Dr Susan Martin
Postdoctoral Research Fellow
S.Martin3@exeter.ac.uk
RILD Building Level 3
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Overview
Dr Susan Martin is a postdoctoral research fellow in the Genetics of Complex Traits group, where she works with Professor Inês Barroso researching the genetics of glycaemic traits and multi-ancestry analyses. She also researches the genetics of favourable adiposity – identifying genetic factors associated with higher fat mass but lower risk of heart disease, and establishing whether or not these genetic factors are associated with less fat in the organs and more under the skin.
Susan joined the University of Exeter in 2018, after completing her PhD on estimating heterogeneity variance under sparsity at the University of Southampton.
Qualifications
- PhD Mathematics, University of Southampton
- MSc Medical Statistics with specialisation in Modern Epidemiology, University of Leicester
- BSc Mathematics with Biology, University of Southampton
Publications
Journal articles
Perez-Cornago A, Smith-Byrne K, Hazelwood E, Watling CZ, Martin S, Frayling T, Lewis S, Martin RM, Yaghootkar H, Travis RC, et al (2023). Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: a Mendelian randomization analysis. Cancer Med, 12(15), 16482-16489. Abstract. Author URL.
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.
Martin S, Sorokin EP, Thomas EL, Sattar N, Cule M, Bell JD, Yaghootkar H (2022). Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: a Mendelian Randomization Study. Diabetes Care, 45(2), 460-468. Abstract.
Holling H, Jansen K, Böhning W, Böhning D, Martin S, Sangnawakij P (2022). Estimation of Effect Heterogeneity in Rare Events Meta-Analysis. Psychometrika, 87(3), 1081-1102. Abstract. Author URL.
Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, et al (2021). Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. Diabetes, 70(8), 1843-1856. Abstract. Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9). Abstract.
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, Freathy RM, Hagenaars SP, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet, 30(24), 2371-2382. Abstract. Author URL.
Böhning D, Martin S, Sangnawakij P, Jansen K, Böhning W, Holling H (2021). Nonparametric Estimation of Effect Heterogeneity in Rare Events Meta-Analysis: Bivariate, Discrete Mixture Model. Lobachevskii Journal of Mathematics, 42(2), 308-317.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.
Conferences
Heald A, Martin S, Yaghootkar H, Fachim H, Siddals K, Cortes G, Narayanan RP, Frayling T, Gibson JM (2019). Do the 'favourable adiposity' genes influence weight / metabolic change over time in type 2 diabetes? Results from a 14 year prospective UK study. Author URL.
External Engagement and Impact
Awards
- Best poster presentation award - Study Group on the Genetics of Diabetes conference 2022.
- One of four nominees for Diabetes UK Young Investigator Award, Diabetes UK conference 2020 (conference/award cancelled).
