). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. Genome Res, 29(7), 1057-1066. Abstract. Author URL.
Warmington RJ, Kay W, Jeffries A, O'Neill P, Farbos A, Moore K, Bebber DP, Studholme DJ (2019). High-Quality Draft Genome Sequence of the Causal Agent of the Current Panama Disease Epidemic. Microbiol Resour Announc, 8(36). Abstract. Author URL.
Toste CC, Duarte RRR, Jeffries AR, Selvackadunco S, Troakes C, O'Donovan MC, Hill MJ, Bray NJ (2019). No Effect of Genome-Wide Significant Schizophrenia Risk Variation at the DRD2 Locus on the Allelic Expression of DRD2 in Postmortem Striatum. Mol Neuropsychiatry, 5(4), 212-217. Abstract. Author URL.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Muto V, Flex E, Kupchinsky Z, Primiano G, Galehdari H, Dehghani M, Cecchetti S, Carpentieri G, Rizza T, Mazaheri N, et al (2018). Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. Neurology, 91(4), e319-e330. Abstract. Author URL.
Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD, et al (2018). Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons. Aging Cell, 17(4). Abstract. Author URL.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (2018). Sex differences in gene expression in the human fetal brain. Abstract.
Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Jeffries AR, Mill J (2017). Profiling Regulatory Variation in the Brain: Methods for Exploring the Neuronal Epigenome. Biol Psychiatry, 81(2), 90-91. Author URL.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract. Author URL.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract. Author URL.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract. Author URL.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract. Author URL.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract. Author URL.
Cocks G, Romanyuk N, Amemori T, Jendelova P, Forostyak O, Jeffries AR, Perfect L, Thuret S, Dayanithi G, Sykova E, et al (2013). Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons. Stem Cell Research & Therapy, 4(3).
Jeffries AR, Collier DA, Vassos E, Curran S, Ogilvie CM, Price J (2013). Random or Stochastic Monoallelic Expressed Genes Are Enriched for Neurodevelopmental Disorder Candidate Genes. PLOS ONE, 8(12).
Cocks G, Curran S, Gami P, Uwanogho D, Jeffries AR, Kathuria A, Lucchesi W, Wood V, Dixon R, Ogilvie C, et al (2013). The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders. Psychopharmacology, 231(6), 1079-1088.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract. Author URL.
Hill MJ, Jeffries AR, Dobson RJB, Price J, Bray NJ (2011). Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human Molecular Genetics, 21(5), 1018-1024.
El-Akabawy G, Medina LM, Jeffries A, Price J, Modo M (2011). Purmorphamine Increases DARPP-32 Differentiation in Human Striatal Neural Stem Cells Through the Hedgehog Pathway. Stem Cells and Development, 20(11), 1873-1887.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract. Author URL.
Buonocore F, Hill MJ, Campbell CD, Oladimeji PB, Jeffries AR, Troakes C, Hortobagyi T, Williams BP, Cooper JD, Bray NJ, et al (2010). Effects of cis-regulatory variation differ across regions of the adult human brain. Human Molecular Genetics, 19(22), 4490-4496.
Morgan SC, Yasin S, Uwanogho D, Jeffries A, Price J (2010). Positional Specification in a Neural Stem Cell Line Involves Modulation of Musashi1 Expression. Stem Cells and Development, 19(4), 579-592.
Greenway DJ, Street M, Jeffries A, Buckley NJ (2006). RE1 Silencing Transcription Factor Maintains a Repressive Chromatin Environment in Embryonic Hippocampal Neural Stem Cells. Stem Cells, 25(2), 354-363.
Jeffries AR, Curran S, Elmslie F, Sharma A, Wenger S, Hummel M, Powell J (2005). Molecular and phenotypic characterization of ring chromosome 22. American Journal of Medical Genetics Part A, 137A(2), 139-147.
Jeffries AR, Mungall AJ, Dawson E, Halls K, Langford CF, Murray RM, Dunham I, Powell JF (2003). beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation. Mol Psychiatry, 8(7), 654-663. Abstract. Author URL.
Ashelford KE, Fry JC, Bailey MJ, Jeffries AR, Day MJ (1999). Characterization of six bacteriophages of <i>Serratia liquefaciens</i> CP6 isolated from the sugar beet phytosphere. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 65(5), 1959-1965. Author URL.
Conferences
Houge G, Lybaek H, Robson M, de Leeuw N, Herir-Kwa JY, Jeffries AR, Haukanes BI, Berland S, de Bruijn D, Mundlos S, et al (2023). LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions. Author URL.
Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN. Author URL.
MacCalman A, De Franco E, Jeffries AR, Burrage J, Walker EM, Franklin A, Owens NDL, Hattersley AT, Mill J (2021). Methylomic trajectories in the human pancreas: from fetal development to adulthood. Author URL.
MacCalman A, De Franco E, Jeffries AR, Hannon EJ, Davies J, Burrage J, Morgan NG, Hattersley AT, Mill J (2020). Regulatory genomic variation in the developing human pancreas. Author URL.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE. Author URL.
Muto V, Flex E, Kupchinsky Z, Primiano G, Galehdari H, Dehghani M, Cecchetti S, Carpentieri G, Rizza T, Mazaheri N, et al (2019). Biallelic <i>SQSTM1</i> mutations in early-onset, variably progressive neurodegeneration. Author URL.
Washer S, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS. Author URL.
Washer S, Oguro-Ando A, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS. Author URL.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN. Author URL.
Tovy A, Park HJ, Reyes JM, Guzman A, Rau RE, Jeffries A, Jonnathan M, Baple E, Crosby A, Petljak M, et al (2018). Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage. Author URL.
Sadahiro R, Bridget K, Smart N, Charity J, Jeffries A, Burrage J, Hannon E, Dempster E, Murphy T, Lunnon K, et al (2017). EPIGENETIC ALTERATIONS THROUGH SURGERY AND POSTOPERATIVE DELIRIUM: PILOT STUDY. Author URL.
Jeffries A, Hannon E, Dempster E, Burrage J, Evans D, Collier D, Mill J (2017). METHYLOME CELLULAR SIGNATURES INDUCED BY ACUTE EXPOSURE TO TWELVE ANTIPSYCHOTIC AND NEUROTRANSMITTER DRUGS. Author URL.
El-Akabawy G, Jeffries A, Price J, Modo M (2010). Purmorphamine Enhances the Neuronal Differentiation of a Human Striatal Neural Stem Cell Line in Vitro. Author URL.
