Clinical and Biomedical Sciences

Dr Asami Oguro-Ando

Dr Asami Oguro-Ando

Lecturer

 A.Oguro-Ando@exeter.ac.uk

 01392 408258

 RILD Building Wellcome Wolfson Centre

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Dr. Oguro-Ando has been interested in life science since she was a child, especially, how lives play rolls in plasticity to the environment. For her interest, she took the basic science course in my bachelor and studied fundamental physics and biology, before studying for an MSc and PhD in the Molecular chaperone and protein degradation at the University of Tokyo, Health Science and Physiology. As she was finishing her PhD thesis, Neuropsychiatric disorders were fascinating to her that there were many genes characterized and few animal models established, but still, it is unclear. She was exhilarated by the potential for growth in the field and spent four years at Prof. Daniel Geschwind lab (UCLA) in US for her first posdoc, next three years at Prof. Peter Burbach lab (UMC Utrecht) in the Netherlands for her second posdoc to develop her specificities of Autism spectrum disorder (ASD) research and joined in University of Exeter medical school in 2016. 

Current Awards

  • 2009 Cold Spring Harbor Laboratories Course Scholarship award, NY, USA 
  • 2010 Keystone Symposia Scholarship award, Utah, USA
  • 2016 FENS satellite meeting travel award, Copenhagen, Denmark
  • 2018 University of Exeter Above and Beyond Award for Collaboration, University of Exeter, UK
  • 2018 Selected as a member for Aurora Leadership programme for women
  • 2019 University of Exeter Above and Beyond Award for Challenge, University of Exeter, UK
  • 2020 Exeter's Teaching Awards, outstanding pastoral support nominated, University of Exeter, UK
  • 2020 University of Exeter Above and Beyond Award for Challenge, University of Exeter, UK

Qualifications

  • Ph.D Life Science (University of Tokyo, Tokyo, Japan)

Career

2016- Lecturer, University of Exeter Medical School

2014-2016 JSPS postdoctoral fellow in abroad, UMC Utrecht, The Netherlands

2013-2014 Canon foundation postdoctoral fellow, UMC Utrecht, The Netherlands

2012-2013 Postdoctoral researcher, UMC Utrecht, The Netherlands

2011-2012 Postdoctoral researcher, UCLA, USA

2010-2011 Uehara life science foundation Postdoctoral fellow, UCLA, USA

2008-2010 JSPS postdoctoral fellow, UCLA, USA

Links

Research group links

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Research

Research interests

Asami’s group research aim is to further our understanding of the molecules, cells and circuits that underlie neurodevelopmental disorders affecting mental health including Autism is critical for developing more effective therapies for these disorders.

Genomics data has recently revealed causal relationships between specific genetic variation and risk for neuropsychiatric disease. However, there still remains a missing link tying genetic variation to changes at the molecular, cellular, and systems biology and behavior levels. My goal is to provide this “missing link” by using both high-throughput rodents model methodologies and experimental validation of their predictions in order to clarify how genetic risk factors exert their mechanistic influence on human behavior. My new research group has focused not only on discovering psychiatric disease-related genetic variation, but also on using model systems to uncover the biological mechanisms that underlie these associations.

Research networks

・EDI Subcommittee member, British Society for Neuroendocrinology (BSN)

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Publications

Journal articles

Bamford RA, Zuko A, Eve M, Sprengers JJ, Post H, Taggenbrock RLRE, Fäβler D, Mehr A, Jones OJR, Kudzinskas A, et al (2024). CNTN4 modulates neural elongation through interplay with APP. Open Biol, 14(5). Abstract.  Author URL.
Firth W, Robb JL, Stewart D, Pye KR, Bamford R, Oguro‐Ando A, Beall C, Ellacott KLJ (2024). Regulation of astrocyte metabolism by mitochondrial translocator protein <scp>18 kDa</scp>. Journal of Neurochemistry Abstract.
D'Atri I, Martin E-R, Yang L, Sears E, Baple E, Crosby AH, Chilton JK, Oguro-Ando A (2024). Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM). Neurosci Lett, 830 Abstract.  Author URL.
Harlow CE, Patel VV, Waterworth DM, Wood AR, Beaumont RN, Ruth KS, Tyrrell J, Oguro-Ando A, Chu AY, Frayling TM, et al (2023). Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk. Hum Mol Genet, 32(3), 496-505. Abstract.  Author URL.
Martin E-R, Gandawijaya J, Oguro-Ando A (2022). A novel method for generating glutamatergic SH-SY5Y neuron-like cells utilizing B-27 supplement. Frontiers in Pharmacology, 13
Washer SJ, Flynn R, Oguro‐Ando A, Hannon E, Burrage J, Jeffries A, Mill J, Dempster EL (2022). Functional characterization of the schizophrenia associated gene <scp><i>AS3MT</i></scp> identifies a role in neuronal development. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189(5), 151-162. Abstract.
Harlow CE, Gandawijaya J, Bamford RA, Martin E-R, Wood AR, van der Most PJ, Tanaka T, Leonard HL, Etheridge AS, Innocenti F, et al (2022). Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet, 109(9), 1638-1652. Abstract.  Author URL.
Eve M, Gandawijaya J, Yang L, Oguro-Ando A (2022). Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder. Front Psychiatry, 13 Abstract.  Author URL.
Josiah SS, Meor Azlan NF, Oguro-Ando A, Zhang J (2022). Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting. Journal of Visualized Experiments(190).
Josiah SS, Meor Azlan NF, Oguro-Ando A, Zhang J (2022). Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting. Journal of Visualized Experiments(190).
Oguro-Ando A, Bamford RA, Sital W, Sprengers JJ, Zuko A, Matser JM, Oppelaar H, Sarabdjitsingh A, Joëls M, Burbach JPH, et al (2021). Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Transl Psychiatry, 11(1). Abstract.  Author URL.
Gandawijaya J, Bamford RA, Burbach JPH, Oguro-Ando A (2020). Cell Adhesion Molecules Involved in Neurodevelopmental Pathways Implicated in 3p-Deletion Syndrome and Autism Spectrum Disorder. Front Cell Neurosci, 14 Abstract.  Author URL.
Bamford RA, Widagdo J, Takamura N, Eve M, Anggono V, Oguro-Ando A (2020). The Interaction Between Contactin and Amyloid Precursor Protein and its Role in Alzheimer’s Disease. Neuroscience, 424, 184-202.
Nelissen TP, Bamford RA, Tochitani S, Akkus K, Kudzinskas A, Yokoi K, Okamoto H, Yamamoto Y, Burbach JPH, Matsuzaki H, et al (2018). CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus. Neuroscience, 372, 114-125. Abstract.  Author URL.
Oguro-Ando A, Zuko A, Kleijer KTE, Burbach JPH (2017). A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders. Mol Cell Neurosci, 81, 72-83. Abstract.  Author URL.
Zuko A, Oguro-Ando A, Post H, Taggenbrock RLRE, van Dijk RE, Altelaar AFM, Heck AJR, Petrenko AG, van der Zwaag B, Shimoda Y, et al (2016). Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis. FRONTIERS IN MOLECULAR NEUROSCIENCE, 9
Zuko A, Oguro-Ando A, van Dijk R, Gregorio-Jordan S, van der Zwaag B, Burbach JPH (2016). Developmental role of the cell adhesion molecule Contactin-6 in the cerebral cortex and hippocampus. Cell Adh Migr, 10(4), 378-392. Abstract.  Author URL.
Bruining H, Matsui A, Oguro-Ando A, Kahn RS, Van't Spijker HM, Akkermans G, Stiedl O, van Engeland H, Koopmans B, van Lith HA, et al (2015). Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development. Biol Psychiatry, 78(7), 485-495. Abstract.  Author URL.
Oguro-Ando A, Rosensweig C, Herman E, Nishimura Y, Werling D, Bill BR, Berg JM, Gao F, Coppola G, Abrahams BS, et al (2015). Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR. Mol Psychiatry, 20(9), 1069-1078. Abstract.  Author URL.
Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Peñagarikano O, Stein JL, Li A, Oguro-Ando A, et al (2015). JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron, 88(6), 1173-1191. Abstract.  Author URL.
Shimizu M, Oguro-Ando A, Ohoto-Fujita E, Atomi Y (2014). Toll-interacting protein pathway: degradation of an ubiquitin-binding protein. Methods Enzymol, 534, 323-330. Abstract.  Author URL.
Zuko A, Kleijer KTE, Oguro-Ando A, Kas MJH, van Daalen E, van der Zwaag B, Burbach JPH (2013). Contactins in the neurobiology of autism. Eur J Pharmacol, 719(1-3), 63-74. Abstract.  Author URL.
Oguro A, Kubota H, Shimizu M, Ishiura S, Atomi Y (2011). Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins. Neurosci Lett, 503(3), 234-239. Abstract.  Author URL.
Oguro-Ando A (2008). Gravity Response and Disuse Atrophy in Skeletal Muscle: Understanding from Extracellular Matrix-Collagen and its Molecular Chaperon HSP47. Biological Sciences in Space, 22(4).
Oguro A, Sakurai T, Fujita Y, Lee S, Kubota H, Nagata K, Atomi Y (2006). The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts. Genes Cells, 11(11), 1253-1265. Abstract.  Author URL.
Sakurai T, Fujita Y, Ohto E, Oguro A, Atomi Y (2005). The decrease of the cytoskeleton tubulin follows the decrease of the associating molecular chaperone alphaB-crystallin in unloaded soleus muscle atrophy without stretch. FASEB J, 19(9), 1199-1201. Abstract.  Author URL.
Oguro A, Sakurai T, Okuno M, Nagata K, Atomi Y (2004). The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions. Biol Sci Space, 18(3), 150-151. Abstract.  Author URL.
Oguro A, Sakurai T, Otawa M, Okuno M, Atomi Y (2003). The content of heat shock protein 47 (HSP47), a collagen-specific stress protein, changes with gravitational conditions in skeletal muscle. Biol Sci Space, 17(3), 206-207. Abstract.  Author URL.

Conferences

Washer S, Oguro-Ando A, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Molenhuis RT, Oguro-Ando A, Burbach JP, Bruining H, Kas MJ (2014). Deletion of contactin-4 leads to cognitive rigidity and aberrant cortex development in mice.  Author URL.
Molenhuis RT, Oguro-Ando A, Burbach JP, Bruining H, Kas MJ (2014). Deletion of contactin-4 leads to cognitive rigidity and aberrant motor cortex development in mice.  Author URL.
Zuko A, Oguro-Ando A, Kleijer KTE, Van der Zwaag B, Post H, Altelaar AFM, Heck AJR, Pasterkamp RJ, Burbach JPH (2014). Interaction of the autism gene product contactin-6 with synaptic proteins.  Author URL.
Zuko A, Oguro-Ando A, Kleijer KTE, van der Zwaag B, Post H, Altelaar AFM, Heck AJR, Pasterkamp RJ, Burbach JPH (2014). Interaction of the autism gene product contactin-6 with synaptic proteins.  Author URL.
Oguro-Ando A, Rosensweig C, Herman E, Nishimura Y, Werling D, Berg J, Gao F, Coppola G, Abrahams B, Geschwind D, et al (2012). Cyfip1, a gene located within the 15q duplication region, regulates neuron morphological changes through the mTOR cascade.  Author URL.

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External Engagement and Impact

Committee/panel activities

British Society for Neuroendocrinology, EDI Sub-committee member

https://www.neuroendo.org.uk

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Supervision / Group

Postgraduate researchers

  • Madie Eve
  • Josan Gandawijaya
  • Charli Harlow
  • Sunday Solomon Josiah
  • Emily-Rose Martin
  • Liming Yang

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