Events 2019

Date  TimeTitleDescriptionLocation
22nd January 2019 10am-1pm

Institute of Health Research


Health Statistics Group – Stats Advice Clinics

Members of the Health Statistics team will be available to assist with your Stats related queries – please email them individually to discuss your query or arrange an appointment

Dr Lauren Rodgers - Email: L.R.Rodgers@exeter.ac.uk

Attendees will be asked to complete a questionnaire prior to their Stats Clinic appointment, to enable the team to offer the best advic.

South Cloisters, St Luke’s
22nd January 2019 1-2pm

APEx Seminar

A future vision for general practice
Helen Stokes-Lampard, Chair, Royal College of General Practitioners

Contact Joy Choules j.l.choules@exeter.ac.uk 01392 722743 http://medicine.exeter.ac.uk/apex/seminars/

G18, St Luke's
23rd January 2019

4.00-5.30pm

Tea & coffee available from 3.30pm

Cardiovascular Health Research Group
Seminar Series, 17th Meeting

Rapid control of moderate and severe hypertension: safety and efficacy
Andrew Jordan
Consultant Cardiologist, Poole Hospital NHS Foundation Trust

Physical activity and cardiac rehabilitation in heart failure
Grace Dibben
PhD Student, University of Exeter Medical School

ALL STAFF AND STUDENTS ARE WELCOME

JS07, Smeall Building, St Lukes

Video linked to Rm F10 Knowledge Spa, Truro

25th January 2019 2.30-3.30pm Seminar Severity Adjusted Probability Of Being Cost-Effective: A Novel Approach To Integrate Severity And Cost-Effectiveness With Applications To Norway And The Netherlands

Dr Matthijs Versteegh
Institute for Medical Technology Assessment, Erasmus University of Rotterdam

In the context of priority setting, a differential cost-effectiveness threshold can be used to reflect a higher societal willingness-to-pay for Quality Adjusted Life Year gains in the worse off. This can reflect distributional concerns for particular groups, such as those who are more severely ill. Now that more countries use such a framework –Norway and The Netherlands have formally adopted it - applying the framework correctly becomes even more important. In order to operationalize a decision model with severity-based thresholds, one needs to define severity and estimate it in the context of treatments. An often ignored issue in this context is the uncertainty surrounding estimates of severity. However, since all estimates of severity, which subsequently translate into higher or lower thresholds, are surrounded with uncertainty, this should be adequately dealt with. In his talk for Exeter staff, Matthijs will present a new method to integrate ‘severity based thresholds’ with cost-effectiveness models. He will also show a simple tool to calculate QALY losses for the UK, including uncertainty.

Please register your attendance at https://bit.ly/2E9cYcg

For further information please contact l.k.watson@exeter.ac.uk

JS07, Smeall Building, St Luke's Campus
5th February 2019

12.30-1.30pm

Refreshments available from 12 noon

IHR & Exeter Clinical Trials Unit Seminar

Measuring site performance in multicenter randomized trials

Prof Alan Montgomery
Director of Nottingham Clinical Trials Unit and Professor of Medical Statistics and Clinical Trials

Large multicentre trials are complex and expensive projects. Researchers focus great efforts on achieving recruitment targets, but this alone does not ensure overall success of a study. Other important factors include how well sites retain participants, and whether they can collect high quality, complete data in a timely manner. There is no consensus on the key metrics that should be used to measure site performance. A standardised set of clear and accessible summaries of site performance could facilitate early identification and resolution of potential problems, minimising their impact.
We used a comprehensive, mixed methods approach that we adapted from the COMET Initiative for developing core outcome sets in order to identify potential metrics and achieve consensus about the final set. I will present methods and results of the different phases of the project, demonstrate a practical tool that we developed to display key metrics during a study, and discuss future use and evaluation of the core set.

For further information please contact: j.jacob@exeter.ac.uk

JS07, Smeall Building, St Luke's
8th February 2019 1-2pm APEx Seminar

Should clinicians measure blood pressure in 2019?
Prof Richard McManus, Professor of Primary Care Research, University of Oxford

Contact Joy Choules j.l.choules@exeter.ac.uk 01392 722743 http://medicine.exeter.ac.uk/apex/seminars/

JS07, Smeall Building, St Luke's
12th February 2019 10am-12pm

Institute of Health Research


Health Statistics Group – Stats Advice Clinics

Members of the Health Statistics team will be available to assist with your Stats related queries – please email them individually to discuss your query or arrange an appointment

Dr Beverley Shields - Email: b.shields@exeter.ac.uk

Attendees will be asked to complete a questionnaire prior to their Stats Clinic appointment, to enable the team to offer the best advic.

RILD Building
(Royal Devon and Exeter Hospital, Wonford site)
14th February 2019 2.30-3.30pm Seminar PERSEPHONE; 6 vs. 12 months of adjuvant trastuzumab in patients with HER2+ early breast cancer: A cost effectiveness analysis.

Professor Claire Hulme
Health Economics Group, Institute of Health Research, UEMS

Adjuvant trastuzumab has significantly improved outcomes for HER2+ EBC, using the 12m duration empirically adopted from pivotal registration trials. Given an annual per patient cost of trastuzumab treatment of over £30,000, a shorter duration has the potential to improve cost-effectiveness if efficacy is maintained.

This cost-effectiveness analysis was based on data from the PERSEPHONE trial, a phase III non-inferiority RCT comparing 6 to 12m Trastuzumab, the largest reduced-duration non-inferiority trial internationally. A landmark analysis 6 months into treatment was conducted, comparing costs and quality of life throughout follow-up (6m – 24m post treatment start). Multiple imputation was required to impute incomplete quality of life data. Quality Adjusted Life Years (QALYs) were adjusted for differences at baseline. Uncertainty is estimated using the non-parametric bootstrap method. 4009 patients were disease free at 6m (6m: n=2000, 12m: n=2009) and therefore eligible for the analysis. The average costs for an individual in the 6m arm and 12 month arm were £2,538.64 (95% CI: £2,383.38 - £2700.72) and £12,333.83 (95% CI: £12,098.58 - £12,562.27), respectively, giving an average cost saving of £9,793.25 (95% CI: £9,515.86 - £10,071.64) per individual. Trastuzumab treatment and administration accounted for £9,699.58 (95% CI: £9,436.20 - £9.954.67) of this cost saving, the remaining arising from cardiac assessment and treatment costs and inpatient days. The average QALYs for an individual in the 6m arm and 12 month arm were 1.146 (95% CI: 1.131 – 1.161) and 1.128 (95% CI: 1.113 – 1.144), respectively, giving an average QALY difference of 0.018 (95% CI: -0.003 – 0.039). Thus, the 6m arm dominated with a probability of being cost effective of 100%. 6m of Trastuzumab was shown to be cost effective compared to 12m with cost-savings and no evidence of a detriment to quality of life.

Authors: Hulme C, Hall P, Shinkins B, Chehadah F, McCabe C, Dunn J, Hiller L, Earl HM. This research was funded by the NIHR HTA Programme (06/303/98). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health

Please register your attendance at https://bit.ly/2E9cYcg

For further information please contact l.k.watson@exeter.ac.uk

JS07, Smeall Building, St Luke's Campus
27th February 2019 2-4pm

NIHR Pitch & Putt Hustings Event

This is a good opportunity to pitch your early grant ideas for NIHR applications.

Please remember everyone is invited whether you are pitching or not.  Post Docs welcome to pitch or be part of the audience.

The aims of the event  are:

  • To pitch early stage research ideas to develop proposals and connect with potential collaborators
  • To pitch formed research proposals to receive funder specific feedback
  • Provide the opportunity, as part of the audience, to gain knowledge of what is happening across the university
  • Provide opportunity for networking across all career stages of the academic community.

Actions:

If you are thinking of pitching, please remember it  isn’t about the fine detail but:

  • what is the question/problem
  • why is it novel
  • what is my approach to answering it
  • why am I in a really good position to answer/tackle it now OR what support/advice are you looking for.
North Cloisters 12 (NC12), St Luke's (VC to Cornwall – ECEHH F083).
27th February 2019 2pm

Guest lecture

Radiological and Microbiological Challenges of Human Spaceflight

Ben Johnson, Marshall’s Scholar from the US
 
Ben is a postgraduate psychology student currently studying at the University of Edinburgh. His main interest is in addressing the challenges of promoting both physical and mental health in extreme environments, especially as found in space travel. He has worked at NASA, Johns Hopkins Medicine, and various universities, researching the psychology, physiology, and microbiology of human space flight. He will be presenting human microbiome research from the NASA HI-SEAS Mars simulation titled, "Inner Space in Outer Space: Microbial monitoring at the HI-SEAS Long Duration Mars Simulations” and radiological research from Johns Hopkins and the NASA Space Radiation Laboratory titled, "Targeting the Medial Prefrontal Cortex to Ameliorate Radiation-Induced Neurobehavioral Deficits.”
 
To book onto this event, please contact s.dick@exeter.ac.uk - Samantha Dick.

If any academic or student groups would like to meet with Ben before or after this event for a more in depth conversation, please also contact Samantha.

3.06, South Cloisters, St Luke's
5th March 2019 12-3pm

Institute of Health Research


Health Statistics Group – Stats Advice Clinics

Members of the Health Statistics team will be available to assist with your Stats related queries – please email them individually to discuss your query or arrange an appointment

Dr Fiona Warren - Email: F.C.Warren@exeter.ac.uk

Attendees will be asked to complete a questionnaire prior to their Stats Clinic appointment, to enable the team to offer the best advic.

Smeall Building, St Luke’s