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Dr Alice Hughes

GW4 Clinical Academic Training PhD Fellow

 01223 4088231

 RILD Building Level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Alice is a clinical trainee in Obstetrics & Gynaecology with a particular interest in Maternal and Fetal Medicine. Her interest in research began whilst studying for her medical degree at the Universities of Exeter and Plymouth. She became interested in Genetics during a BSc in Reproductive and Developmental Sciences at Imperial College London. She went on to work as an Academic Foundation Doctor in Exeter and completed a MSc in Genomic Medicine alongside her research work. Following an Academic Clinical Fellowship in Cambridge, Alice has returned to the South West to complete a PhD and build upon her previous research in Exeter, focusing on birth weight, genetics and fetal insulin.

Qualifications

  • BSc (Hons) Medical Sciences with Reproductive and Developmental Sciences, Imperial College London, 2014. Awarded with First Class Honours.
  • BMBS, Universities of Exeter and Plymouth, 2015. Awarded with Distinction.
  • MSc Genomic Medicine, University of Exeter, 2018. Awarded with Distinction.

Research

Research interests

Alice’s PhD is focusing on fetal growth and the role of insulin, using monogenic and polygenic data to find out how and why babies are born very small or very large. She is also interested in prediction of adverse pregnancy outcomes, particularly in relation to pre-eclampsia, fetal growth restriction and diabetes in pregnancy.

Research projects

Current Projects:

  • PhD project 2019-2022: Investigating the importance of fetal insulin in birth weight and early postnatal growth. Supervised by Dr Rachel Freathy, Dr Sarah Flanagan and Professor Andrew Hattersley.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2022). Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures. BMC Pediatrics, 22(1). Abstract.
Locke JM, Dusatkova P, Colclough K, Hughes AE, Dennis JM, Shields B, Flanagan SE, Shepherd MH, Dempster EL, Hattersley AT, et al (2022). Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study. Diabetologia, 65(1), 246-249. Author URL.
Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2021). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.
Hughes AE, De Franco E, Globa E, Zelinska N, Hilgard D, Sifianou P, Hattersley AT, Flanagan SE (2021). Identification of GCK-maturity-onset diabetes of the young in cases of neonatal hyperglycemia: a case series and review of clinical features. Pediatr Diabetes, 22(6), 876-881. Abstract.  Author URL.
Hughes AE, Hattersley AT, Flanagan SE, Freathy RM (2021). Two decades since the fetal insulin hypothesis: what have we learned from genetics?. Diabetologia, 64(4), 717-726. Abstract.
Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2020). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.
Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2020). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.
Jayasuriya NA, Hughes AE, Sovio U, Cook E, Stephen Charnock-Jones D, Smith GCS (2019). A lower maternal cortisol-to-cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. Journal of Clinical Endocrinology and Metabolism, 104(6), 2355-2366. Abstract.
Hughes AE, Smart NJ, Daniels IR (2019). Acute colonic pseudo‐obstruction after caesarean section: a review and recommended management algorithm. The Obstetrician & Gynaecologist, 21(4), 283-290.
Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS (2019). The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta, 81, 25-31. Abstract.
Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract.  Author URL.
Brew O, Nikolopoulou E, Hughes A, Christian M, Lee Y, Oduwole O, Sullivan MHF, Woodman A (2016). Quality of placental RNA: Effects of explant size and culture duration. Placenta, 46, 45-48. Abstract.  Author URL.
Hughes A, Greisen G, Arce JC, Thornton S (2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year. Acta Obstetricia et Gynecologica Scandinavica, 93(1), 109-112. Abstract.
Hughes A, Greisen G, Arce J-C, Thornton S (2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year. Acta Obstet Gynecol Scand, 93(1), 109-112. Abstract.  Author URL.
Kay O, Hughes A, Saade G, Bennett P, Terzidou V, Thornton S (2014). Recent advances in the prevention and treatment of preterm labour: Oxytocin antagonists and the silicone (Arabin) pessary. Fetal and Maternal Medicine Review, 25(2), 134-145. Abstract.

Chapters

Hughes AE, Smith GCS (2019). Screening and Intervention for Fetal Growth Restriction. In  (Ed) Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits, 279-286.  Abstract.

Conferences

Hughes AE, Kuang A, Lim B, Fore R, Hatem G, Allard C, Morris AP, Lawlor DA, Beaumont RN, Jr LWL, et al (2022). A multi-ancestry genome-wide association study of umbilical cord insulin and c-peptide levels will form the basis of an important future bioresource.  Author URL.
Hughes AE, Lim B, Beaumont RN, Hattersley AT, Lawlor DA, Freathy RM (2022). Fetal genetics is a critical determinant of fetal growth that is independent of maternal glucose and fetal insulin in individuals of South Asian ancestry.  Author URL.
Haulder MH, Hughes AEH, Beaumont RNB, Lim BL, Leirer DL, Hattersley ATH, Shields BMS, Freathy RMF (2022). Lower birthweight of South Asian babies compared with Europeans is not explained by variation in contributions of a fetal genetic score, maternal glycemia or other basic maternal characteristics.  Author URL.
Hughes AE, De Franco E, Freathy RM, Flanagan SE, Hattersley AT (2021). 493 Using human monogenic disease to quantify the contribution of fetal insulin to birth weight.
Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2021). Genetic scores explain variation in birthweight that is not captured by measured clinical variables such as maternal glucose.  Author URL.
Hughes AE, Houghton JAL, Chakera AJ, Spyer G, Shepherd MH, Flanagan SE, Hattersley AT (2021). Non-invasive prenatal diagnosis of fetal genotype in pregnant women with GCK-MODY: the impact of precision medicine on antenatal care.  Author URL.
Hughes AE, De Franco E, Freathy RM, Flanagan SE, Hattersley AT (2021). Using human monogenic disease to quantify the contribution of fetal insulin to birth weight.  Author URL.
Sovio U, Gaccioli F, Hughes AE, Charnock-Jones DS, Smith GCS (2019). First Trimester AFP: PAPP-A Ratio in the Prediction of Adverse Pregnancy Outcome.  Author URL.
Smith G, Jayasuriya NA, Hughes AE, Sovio U, Cook E, Charnock-Jones DS (2019). Low cortisol to cortisone ratio precedes pre-eclampsia (PE) and fetal growth restriction (FGR).  Author URL.
Hughes AE, Patel KA, Lowe LP, Jr LWL, Dunne FP, Hattersley AT, Freathy RM (2018). Women with isolated fasting hyperglycaemia in pregnancy are at a higher genetic risk for diabetes type 2.  Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Birth weight is not just influenced by maternal glycaemia: there is an independent effect of fetal genetics, which has a similar impact to maternal fasting plasma glucose.  Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Fetal genetics impacts on risk of macrosomia independently of maternal hyperglycaemia.  Author URL.

Publications by year


In Press

Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (In Press). Genetic scores explain variation in birthweight that is not captured by easily measured clinical and anthropometric variables.  Abstract.

2022

Hughes AE, Kuang A, Lim B, Fore R, Hatem G, Allard C, Morris AP, Lawlor DA, Beaumont RN, Jr LWL, et al (2022). A multi-ancestry genome-wide association study of umbilical cord insulin and c-peptide levels will form the basis of an important future bioresource.  Author URL.
Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2022). Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures. BMC Pediatrics, 22(1). Abstract.
Locke JM, Dusatkova P, Colclough K, Hughes AE, Dennis JM, Shields B, Flanagan SE, Shepherd MH, Dempster EL, Hattersley AT, et al (2022). Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study. Diabetologia, 65(1), 246-249. Author URL.
Hughes AE, Lim B, Beaumont RN, Hattersley AT, Lawlor DA, Freathy RM (2022). Fetal genetics is a critical determinant of fetal growth that is independent of maternal glucose and fetal insulin in individuals of South Asian ancestry.  Author URL.
Haulder MH, Hughes AEH, Beaumont RNB, Lim BL, Leirer DL, Hattersley ATH, Shields BMS, Freathy RMF (2022). Lower birthweight of South Asian babies compared with Europeans is not explained by variation in contributions of a fetal genetic score, maternal glycemia or other basic maternal characteristics.  Author URL.

2021

Hughes AE, De Franco E, Freathy RM, Flanagan SE, Hattersley AT (2021). 493 Using human monogenic disease to quantify the contribution of fetal insulin to birth weight.
Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2021). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.
Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2021). Genetic scores explain variation in birthweight that is not captured by measured clinical variables such as maternal glucose.  Author URL.
Hughes AE, De Franco E, Globa E, Zelinska N, Hilgard D, Sifianou P, Hattersley AT, Flanagan SE (2021). Identification of GCK-maturity-onset diabetes of the young in cases of neonatal hyperglycemia: a case series and review of clinical features. Pediatr Diabetes, 22(6), 876-881. Abstract.  Author URL.
Hughes AE, Houghton JAL, Chakera AJ, Spyer G, Shepherd MH, Flanagan SE, Hattersley AT (2021). Non-invasive prenatal diagnosis of fetal genotype in pregnant women with GCK-MODY: the impact of precision medicine on antenatal care.  Author URL.
Hughes AE, Hattersley AT, Flanagan SE, Freathy RM (2021). Two decades since the fetal insulin hypothesis: what have we learned from genetics?. Diabetologia, 64(4), 717-726. Abstract.
Hughes AE, De Franco E, Freathy RM, Flanagan SE, Hattersley AT (2021). Using human monogenic disease to quantify the contribution of fetal insulin to birth weight.  Author URL.

2020

Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2020). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.
Hughes AE, Hayes MG, Egan AM, Patel KA, Scholtens DM, Lowe LP, Lowe Jr WL, Dunne FP, Hattersley AT, Freathy RM, et al (2020). All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes. Wellcome Open Research, 5, 175-175. Abstract.

2019

Jayasuriya NA, Hughes AE, Sovio U, Cook E, Stephen Charnock-Jones D, Smith GCS (2019). A lower maternal cortisol-to-cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. Journal of Clinical Endocrinology and Metabolism, 104(6), 2355-2366. Abstract.
Hughes AE, Smart NJ, Daniels IR (2019). Acute colonic pseudo‐obstruction after caesarean section: a review and recommended management algorithm. The Obstetrician & Gynaecologist, 21(4), 283-290.
Sovio U, Gaccioli F, Hughes AE, Charnock-Jones DS, Smith GCS (2019). First Trimester AFP: PAPP-A Ratio in the Prediction of Adverse Pregnancy Outcome.  Author URL.
Smith G, Jayasuriya NA, Hughes AE, Sovio U, Cook E, Charnock-Jones DS (2019). Low cortisol to cortisone ratio precedes pre-eclampsia (PE) and fetal growth restriction (FGR).  Author URL.
Hughes AE, Smith GCS (2019). Screening and Intervention for Fetal Growth Restriction. In  (Ed) Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits, 279-286.  Abstract.
Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS (2019). The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta, 81, 25-31. Abstract.

2018

Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract.  Author URL.
Hughes AE, Patel KA, Lowe LP, Jr LWL, Dunne FP, Hattersley AT, Freathy RM (2018). Women with isolated fasting hyperglycaemia in pregnancy are at a higher genetic risk for diabetes type 2.  Author URL.

2017

Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Birth weight is not just influenced by maternal glycaemia: there is an independent effect of fetal genetics, which has a similar impact to maternal fasting plasma glucose.  Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Fetal genetics impacts on risk of macrosomia independently of maternal hyperglycaemia.  Author URL.

2016

Brew O, Nikolopoulou E, Hughes A, Christian M, Lee Y, Oduwole O, Sullivan MHF, Woodman A (2016). Quality of placental RNA: Effects of explant size and culture duration. Placenta, 46, 45-48. Abstract.  Author URL.

2014

Hughes A, Greisen G, Arce JC, Thornton S (2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year. Acta Obstetricia et Gynecologica Scandinavica, 93(1), 109-112. Abstract.
Hughes A, Greisen G, Arce J-C, Thornton S (2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year. Acta Obstet Gynecol Scand, 93(1), 109-112. Abstract.  Author URL.
Kay O, Hughes A, Saade G, Bennett P, Terzidou V, Thornton S (2014). Recent advances in the prevention and treatment of preterm labour: Oxytocin antagonists and the silicone (Arabin) pessary. Fetal and Maternal Medicine Review, 25(2), 134-145. Abstract.

ALice_Hughes Details from cache as at 2022-10-04 10:49:36

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External Engagement and Impact

Awards

  • Association of Physicians of Great Britain and Ireland Prize, 2013
  • Peninsula Student Clinical Academics' Award winner, 2015
  • Nominated for the Diabetes UK Nick Hales Young Investigator Award, 2017
  • First prize abstract winner, Diabetes UK Diabetes in Pregnancy Conference, 2021
  • Young Diabetologist and Endocrinologist Endocrine Forum Travel Award winner, 2022

Competitively funded studentships and postdoctoral fellowships

  • Association of Physicians of Great Britain and Ireland Intercalation Studentship, 2013-14
  • EASD Diabetes in Pregnancy Study Group Young Investigator Travel Fellowship, 2019
  • Wellcome Trust Funded GW4 Clinical Academic Training PhD Fellowship

External positions

  • American Diabetes Association Precision Medicine in Diabetes initiative, Gestational Diabetes Precision Prognostics group member

Teaching

BMBS Healthcare in Practice SSU theme lead, Exeter Locality 2020-22.

Awarded “Above and Beyond” award for contribution to BMBS teaching programme 2022.

Supervision / Group

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